• Asia-Pacific Journal of Business Venturing and Entrepreneurship
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• v.14 no.5
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• pp.1-11
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• 2019

Financing plays an important role in the survival and growth of startups. This study investigates key factors that improve startup financing performance. To this end, we analyze the relationship between the proportion of intellectual property and the financing performance. In addition, this study also examine the impact of the founder's education level on the financing of startups, and the moderating effect of the founder's education level on the relationship between intellectual property proportion and financing. Based on the survey data of 331 startups, this study found that the proportion of intellectual property and the financing performance have an inverted U-shaped nonlinear relationship. While the founder's education level has a positive impact on the financing performance, it negatively moderate the relationship between the intellectual property proportion and the financing performance. Through these findings, this study suggests that it is necessary to maintain an adequate proportion of intellectual property in order to maximize startup financing performance. The higher education level of founder enhances the startup financing. Since the founder's education level weaken the effect of intellectual proporty's effect on startup financing, however, startups need to control the proportion of intellectual property to improving financing according to the founder's education level. Based on signal theory, this study proposes a new strategy of intellectual property to enhance startup financing performance.

• Journal of the Korean earth science society
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• v.40 no.2
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• pp.149-162
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• 2019

In the macro-tide open coast of the Korean western coast, typhoon effects were investigated in terms of variations on topography, surface sediment, and sedimentary environment, which appeared before and after the typhoon Kompasu of 2010. The Kompasu of small size and strong intensity landed on the southwestern coast of the Korean Peninsula and passed across the inland between September 1st and 2nd in 2010. Topography and surface sediments before and after the typhoon were measured and sampled along the survey line of 22 sites in the Gochang Donghori intertidal flat. The intertidal area was divided into high tidal zone, middle tidal zone, and lower tidal zone on the basis of mean high water level, mean sea level, and mean low water level. Topographic variation before and after the typhoon represented deposition of average 0.03 m in high tidal zone, erosion of average -0.15 m in middle tidal zone, and erosion of average -0.39 m in lower tidal zone, respectively. Surface sediments of the intertidal flat consisted mainly of fine to medium sands, and the ratio of fine sand was the largest both before and after the typhoon. Surface sediments after the typhoon became finer in mean grain size showing well sorting rather than those before the typhoon.

• Journal of Microbiology and Biotechnology
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• v.29 no.2
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• pp.330-338
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• 2019

Chronic infection with intracellular Brucella abortus (B. abortus) in livestock remains as a major problem worldwide. Thus, the search for an ideal vaccine is still ongoing. In this study, we evaluated the protective efficacy of a combination of B. abortus recombinant proteins; superoxide dismutase (rSodC), riboflavin synthase subunit beta (rRibH), nucleoside diphosphate kinase (rNdk), 50S ribosomal protein (rL7/L12) and malate dehydrogenase (rMDH), cloned and expressed into a pMal vector system and $DH5{\alpha}$, respectively, and further purified and applied intraperitoneally into BALB/c mice. After first immunization and two boosters, mice were infected intraperitoneally (IP) with $5{\times}10^4CFU$ of virulent B. abortus 544. Spleens were harvested and bacterial loads were evaluated at two weeks post-infection. Results revealed that this combination showed significant reduction in bacterial colonization in the spleen with a log protection unit of 1.31, which is comparable to the average protection conferred by the widely used live attenuated vaccine RB51. Cytokine analysis exhibited enhancement of cell-mediated immune response as IFN-${\gamma}$ is significantly elevated while IL-10, which is considered beneficial to the pathogen's survival, was reduced compared to control group. Furthermore, both titers of IgG1 and IgG2a were significantly elevated at three and four-week time points from first immunization. In summary, our in vivo data revealed that vaccination with a combination of five different proteins conferred a heightened host response to Brucella infection through cell-mediated immunity which is desirable in the control of intracellular pathogens. Thus, this combination might be considered for further improvement as a potential candidate vaccine against Brucella infection.

• Molecules and Cells
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• v.41 no.12
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• pp.1061-1071
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• 2018

From Xenopus embryo studies, the BMP4/Smad1-targeted gene circuit is a key signaling pathway for specifying the cell fate between the ectoderm and neuro-ectoderm as well as the ventral and dorsal mesoderm. In this context, several BMP4/Smad1 target transcriptional factors have been identified as repressors of the neuro-ectoderm. However, none of these direct target transcription factors in this pathway, including GATA1b, Msx1 and Ventx1.1 have yet been proven as direct repressors of early neuro-ectodermal gene expression. In order to demonstrate that Ventx1.1 is a direct repressor of neuro-ectoderm genes, a genome-wide Xenopus ChIP-Seq of Ventx1.1 was performed. In this study, we demonstrated that Ventx1.1 bound to the Ventx1.1 response cis-acting element 1 and 2 (VRE1 and VRE2) on the promoter for zic3, which is a key early neuro-ectoderm gene, and this Ventx1.1 binding led to repression of zic3 transcription. Site-directed mutagenesis of VRE1 and VRE2 within zic3 promoter completely abolished the repression caused by Ventx1.1. In addition, we found both the positive and negative regulation of zic3 promoter activity by FoxD5b and Xcad2, respectively, and that these occur through the VREs and via modulation of Ventx1.1 levels. Taken together, the results demonstrate that the BMP4/Smad1 target gene, Ventx1.1, is a direct repressor of neuro-ectodermal gene zic3 during early Xenopus embryogenesis.

• Economic and Environmental Geology
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• v.51 no.6
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• pp.509-520
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• 2018

Alkalinity is one of the basic variables, which determine geochemical characteristics of natural waters and participate in processes changing concentrations of various contaminants either directly or indirectly. However, not a few laboratories and researchers of Korea still use alkalinity-measurement methods not appropriate for groundwaters, and which becomes one of the major reasons for the poor ion balance errors of the geochemical analysis. This study was performed to review alkalinity-measurement methods, to discuss their advantages and disadvantages, and, thus, to help researchers and analytical specialists in analyzing alkalinity of groundwaters. The pH-titration-curve-inflection-point (PTC-IP) methods, which finds the alkalinity end point from the inflection point of the pH titration curve are revealed to be most accurate. Gran titration technique among them are likely to be most appropriate for accurate estimation of titrant volume to the end point. In contrast, other titration methods such as pH indicator method and pre-selected pH method, which are still commonly being used, are likely to cause erroneous results especially for groundwaters of low ionic strength and alkalinity.

• 대한공업교육학회지
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• v.44 no.1
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• pp.141-161
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• 2019

The purpose of this study was to elucidate the necessity of opening a lecture on intellectual property education by confirming the effect of the lecture on intellectual property education in the college students. For the study, IP program was developed for the course through literature review, and supplemented it with expert review. The developed course program was applied to 39 students for 15 weeks. In order to verify the effectiveness of the lecture, the survey was performed. And analysis method for the concept change analysis and the keyword formation analysis were performed. For the analysis, SPSS 24, UCINET and Netdraw were used. The results were as follows. First, the lecture on intellectual property education positively changed the value, necessity, and perception of intellectual property to the students. Second, the students of the lecture on intellectual property education responded that the lecture on the intellectual property should be increased. Third, through the lecture on intellectual property education, students formed basic concept about intellectual property centered on key word. The intellectual property lecture program developed and applied in this study is difficult to apply to all university situations, but it is expected to be referenced in the establishment and operation of related lectures and to be derived in various forms.

• The Korean Journal of Oral and Maxillofacial Pathology
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• v.41 no.3
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• pp.121-129
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• 2017

Coffee (Coffea spp.) is one of the most important agricultural commodities, being widely consumed in the world. Various beneficial health effects of coffee have been extensively investigated, but data on habitual coffee consumption and its bio-physiological effect have not been clearly explained as well as it is not proved the cause and effect between drinking coffee and its bio-physiological reactions. We made the dialyzed coffee extract (DCE), which is absorbable through gastrointestinal tract, in order to elucidate the cellular effect of whole small coffee molecules. RAW 264.7 cells, a murine macrophage lineage, were directly treated with DCE, i.e., DCE-2.5 (equivalent to 2.5 cups of coffee a day), DCE-5, and DCE-10, for 12 hours, and their protein extracts were examined by immunoprecipitation high performance liquid chromatography (IP-HPLC). RAW 264.7 cells differently expressed the inflammation-related proteins depending on the doses of DCE. RAW 264.7 cells treated with DCE showed marked increase of cathepsin C, cathepsin G, CD20, CD28, CD31, CD68, indicating the activation of innate immunity. Particularly, the macrophage biomarkers, cathepsin G, cathepsin C, CD31, and CD68 were markedly increased after DCE-5 and DCE-10 treatments, and the lymphocyte biomarkers, CD20 and CD28 were consistently increased and became marked after DCE-10 treatment. On the other hand, RAW 264.7 cells treated with DCE showed consistent increase of IL-10, an anti-inflammatory factor, but gradual decreases of different pro-inflammatory proteins including $TNF{\alpha}$, COX-2, lysozyme, MMP-2, and MMP-3. In particular, the cellular signaling of inflammation was gradually mitigated by the reduction of $TNF{\alpha}$, COX-2, IL-12, and M-CSF, and also the matrix inflammatory reaction was reduced by marked deceases of MMP-2, MMP-3, and lysozyme. These anti-inflammatory expressions were consistently found until DCE-10 treatment. Therefore, it is presumed that DCE may have dynamic effects of innate immunity activation and pro-inflammation suppression on RAW264.7 cells simultaneously. These effects were consistently found in the highest dose of coffee, DCE-10 (equivalent to 10 cups of coffee a day in man), that might imply the small coffee molecules were accumulated in RAW 264.7 cells after DCE-10 treatment and produce synergistic cytokine effects for innate immunity activation and anti-inflammatory reaction concurrently.

• Journal of IKEEE
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• v.23 no.2
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• pp.743-746
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• 2019

In this paper we proposed a new ocean radiation automatic monitoring system. The proposed system has the following characteristics: First, using NaI + PVT mixed detectors, the response speed is fast and precision analysis is possible. Second, the application of temperature compensation algorithm to scintillator-type sensors does not require additional cooling devices and enables stable operation in the changing ocean environment. Third, since cooling system is not needed, electricity consumption is low, and electricity can be supplied reliably by utilizing solar energy, which can be installed at the observation deck of ocean environment. Fourth, using GPS and wireless communications, accurate location information and real-time data transmission function for measurement areas enables immediate warning response in the event of nuclear accidents such as those involving neighboring countries. The results tested by the authorized testing agency to assess the performance of the proposed system were measured in the range of $5{\mu}Sv/h$ to 15mSv/h, which is the highest level in the world, and the accuracy was determined to be ${\pm}8.1%$, making normal operation below the international standard ${\pm}15%$. The internal environmental grade (waterproof) was achieved, and the rate of variation was measured within 5% at operating temperature of $-20^{\circ}C$ to $50^{\circ}C$ and stability was verified. Since the measured value change rate was measured within 10% after the vibration test, it was confirmed that there will be no change in the measured value due to vibration in the ocean environment caused by waves.

• Atmosphere
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• v.29 no.3
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• pp.257-267
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• 2019

This study is to assess the applicability of the Extreme Forecast Index (EFI) algorithm of the ECMWF seasonal forecast system to the Global Seasonal Forecasting System version 5 (GloSea5), operational seasonal forecast system of the Korea Meteorological Administration (KMA). The EFI is based on the difference between Cumulative Distribution Function (CDF) curves of the model's climate data and the current ensemble forecast distribution, which is essential to diagnose the predictability in the extreme cases. To investigate its applicability, the experiment was conducted during the heat-wave cases (the year of 1994 and 2003) and compared GloSea5 hindcast data based EFI with anomaly data of ERA-Interim. The data also used to determine quantitative estimates of Probability Of Detection (POD), False Alarm Ratio (FAR), and spatial pattern correlation. The results showed that the area of ERA-Interim indicating above 4-degree temperature corresponded to the area of EFI 0.8 and above. POD showed high ratio (0.7 and 0.9, respectively), when ERA-Interim anomaly data were the highest (on Jul. 11, 1994 (> $5^{\circ}C$) and Aug. 8, 2003 (> $7^{\circ}C$), respectively). The spatial pattern showed a high correlation in the range of 0.5~0.9. However, the correlation decreased as the lead time increased. Furthermore, the case of Korea heat wave in 2018 was conducted using GloSea5 forecast data to validate EFI showed successful prediction for two to three weeks lead time. As a result, the EFI forecasts can be used to predict the probability that an extreme weather event of interest might occur. Overall, we expected these results to be available for extreme weather forecasting.

• The Journal of Korean Philosophical History
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• no.56
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• pp.209-238
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• 2018

The purpose of this research is to analyze characteristics of the method of education or learning reflected in the teacher-student relationship in On Haeng Lok By Toe-gye and explore their relevance to modern education. By writing various works and conversing with his students, Toe-gye devoted himself in the education of the traditional Confucian principles. Specially, he taught his students based on two Confucian educative principles, namely Shim Deuk(心得) and Goong Haeng(躬行). Judging from this, Toe-gye can be seen as someone who tries to fulfill the role of teacher as dictated in the educative principles of the Confucianism. In Confucianism, teacher is responsible for forming a well-rounded view on life in student, rather than simply transmitting knowledge. As such, the teacher was supposed to find a harmonious way to create something new based on what was inherited from the past generation and try to do his best in learning new things himself and teaching his students. These Toe-gye managed to do successfully, earning his students' trust and respect. Being moved and inspired by their teacher, the students continued their intellectual pursuit. This relationship between Toe-gye and his students can be analyzed from the perspective of education method and discussed in terms of cognitive learning and adult learning. In terms of cognitive learning, the education method reflected in the relationship is similar to potential learning, insight learning, and imitation learning. In terms of adult learning, it is similar to self-directed learning and communicative learning.!