• Title/Summary/Keyword: IND

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Fatigue Analysis for Transportation of Harmony Jacket (하모니 자켓 운송을 위한 피로 해석)

  • Kim, D. Y.
    • Journal of Ocean Engineering and Technology
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    • v.1 no.1
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    • pp.39-48
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    • 1987
  • 지금까지 건조된 jacket 중에서 가장 큰 것으로 알려진 미국 Exxon사의 Harmony jacket 이 현재 현대 중공업에 의해 제작되고 있다. Harmony jacket은 제작완료 후 울산으로부터 미국 California서안의 Santaynez해역으로 운송될 예정인데, 이와 같이 긴 해상운송시에 jacket과 seafasening 부재들은 피로에 의하여 상당히 손상을 입을 수 있다. 본 연구에서는 두가지의 가능한 운송항로에 대해, jacket과 tie-down 부재가 받는 피로에 의한 손상정도를 계산하고 그 결과를 비교 하였다. 몇 가지 가정하에 행하여진 해석 결과에 따르면, 피로에 의한 손상을 적게 주는 운송항로는 Hawaii를 경유하는 남쪽할로이며, 운송 barge와 인접하는 부분, 특히 barge 양단 부근의 jacket joint들이 손상을 받기 쉽다는 것을 알 수 있다.

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The Development of 25.8kV 25kA Outdoor Type GCB (25.8kV 25kA 옥외용 GCB 개발)

  • Yoon, K.S.;Song, W.P.;Lee, C.H.;Noh, C.W.
    • Proceedings of the KIEE Conference
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    • 1994.07a
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    • pp.214-215
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    • 1994
  • The VCB(Vacuum Circuit Breaker), which has been used in power distribution system, have prevented the performance of the phase modifying equipment (Condenser Bank and Shunt Reactor) and the important parts in the electric power system because of the transient voltage in opening and closing circuit. So, we developed the 25.8kV $SF_6$ gas GCB(GAS Circuit Breaker), which had the few occurance of the surge in opening & closing circuit and had the high reliability, based in our own technology.

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Preparation of NR/MG Latex Blend Films and its Mechanical Properties (NR/MG Latex 블랜드필름의 제조 및 그의 기계적특성)

  • Kim, K.S.;Park, J.H.;Eum, J.S.;Kim, S.J.
    • Elastomers and Composites
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    • v.29 no.1
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    • pp.9-17
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    • 1994
  • Methylmetharylate grafted latex(MGL) was prepared by emulsion graft copolymerization of methyl methacrylate onto natural rubber latex(NRL) by using t-butyl hydroperoxide and tetraethylene pentamine in an aqueous medium. Blending of MGL and NRL with different mixing ratio carried out and viscosity and particle size distribution of blend latex were determined. It was found that the optimum condition of mature time, vulcanizing temperature and time for preparation of blend latex films were investigated. latex films prepared by dipping process were meaured. As the reuslt, blend latex(NR-d-MG) films obtained from two-dipping system were more excellent than NR and MG film obtained from one-dipping system.

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Suggestions for Radiopharmaceutical Drug Development in Korea Focusing on FDA Exploratory IND Guideline (FDA exploratory IND의 기준을 중심으로 본 국내 방사성 의약품 기술개발을 위한 제언)

  • Ryu, Young-Hoon;Choi, Tae-Hyun
    • Nuclear Medicine and Molecular Imaging
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    • v.41 no.6
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    • pp.525-529
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    • 2007
  • Regulation for the radiopharmaceuticals should be reasonably different from that of other drugs. Radiopharmaceuticals are always used by compounding based on the doctor's order, have short half life and very low administration dose. Its pharmacological effect is not from its chemical effect but from radiation. The background for exploratory IND (Investigational New Drug) explained by the FDA was to reduce the time and resources expended on candidate products that are unlikely to suceed, new tools are needed to distinguish earlier in the process those candidates that hold promise from those that do not. In this review, basic concept for exploratory IND and RDRC guideline is summarized and various suggestions for improving and expediting procedure for new radiopharmaceutical development would be described.

Analysis of Diffusion Bonded Parts Using Immersed UT Method (수침초음파를 이용한 확산접합부평가)

  • Park, J.C.;Oh, C.S.;Kim, Y.S.;Kim, J.G.
    • Journal of the Korean Society for Nondestructive Testing
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    • v.12 no.3
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    • pp.33-39
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    • 1992
  • This paper presents a summary of the immersion ultrasonic test to analyze the quality of diffusion bonding parts. The most important property of diffusion bonding parts is bonding strength, and that can be obtained by shear test. By comparing among data obtained by ultrasonic test(C-Scan) and those by shear test (bonding strength), these data are shown to be in good relation. Therefore ultrasonic C-Scan test result can be used successfully in quantitative quality control for diffusion bonded parts.

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Rosin Microparticles as Drug Carriers: Influence of Various Solvents on the Formation of Particles and Sustained-release of Indomethacin

  • Lee Chang Moon;Lim Seung;Kim Gwang Yun;Kim Do Man;Kim Dong Woon;Lee Hyun Chul;Lee Ki Young
    • Biotechnology and Bioprocess Engineering:BBE
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    • v.9 no.6
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    • pp.476-481
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    • 2004
  • The aim of this study was to formulate a sustained release system for indomethacin (IND) with rosin gum obtained from a pine tree. Rosin microparticles were prepared by a disper­sion and dialysis method without the addition of surfactant. In order to investigate the influence of solvents on the formation of colloidal microparitcles, various solvents like ethanol, DMF, DMAc, and acetone were used. The rosin microparticles containing IND were characterized by X­ray differactometry (XRD) and differential scanning calorimetry (DSC). The morphologies of rosin microparticles observed by scanning electron microscopy (SEM) were spherical. The solvents used to dissolve rosin significantly affected the drug content and drug release rate of IND. The release behaviors of IND from the rosin microparticles were dependent on the drug content and size of the particles. Rosin micorparticles with a higher drug content and of a larger particle size had a slower drug release rate. Also, the IND release rate from the rosin microparticles could be regulated by the rosin content in the microparticles. From these results, rosin microparticles have the potential of being used as a sustained release system of IND.