• Title/Summary/Keyword: IM Won-jun

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Comparative evaluation to select optimal adjuvant of novel type Salmonella Typhimurium inactivated bacteria for protecting Salmonella infections in a murine model (마우스에서 살모넬라 감염증 예방을 위한 신개념 Salmonella Typhimurium 불활화 사균체에 최적 adjuvant 선택을 위한 효능 비교 시험)

  • Moon, Ja-Young;Ochirkhuyag, Enkhsaikhan;Kim, Won-Kyong;Lee, Jun-Woo;Jo, Young-Gyu;Kwak, Kil Han;Park, Byung Yong;Hur, Jin
    • Korean Journal of Veterinary Service
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    • v.43 no.2
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    • pp.89-97
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    • 2020
  • This study was carried out to examine a novel inactivated Salmonella Typhimurium (S. Typhimurium) vaccine candidate for protection of mice against salmonellosis by immunization of BALB/c mice using various type adjuvant. The novel type-inactivated vaccine candidate was constructed by adding Chlorhexidine digluconate solution. BALB/c mice were divided into 6 groups of 15 mice apiece. The mice were intramuscularly (IM) primed at 6 weeks of age and were IM boosted 8 weeks of age. Groups A and B mice were injected with sterile phosphate-buffered saline as controls; group C mice were inoculated with 5×108 cells/100 µL of formalin-inactivated S. Typhimurium cells and adjuvant ISA70; groups D~F mice were immunized with 5×108 cells/100 µL of the inactivated vaccine candidate and adjuvant ISA70, adjuvant IMS1313 and adjuvant IMS1313 containing 30 ㎍/mL of GI24, respectively. All mice (except group A mice) were orally challenged with a virulent S. Typhimurium strain at 10 weeks of age. Mice from groups C-F had significantly increased IgG levels compared to control groups (A-B) mice. The levels of splenocyte IFN-γ and IL-4 in mice of all groups were measured by ELISA, resulting in increased immunity in group F mice compared to those of groups A-E mice. These data suggested that systemic and cell-mediated immune responses were highly induced by IM immunization with the vaccine candidate and adjuvant IMS1313 containing GI24. Furthermore, clinical signs such as death were observed in only 20% of group F mice after virulent Salmonella strain challenge, however, groups B and C (100%), and groups D and E (60%) mice died. This data suggested that mice immunized by intramuscular prime and booster with this vaccine candidate and adjuvant IMS1313 containing GI24 effectively protected mice from salmonellosis.

Paleomagnetism and K-Ar Age of Volcanic Rocks from Guryongpo Area, Korea (구룡포에서 산출(産出)되는 화산암(火山岩)에 대(對)한 고지자기(古地磁氣)와 K-Ar연령(年齡))

  • Kim, Kwang Ho;Won, Jong Kwan;Matsuda, Jun-ichi;Nagao, Keisuke;Lee, Moon Won
    • Economic and Environmental Geology
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    • v.19 no.3
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    • pp.231-237
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    • 1986
  • Samples of porphyries, andesites, decites and sandstones were collected from 14 sites in order to study paleomagnetism and to determine K-Ar age in Guryongpo area. K-Ar age dating indicates that porphyries and volcanic rocks formed 41.7 and 22.7~19.4Ma, respectively. The mean direction of remanent magnetization for each site was generally well grouped after alternating field demagnetization. Both normal and reversed directions are present. The mean magnetic direction of the porphyries of Late Eocene and that of the volcanic rocks of Late Oligocene to Early Miocene have similar, easterly declinations. Overall magnetic direction is $Dm=43.8^{\circ}$, $Im=53.5^{\circ}$, ${\alpha}95=12.2^{\circ}$. the reliability of the observed paleomagnetic directions is ascertained by the presence of normal and reversed polarities. This is also conformed by the similarity of the declinations of the normal and reversed polarities. Observed easterly declinations in this area are attributed to local clockwise rotation of the land mass by approximately 40~50 degrees since early Miocene.

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A Study on the Occurrence of Seedlings and Saplings of Korean fir (Abies koreana E.H. Wilson) on the East slope of Mt. Hallasan National Park (한라산국립공원 동사면의 구상나무(Abies koreana E.H. Wilson) 유묘 및 치수 발생 현황)

  • Lee, Jong-Won;Choi, Im Jun;Lee, Su Hong;Lim, Won Taek;Kim, Jin-Won;Kang, Shin-Ho
    • Proceedings of the Plant Resources Society of Korea Conference
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    • 2019.04a
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    • pp.36-36
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    • 2019
  • 본 연구는 한라산국립공원 동사면에 위치한 구상나무숲 장기생태 모니터링 5ha 조사지역 ($20{\times}20m$, 125개 방형구)에서 구상나무의 유묘 및 치수 발생 현황을 파악하기 위하여 수행되었다. 조사는 2016년 6~8월 사이에 $5{\times}5m$ 방형구 125곳에 대해 계통추출법을 적용하여 실시하였다. 조사한 전체 125개 방형구 중에서 54개에서만 유묘가 관찰되었으며, 그 내용은 유묘 615개체 및 치수 1개체로 총 616개체가 발견되었다. 그러나 과반수의 71개 방형구에서 치수뿐만 아니라 유묘도 출현하지 않았다. 심지어 전체 125개 방형구에서 유묘가 가장 많이 관찰된 방형구(2-6지역, 95개체)를 제외하면, 나머지 124개 방형구의 평균 유묘 개체수는 4.2개로 매우 적었고 높이도 35cm 이하에 불과했다. 이와 함께 장기생태 모니터링 조사 지역 내에서 $1{\times}1m$ 방형구 183곳에 대해 단순 무작위 추출법으로 발생지 조사를 수행하였다. 발생지 조사 결과 유묘 2,518개체, 치수 2개체 및 유목 2개체 등 총 2,522개체가 발견되어 계통추출법을 적용한 조사와 유사한 결과가 나타났다. 본 연구를 통해 한라산국립공원 동사면 구상나무숲 내에서 구상나무 유묘의 발생은 어느 정도 이루어지고 있으나, 교란으로 인하여 치수로의 발달이 제한되는 것으로 판단된다. 여러 교란 요인 중에서 조사된 총 3,138개체 중 12.1%, 381개체에서 유제류인 노루에 의한 섭식이 확인되어 노루의 섭식이 유묘 발생 및 치수 발달에 교란을 야기하는 가장 중요한 요인으로 추정해볼 수 있다. 한반도 특산식물 구상나무의 보전 대책 수립을 위한 유묘 및 치수 교란 원인에 대한 지속적인 모니터링이 진행되어야 한다고 사료된다.

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InAs/GaAs 양자점 태양전지의 Photoreflectance Spectra에서 AlGaAs Potential Barrier 두께에 따른 Franz Keldysh Oscillation 주파수 특성

  • Son, Chang-Won;Lee, Seung-Hyeon;Han, Im-Sik;Min, Seong-Sik;Ha, Jae-Du;Lee, Sang-Jo;Smith, Ryan P.;Kim, Jong-Su;Lee, Sang-Jun;No, Sam-Gyu;Kim, Jin-Su;Choe, Hyeon-Gwang;Im, Jae-Yeong
    • Proceedings of the Korean Vacuum Society Conference
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    • 2012.02a
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    • pp.441-441
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    • 2012
  • Franz Keldysh Oscillation (FKO)은 p-n 접합 구조의 Photoreflectance (PR) spectra에서 표면 및 계면의 전기장(electric field) 특성을 반영한다. InAs/GaAs 양자점 태양전지(Quantum Dot Solar Cell, QDSC) 구조에서 InAs 양자점 층 전후에 AlGaAs 층을 삽입하여 퍼텐셜 장벽(potential barrier) 두께에 따른 PR spectra 및 GaAs-matrix에서 FKO 주파수 특성을 비교 분석하였다. InAs/GaAs 양자점 태양전지는 p-i-n 구조의 i-GaAs에 2.0 monolayer (ML), 8주기의 InAs 양자점 층을 삽입하여 Molecular Beam Epitaxy (MBE) 방법으로 성장하였다. 각 양자점 층 전후에 두께가 각각 0.0, 1.6, 2.8, 6.0 nm인 AlGaAs 층을 삽입하여 퍼텐셜 장벽 두께에 따른 FKO 주파수 변화를 관측하였다. 또한 태양전지 구조의 전기장 분포를 좀 더 용이하게 관측하기 위해 여기 광의 세기(power intensity)를 충분히 낮추어 Photovoltaic effect에 의한 내부 전기장의 변화를 최소화하여 비교 분석하였다. InAs/GaAs 양자점 태양전지 구조에서 AlGaAs 장벽층이 없는 경우, PR spectra의 Fast Fourier Transform 결과에 반영되는 FKO 주파수 특성은 p-i-n 구조 계면에서 공핍층(depletion region)의 space charge field보다 양자점 층의 내부 전기장에 의한 FKO 주파수가 더 큰 진폭(amplitude)을 보였다. 반면에, AlGaAs 장벽층이 삽입되면 두께가 커짐에 따라 p-i-n 구조 계면의 space charge field에 의해 더 큰 진폭의 FKO 주파수가 관측되었다. 이는 AlGaAs 장벽층이 삽입됨으로써 양자점 층 내 양자 상태 수 및 여기광에 의한 캐리어의 수와 관련이 있음을 확인하였으며, 결과적으로 GaAs-matrix에서 p-i-n 구조 계면의 space charge field에 영향을 미치게 됨을 알 수 있다. 이러한 PR 특성 결과들을 InAs/GaAs 양자점 태양전지의 설계 및 제조에 반영함으로써 양자효율 증대에 기여할 것으로 기대된다.

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Feminizing of Real Estate Speculation -A Study on the Bokbuin in the Korean Narratives in 1970s~1980s (주거의 투기화, 투기의 여성화 -1970~1980년대 한국 서사에 나타난 복부인의 형상화 양상 연구)

  • Jun, Bong-Gwan
    • Journal of Popular Narrative
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    • v.25 no.4
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    • pp.321-359
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    • 2019
  • In the 1970s, the full-scale development of the area now known as Gangnam began, ushering in the era of real estate investment on apartments which transformed housing styles in Korea. Apartments were pitched as the most ideal type of housing, creating a competitive market of high demand and skyrocketing prices. The apartments were also viewed as a means of quick asset investment among middle-class Koreans. Within this apartment frenzy stood the female real estate speculator, the bokbuin. This study seeks to locate the bokbuin in the real estate development market after the late 1970s. The apartment speculation boom cannot be attributed to the bokbuin alone, yet she became the target of public anger and criticism, singled-out as being responsible for fueling illegal and unethical investments. The apartment boom of the 1970s was in fact generated in large part by the government, developers, construction companies and realtors. While their pursuit of profit was deemed as legitimate, the bokbuin's conduct was mostly tainted by presumed illegitimate and greedy motivations. This study problematizes this gendering of real estate investment and treat the bokbuin as a byproduct of the family-centered culture in East Asia. Analyzing Im Kwon Taek's film "Mrs. Speculator", Park Ki Won's conte, "Bokbuin", Park Wan Seo's short story, "Children of Paradise", "The People of Seoul", this study shows that bokbuin's pursuit was not hers alone; it was the collective pursuit with her husband for the enhancement of family finances. This stud y argue that the bokbuin embodied the thickly misogynistic climate of the 1970s that projected the chaotic rise of greed onto the woman.

Errects of $SiH_4/WF_6$Ratio on the Electrical Properties of LPCVD W Films for Contact Metal (Contact Barrier metal용 LPCVD W막의 전기적 특성에 대한 $SiH_4/WF_6$비의 효과)

  • Lee, Jong-Mu;Park, Won-Gu;Im, Yeong-Jin;Son, Jae-Hyeon;Kim, Hyeong-Jun
    • Korean Journal of Materials Research
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    • v.3 no.6
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    • pp.661-667
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    • 1993
  • Effects of $SiH_4//WF_6$(=R) ratio on the electrical properties of W films such as resistvity, contact resistance, junction leakage current in the selective W CVD technology for contact barrier metal were investigated with the emphasis on the role of $\alpha$-W Resistivity of W increases with increasing R, which is primarily due to the phase transformation from $\alpha$-W to , $\alpha$-W. $\alpha$-W found in the SiH4 reduced CVD W film is stabilized by Si incorporated into the W film rather than by oxygen. $\alpha$-W is found in the W film deposited on the Si substrate for high R, while $\alpha$-W is not found in the W film deposited on the TiN substrate even for high R. Also junction leakages increase with increasing R, which is caused not only by the vertical Si consumption but also the lateral Si consumption.

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A Comparative Study of the Effects of Jungsongouhyul Pharmacopuncture Treatment and Bee Venom Pharmacopuncture Treatment on Peripheral Facial Paralysis (말초성 안면신경마비에 대한 중성어혈약침과 봉약침 효과 비교 연구)

  • Im, Se Hoon;Lee, Min Jun;Lee, Seung Min;Kim, Eun Seok;Lee, Seung Hoon;Kang, Jung Won;Kim, Yong Suk
    • Journal of Acupuncture Research
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    • v.31 no.2
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    • pp.135-144
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    • 2014
  • Objectives : This study was designed to compare the effects of Jungsongouhyul pharmacopuncture treatment with bee venom pharmacopuncture treatment in hospitalized patients with peripheral facial paralysis. Methods : This study was done on a total of 41 patients with peripheral facial paralysis who were admitted into the Korean Medicine Hospital from February 1st, 2013 to April 30th, 2014. Wedivided patients into two groups. The Jungsongouhyul group was treated by Jungsongouhyul pharmacopuncture once a day and the bee venom group was treated by bee venom pharmacopuncture once a day. To compare the therapeutical effects of the two treatments, we used Yanagihara's unweighted grading system, House-Brachmann grading system, lip-length & snout indices and facial disablity index twice - before initial treatment and after final treatment. Results : Both Yanagihara's score and House-Brachmann grading system score improved in each group. However, there were no significant differences in improvement between the bee venom group and the Jungsongouhyul group. Conclusions : Jungsongouhyul pharmacopuncture treatment appears to be as effective as bee venom pharmacopuncture treatment to improve symptoms of peripheral facial paralysis.

Anti-nociceptive Activity of Acer tegmentosum MeOH Extract (산청목 메탄올 추출물의 진통 효과)

  • Seo, Hyun Won;Park, Kyung Jae;Guahk, Gui Hee;Im, Jun Sang;Kim, Dae Keun;Leem, Jae Yoon;Cha, Dong Seok;Kwon, Jin;Oh, Chan Ho;Jeon, Hoon
    • Korean Journal of Pharmacognosy
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    • v.44 no.2
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    • pp.188-192
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    • 2013
  • Acer tegmentosum which is belongs to Aceraceae has been widely used as a traditional medicine for the treatment of lots of diseases including pain management. In this study, we evaluated the anti-nocicepitve effects of methanolic extract of A. tegmentosum (MAT) in mice using various pain models. MAT presented strong and dose-dependent anti-nociceptive activities on thermal nociception models such as tail-immersion test and hot plate test. Moreover, acetic acid-induced chemical nociception was signigicantly reduced by MAT treatment. We could confirm MAT's central and peripheral analgesic properties by formalin test. We also found that the pre-treatment of opioid receptor antagonist did not alter the MAT's anti-nociception, suggesting opioid receptor is not involved in analgesic activity of MAT. Based on our results, we could conclude that MAT may be possibly used as an anti-nociceptive agent for the treatment of various nociceptive pains.

50 W 급 저전력 원통형 이온빔 소스의 개발 및 연구

  • Kim, Ho-Rak;Lee, Seung-Hun;Im, Yu-Bong;Kim, Jun-Beom;Choe, Won-Ho
    • Proceedings of the Korean Vacuum Society Conference
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    • 2016.02a
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    • pp.192.2-192.2
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    • 2016
  • 전기추력기는 화학식 추력기에 비해 비추력이 높아 인공위성의 자세제어, 궤도수정, 궤도천이를 포함한 행성 탐사활동 및 우주 임무수행을 위한 우주선의 엔진 등으로 다양하게 활용된다. 홀 추력기는 전기추력기 중 하나로 고리형 방전공간을 가진 고리형 추력기와 원통형 방전영역을 가진 원통형 추력기가 있으며, 원통형 추력기는 고리형에 비하여 넓은 방전공간으로 저전력 방전에 적합한 추력기이다. 또한, 저전력 추력기는 큐브셋(cubesat) 및 마이크로 위성(microsatellite)의 증가하는 수요에 따라 필요성이 증가하고 있으며, 활용도가 높아 다양하게 연구 및 개발되고 있다. 홀 추력기는 자기장과 전기장을 서로 수직되게 인가하여, 자화된 전자는 플라즈마 방전을 유지시키고 자화되지 않은 이온은 전기장 방향으로 가속되어 이온빔을 발생시킨다. 하지만, 저전력 소형 추력기는 작은 소모전력과 방전채널로 인한 성능 저하 및 자기장 구조 설계 등 많은 어려움들을 가지고 있다. 본 연구에서는, 약 50 W급의 소모전력을 바탕으로 영구자석을 이용한 저전력 플라즈마 추력기를 개발하였다. 방전 채널은 지름 15 mm, 길이 16 mm, 무게는 약 0.6 kg으로 원통형 구조의 채널로 제작되었으며, 약 1500-2000 G의 자기장 세기를 갖도록 설계하였다. 방전 기체는 제논을 사용하여 1-5 sccm영역에서 방전 특성을 살펴보았으며, 방전 전류는 0.02-0.4 A로 나타났다. 100-550 V영역에서 방전을 시도하였고, 채널길이를 16-24 mm 에서 약 1mN 급의 추력특성을 보였다. 본 발표에서, 홀 추력기의 제작 특성과 성능 및 플라즈마 특성에 대한 더 자세한 연구결과가 발표될 예정이다.

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Characteristics of Ceramic Separator Impregnated by Molten Salt for Thermal Batteries (열전지용 세라믹 분리막의 용융염 전해질 함침 특성)

  • Kang, Seung-Ho;Im, Chae-Nam;Park, Byung-Jun;Cho, Sung-Baek;Cheong, Hae-Won;Yi, Junsin
    • Journal of the Korean Institute of Electrical and Electronic Material Engineers
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    • v.28 no.7
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    • pp.467-472
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    • 2015
  • Thermal batteries are primary power sources for military applications requiring high reliability, robustness and long storage life. Conventional electrodes for thermal batteries are prepared by compacting powder mixtures into pellets. Separator is composed of halide mixture, such as LiCl-KCl eutectic salt, blended with MgO to immobilize the molten salt. In order to increase the power density and energy density, the resistance of electrolyte should be reduced because the resistance of electrolyte is predominant in thermal batteries. In this study, wetting behaviors and impregnation weight of molten salts as well as the micro structures of ceramic felt were investigated to be applicable to thin electrolyte. Discharge performances of single cell with the ceramic separator impregnated by molten salt were evaluated also. Zirconia felt with high porosity and large pore outperformed alumina felt in wetting characteristics and molten salt impregnation as well as discharge performances. Based on the results of this study, ceramic felt separator impregnated with molten salt have revealed as an alternative of conventional thick MgO based separator with no conspicuous sign of thermal runaway by short circuit.