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Anti-nociceptive Activity of Acer tegmentosum MeOH Extract  

Seo, Hyun Won (College of Pharmacy, Woosuk University)
Park, Kyung Jae (College of Pharmacy, Woosuk University)
Guahk, Gui Hee (College of Pharmacy, Woosuk University)
Im, Jun Sang (College of Pharmacy, Woosuk University)
Kim, Dae Keun (College of Pharmacy, Woosuk University)
Leem, Jae Yoon (College of Pharmacy, Woosuk University)
Cha, Dong Seok (College of Pharmacy, Woosuk University)
Kwon, Jin (Department of Prosthetics and Orthotics, Korea National College of Welfare)
Oh, Chan Ho (Department of Food & Biotechnology, Woosuk University)
Jeon, Hoon (College of Pharmacy, Woosuk University)
Publication Information
Korean Journal of Pharmacognosy / v.44, no.2, 2013 , pp. 188-192 More about this Journal
Abstract
Acer tegmentosum which is belongs to Aceraceae has been widely used as a traditional medicine for the treatment of lots of diseases including pain management. In this study, we evaluated the anti-nocicepitve effects of methanolic extract of A. tegmentosum (MAT) in mice using various pain models. MAT presented strong and dose-dependent anti-nociceptive activities on thermal nociception models such as tail-immersion test and hot plate test. Moreover, acetic acid-induced chemical nociception was signigicantly reduced by MAT treatment. We could confirm MAT's central and peripheral analgesic properties by formalin test. We also found that the pre-treatment of opioid receptor antagonist did not alter the MAT's anti-nociception, suggesting opioid receptor is not involved in analgesic activity of MAT. Based on our results, we could conclude that MAT may be possibly used as an anti-nociceptive agent for the treatment of various nociceptive pains.
Keywords
Acer tegmentosum; pain; anti-nociception;
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Times Cited By KSCI : 2  (Citation Analysis)
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