• 한국도로학회논문집
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• 제19권6호
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• pp.83-95
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• 2017

PURPOSES : The purpose of this study is to develop a regression model to predict the International Roughness Index(IRI) and Surface Distress(SD) for the estimation of HPCI using Expressway Pavement Management System(PMS). METHODS : To develop an HPCI prediction model, prediction models of IRI and SD were developed in advance. The independent variables considered in the models were pavement age, Annual Average Daily Traffic Volume(AADT), the amount of deicing salt used, the severity of Alkali Silica Reaction(ASR), average temperature, annual temperature difference, number of days of precipitation, number of days of snowfall, number of days below zero temperature, and so on. RESULTS : The present IRI, age, AADT, annual temperature differential, number of days of precipitation and ASR severity were chosen as independent variables for the IRI prediction model. In addition, the present IRI, present SD, amount of deicing chemical used, and annual temperature differential were chosen as independent variables for the SD prediction model. CONCLUSIONS : The models for predicting IRI and SD were developed. The predicted HPCI can be calculated from the HPCI equation using the predicted IRI and SD.

• Journal of Chest Surgery
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• 제54권1호
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• pp.9-16
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• 2021

Background: The deposition of monomeric C-reactive protein (mCRP) in the myocardium aggravates ischemia-reperfusion injury (IRI) and myocardial infarction. Ischemic preconditioning (IPC) is known to protect the myocardium against IRI. Methods: We evaluated the effects of IPC on myocardium upon which mCRP had been deposited due to IRI in a rat model. Myocardial IRI was induced via ligation of the coronary artery. Direct IPC was applied prior to IRI using multiple short direct occlusions of the coronary artery. CRP was infused intravenously after IRI. The study included sham (n=3), IRI-only (n=5), IRI+CRP (n=9), and IPC+IRI+CRP (n=6) groups. The infarcted area and the area at risk were assessed using Evans blue and 2,3,5-triphenyltetrazolium staining. Additionally, mCRP immunostaining and interleukin-6 (IL-6) mRNA reverse transcription-polymerase chain reaction were performed. Results: In the IRI+CRP group, the infarcted area and the area of mCRP deposition were greater, and the level of IL-6 mRNA expression was higher, than in the IRI-only group. However, in the IPC+IRI+CRP group relative to the IRI+CRP group, the relative areas of infarction (20% vs. 34%, respectively; p=0.079) and mCRP myocardial deposition (21% vs. 44%, respectively; p=0.026) were lower and IL-6 mRNA expression was higher (fold change: 407 vs. 326, respectively; p=0.376), although the difference in IL-6 mRNA expression was not statistically significant. Conclusion: IPC was associated with significantly decreased deposition of mCRP and with increased expression of IL-6 in myocardium damaged by IRI. The net cardioprotective effect of decreased mCRP deposition and increased IL-6 levels should be clarified in a further study.

• Biomolecules & Therapeutics
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• 제25권3호
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• pp.272-278
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• 2017

Fucoidan has been reported to exhibit various beneficial activities ranging from to antivirus and anticancer properties. However, little information is available about the effects of fucoidan on cerebral ischemia-reperfusion injury (IRI). Our study aimed to explore the effects of fucoidan on cerebral IRI, as well as the underlying mechanisms. Sprague-Dawley (SD) rats were randomly subjected to four groups: Sham, IRI+saline (IRI+S), IRI+80 mg/kg fucoidan (IRI+F80), and IRI+160 mg/kg fucoidan (IRI+F160). Fucoidan (80 mg/kg or 160 mg/kg) was intraperitoneally injected from 7 days before the rats were induced to cerebral IRI model with middle cerebral artery occlusion (MCAO) method. At 24 h after reperfusion, neurological deficits and the total infarct volume were determined. The levels of inflammation-associated cytokines (interleukin (IL)-$1{\beta}$, IL-6, myeloperoxidase (MPO), and tumor necrosis factor (TNF)-${\alpha}$), oxidative stress-related proteins (malondialdehyde (MDA) and superoxide dismutase (SOD)) in the ischemic brain were measured by enzyme-linked immunosorbent assay (ELISA). Besides, the levels of apoptosis-related proteins (p-53, Bax, and B-cell lymphoma (Bcl)-2) and mitogen-activated protein kinase (MAPK) pathway (phosphorylation-extracellular signal-regulated kinase (p-ERK), p-c-Jun N-terminal kinase (JNK), and p-p38) were measured. Results showed that administration of fucoidan significantly reduced the neurological deficits and infarct volume compared to the IRI+S group in a dose-dependent manner. Also, fucoidan statistically decreased the levels of inflammation-associated cytokines, and oxidative stress-related proteins, inhibited apoptosis, and suppressed the MAPK pathway. So, Fucoidan plays a protective role in cerebral IRI might be by inhibition of MAPK pathway.

• Journal of Astronomy and Space Sciences
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• 제14권2호
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• pp.269-274
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• 1997

Langmuir probe was housed in the sounding rocket to test the probe's performance and to find the environmental parameters at the F layer of the ionosphere. The gold plated cylindrical probe had a length of 14㎝ and a diameter of 0.096 ㎝. The applied voltage to the probe consisted of 0.9 sec fixed positive bias followed by 0.1 sec of down/up sweep. This ensured that the probe swept through the probe's current-voltage characteristic at least once during 1 second quiescent periods enabling the electron temperature to be measured during the undisturbed times of the flight. The experimental results showed good agreement of the temperature distribution with IRI model at the lower F layer. In the upper layer, the experimental temperatures were 100-200K lower than the IRI model's because of the different geomagnetic conditions: averaged conditions were used in IRI model and specific conditions were reflected in the experiment.

• 한국측량학회지
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• 제28권4호
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• pp.413-420
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• 2010

현재 전리층 지연은 GNSS 측량의 가장 큰 오차이다. 단일 주파수 수신기 사용자는 전리층 지연을 모델링 하거나 보정하기 위하여 전리층 보정 알고리즘을 적용해야 한다. 실시간 보정이 가능한 전리층 모델로는 항법메시지로 제공되는 GPS의 Klobuchar 모델과 Galileo의 NeQuick 모델이 있다. 이 연구에서는 두 모델의 효용성을 계절과 위도에 따라 평가하였다. 첫 번째 검증으로, 각 계절별로 수원 GPS 상시관측소 상공의 연직방향 총전자수를 산출하였다. 두 번째 검증으로는 위도가 서로 다른 3개 상시관측소(철원, 수원, 제주)에서의 VTEC을 계산해 관측소 위도와의 상관성을 분석하였다. 산출된 총전자수는 전지구 전리층 모델인 GIM 모델과 IRI 모델에서 제공하는 총전자수와 비교하였다. 그리고 GIM 모델과 IRI 모델을 기준으로 Klobuchar 모델과 NeQuick 모델의 RMS 차이를 각각 산출하였다. 그 결과, 계절과 관측소 위도와 무관하게 NeQuick 모델의 RMS 차이가 Klobuchar 모델의 RMS 차이보다 약 0.01~3.50 TECU 낮게 나타났다.

• 대한원격탐사학회지
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• 제30권2호
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• pp.331-339
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• 2014

지상기반 전리층모델로 계산한 전리층 지연값을 저궤도에서의 전리층 지연값으로 변환하기 위해서는 전리층 변환 배율 적용해야 하는데, 이러한 배율을 IRI 전리층모델을 사용하여 결정하는 기법을 제안하였다. IGS 전리층모델에 전리층 배율을 적용하여 계산한 전리층 지연값을 NASA GRACE 위성의 관측값과 비교하였다. 약 480 km 고도에서 2004년 평균 배율은 0.25이며, 표준편차는 0.01이다. 전리층 배율은 주간에 비해 야간에 상대적으로 증가하며, 계절적으로는 봄, 가을에 높은 값을 가진다. IGS모델에 전리층배율을 결합해서 추정한 저궤도 전리층 지연값 추정 오차 평균은 3.50 TECU이다.

• Journal of Astronomy and Space Sciences
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• 제16권2호
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• pp.293-306
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• 1999

태양 활동에 의해 방출된 고에너지 입자들은 위성 및 전기, 전파 통신 등의 기기의 작동에 여러 가지 영향을 끼치고 지구 자기권을 크게 섭동시킨다. 태양 활동의 영향에 따른 지구 근접 우주 환경의 변화를 이해하기 위해서는 지구 자기권과 전리층 및 대기에 관한 연구가 선행되어야 한다. 이러한 연구의 일환으로 지구의 자기장과 전리층 및 대기에 대한 여러 모델들을 제시하고 널리 사용되는 대표적인 모델들의 특징을 분석하였다. 본 연구에서는 국내 최초로 전리층 및 지자기 모델용 GUI 프로그램을 개발하였으며 특히 WEB 상에서 종합적인 자료 분석이 가능한 시스템을 개발하였다.

• 한국항해항만학회:학술대회논문집
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• 한국항해항만학회 2006년도 International Symposium on GPS/GNSS Vol.2
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• pp.181-184
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• 2006

Knowledge of the ionospheric peak parameter foF2 (the critical frequency of F2 layer) is one of key essential factors for predicting ionospheric characteristics and delay correction of satellite positioning. However, the foF2 was almost estimated using an empirical model of International Reference Ionosphere (IRI) or other expensive observing techniques, such as ionosondes and scatter radar. In this paper, the ionospheric peak parameter foF2 is the first observed by ground-based GPS with all weather, low-cost and near real time properties. Compared with the IRI-2001 and independent ionosondes at or near the GPS receiver stations, the foF2 obtained from ground-based GPS is in better agreement, but closer to the ionosonde. However, during nighttime, the IRI model overestimated the GPS observed values during winter and equinox months.Furthermore, seasonal variation trend of the foF2 in 2003 is studied using foF2 monthly median hourly data measured over South Korea. It has shown that the systematic diurnal changes of foF2 are apparent in each season and the higher values of foF2 are observed during the equinoxes (semiannual anomaly) as well as in mid-daytime of each season.

• 한국도로학회논문집
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• 제16권5호
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• pp.67-72
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• 2014

PURPOSES : This study focuses on conducting pavement rehabilitation for more deteriorated roads given a limited government budget. METHODS : Therefore, we apply a optimization programming model of the permutation algorithm used for rehabilitating more deteriorated pavement areas, which is subjected to the limited budget. RESULTS : The permutation algorithm was evaluated in terms of determining the maximized rehabilitation of deteriorated pavement areas, using the newly developed performance models such as fatigue cracking, rutting, international roughness index(IRI) through the surveying data from 2006 to 2012. When compared with a traditional model of the so-called worst-first sequence(WFS) method, the permutation algorithm worked better than the WFS method, resulting in covering more deteriorated pavement areas given the limited government budget. CONCLUSIONS : Through a case study, it could be concluded that the permutation algorithm provides more reliable results in terms of rehabilitating more deteriorated pavement areas given the limited budget.

• 한국도로학회:학술대회논문집
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• 한국도로학회 2009년도 추계학술대회 논문집
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• pp.111-116
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• 2009