• Title/Summary/Keyword: IL-23

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Antitumor and Immunomodulatory Activities of Platycodon grandiflorum (길경(桔梗)이 면역활성(免疫活性) 및 항암(抗癌)에 미치는 영향)

  • Lee, Ji-Yung;Lee, Jin-Moo;Lee, Chang-Hoon;Cho, Jung-Hoon;Jang, Jun-Bock;Lee, Kyung-Sub
    • The Journal of Korean Obstetrics and Gynecology
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    • v.23 no.4
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    • pp.10-19
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    • 2010

  • Methods: Intravenous administration of Platycodon grandiflorum was performed 2 days before tumor inoculation, then mice were killed 14 days after tumor inoculation, then number of tumor colonies were counted. Methanol extracts of Platycodon grandiflorum was added to colon26-M3.1 carcinoma cells, L5178Y-R lymphoma cells and Hela cells, and then cell growth was counted. To observe the immunomodulating effects of Platycodon grandiflorum, production of IL-6, IL-10, IL-12 and TNF-$\alpha$ were measured with ELISA assay and the cell growth of macrophage were also counted. Furthermore, antimetastatic experiment after depletion NK cells by injection of anti-asialo GM1 serum was also administered. Results: Intravenous administration of Platycodon grandiflorum significantly inhibited metastasis of colon26-M3.1 carcinoma cells. In an in vitro cytotoxicity analysis, Platycodon grandiflorum affected tumor cell growth above specific concentration. As compared with control, the production of IL-6, IL-10, IL-12 and TNF-$\alpha$ were incresed. And depletion NK cell completly abolished the inhibitory effect of metastasis. Conclusion: Platycodon grandiflorum appears to have considerable activity on immunomodulating effects and inhibit the metastasis of tumor. Further evaluation is needed for settling this.

  • https://doi.org/10.15204/jkobgy.2010.23.4.010 인용 PDF KSCI

Experimental Studies on Antimetastatic and Immunomodulating Effects of Ulmus davidiana (유근피(楡根皮)의 선천 면역 활성화에 의한 암 전이 억제 효과)

  • Kim, Heung-Soo;Cho, Jung-Honn;Lee, Jin-Moo;Lee, Chang-Hoon;Jang, Jun-Bock;Lee, Kyung-Sub
    • The Journal of Korean Obstetrics and Gynecology
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    • v.23 no.1
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    • pp.1-11
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    • 2010

  • Purpose: This study was designed to investigate the antimetastatic and immunomodulating effects of extracts of Ulmus davidiana extracts(U. D. Ex.). Methods: Antimetastatic experiments were conducted in vitro and in vivo by using colon 26-M3.1 carcinoma, L5178Y-R lymphoma cell and Hela cell. To observe the immunomodulating effects of U. D. Ex., we measured IL-6, IL-10, IL-12 and TNF-$\alpha$ from peritoneal macrophages. And we evaluated the activation of NK cell by using anti-asialo-GM1 serum. Results: We found that the administration of U. D. Ex. significantly inhibited tumor metastasis in vivo. In vitro cytotoxicity analysis, cell growth are closer to 100% in case of Colon 26-M3.1 carcinoma, L5178Y-R lymphoma cell and Hela cell at low concentration. In case of macrophage, cell proliferation is closer to 100% less than $250{\mu}g/ml$ of U. D. Ex.. The level of cytokine such as IL-6, IL-10, IL-12 which stimulates U. D. Ex. was increased in dose-dependent manner compared to the control group. In case of TNF-$\alpha$, the level was increased at concentration of $1,000{\mu}g/ml$. The depletion of NK cells by anti-asialo GM1 serum partly abolished the inhibitory effect of U. D. Ex. on tumor metastasis. Conclusion: Ulmus davidiana appears to have considerable activity on the anti-metastasis by activation the immune system.

  • https://doi.org/10.15204/jkobgy.2010.23.1.001 인용 PDF KSCI

Seasonal Variation Estimation of Inflow Pollutant Loads of Yeong-il Bay by using Tank Model (Tank모델에 의한 영일만 유입오염부하량의 계절변동 예측)

  • Lee In-Cheol
    • Journal of the Korean Society for Marine Environment & Energy
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    • v.6 no.3
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    • pp.63-71
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    • 2003

  • This study investigated about the seasonal variation of pollutant loads flowing into the Yeong-il bay from constructing Tank model which is the simulation model to evaluate the daily river discharge and pollutant load in the Hyeong-san river watershed. The estimated annual average river discharge of Hyeong-san river flowing into Yeong-il bay is about 878.34×10/sup 6/㎥/year which is about 73% of annual average of total precipitation in Hyeong-san river watershed. The annual average of pollutant load flowing into Yeong-il bay was estimated each 15.11 ton-COD/year, 23.24 ton-SS/year, 10.65 ton-TN/year, and 0.54 ton-Tp/year. For the seasonal variation of pollutant loads, it was tended as increasing of river discharge as increasing of inflow pollutant loads at June and July of summer and October of autumn. The main source of pollutant loads was found to be the Pohang city and Pohang industrial complex which are located near the mouth of Hyeong-san river. Therefore, for effective water quality management of Yeong-il bay, the counterplan to reduce pollutant loads from the main source of pollutant loads is required.

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