• 천문학회보
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• 제46권1호
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• pp.30.2-30.2
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• 2021

The extended Lyα nebulae (also known as Lyα blobs or LABs) observed at z=2-6 can provide clues to galaxy formation in the early universe. The connection of LABs with the overdensities of compact Lyα emitters suggests that they are associated with matter density peaks in the universe and thus likely to evolve into the present-day groups and clusters of galaxies. However, the mechanism powering the extended Lyα emission in LABs is remained controversial. The detection of polarization signals that follow the theoretically predicted trend is interpreted as strong evidence supporting that the LABs are caused primarily by the resonance scattering of Lyα originating from star-forming galaxies and AGNs. However, Trebitsch et al. (2016) claimed that the radial profile of polarization could be better explained by the scenario in which Lyα photons are produced in the cooling gas surrounding galaxies and then self-scattered by the gas, rather than by the scattering scenario of photons originating from the central galaxies. In this presentation, using LaRT, a state-of-art Lyα radiative transfer code, it is demonstrated that the observed polarization pattern can be reproduced even with the scattering scenario.

• BMB Reports
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• 제32권4호
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• pp.379-384
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• 1999

Taxol, a natural product with significant anti-tumor activity, stabilizes microtubules and arrests cells in the G2/M phase of the cell cycle. It has been reported that taxol has additional effects on the cell such as an increase in tyrosine phosphorylation of proteins and activation of mitogen-activated protein (MAP) kinase. This phosphorylated kinase translocates into the nucleus and phosphorylates its substrate c-jun, c-fos, ATF2, and ATF3. The MAP kinase family is comprised of key regulatory proteins that control the cellular response to both proliferation and stress signals. First examination was cytotoxicity and apoptosis-induced concentration with paclitaxel in HeLa cell. A half-maximal inhibition of cell proliferation ($IC_{50}$) occurred at 13 nM paclitaxel. When DNA fragmentation was analyzed by agarose gel electrophoresis, a nucleosomal ladder became evident 24 h after a taxol (50 nM) addition to the cells. In addition, an apoptotic body was detected by electron microscopy. Taxol-treated cells were arrested at the S phase at 10 nM. Treatment of 50 nM taxol activated the extracellular signal-regulated protein kinase (ERK1), and a fraction of the activated MAP kinases entered the nucleus. It was also discovered that nucleus substrates c-jun was phosphorylated and activated in the cell. The activated ERK1 could subsequently translocate into the nucleus and phosphorylate its substrate c-jun as well. This study suggests that taxol-induced apoptosis might be related with signal transduction via MAP kinases.

• 한국식품과학회지
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• 제43권1호
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• pp.114-118
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• 2011

본 연구에서는 다양한 생리활성이 보고된 폴리페놀 화합물인 resveratrol의 항산화 활성과 산화촉진 작용을 세포 내에 조성될 수 있는 여러 pH 조건에서 시간별로 분석하고, resveratrol의 세포독성에 미치는 antioxidant들의 작용을 조사하였다. Resveratrol을 pH 6.5에서 저장하였을 경우 pH 7.4에서 저장하였을 때보다 유의적으로 높은 DPPH 라디칼 소거활성을 나타내었다. Resveratrol을 pH 8.0에서 저장시 항산화 활성을 나타내지 않았으며, 오히려 다른 조건에서 보다 현저히 많은 $H_2O_2$를 생성하는 산화촉진 효과를 나타내었다. Resveratrol의 HeLa 세포에 대한 독성은 SOD, NAC, glutathione, ascorbic acid 등과 같은 antioxidant 존재하에 유의적으로 증가하였으며, 이러한 독성의 강화는 첨가된 antioxidant 의 농도에는 크게 영향 받지 않았다. 본 결과는 resveratrol이 세포 내 pH 환경에 따라 antioxidant 또는 $H_2O_2$와 같은 활성산소종을 생성하는 prooxidant로 작용할 수 있으며, resveratrol로부터 생성되는 활성산소종의 제거가 세포독성을 증가시킬 수 있음을 시사한다.

• 한국도로학회논문집
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• 제13권1호
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• pp.169-175
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• 2011

콘크리트에서 강도는 콘크리트의 물리적 특성을 평가할 수 있는 중요한 인자 중 하나이며 콘크리트에 가장 많은 부피를 차지하는 것이 골재이다. 또한 시멘트는 콘크리트 만드는 결합재로서 이 역시 강도와 매우 밀접한 관계가 있다. 이러한 골재와 시멘트의 특성이 콘크리트 압축강도와 전단파 속도의 상관관계에 미치는 영향을 파악하고자 굵은 골재 최대치수와 시멘트 종류별로 실험을 실시하였다. 시멘트는 1종 시멘트와 초속경 시멘트를 사용했고, 골재는 서로 다른 지역의 3가지 골재를 사용하였다. 골재의 입도는 굵은 골재 최대치수 19mm와 13mm의 단입도 골재를 사용하여 동일 배합시 압축강도와 전단파 속도의 상관관계를 살펴보았다. 또한 골재의 특성을 정량화 하고자 LA마모시험을 실시하였다. 그 결과 압축강도와 전단파 속도의 상관관계는 시멘트 종류에 따라 달랐으나, 골재의 종류, 입도 및 마모감량에 관계없이 일정한 상관성을 보이는 것으로 나타났다.

• Natural Product Sciences
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• 제20권4호
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• pp.274-280
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• 2014

Six compounds were isolated from the n-BuOH fraction of the aerial parts of Aruncus dioicus var. kamtschaticus including: sambunigrin (1), prunasin (2), aruncide A (3), aruncide C (4), 1-O-caffeoyl-${\beta}$-D-glucopyranose (5), and caffeic acid (6). Their structures were confirmed by comparing the spectral data with those reported in the literature. The isolated compounds (1 - 6) were then examined for their cytotoxic effects towards MCF-7, HL-60, and HeLa cancer cell lines, as well as their DPPH radical scavenging activity. The results indicated that compound 4 possessed the strongest inhibitory effect toward HeLa cell line with $IC_{50}$ value of $5.38{\pm}0.92{\mu}M$. Compound 3 possessed selective cytotoxic activity on HL-60 cells with $IC_{50}$ value of $6.27{\pm}0.17{\mu}M$, compound 5 was found as the best in inhibiting proliferation with $IC_{50}$ value of $2.25{\pm}0.09{\mu}M$, and the other compounds showed significant inhibition with $IC_{50}$ values ranging from 6.10 to $11.27{\mu}M$. Compound 5 also displayed the strongest cytotoxic effect toward MCF-7 cell line ($IC_{50}$ $4.32{\pm}0.15{\mu}M$). Both 5 and 6 demonstrated strong radical scavenging activity ($IC_{50}$ $6.87{\pm}0.03$ and $4.33{\pm}0.22{\mu}M$, respectively). Compounds 1 and 5 were isolated for the first time from this plant.

• 한국마이크로전자및패키징학회:학술대회논문집
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• 한국마이크로전자및패키징학회 2003년도 기술심포지움 논문집
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• pp.221-225
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• 2003

The MFIS-FET(Field Effect Transistor) devices using $BLT/Y_2O_3$ buffer layer on p-Si(100) substrates were fabricated by the Sol-Gel method and conventional memory processes. The crystal structure, morphologies and electrical properties of prepared devices were investigated by using various measuring techniques. From the C-V(capacitance-voltage) data at 5V, the memory window voltage of the $Pt/BLT/Y_2O_3/si$ structure decreased from 1.4V to 0.6V with increasing the annealing temperature from $700^{\circ}C\;to\;750^{\circ}C$. The drain current (Ic) as a function of gate voltages $(V_G)$ for the $MFIS(Pt/BLT/Y_2O_3/Si(100))-FET$ devices at gate voltages $(V_G)$ of 3V, 4V and 5V, the memory window voltages increased from 0.3V to 0.8V as $V_G$ increased from 3V to 5V.

• 한국세라믹학회지
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• 제48권2호
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• pp.183-188
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• 2011

In this article, the effect of the crystal structural environment of $Pr^{3+}$ ions on the photoluminescence (PL) characteristics of double tungstates, such as $A(M_{1-X}Pr_X)W_2O_8$ (A=Li, Cs, M = In, Y, Sc, La; $0.007{\leq}x{\leq}0.1$) and $La_{1.96}Pr_{0.04}W_3O_{12}$ are characterized. By varying the ion radius in A and M sites, the structural environment of $Pr^{3+}$ ions were modified. The structural criteria, that is, the point charge electrostatic potentials V around the $Pr^{3+}$ activator, were calculated using the crystal structural parameters. The point charge potential V can be a valid criterion for $^3P_o$ quenching in various double tungstates. When the calculated V values are large (> 6.0), the luminescence from the $^3P_0$ level becomes dominant. When the calculated V values are about 3.8, the $^1D_2$ line appears weakly but $^3P_0$-level luminescence is absent. When the calculated V values are small (< 2.0), the luminescence from the $^1D_2$ level becomes dominant and $^3P_0$-level luminescence is absent. At 2.0$^3P_o$ quenching to $^1D_2$ level occurs substantially in accordance with the structural criterion of the point charge potential model.

• 대한핵의학회지
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• 제27권1호
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• pp.104-111
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• 1993

Trace elements are important components in the biological system, as a structural material and metabolic controller. Neutron activation analysis (NAA) with high neutron flux and high energy resolution Ge (Li) detector coupled to multichannel analyzer (MCA) has been one of the most accurate method for the determination of ultra-trace level components, and is applicable to biological material. In human body, the NAA can be used for quantitation of trace elements in various organs and tissue with endocrinological and metabolic disease and industrial metal poisoning. In this study, Triga Mark III nuclear reactor in Korea Atomic Research Institute was used for quantitation of trace eleement in human lung cancer tissues by neutron activation analysis. In the squamous cell carcinoma tissues, Br, Hg, La, Sb, Sc, Cl, Fe and I content were lower than normal lung tissues, and K, Rb and Se content were higher. In the adenocarcinoma tissues, Fe, Au, La, Sc and Zn content were lower than normal lung tissues, and Rb, Co and Se content were higher. Rb content was higher in the adenocarcinoma tissues than in the squamous cell carcinoma tissues. Fe and Na content were higher in the squamous cell carcinoma tissues than in the adenocarcinoma tissues.

• 한국세라믹학회지
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• 제40권10호
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• pp.925-930
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• 2003

The dielectric polarizability-related factors contributing to the $\tau$$_{\varepsilon}$ have been analysed in terms of dielectric permittivity $\varepsilon$, Tolerance Factor (TF), and octahedron tilt angles in (1-x)CaTi $O_3$-x[A(B', B″) $O_3$] (A=Ca, La, Li, B'=Al, Fe, Mg, B″=Nb, Ta) and (S $r_{0.2}$C $a_{0.8}$)( $Ti_{1-x}$ Z $r_{x}$) $O_3$. All the compounds have the orthorhombic Pbnm structure except the end members A(B', B″) $O_3$ and the solid solutions of x$\geq$0.8. The additional dipole field effect is suggested as a dominant factor contributing to $\tau$$_{\varepsilon}$ in CaTi $O_3$-based ceramics having relatively large $\varepsilon$, which has not been generally considered in the previous reports dealing with the $\tau$$_{\varepsilon}$. This study has been focussed on delineating the dipole field effect on the $\tau$$_{\varepsilon}$ in comparison to the octahedron tilt effect in CaTi $O_3$-based ceramics.cs..cs.

• Korean Journal of Radiology
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• 제22권4호
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• pp.525-534
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• 2021

Objective: To assess the effect of left atrial appendage (LAA) isolation on LAA emptying and left atrial (LA) function using cardiac MRI in patients who underwent successful catheter ablation of atrial fibrillation (AF). Materials and Methods: This retrospective study included 84 patients (mean age, 59 ± 10 years; 67 males) who underwent cardiac MRI after successful catheter ablation of AF. According to the electrical activity of LAA after catheter ablation, patients showed either LAA isolation or LAA normal activity. The LAA emptying phase (LAA-EP, in the systolic phase [SP] or diastolic phase), LAA emptying flux (LAA-EF, mL/s), and LA ejection fraction (LAEF, %) were evaluated by cardiac MRI. Results: Of the 84 patients, 61 (73%) and 23 (27%) patients showed LAA normal activity and LAA isolation, respectively. Incidence of LAA emptying in SP was significantly higher in LAA isolation (91% vs. 0%, p < 0.001) than in LAA normal activation. LAA-EF was significantly lower in LAA isolation (40.1 ± 16.2 mL/s vs. 80.2 ± 25.1 mL/s, p < 0.001) than in LAA normal activity. Furthermore, LAEF was significantly lower in LAA isolation (23.7% ± 11.2% vs. 31.1% ± 16.6%, p = 0.04) than in LAA normal activity. Multivariate analysis demonstrated that the LAA-EP was independent from LAEF (p = 0.01). Conclusion: LAA emptying in SP may be a critical characteristic of LAA isolation, and it may adversely affect the LAEF after catheter ablation of AF.