• The Journal of Korean Medical History
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• v.17 no.1
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• pp.3-29
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• 2004

This study is on the philosophy and medical science of Lee Gyu Jun, who is the author of SoMunDaeYo and UiGamJungMa. Lee Gyu Jun proposed that Providence is made of Ki, and the Pure Good of Ki is the composing principle of the universe. The Ki could be Pure Good because it embraces Reason of Law inside itself, as a part of itself. This developed as a result of absorbing the ideas from Han and Tang Dynasty's' Ki-Philosophy trend, the latter half of the Joseon Dynasty's Heart Nature Doctrine centered Ri(理:reason)-Monism trend, and Sim (心:heart) centered teachings of Wang Yang Ming, etc. Later, his philosophical Ki-Monism(氣一元 GiIlWon) and SimAngKiReon(心陽氣論) appears exactly in medical science and continues on to Ki-Monism(氣一元 GiIlWon) and SimHwaReon(心火論).

• Journal of the Korean Geophysical Society
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• v.7 no.2
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• pp.89-97
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• 2004

Earthquake records written in the history documents such as “SeungJeongWon IlKi” and “Chosun Wangjo Shilok” for the earthquakes occurred around the offshore near Yangyang and Samcheok area in June, 1681, have been analyzed to estimate the intensity distribution and epicenters as well as magnitudes. Three consecutive earthquakes were analysed, which occurred near those area on June 12, 17, and 26, 1681. The Main-shock occurred on June 12, 1681 was felt in almost every provinces of Korea while after-shocks occurred on June 17 and 26, 1681, were felt in several provinces restrictively. Although the main-shock was felt in the entire provinces, the real damage had been concentrated in Kangwon province. A block of rock collapsed to fall due to main-shock in the mountain near Samcheok. No other man casualties were reported except a death due to being thrown off a horse by ground shaking in Seoul. Local micro-tsunami seems to be generated at the offshore of Samcheok due to the main-shock. The main-shock seems to be occurred in the offshore between Yangyang and Samcheok (38.0oN and 129.0oE) , the epicenter intensity and magnitude of which is over 8 in MMI and 6½ in Ms, respectively.

• Journal of Korean Biological Nursing Science
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• v.17 no.4
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• pp.341-347
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• 2015

Purpose: Chrysanthemum indicum (CHI) has been used for edible and medical purposes for a long time in Korea. The purpose of this study was to evaluate the anti-inflammatory effects of CHI water extract in lipopolysaccharides (LPS)-induced RAW 264.7 macrophage cells. Methods: To investigate the anti-inflammatory effects on LPS-induced RAW 264.7 macrophage cells, CHI extract as a whole plant was used in this study. RAW 264.7 cells were treated with various concentrations of CHI extract (1, 10, and $100{\mu}g/mL$). After that Nitric Oxide (NO), inducible nitric oxide synthase (iNOS), interleukin (IL)-$1{\beta}$, cyclooxygenase (COX)-2 and prostaglandin $E_2$ ($PGE_2$) expression level were measured. Results: CHI extract significantly suppressed the LPS-induced NO production and decreased the level of iNOS, IL-$1{\beta}$, COX-2 messenger ribonucleic acid (mRNA) expression and also the down regulation of $PGE_2$ expression in a dose-dependent manner. Conclusion: The present study suggested that CHI extract can be substituted for anti-inflammatory drugs and provide a safe and effective non pharmacological therapeutic approach.

• Tuberculosis and Respiratory Diseases
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• v.43 no.6
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• pp.945-953
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• 1996

Background : Many acute and chronic lung diseases including pneumoconiosis are characterized by the presence of increased numbers of activated macrophages. These macrophages generate several inflammatory cell chemoattractants, by which neutrophil migrate from vascular compartment to the alveolar space. Recruited neutrophils secrete toxic oxygen radicals or proteolytic enzymes and induce inflammatory response. Continuing inflammatory response results in alteration of the pulmonary structure and irreversible fibrosis. Recently, a polypeptide with specific neutrophil chemotactic activity, interleukin-8(IL-8), has been cloned and isolated from a number of cells including : monocytes, macrophages and fibroblasts. IL-1 and/or TNF-${\alpha}$ preceded for the synthesis of IL-8, and we already observed high level of IL-1 and TNF-${\alpha}$ in the pneumoconioses. So we hypothesized that IL-8 may be a central role in the pathogenesis of pneumoconiosis. In order to evaluate the clinical utility of IL-8 as a biomarker in the early diagnosis of pneumoconiosis, we investigated the increase of IL-8 in the pneumoconiotic patient and the correlation between IL-8 level and progression of pneumoconiosis. Method : We measured IL-8 in the serum of 48 patients with pneumoconiosis and 16 persons without dust exposure history as a control group. Pneumoconiotic cases were divided into 3 groups according to ILO Classification : suspicious group(n=16), small opacity group(n=16) and large opacity group(n=16). IL-8 was measured by a sandwich enzytne immunoassay technique. All data were expressed as the $mean{\pm}standard$ deviation. Results: 1) The mean value of age was higher in the small opacity and large opacity group than comparison group, but smoking history was even. Duration of dust exposure was not different among 3 pneumoconiosis groups. 2) IL-8 level was $70.50{\pm}53.63pg/m{\ell}$ in the suspicious group, $107.50{\pm}45.88pg/m{\ell}$ in the small opacity group, $132.50{\pm}73.47pg/m{\ell}$ in the large opacity group and $17.85{\pm}33.85pg/m{\ell}$ in the comparison group. IL-8 concentration in all pneumoconiosis group was significant higher than that in the comparison group(p<0.001). 3) IL-8 level tended to increase with the progression of pneumoconiosis. Multiple comparison test using Anova/Scheffe analysis showed a significant difference between suspicious group and large opacity group(p<0.05). 4) The level of IL-8 was correlated with the progression of pneumoconiosis(r=0.4199, p<0.05). Conclusion : IL-8 is thought to be a good biomarker for the early diagnosis of pneumoconiosis.

• The Journal of Korean Obstetrics and Gynecology
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• v.21 no.3
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• pp.1-17
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• 2008

Purpose: Scutellaria baicalensis is a herb which has effect of eliminating heat, drying dampness, purging away fire, detoxicating. Clinically, has been used to remove fever and control of inflammation. We have studied in series to investigate the effective traditional oriental medicines of treatment for endometriosis. In this study, the effects of Scutellaria baicalensis administrated orally or rectally on surgically induced endometriosis in rat were investigated. Methods: The endometrial tissues of rats were autografted to their small intestine. Rats with surgically induced endometriosis were administered with Scutellaria baicalensis extracts for 40 days orally or rectally. We observed the tissue size of ectopic uterine implants at the mesenteric with the naked eye and examined the concentration of estradiol, progesterone, $TNF-{\alpha}$ and IL-2, IL-4, IL-6 and IL-10 in serum. Also, we inquired which was more effective between oral administration groups and rectal administration groups. Results: The size of ectopic uterine implants of orally or rectally treated groups was much smaller than those of control groups. The concentrations of estradiol, progesterone, $TNF-{\alpha}$, IL-2 and IL-6 were significantly decreased in oral administration experimental group compared with the control group. The concentrations of progesteron, $TNF-{\alpha}$, IL-2 and IL-6 were significantly decreased in rectal administration experimental group compared with the control group. The efficiency of oral administration group was better than that of rectal administration group at the serum concentration of estradiol and IL-4. Conclusion: Our data suggest that Scutellaria baicalensis inhibit the inflammation induced from ectopic uterine implants at the mesenteric wall and inhibit the growth of ectopic uterine implants. Judging from the above results, it can be suggested that Scutellaria. baicalensis should be a useful agent for inhibiting the inflammation induced from ectopic uterine implants and the proliferation of endometriosis. Maybe, oral administration of Scutellaria baicalensis is more effective than rectal administration.

• Journal of Life Science
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• v.17 no.9 s.89
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• pp.1303-1307
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• 2007

A tumor suppressor, merlin is a member of ERM family proteins. It consists of N-terminal FERM domain, ${\alpha}-helical$ region, and C-terminal domain. Alternative splicing of merlin's mRNA generates two isotypes of merlin. Isotype I, which has exon17 at the C-terminus instead of exon16 in isotype II, is known to have tumor suppressor activity. Like other ERM proteins, the C-terminal domain of merlin isotype I interacts to its FERM domain. That of isotype II, however, was reported not to bind FERM domain despite the large common part of C-terminal domain, which possibly binds FERM domain. Here, we show the binding of FERM domain to both C-terminal domains of merlin's two isotypes by isothermal titration calorimetry. These results support that merlin isotype II also can form a closed conformation or a multimer by intramolecular or intermolecular interactions using their FERM domain and C-terminal domain.

• Journal of the Korean Vacuum Society
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• v.17 no.6
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• pp.523-527
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• 2008

GaAs/AlGaAs based quantum cascade lasers were fabricated with two different types of i) the shallow mesa type which was etched up to above active region and ii) the deep mesa type which was etched through active region. While the threshold current density of shallow mesa type was $26-32\;kA/cm^2$, the one of deep mesa type was reduced drastically up to $13\;kA/cm^2$. Such lowered threshold current density at deep mesa type attributed to the reduction of current loss to the lateral directions.

• Journal of the Korean Vacuum Society
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• v.17 no.6
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• pp.555-559
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• 2008

Junction temperature of quantum dot laser diodes is investigated by utilizing forward voltage-temperature method. In the case of ridge type laser diodes with deep mesa the increasing rate of junction temperature to current is about 0.05 K/mA, while in the case of shallow mesa the increasing rate is about 0.07 K/mA. It is explained that the relatively low increasing rate in the deep mesa results from the heat expansion to the lateral direction of mesa.

• Journal of Ocean Engineering and Technology
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• v.17 no.4
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• pp.23-30
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• 2003

This study investigates the seasonal variation and spatial distribution characteristics of pollutant load, as executing the quality valuation of pollutant load inflowing into Yeong-il Bay from on-land including the Hyeong-san River. Annual total pollutant generating rate from Yeong-il Bay region are 202ton-BOD/day, 620ton-SS/day, 42ton-TN/day, and 16ton-TP/day, respectively. Particularly, the generating ration of the pollutant loads from the Hyeong-san River is greater than that of any other watershed of the Yeong-il Bay, of which BOd is about 78.2％, SS 88.5％, T-N 62.5％, T-P 73.1％, As calculating Tank model with input value of daily precipitation and evaporation of 2001 year in drainage basin of the Hyeong-san River, the estimated result of the annual river discharge effluence from this river is 830106㎥, As a result to estimating annual effluence rate outflowing at the rivers from each drainage basin. annual inflow pollutant rates are 10,633ton-BOD/year, 19,302ton-SS/year, 15,369ton-TN/year, 305ton-TP/year, respectively. The population congestion region of the Pohang-city is a greater source of pollutant loads than the Neang-Chun region with wide drainage area. Therefore, the quantity of TN inflowing into Yeong-il Bay is much more than T-P. The accumulation of pollutant load effluenced from on-land will happen at the inner coast region of Yeon-il Bay. Finally, We would make a prediction that the water quality will take a bad turn.

• Journal of the Optical Society of Korea
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• v.17 no.1
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• pp.57-62
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• 2013

We have numerically implemented a receiver side all-optical signal processing method, i.e. optical backward propagation (OBP), by dispersion compensating fiber (DCF) and non-linear compensator (NLC) devised by effective negative Kerr non-linear coefficient using two highly non-linear fibers (HNLFs). The method is implemented for the post-processing of fiber transmission impairments, i.e. chromatic dispersion (CD) and non-linearities (NL). The OBP module is evaluated for dual-polarization (DP) m-ary (m=4,16,32,64,256) quadrature amplitude modulation (QAM) in 112 Gbit/s coherent transmission over 1200 km standard single mode fiber (SMF). We have also investigated an intensity limited optical backward propagation module (IL-OBP) by using a self-phase modulation-based optical limiter with an appropriate pre-chirping to compensate for the intensity fluctuations in the transmission link. Our results show that in highly non-linear sensitive 256QAM transmission, we have observed a 66% increase in the transmission distance by implementing IL-OBP as compared to conventional OBP.