• 정보관리학회지
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• 제18권2호
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• pp.165-186
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• 2001

이 연구의 목적은 웹상에서 정보검색시스템과 상호대차시스템을 연계하여 이용할 수 있는 현실적 방안을 모색하는 것이다. 이를 위해 상호대차가 가장 활발하게 수행되고 있는 의학 도서관을 대상으로 상호대차현황을 조사, 분석하였고, 상호대차가 처리되는 과정을 단계적으로 분석하였다. 정보검색과 동시에 문헌을 신청할 수 있는 방안을 찾기 위하여 PubMed와 종합목록, 상호대차시스템이 연동될 수 있는 방안을 모색하였다. 연구결과 정부검색시스템의 결과물을 MEDLINE,XML/SGML 형태로 저장할 수 있어서 이를 활용할 수 있었고, 종합목록시스템 유지관리는 모든 도서관이 공동관리하고, 서버와 클라이언트에서 모두 검색되는 방안이 효율적으로 나타났다. 또한 상호대차시스템은 이용자사항은 IP 체크로, 신청내용은 정보검색결과를 저장하여 이것을 상호대차시스템에 그대로 이용하는 방안이 현실적 실현가능성이 있는 방안으로 모색되었다.

• 천문학회보
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• 제37권2호
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• pp.74.1-74.1
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• 2012

We observed the radio sources found from the First Look Survey (FLS) field at the 1.4 GHz radio continuum emission with the Very Large Array (VLA) using the A configuration. We identify point sources and multi component sources at ${\geq}4{\sigma}$ level. We also present the submillimeter properties of the selected radio sources in the FLS field from the Herschel/SPIRE 250/350/500/${\mu}m$ and AzTEC 1.1mm surveys. The counterparts of the radio sources at submillimeter for these called 'submillimeter galaxies (SMGs)' are detected at infrared wavelength with the Spitzer MIPS 24 & 70 ${\mu}m$ sources. Based on the MMT/HECTOSPEC red-shift survey, IRS spectroscopy, and SDSS photometric red-shift survey, the radio sources are likely to be the extragalactic sources. Here, we use the star formation rate (SFR) derived from the MIPS 24 and 70 ${\mu}m$ luminosity to compare the measured SFR from the VLA 1.4 GHz luminosity. These results show that a tight correlation between the SFR from the radio luminosity and the MIPS $24{\mu}m$ rather than that from the MIPS $70{\mu}m$ luminosity. Radio and IR correlation is also used to indicate the radio and IR properties of star-formation in the galaxies and active galactic nuclei (AGNs). Using the counterpart sources selected at IR and radio wavelengths, we employ the IR/radio flux ratios to determine the properties and population of the selected galaxies.

• 대한원격탐사학회:학술대회논문집
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• 대한원격탐사학회 2003년도 Proceedings of ACRS 2003 ISRS
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• pp.654-655
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• 2003

Korea has experienced 10 a Cochlodinium polykrikoides red tide outbreaks during the last 10 years (1993-2002). The monitoring activities at National Fisheries Research and Development Institute (NFRDI) in Korea have been extended to all the coastal waters after the worst of fish killing by C. polykrikoides blooms in 1995. NFRDI is looking forward to finding out the feasibility of red tide detection around Korean waters using satellite remote sensing of NOAA/AVHRR, Orbview-2/SeaWiFS, IRS-P4/OCM and Terra/MODIS on real time base. In this study, we used several alternative methods including climatological analysis, spectral and optical methods which may offer a potential detection of the major species of red tide in Korean waters. The relationship between the distribution of SST and C. polykrikoides bloom areas was studied. In climatological analysis, NOAA, SeaWiFS, OCM satellite data in 20th and 26th August 2001 were chosen using the known C. polykrikoides red tide bloom area mapped by helicopter reconnaissance and ground observation. The 26th August, 2001 SeaWiFS chlorophyll a anomaly imageries against the imageries of non-occurring red tide for August 20, 2001 showed the areas C. polykrikoides occurred. The anomalies of chlorophyll a concentration from satellite data between before and after red tide outbreaks showed the similar distribution of C. polykrikoides red tide in 26th August, 2001. The distribution of the difference in SST between daytime and nighttime also showed the possibility of red tide detection. We used corrected vegetation index (CVI) to detect floating vegetation and submerged vegetation containing algal blooms. The simple result of optical absorption from C. polykrikoides showed that if we use the optical characteristics of each red tide we will be able to get the feasibility of the red tide detection.

• 대한원격탐사학회지
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• 제24권5호
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• pp.483-496
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• 2008

Qualified ground control points (GCPs) are required to construct a digital elevation model (DEM) from a pushbroom stereo pair. An inverse geolocation algorithm for extracting GCPs from ERS SAR data and the SRTM DEM was recently developed. However, not all GCPs established by this method are accurate enough for direct application to the geometric correction of pushbroom images such as SPOT, IRS, etc, and thus a method for selecting and removing inaccurate points from the sets of GCPs is needed. In this study, we propose a method for evaluating GCP accuracy and winnowing sets of GCPs through orientation modeling of pushbroom image and validate performance of this method using SPOT stereo pair of Daejon City. It has been found that the statistical distribution of GCP positional errors is approximately Gaussian without bias, and that the residual errors estimated by orientation modeling have a linear relationship with the positional errors. Inaccurate GCPs have large positional errors and can be iteratively eliminated by thresholding the residual errors. Forty-one GCPs were initially extracted for the test, with mean the positional error values of 25.6m, 2.5m and -6.1m in the X-, Y- and Z-directions, respectively, and standard deviations of 62.4m, 37.6m and 15.0m. Twenty-one GCPs were eliminated by the proposed method, resulting in the standard deviations of the positional errors of the 20 final GCPs being reduced to 13.9m, 8.5m and 7.5m in the X-, Y- and Z-directions, respectively. Orientation modeling of the SPOT stereo pair was performed using the 20 GCPs, and the model was checked against 15 map-based points. The root mean square errors (RMSEs) of the model were 10.4m, 7.1m and 12.1m in X-, Y- and Z-directions, respectively. A SPOT DEM with a 20m ground resolution was successfully constructed using a automatic matching procedure.

• 한국식품과학회지
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• 제46권1호
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• pp.100-107
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• 2014

본 연구에서는 염생식물인 칠면초와 세발나물의 인슐린 저항성을 개선하는 효과를 조사하였다. 본 실험에 사용한 OLETF쥐는 CCK-1 수용체의 결함으로 인해 인슐린 저항성을 걸쳐 제 2형 당뇨병이 유발되는데, 인슐린 저항성이 진행되는 10주령부터 28주령이 될 때까지 칠면초와 세발나물을 18주 동안 섭취시켰다. 염생식물식이군들의 체중이나 공복혈당 변화는 식이기간 동안 전반적으로 대조군과 유의적인 차이를 보이지 않았다. Oral glucose tolerance test에서 염생식물 섭취가 당 내성을 개선하는 효과를 보였으나 그 혈당 변화를 면적으로 환산하였을 때 각 식이군들 간의 유의적인 차이는 관찰되지 않았다. 혈중 insulin 및 HbA1c 수치는 유의하게 낮은 수치를 보였으며, adiponectin 수치는 높고 leptin과 ghrelin 수치는 낮았으나 현저한 차이는 관찰되지 않았다. 세발나물식이군의 혈중 중성지질과 총 cholesterol 수치는 대조군에 비해 유의적으로 더 낮았다. 혈중 지질산화물 함량은 각 식이군 간 유의차가 관찰되지 않았으나 염생식물식이군에서 더 낮은 경향을 보였으며, NF-${\kappa}B$ p65는 지방조직에서 유의적으로 낮은 발현량을 보였다. 또한 두 염생식물식이군에서 인슐린 신호전달의 negative regulator인 $pIRS1^{Ser307}$의 발현량은 대조군에 비해 더 낮음을 확인하였다. 그러므로 칠면초와 세발나물은 생후 성장하면서 인슐린 저항성이 생기는 OLETF쥐의 인슐린 저항성을 현저하게 줄여주지는 못하였으나 그 개선 효과는 있는 것으로 시사되며, 두 염생식물의 급여 기간을 늘려 제 2형 당뇨병을 예방하는 효과에 대한 섬세한 검토가 보완되어야 할 것으로 사료된다.

• 국제학술발표논문집
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• The 9th International Conference on Construction Engineering and Project Management
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• pp.1253-1253
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• 2022

Although the construction industry is changing from a 2D-based to a 3D BIM-based management process, 2D drawings are still used as standards for permits and construction. For this reason, 2D deliverables extracted from 3D BIM are one of the essential achievements of BIM projects. However, due to technical and institutional problems that exist in practice, the process of extracting 2D deliverables from BIM requires additional work beyond generating 3D BIM models. In addition, the consistency of data between 3D BIM models and 2D deliverables is low, which is a major factor hindering work productivity in practice. To solve this problem, it is necessary to build BIM data that meets information requirements (IRs) for extracting 2D deliverables to minimize the amount of work of users and maximize the utilization of BIM data. However, despite this, the additional work that occurs in the BIM process for drawing creation is still a burden on BIM users. To solve this problem, the purpose of this study is to increase the productivity of the BIM process by automating the process of extracting 2D deliverables from BIM and securing data consistency between the BIM model and 2D deliverables. For this, an expert interview was conducted, and the requirements for automation of the process of extracting 2D deliverables from BIM were analyzed. Based on the requirements, the types of drawings and drawing expression elements that require automation of drawing generation in the design development stage were derived. Finally, the method for developing automation technology targeting elements that require automation was classified and analyzed, and the process for automatically extracting BIM-based 2D deliverables through templates and rule-based automation modules were derived. At this time, the automation module was developed as an add-on to Revit software, a representative BIM authoring tool, and 120 rule-based automation rulesets, and the combinations of these rulesets were used to automatically generate 2D deliverables from BIM. Through this, it was possible to automatically create about 80% of drawing expression elements, and it was possible to simplify the user's work process compared to the existing work. Through the automation process proposed in this study, it is expected that the productivity of extracting 2D deliverables from BIM will increase, thereby increasing the practical value of BIM utilization.

• 생명과학회지
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• 제31권8호
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• pp.729-735
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• 2021

제 2 형 당뇨병은 조직의 포도당 흡수 능력에 이상이 있을 때 발생하며, 인슐린에 의한 포도당 섭취와 신진대사는 혈당을 유지하는 기본 활동이며 포도당 섭취는 인슐린이 세포 표면의 수용체에 결합하여 시작되는 다양한 신호 단계를 거친다. 본 연구는 Ecklonia cava에서 분리된 활성 화합물 인 2,7-phloroglucinol-6,6-bieckol이 3T3-L1 지방 세포에서 인슐린 신호전달체계에 따른 포도당 흡수 증가에 미치는 영향에 대한 것이다. 2,7-phloroglucinol-6,6-bieckol 은 3T3-L1 지방 세포에서 농도의존적으로 GLUT4의 발현을 증가시켜 원형질막에서의 glucose uptake 를 증가시켰다. 이는 인슐린 신호 전달 경로에서 2,7-phloroglucinol-6,6-bieckol 에 의한 IRS-1, AKT의 인산화 및 PI3K 활성화에 의한 것이다. PHB는 또한 AMPK 인산화와 활성화를 자극했다. 2,7-phloroglucinol-6,6-bieckol에 의한 PI3K/AKT 및 AMPK 경로의 인산화 및 활성화는 wortmannin (PI3K 억제제) 및 화합물 C (AMPK 억제제)를 사용하여 확인하였다. 본 연구에서 2,7-phloroglucinol-6,6-bieckol 이 3T3-L1 지방 세포에서 PI3K 및 AMPK 경로를 통해 원형질막으로의 GLUT4 전위를 촉진함으로써 포도당 흡수를 증가시킬 수 있음을 나타내었다. 이러한 결과는 2,7-phloroglucinol-6,6-bieckol 가 인슐린 감수성을 개선하는 데 도움이 될 수 있음을 시사한다.

• Asian Pacific Journal of Cancer Prevention
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• 제16권8호
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• pp.3447-3450
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• 2015

Objective: To explore the sensitivity of gastric cancer cells to chemotherapy drugs in elderly patients and its correlation with cyclooxygenase-2 (COX-2) expression in cancer tissue. Materials and Methods: Forty-three elderly patients with gastric cancer (observation group) and 31 young patients with gastrointestinal tumors (control group) who were all diagnosed by pathology and underwent surgery in the 89th Hospital of Chinese People's Liberation Army were selected. Drug sensitivity testing of tumor cells in primary culture was carried out in both groups using a methyl thiazolyl tetrazolium (MTT) method, and the expression of COX-2 and the factors related to multi-drug resistance (MDR) in cancer tissue were assessed by immunohistochemistry. Results: The inhibition rates (IR) of vincristine (VCR), 5-fluorouracil (5-FU), oxaliplatin (L-OHP), mitomycin (MMC) and epirubicin (eADM) on tumor cells in the observation group were dramatically lower than in the control group, with statistical significance (P<0.05 or P<0.01). The positive rates of COX-2, glutathione s-transferase-${\pi}$ (GST-${\pi}$) and P glycoprotein (P-gp) expression in cancer tissue in the observation group were all higher than in control group (P<0.05), while that of DNA topoisomerase $II{\alpha}$ ($TopoII{\alpha}$) expression lower than in the control group (P<0.01). In the observation group, COX-2 expression in cancer tissue had a significantly-positive correlation with GST-${\pi}$ and P-gp (r=0.855, P=0.000; r=0.240, P=0.026), but a negative correlation with $TopoII{\alpha}$ (r=-0.328, P=0.002). In the control group, COX-2 expression in cancer tissue was only correlated with P-gp positively (r=0.320, P=0.011). Bivariate correlation analysis displayed that COX-2 expression in cancer tissue in the observation group had a significantly-negative correlation with the IRs of 5-FU, L-OHP, paclitaxel (PTX) and eADM in tumor cells (r=-0.723, P=0.000; r=-0.570, P=0.000; r=-0.919, P=0.000; r=-0.781, P=0.000), but with hydroxycamptothecine (HCPT), VCR and 5-FU in the control group (r=-0.915, P=0.000; r=-0.890, P=0.000; r=-0.949, P=0.000). Conclusions: Gastric cancer cells in elderly patients feature stronger MDR, which may be related to high COX-2 expression.

• 대한한방부인과학회지
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• 제24권3호
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• pp.28-47
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• 2011

Objectives: This study was performed to investigate the effects of Angelicae gigantis Radix (AGR) which is one of the most useful herbal-drug to treat patients with Polycystic Ovary Syndrome (PCOS) in Oriental medicine on gene expression of ovary tissue. Methods: The effects of AGR on gene expression of ovary tissue resected from PCOS induced rats using single injection of $\ss$-Estradiol 17-valerate (EV) was measured using microarray technique, and the functional analysis on these genes was conducted. Results: Total 2,812 genes were up-regulated or down-regulated, 1,421 genes were up-regulated, 1,391 genes were down-regulated by induction of PCOS. Up-regulated genes were mainly involved in biological function such as cell signalling pathways and inflammatory response. Expression levels of 1,442 genes were restored to those of naive animals by administration of AGR. 558 genes were restored to those of naive animals, which were lowered by induction of PCOS. 884 genes were lowered to naive levels, which were elevated by induction of PCOS. The functions of restored genes were partially involved in the restoration of expression levels, which were changed by induction of PCOS. Especially, up-regulated gene by induction of PCOS were mainly involved in these changes. These results mean restorative effects of AGR on damaged functions by induction of PCOS. The network of total protein interactions was measured using cytoscape program, and some key molecules, such as IRS2, MCM10, ORC2L related in up-regulated genes, CTBP2, CD44, RHOA, related in down-regulated genes that can be used for elucidation of therapeutical mechanism of medicine in future were identified. Conclusion: Restored genes by AGR were thought to have common pathways related in regulation of gene expressions. Especially, genes in restored expression levels by AGR, which were up-regulated by induction of PCOS, were regulated by 9 of common transcription factors, genes in restored expression levels by AGR, which were down-regulated by induction of PCOS, were involved in 25 of common transcription factors.

• 한국균학회지
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• 제31권2호
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• pp.103-113
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• 2003

국내의 가지과 작물에서 분리한 Alternaria 25 균주를 공시하여 분생포자의 형태적 특징을 조사하였고 A. solani와 A. tomaotphilad의 대표균주와 비교하였다. 분리균주 중 형태적으로 구별되는 몇 균주들과 대표균주를 공시하여 감자, 토마토, 가지, 고추에 대한 병원성 검정을 실시하였다. 대표균주를 포함한 Alternaria 17개 균주를 공시하여 ITS 영역과 histone h3 유전자의 염기서열분석, URP (universal rice primer)에 의한 핵산지문분석을 실시하였다. Alternaria 균주들은 분생포자의 형태적 특징에 의하여 A. tomaotophila(ATO), A. solani(ASO) 및 미동정의 Alternaria sp.(ASP)의 group으로 나눌 수 있었고 A. solani(ASO)는 분생포자 부리(beak)의 특징에 의하여 다시 ASO(1)과 ASO(2)의 2 type으로 나눌 수 있었다. ATO와 ASO 균주들은 실험에 사용한 감자, 토마토, 가지, 고추에 모두 병원성이 있었고 ATO 균주는 특히 토마토에 강한 병원성이 있었으나, ASP 균주는 감자에만 병원성이 있었다. 이 연구에서 사용한 molecular marker중 ITS와 histon H3 유전자의 염기서열 분석은 4개의 형태적 group을 명확히 구분할 수 없었지만, URP-PCR 핵산지문분석법은 이들 group을 명확히 구분할 수 있었다. 분생포자의 형태, 병원성검정, 분자생물학적 특징을 종합할 때 토마토 겹무늬병에 관여하는 A. tomatophila는 감자겹둥근무늬병에 관여하는 A. solani와 뚜렷이 구분할 수 있었다. 또한 감자에서 분리한 Alternaria sp.(ASP)는 A. solani(ASO)와 형태적으로 유사하였지만 분생포자의 폭이 두껍고 부리(beak)가 작다는 점에서 ASO와 구별되었으며 가지과 작물에서 보고된 바 없는 신종으로 추정되었다.