• 한국식품영양과학회지
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• 제23권2호
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• pp.251-260
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• 1994

Lipophilic brown pigments produced during the fermentation of domestic Meju and Doenjang were fractionated by column and thin -layer chromatography (TLC). Each of the fractions was tested for the antioxidant activity and then characterized by spectroscopic analysis. The lipophilic brown pigments were separated into chloroform -soluble and methanol-soluble parts in which Meju resulted the higher content of chloroform-soluble part than that of methanol-soluble part ; however, Doenjang exhibited the opposite result to that of Meju. More strong antioxidant activity was found in the methanol-soluble part than the chloroform-soluble part. Four and five fractions were separated from chloroform-soluble and methanol-soluble parts respectively. by silicagel TLC. The fraction that exhibited the high antioxidant activity showed a strong absorption at 260nm caused by amino compounds in UV spectrum The other fractions which did not have antioxidant activity absorbed at 240nm by carbonic acid and it ester,. IR spectrum of each fraction commonly showed absorption at 3400cm-1 , 2800cm-1 , 1700cm-1, 1600cm-1, 1400cm-1 , 1300cm-1 and 1100cm-1. Especially , the fraction which had a strong antioxidant activity showed absorption at 2800cm-1, 1400cm-1, 1600cm-1 suggesting that the fraction contain Schiff's base and primary amine structure.

• 대한의용생체공학회:학술대회논문집
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• 대한의용생체공학회 1996년도 추계학술대회
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• pp.240-242
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• 1996

Use of electrical stimulation for diagnosis and treatment of pyhsiolgocial impairment on the auditory system was reported by many researchers since 1800. Unfortunately, there were no standard methods or theoretical bakground for choosing stimulus conditions because of the lack of understanding on the transmission of sound through the auditory pathways. Therefore, if we could find the mechanisms of normal and abnormal functions for the system objectively, it may be possible to establish the conditions for the appropriate treatment This study was devised with three experimental conditions of electrical stimulation(0.1, 1, and 10mA) to verify the effect of electrical stimulation on the auditory system. ABRs and ECochGs were obtained from 3 Guinea Pigs before and after each stimulation, and five parameters were extracted from ABR and ECochG waveforms. The results showed that the mean differences of the first peaks of ABR, I, before and after all the stimulus conditions were significant at the significant level of p<0.05. Also, amplitude of ECochGs peak(AP) showed higher degrees of differences for the electrical stimulation than that of ABRs. Based on the results of this experiment establishment of an electrical model which characterizes the auditory system could be achieved by computer simulation. This will lead to the design of most accurate model for the real auditory system, which provide the quantitive information regarding diagnosis and treatment.

• Mass Spectrometry Letters
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• 제10권2호
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• pp.61-65
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• 2019

Korean ginseng (Panax ginseng Meyer) is a traditional herb used across the world to treat various diseases. Although, red ginseng is this herb's most famous product and has demonstrated diverse pharmacological activities, white ginseng (WG) is another ginseng product that is made fresh and individually regulated in Eastern Asia. Red and white ginseng show different characteristics due to distinct processing steps despite originating from the same plant, and the drug interactions induced by WG have not been well documented. Selegiline is a selective monoamine oxidase (MAO) inhibitor used as an antidyskinetic and antiparkinsonian agent. Here we developed a quantification method for selegiline in mouse plasma using a C8 stationary phase in triple quadrupole-mass spectrometry (LC-MS/MS) with multiple reaction monitoring (MRM). The validated LC-MS/MS method was successfully applied to determine the potential interaction with WG extract (0.1 g/kg/day) pre-administered for 4 weeks. The $AUC_{0-240min}$ of selegiline was altered due to a decrease in the absorption of selegiline with repeated administration of WG extract.

• 한국물환경학회지
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• 제35권1호
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• pp.19-27
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• 2019

The purpose of this study is to evaluate the water quality and phytoplankton community in Bukhan River which account for 44.4 % of the total inflow into Lake Paldang, using multivariate statistical techniques (i.e., correlation analysis, principal component analysis (PCA)/factor analysis (FA)). Water samples were collected from March to November 2015 and the following parameters measured; water temperature, pH, DO, EC, SS, BOD, Chl-a, COD, TN, $NO_3-N$, $NH_3-N$, TP, DTP, $PO_4-P$, and phytoplankton community. The water quality of the main stream and the tributaries were not significantly different apart from the relatively high concentration of BOD, COD and nutrients recorded in MH. The highest cell density of Stephanodiscus hantzschii and Merismopedia glauca dominated phytoplankton was observed in PD. Based on the correlation analysis, total phytoplankton and cyanophyceae were highly correlated with BOD, COD and nutrients. PCA/FA resulted in four main factors accounting for 82.240 % of the total variance in the water quality dataset. The group of component 1 (TN, DTN, DO, $NO_3-N$, water temperature) and component 2 ($PO_4-P$, T-P, DTP, SS) were classified as nutrient element factor whereas component 3 (Chl-a, COD, BOD, $NH_3-N$, pH) was related to organic substances. Hence, the identification of the main potential environmental pollution factors in Bukhan River will help policy makers make better and more informed decisions on how to improve the water quality.

• 치위생과학회지
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• 제22권4호
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• pp.233-240
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• 2022

Background: In modern society, rapid changes in the medical environment have required medical staff to access various information and be competent in active and effective problem-solving through collegial interactions. In line with these changes, universities are aiming to connect education. This study aimed to provide basic data of connected-convergence education by survey the awareness and needs of college students in health-related fields. Methods: This study included 122 college students from the health field. A survey regarding "the awareness and need of connected-convergence education" was conducted and general characteristics of the participants were collected from June to July 2022. Results: The awareness of connected-convergence education was low at 19.7%, but the intention to participate was high at 74.6%. Subject requirements were 18.0% for medical psychology, 13.5% for communication and counseling, 13.5% for medical artificial intelligence technology convergence, and 10.4% for sports health management. In the group showing high satisfaction with the major curriculum, the demand for connected education was also high. For efficient operation, it was investigated that it was necessary to secure specialized training courses, recognition of liberal arts credits, the right to register for courses equal to those of major students, and secure dedicated classrooms. Conclusion: Although the awareness and experience of connected-convergence education among the participants were low, the intention to participate was high. As such a plan to revitalize the university curriculum was required. It is timely to discuss the nurturing of convergence-type talents and multidisciplinary thinking skills. It is meaningful to provide basic data necessary for connected-convergence education in health-related fields at university. Universities should strive to enhance job competency in the health field by providing connected-convergence education based on student demands.

• 한국의류산업학회지
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• 제25권2호
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• pp.230-240
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• 2023

This study attempts to reveal the causal relationship between certain variables, with the objective being to investigate the influence of career disability on self-efficacy and career preparation behavior of Chinese college students. In terms of data collection, online surveys were conducted during the period spanning September 1 to September 20, 2022 targeting fourth-year university students living in Liaoning, China. A total of 536 completed surveys were used for the final analysis, and the SPSS 25.0 program was employed in this regard. The results of the study confirmed that the career barriers of Chinese college students had both positive and negative effects on career decision-making self-efficacy and career preparation behavior, signaling a partial causal relationship. This indicates that career barriers are not only negative factors in career decision-making or career preparation. The current study is meaningful in that the results can serve as the basis for future studies, as the work itself investigated the influence of career barriers on career decision self-efficacy and career preparation behavior; additionally, the results were quantified. It is anticipated that there will be further studies on such influences considering the diverse variables of career barriers, career decision self-efficacy, and career preparation behavior. The results of this study are expected to provide useful information on career preparation to Chinese college students - information which can be used as empirical data.

• 대한토목학회논문집
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• 제30권3D호
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• pp.231-240
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• 2010

교차로 교통사고의 주요 원인은 인적요인에 의한 교통사고가 대부분 차지하고 있어 운전자들의 주행특성 및 교통상황에 따른 심리적 생리적 변화측정을 통해 영향 요인 규명이 필요하다. 이에 본 연구에서는 운전자들의 인적요인을 고려한 개별 교차로 안전성 평가를 위하여 최첨단 계측장비를 활용한 뇌파반응을 측정하고 설문조사를 통해 평상시와 주행 실험시 운전자들의 인지특성 조사를 실시하였다. 교차로 접근시 뇌파변화와 주행실험 인지평가조사 자료의 관계성을 규명하고, 주행실험의 인지평가요인과 생체적 반응 뇌파데이터를 고려한 개별 교차로 안전성 평가 모형을 구축하였다. 그 결과, 교차로의 물리적 특성에 따라 생체반응 뇌파가 다르게 나타나고 인지평가 또한 차이가 있어 주행시 생체반응(뇌파)과정을 통해 인지평가를 하고 있음을 확인할 수 있었다.

• Korean Journal of Radiology
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• 제21권9호
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• pp.1095-1103
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• 2020

Objective: The present study aimed to investigate whether quantitative dual-energy computed tomography (DECT) parameters offer an incremental risk stratification benefit over the CT ventricular diameter ratio in patients with acute pulmonary embolism (PE) by using propensity score analysis. Materials and Methods: This study was conducted on 480 patients with acute PE who underwent CT pulmonary angiography (CTPA) or DECT pulmonary angiography (DE CT-PA). This propensity-matched study population included 240 patients with acute PE each in the CTPA and DECT groups. Altogether, 260 (54.1%) patients were men, and the mean age was 64.9 years (64.9 ± 13.5 years). The primary endpoint was all-cause death within 30 days. The Cox proportional hazards regression model was used to identify associations between CT parameters and outcomes and to identify potential predictors. Concordance (C) statistics were used to compare the prognoses between the two groups. Results: In both CTPA and DECT groups, right to left ventricle diameter ratio ≥ 1 was associated with an increased risk of all-cause death within 30 days (hazard ratio: 3.707, p < 0.001 and 5.573, p < 0.001, respectively). However, C-statistics showed no statistically significant difference between the CTPA and DECT groups for predicting death within 30 days (C-statistics: 0.759 vs. 0.819, p = 0.117). Conclusion: Quantitative measurement of lung perfusion defect volume by DECT had no added benefit over CT ventricular diameter ratio for predicting all-cause death within 30 days.

• 환경생물
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• 제30권3호
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• pp.210-218
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• 2012

일반적으로 많이 양식되는 방사무늬김(Porphyra yezoensis Ueda)에 대하여 방사무늬김 엽체의 형태적 특성, 탄소 및 질소 성분의 농도, 안정동위원소 비값, 광합성 효율을 방사무늬김 양식이 이루어 지고 있는 남서해역에서 조사를 하였다. 방사무늬김의 형태적 특성에 대해서 살펴보면 평균 엽장은 11.6~16.3 (13.8) cm, 평균 엽폭은 4.6~6.3 (5.4) cm이었고, 단위면적당 방사무늬김 엽체의 평균 엽중량은 $1.1{\sim}2.6(1.86)g\;DW\;m^{-2}$이었다. 단위면적당 Chl a 농도는 2.18~17.77 (평균 9.65) mg DW Chl a $m^{-2}$이었다. 방사무늬김의 탄소 농도는 $201{\sim}317(240)mg\;DW\;g^{-1}$이었고, 질소 농도는 $39.8{\sim}50.0(43.5)mg\;DW\;g^{-1}$이었으며, C/N비는 5.0~6.7 (5.5)이었다. 방사무늬김의 방사성 안정동위원소비 중에서 탄소 안정동위원소 비는 ${\delta}^{13}C$=-25.6‰ 에서 ${\delta}^{13}C$=-24.0‰ (평균 -24.7‰)의 값을 보였고, 질소 안정동위원소 비는 ${\delta}^{15}N$=1.3‰ 에서 ${\delta}^{15}N$=4.1‰ (평균 2.1‰)의 값을 보였다. PAM에 의한 해조류의 광합성 특성은 광합성 활동의 지시자로서 사용될 수 있다. 우리는 Diving-PAM을 이용하여 각 정점 해조류인 방사무늬김의 광합성율을 분석하였다. 최대양자수율은 0.46~0.55 (평균 0.52)로서 최대 양자수율의 변동은 정점간 큰 차이는 없었다. 최대상대전자전달률은 4.71~5.84 (평균 5.33) ${\mu}mol\;electrons\;m^{-2}\;s^{-1}$ 로서 최대양자수율과 비슷한 분포를 보였다. 기울기 (${\alpha}$)는 0.027~0.045 (평균 0.036)을 보였고, 전자전달을 위한 포화광은 지역에 따라서 일부 차이를 보였으나 $139{\sim}180(156){\mu}mol\;photons\;m^{-2}\;s^{-1}$이었다. 남서해역 방사무늬김 엽체의 탄소 및 질소 농도와 광합성 효율은 지역에 따른 큰 차이는 보이지 않았다. 광합성 특성은 낮은 최대양자수율과 최대 상대전자전달률로 인한 낮은 광합성 효율이 나타났다.

• Preventive Nutrition and Food Science
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• 제7권3호
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• pp.282-286
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• 2002

Anemia is prevalent among pregnant women in Korea, and Fe deficiency anemia is a major nutritional problem throughout the world. Because studies of Cu, Mn, and Cr levels excluding Fe are rare, we were interested in changes in the nutritional status of these trace minerals and their relationship to hematogenesis. Accordingly, we determined the changes in plasma Fe, Cu, Mn, and Cr concentrations of maternal and umbilical cord blood during pregnancy, and evaluated the relationships between them at different time points during pregnancy. A total of 81 women participated in the study: 26 subjects in the first trimester, 23 in the second, and 32 in the third trimester. Plasma Fe levels were lower significantly (p<0.05) in the third trimester. Plasma Cu level ($\mu\textrm{g}$/dL) in each trimester were 86.6$\pm$13.8, 111.6$\pm$27.9, and 114.0$\pm$29.7, respectively; with significant increases (p<0.()5) in the second and third trimester. Plasma Mn concentrations (pg/dL) in each trimester were 212.6$\pm$89.0, 234.0$\pm$140.0, and 240.3$\pm$166.0, respectively and tended to increase, though not significantly, as the pregnancies progressed. The plasma concentrations of Cr (pg/dL) in each trimester were 3.7$\pm$2.0, 3.1$\pm$1.0, and 2.4$\pm$1.2, respectively; and was significantly lower (p<0.05) in the third trimester. In umbilical cord blood, the plasma level of Fe was 194.8$\pm$74.6 $\mu\textrm{g}$/dL, Cu was 57.5$\pm$10.9 $\mu\textrm{g}$/dL, Mn was 482.4$\pm$111.1 pg/dL, and Cr was 9.3$\pm$2.8 pg/dL. Plasma concentrations of Fe, Cu, Mn, and Cr of cord blood were 300 %, 50 %, 200 %, and 370% as compared to those of maternal blood in the third trimester. These results suggest that an active transport mechanism for the transport of Fe, Mn, and Cr from mother to fetus may exist, whereas, for Cu, the placenta appears to have a blocking effect on the transport from mother to baby.