• Asian Pacific Journal of Cancer Prevention
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• v.17 no.7
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• pp.3265-3269
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• 2016

Background: Around half of input data in the global burden of disease cancer collaboration (GBD-CC) and GLOBOCAN projects come from low quality sources, mainly from developing countries. This may lead to loss of precision in estimates. Our question was: Are the absolute values and trends of the GBD-CC and GLOBOCAN estimates for lung cancer (LC) in Iran consistent with available statistics?. Materials and Methods: Incidence and mortality statistics were extracted from national reports (N.IRs & N.MRs) and GBD-CC (GBD-incidence & mortality) and GLOBOCAN databases for 1990-2013 where available. Trends were analyzed and absolute values and annual percentage changes (APCs) were estimated and compared. Incompleteness of case ascertainment at the Iranian national cancer registry and Iranian national civil registration was assessed for better understanding. Results: Trends of N.IRs were significantly rising for males (APC: 19.4; 95% CI: 12.5-26.7) and females (23.2; 16.0-30.8). Trends of GBD-incidence were stable for males (-0.2; -1.5-1.1) and females (-1.0; -2.3-0.4). Absolute N.IRs were less than GBD-incidence steadily except for 2009. Trend of N.MRs was increasing up to 2004, but stable thereafter. Trends of GBD-mortality were also stable. Absolute N.MRs were less than GBD-mortality for years up to 2003 and more than GBD-mortality since 2005. The estimates of GLOBOCAN were more than N.IRs and N.MRs. Conclusions: The GBD-CC and GLOBOCAN values for LC in Iran are underestimates. Generation of data quality indices to present along with country specific estimates is highly recommended.

• Journal of Life Science
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• v.29 no.9
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• pp.964-971
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• 2019

Hepatic lipid accumulation and insulin resistance increases in patients with non-alcoholic fatty liver disease. Piperine is a major compound found in black pepper (Piper nigrum) and long pepper (P. longum). Piperine has been used in fine chemical for its anti-cancer, anti-obesity, anti-diabetic, anti-inflammatory and anti-oxidant properties. However, the signaling-based mechanism of piperine and its role as an inhibitor of lipogenesis and insulin resistance in human hepatocyte cells remains ill-defined. In the present study, we explored the effects of piperine on lipid accumulation and insulin resistance, and explored the potential underlying molecular mechanisms in palmitate-treated HepG2 cells. Piperine treatment resulted in a significant reduction of triglyceride content. Furthermore, piperine treatment decreased palmitate-treated intracellular lipid deposition by inhibiting the lipogenic target genes, sterol-regulatory-element-binding protein 1c (SREBP-1c) and fatty acid synthase (FAS); whereas the expression of carnitine palmitoyl transferase (CPT-1) and phosphorylation of acetyl coenzyme A carboxylase (ACC) gene involved in fatty acid oxidation was increased. Moreover, piperine also inhibited the phosphorylation of insulin receptor substrate (IRS)-1 (Ser307). Piperine treatment modulated palmitate-treated lipid accumulation and insulin resistance in HepG2 cells with concomitant reduction of lipogenic target genes, such as SREBP-1 and FAS, and induction of CPT-1-ACC and phosphorylation of IRS-1 (Tyr632)-Akt pathways. Therefore, piperine represents a promising treatment for the prevention of lipid accumulation and insulin resistance.

• Korean Journal of Food Science and Technology
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• v.39 no.6
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• pp.701-707
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• 2007

Anti-diabetic effect of Platycodi radix (PR) extract fractions was determined if vitro by investigating insulin-like action, insulin sensitizing action, glucose-stimulated insulin secretion, gene expression related to ${\beta}-cell$ function and mass, and ${\alpha}$-glucoamylase suppressing action. Insulin-like activity was not promoted by the treatment of PR methanol factions in 373-L1 fibroblast. However, treatment with 0, 20 and 100% PR methanol fractions along with 1 ng/mL insulin increased insulin-stimulated glucose uptake in 373-L1 adipocytes. In addition, the treatment of 0% and 100% methanol fractions along with differentiation inducers significantly increased the differentiation of 373-L1 fibroblasts to adipocytes. These fractions may contain insulin sensitizer. The 20%, 80% and 100% methanol fractions enhanced glucose-stimulated insulin secretion in Min6 cells, insulin secreting cell line. This was related to the mechanism to promote glucose sensing and ${\beta}-cell$ proliferation, which was regulated by the induction of IRS-2, glucokinase and PDX-1 genes. As expected, 20, 80 and 100% methanol fractions increased mRNA levels of IRS-2, glucokinase and PDX-1 genes. However, PR fractions did not affect the ${\alpha}-glucoamylase$ activity in vitro. These data suggested that PR extract fractions have anti-diabetic actions through improving insulin sensitization, glucose-stimulated insulin secretion, and ${\beta}-cell$ proliferation. Therefore, PR extracts can be beneficial for anti-diabetic treatment in lean diabetic patients.

• Korean Journal of Remote Sensing
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• v.14 no.2
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• pp.149-164
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• 1998

The main object of this study was to prove the effectiveness of different merging methods by using the high resolution IRS(Indian Remote Sensing Satellite)-1C panchromatic data and the multispectral Landsat TM data. The five methods used to merging the information contents of each of the satellite data were the intensity-hue-saturation(IHS), principal component analysis(PCA), high pass filter(HPF), ratio enhancement method and look-up-table(LUT) procedures. Two measures are used to evaluate the merging method. These measures include visual inspection and comparisons of the mean, standard deviation and root mean square error between merged image and original image data values of each band. The ratio enhancement method was well preserved the spectral characteristics of the data. From visual inspection, PCA method provide the best result, HPF next, ratio enhancement, IHS and LUT method the worst for the preservation of spatial resolution.

• The Bulletin of The Korean Astronomical Society
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• v.38 no.2
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• pp.65.1-65.1
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• 2013

Our understanding of how brown dwarfs form is limited by observational evidence. We report identification of a L328-IRS as a proto-brown dwarf embedded in an isolated dense molecular core. This source exhibits typical properties of a protostar, however, its luminosity (~0.05 $L{\odot}$) is far below than expected from the least massive protostar by the standard star formation theory. The most likely mass accretion rate (~2.4 10-7 $M{\odot}$ yr-1) inferred from its small bipolar outflow is an order of magnitude less than the canonical value for a protostar. The mass available in its envelope is less than 0.1 $M{\odot}$. These points suggest that L328-IRS will accrete the mass of a brown dwarf, but not that of a star. L328 is found to be fairly well isolated from other nearby clouds and seems to be forming three sub-cores simultaneously through a gravitational fragmentation process. Altogether with these, our direct detection of inward motions in L328 which harbors this proto-brown dwarf clearly supports the idea that a brown dwarf forms like a normal star.

• Transactions of the Korean Society of Mechanical Engineers A
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• v.31 no.2 s.257
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• pp.211-220
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• 2007

This work presents an iterated improved reduced system (IIRS) procedure combined with sub-structuring scheme for large structures. Iterated IRS methods are usually more efficient than others because the dynamic condensation matrix is updated repeatedly until the desired convergent values are obtained. However, using these methods simply for large structures causes expensive computational cost and even makes analyses intractable because of the limited computer storage. Therefore, the application of sub-structuring scheme is necessary. Because the large structures are subdivided into several (or more) sub-domains, the construction of dynamic condensation matrix does not require much computation cost in every iteration. This makes the present method much more efficient to compute the eigenpairs both in lower and intermediate modes. In Part I, iterated IRS method combined with sub-structuring scheme for undamped structures is presented. The validation of the proposed method and the evaluation of computational efficiency are demonstrated through the numerical examples.

• Transactions of the Korean Society of Mechanical Engineers A
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• v.31 no.2 s.257
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• pp.221-230
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• 2007

An iterated improved reduced system (IIRS) procedure combined with sub-structuring scheme for nonclassically damped structural systems is presented. For dynamic analysis of such systems, complex eigenproperties are required to incorporate properly the nonclassical damping effect. In complex structural systems, the equations of motion are written in the state space from. Thus, the number of degrees of freedom of the new equations of motion and the size of the associated eigenvalue problem required to obtain the complex eigenvalues and eigenvectors are doubled. Iterated IRS method is an efficient reduction technique because the eigenproperties obtained in each iteration step improve the condensation matrix in the next iteration step. However, although this reduction technique reduces the size of problem drastically, it is not efficient to apply this technique to a single domain finite element model with degrees of freedom over several thousands. Therefore, for a practical application of the reduction method, accompanying sub-structuring scheme is necessary. In the present study, iterated IRS method combined with sub-structuring scheme for nonclssically damped structures is developed. Numerical examples demonstrate the convergence and the efficiency of a newly developed scheme.

• The Bulletin of The Korean Astronomical Society
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• v.36 no.1
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• pp.83.2-83.2
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• 2011

I present results from the Spitzer/IRS study to identify massive young stellar objects (YSOs) in the Galactic Center (GC). Our sample of 107 YSO candidates was selected based on Spitzer/IRAC colors in the central 300 pc region of the Milky Way Galaxy. We obtained IRS spectra over $5{\mu}m$ to $35{\mu}m$, and identified massive YSOs by the presence of a $15.4{\mu}m$ shoulder on the absorption profile of $15{\mu}m$ $CO_2$ ice, suggestive of high $CH_3OH$ abundance on $CO_2$ ice grains. This $15.4{\mu}m$ shoulder is clearly observed in 16 sources and possibly observed in an additional 19 sources. We further show that 9 massive YSOs reveal molecular gas-phase absorption from $CO_2$, $C_2H_2$, and/or HCN, which traces warm and dense gas in YSOs. Our results provide the first spectroscopic census of the massive YSO population in the GC.

• The Bulletin of The Korean Astronomical Society
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• v.28 no.2
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• pp.87-87
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• 2003

• Journal of Physiology & Pathology in Korean Medicine
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• v.34 no.3
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• pp.136-141
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• 2020

The purpose of this study was to investigate the action mechanism of the roots of Adenophora triphylla var. japonica extract (ATE) in 3T3-L1 adipocytes. Cell toxicity test by MTT assay and lipid accumulation was performed to evaluate the inhibitory effect on the differentiation of adipocyte from preadipocytes induced by MDI differentiation medium, while adipogenesis related proteins expression level were evaluated by western blotting. As a result, ATE inhibited MDI-induced adipocyte differentiation in 3T3-L1 cells dose-dependently without cytotoxicity. Our results showed that ATE inhibited the phosphorylation of IRS1, thereby decreasing the expression of PI3K110α and reducing the phosphorylation of AKT and mTOR, resulting in attenuated protein expression of C/EBPα, PPARγ, ap2 and FAS in 3T3-L1 cells. These results suggest anti-adipogenic functions for ATE, and identified IRS1 as a novel target for ATE in adipogenesis.