• Title/Summary/Keyword: IL- 6

Search Result 14,000, Processing Time 0.056 seconds

Mid-Term Results of Fixed Bearing Unicompartmental Knee Arthroplasty: Minimum 5-Year Follow-Up (고정형 슬관절 단일 구획 치환술의 중기 추시 결과: 최소 5년 추시)

  • Oh, Jeong Han;Joo, Il-Han;Kong, Dong-Yi;Choi, Choong-Hyeok
    • Journal of the Korean Orthopaedic Association
    • /
    • v.53 no.6
    • /
    • pp.498-504
    • /
    • 2018
  • Purpose: To evaluate the clinical and radiological outcomes, and the complications of unicompartmental knee arthroplasty (UKA) using a fixed bearing prosthesis after 5-year follow-up. Materials and Methods: Twenty-six knees (25 patients) that underwent fixed bearing UKA between May 2003 and August 2011 were included. The subjects were 3 males (3 knees) and 22 females (23 knees), and the average age was 63.5 years. The preoperative diagnosis was osteoarthritis (23 knees) and osteonecrosis (3 knees). The mean follow-up duration was 67 months (from 60 to 149 months). The clinical evaluation included pre- and postoperative American knee society knee and function score, and range of motion. The radiology evaluation included standing antero-posterior, lateral view, and fluoroscopic film to analyze the postoperative alignment and osteolysis. Results: The mean American Knee Society knee score and function score were improved from 42.0 and 57.5 to 87.9 and 85.0, respectively (p<0.001). The mean preoperative and postoperative range of motion was $132.9^{\circ}$ and $132.5^{\circ}$, respectively. The mean femorotibial angle were varus $0.5^{\circ}$ preoperatively and valgus $2.2^{\circ}$ postoperatively. A radiolucent line was observed in 2 knees; one knee had a stable implant, while in the other knee, patellofemoral arthritis was identified during UKA. Diffuse pain of the knee joint with tenderness of the medial joint line was identified at the follow-up, so conversion to total knee arthroplasty was recommended. No other complications, such as osteolysis, infections, postoperative stiffness, and dislocation, were encountered. Conclusion: The midterm results of fixed bearing UKA were clinically and radiologically satisfactory.

Effect of Wildlife Access on Microbial Safety of Irrigation Water Used in the Cultivation of Chinese Cabbage in Goesan (야생동물 출입이 괴산 지역 배추 재배 농업용수의 미생물 안전성에 미치는 영향)

  • Yun, Bohyun;Lim, Sang-Jin;Park, Young-Chul;Hung, Nguyen Bao;Park, Daesoo;Kim, Won-Il;Jung, Gyu Seok;Ham, Hyeonheui;Kim, Hyun Ju;Ryu, Kyoungyul;Kim, Se-Ri
    • Journal of Food Hygiene and Safety
    • /
    • v.33 no.6
    • /
    • pp.447-452
    • /
    • 2018
  • Water is an important component in the production of fresh produce. It is mainly used for irrigation and application of pesticides and fertilizers. Several outbreaks cases related to fresh produce have been reported and water has been identified as the most likely source. On the other hand, wildlife has been identified as a possible source of the waterborne pathogens. The purpose of this study was to investigate the effect of wildlife access on irrigation water used in the cultivation of Chinese cabbage in Goesan. The frequency of wild animals access to upstream water source and the contamination level of bacteria such as Escherichia coli and Enterococci of irrigation water used in Chinese cabbage farm was examined. A total of 37 wildlife including the wild bear and water deer were observed in upstream of water source during the cultivation of Chinese cabbage. The result indicated the presence of hygienic indicator bacteria from the upstream where there is no human access. The contamination range of coliforms, E. coli, and Enterococcus spp. Detected in the irrigation water were 2.13~4.32 log MPN / 100 mL, 0.26~2.03 log MPN / 100 mL, and 1.43~3.49 log MPN / 100 mL, respectively. Due to low water temperatures, the contamination levels of coliform bacteria and E. coli in the irrigation water during harvesting time was lower compared to those recorded during transplanting of Chinese cabbage. However, no significant difference was detected in the number of Enterococci during the cultivation of Chinese cabbage. The results indicated the need to manage the microbial risk in irrigation water to enhance safety in cultivation of Chinese cabbage.

Study on the Home-range and Winter Habitat Pintail using the Wild-Tracker (WT-300) in Korea (WT-300을 이용한 월동기 고방오리(Anas acuta)의 행동권 및 서식지 이용연구)

  • Jung, Sang-Min;Shin, Man-Seok;Cho, Hae-jin;Han, Seung-Woo;Son, Han-Mo;Kim, Jeong Won;Kang, Sung-Il;Lee, Han-soo;Oh, Hong-Shik
    • Korean Journal of Environment and Ecology
    • /
    • v.33 no.1
    • /
    • pp.1-8
    • /
    • 2019
  • Pintail (Anas acuta) is the major wintering bird in South Korea and known as a major mediator of the highly pathogenic avian influenza (HPAI). Pintail migrates long distances between Russian Siberia and Korea. This species prefers a rice paddy area as their winter habitat. The purpose of this study is to provide the data necessary for the conservation and management of bird habitats in Korea by understanding the wintering home-range and habitat of pintail in Korea. We captured six pintails using a cannon-net in the winter of 2015 and attached the GPS-mobile phone based telemetry (WT-300) on them to study the wintering home-range and wintering habitat. We analyzed the tracking location data using ArcGIS 9.0 Animal Movement Extension and calculated Kernel Density Estimation (KDE) and Minimum Convex Polygon (MCP). The average home-range in the wintering ground analyzed by MCP was $677.3km^2$ (SD=130.2, n=6) while the maximum and minimum were $847.7km^2$ and $467.5km^2$, respectively. Extents of home-range analyzed by KDE were $194.7km^2$ (KDE 90%), $77.4km^2$ (KDE 70%), and $35.3km^2$ (KDE 50%). The pintails mostly used both sea and paddy field as habitat in the winter season and utilized paddy fields more during the nighttime and than the daytime. We concluded that the home-range and habitat of pintails in the winter could be used as the reference data for the preservation of species, management of habitats, and coping with a breakout of HPAI.

Effects of Dietary Zinc Supplements on the Antioxidant Indicators and the Expression of Zinc Transport Genes in Korean Native Chicks (한국 재래닭에서 아연 보충급여가 항산화 지표 및 아연 운반 유전자 발현에 미치는 영향)

  • Jeon, Dong-Gyung;Kim, Min-Jeong;Yoon, Il-Gyu;Ahn, Ho-Sung;Sohn, Sea-Hwan;Jang, In-Surk
    • Korean Journal of Poultry Science
    • /
    • v.46 no.3
    • /
    • pp.161-171
    • /
    • 2019
  • Four-week-old male Korean native chicks (KNC) were assigned to 3 groups with 6 replicates (8 birds/replicate) in each group: a basal diet (CON, 100 ppm of Zn), basal diet fortified with 50 ppm of Zn with zinc oxide (ZnO), or basal diet fortified with 50 ppm of Zn with Zn-methionine (ZnM). Immediately after a 4-week-feeding trial, 6 birds per group were used to evaluate the effects of zinc supplements on antioxidant indicators and the mRNA expression of zinc transport genes. The nitrogen components, lipid peroxidation, and total antioxidant status in blood were not influenced by Zn fortified diets. However, the ZnM group showed a significant (P<0.05) increase in uric acid levels than those in the ZnO group. In the small intestine, superoxide dismutase (SOD) and glutathione peroxidase (GPX) activities, and malondialdehyde (MDA) level were unaffected by zinc supplements. The activity of glutathione S-transferase (GST) was significantly (P<0.05) enhanced by Zn-methionine supplementation. In the liver, the activity of GST was significantly (P<0.05) increased by Zn-methionine supplement without affecting SOD, GPX, and MDA levels. With respect to the mRNA expression of zinc transport genes, the ZnM group displayed a strong tendency for increases in intestinal ZnT-1 (P=0.09) and ZnT-5 (P=0.06) levels, compared to those in the CON group. Moreover, the ZnM group showed a tendency (P=0.10) for up-regulation of hepatic metallothionein mRNA as compared with the CON group. In conclusion, the Zn-fortified diet with 50 ppm of Zn-methionine helped to improve GST activity and Zn transport gene expression in the small intestine or liver of KNC.

Optimization of GFR value according to Kidney Depth Measurement Methods (신장 Depth 측정 방법에 따른 GFR 값의 최적화)

  • Kwon, Hyeong-Jin;Moon, Il-Sang;Noh, Gyeong Woon;Kang, Keon Wook
    • The Korean Journal of Nuclear Medicine Technology
    • /
    • v.23 no.2
    • /
    • pp.25-28
    • /
    • 2019
  • Purpose In patients with unusual kidney position after $^{99m}Tc-DTPA$ renal dynamic imaging study, the GFR(Glomerular Filtration Rate) values are significantly different according to the depth of the kidney. Thus, we tried to compare the difference of the GFR values between the depth measurement methods and in-vitro test. 30 adult patients who were subjected to renal study. 27 patients were in usual position and 3 patients were in unusual. $555{\pm}37MBq$ of $^{99m}Tc-DTPA$ was administrated to all patients. GE infinia gamma camera was used. GFR values were obtained in-vivo(gates method) and in-vitro(blood). The kidney depth in-vivo was calculated by three methods(tonnensen, manual, taylor). In-vitro, GFR was performed by blood test. Differences in the mean values of GFR and correlation between depth and GFR values were evaluated using the SPSS 12.0 statistical program. The GFR values for 27 patients with kidney in the usual position are as follows(1.tonnensen 2.manual 3.taylor 4.invitro); $69.3{\pm}4.2$, $88.2{\pm}5.6$, $77.8{\pm}4.3$, $82.2{\pm}5.8ml/min$. The three unusual cases are as follows, first(congenital renal anomaly): 66.4, 101.24, 69.07, 94.8 ml/min. second(transplantation kidney): 12.22, 29.99, 19.36, 23.5 ml/min. third(horseshoe kidney): 37.37, 93.54, 35.9, 92.5 ml/min. There was a difference between tonnensen and manual in the usual position of the kidney(p<0.05). There was no significant difference between the other methods. However, there was a significant difference in case of the unusual position of the kidneys. Correlation analysis between both kidney depth and GFR value shows person correlation as follows; Rt kidney: 0.298, Lt kidney: 0.322. When compared with the GFR values in-vitro test, it was useful to calculate the GFR value by measuring the kidney depth using a manual formula in the unusual position of the kidneys. GFR values and kidney depth were significantly related.

Effect of Heat-Killed Enterococcus faecalis, EF-2001 on C2C12 Myoblast Damage Induced by Oxidative Stress and Muscle Volume Decreased by Sciatic Denervation in C57BL/6 Mice (산화스트레스에 의해 유도된 C2C12 근세포 손상과, 신경절제에 의해 근감소가 유도된 C57BL/6 마우스에서 열처리 사균체 엔테로코커스 패칼리스 EF-2001의 효과)

  • Chang, Sang-Jin;Lee, Myung-Hun;Kim, Wan-Joong;Chae, Yuri;Iwasa, Masahiro;Han, Kwon-Il;Kim, Wan-Jae;Kim, Tack-Joong
    • Journal of Life Science
    • /
    • v.29 no.2
    • /
    • pp.215-222
    • /
    • 2019
  • Muscle dysfunction may arise from skeletal muscle atrophy caused by aging, injury, oxidative stress, and hereditary disease. Powdered heat-killed Enterococcus faecalis (EF-2001) has anti-allergy, anti-inflammatory, and anti-tumor effects. However, its antioxidant and anti-atrophy effects are poorly characterized. In this study, we examined the effects of EF-2001 on muscle atrophy. To determine the protective effect of EF-2001 on oxidative stress, C2C12 myoblasts were treated with $H_2O_2$ to induce oxidative stress. This induced cell damage, which was reduced by treatment with EF-2001. The mechanism of EF-2001's effect was examined in response to oxidative stress. Treatment with EF-2001 reversed the expression of HSP70 and SOD1 proteins. Also, mRNA levels of Atrogin-1/MAFbx and MuRF1 increased under oxidative stress conditions but decreased following EF-2001 treatment. To evaluate muscle volume, two and three dimensional models of the muscles were analyzed using micro-CT. As expected, muscle volume decreased after sciatic denervation and recovered after oral administration of EF-2001. Therefore, EF-2001 is a candidate for the treatment of muscular atrophy, and future discovery of the additional effects of EF-2001 may yield further applications as a functional food with useful activities in various fields.

Cultural Homelessness and Psychological Well-Being of Young Cross-Cultural Individuals: Moderating Role of Emotional Clarity (교차문화 청소년들의 문화적 소속감의 부재와 심리적 안녕감의 관계: 정서인식 명확성의 조절효과를 중심으로)

  • Nam, Ji-Eun;Nam, Ji-Hye;Kim, Dong-il
    • (The) Korean Journal of Educational Psychology
    • /
    • v.32 no.3
    • /
    • pp.571-596
    • /
    • 2018
  • Objectives: This study investigated the challenges of young cross-cultural individuals (CCIs) through the cultural homelessness (CH) framework. Methods: Through a survey of 151 CCIs, the study empirically examined the relationship between CH and psychological well-being (PWB), as well as the moderating role of emotional clarity (EC). Results: Results indicated that CH was significantly and negatively associated with PWB, especially on the Positive Relations with Others and Environmental Mastery dimensions. Individuals with high CH tended to have less satisfactory relationships and a reduced sense of control over daily life situations, regardless of their EC level. A significant interaction effect between CH and EC was found, specifically in Positive Relations with Others (PR) and Personal Growth (PG). For individuals with high CH, however, satisfactory relationships were dependent on their EC level; they reported more positive relationships with others when their EC levels were high. Interestingly, individuals with high CH were likely to report a high desire for personal growth regardless of their EC level, indicating that they may appear ambitious but may be experiencing unclear emotions. Conclusions: These findings suggest that CH and EC are issues that need to be dealt with simultaneously. As individuals' PWB depends not only on their CH level, but also on their EC, reducing the level of CH should not be the only goal in promoting the well-being of CCIs. Increasing individuals' EC would be just as important, as high EC, along with low CH, predicts important dimensions of PWB.

Effect of Transportation Temperature and Treatment Time of Ethylene in the Simulated Export on Ripening and Quality of 'Cheongdobansi' Astringent Persimmon (떫은감 '청도반시' 모의 수출에서 수송 온도와 에틸렌 발생제 투입시기가 과실의 숙성 및 품질에 미치는 영향)

  • Kim, Ji-Young;Kim, Il-Ho;Nam, Hyun-Jin;Park, Young-Hoon;Kang, Jum-Soon;Choi, Young-Whan;Son, Beung-Gu;Lee, Yong-Jae
    • Journal of agriculture & life science
    • /
    • v.51 no.4
    • /
    • pp.79-86
    • /
    • 2017
  • We performed simulations of shipping conditions to export 'Cheongdobansi' astringent persimmon to tropical regions. We stored the fruits at $0^{\circ}C$, $5^{\circ}C$, or $10^{\circ}C$ temperature for 15 days to simulate the transport conditions, and then maintained the fruits at $30^{\circ}C$ for 5 days to simulate the distribution condition. Variables that we focused on are 1) the transport temperature($0^{\circ}C$, $5^{\circ}C$, or $10^{\circ}C$) and 2) the treatment time of ethylene generator(before or after shipping). We examined the ripening ratio and quality of the fruits at the end of the shipping and at that of the distribution. The examination at the end of the shipping showed that all of the fruits were ripened at $10^{\circ}C$ transportation but not ripened at $0^{\circ}C$ or $5^{\circ}C$ transportation in the ethylene treated condition. The untreated fruits were not ripened regardless of the transportation temperature. The examination at the end of the distribution showed that all of the fruits were ripened at $5^{\circ}C$ and $10^{\circ}C$ transportation, while 38.5% of fruits were ripened at $0^{\circ}C$ transportation in the ethylene treated fruits before shipping. The fruits treated after shipping were 63.5% and 59.6% ripened at $0^{\circ}C$ and $5^{\circ}C$ transportation, respectively. Unexpectively, only 19.2 % of fruits treated after shipping ripened at $10^{\circ}C$ transportation.

Estimation of Genetic Parameters for Linear Type and Conformation Traits in Hanwoo Cows (한우 암소의 선형 및 외모심사형질에 대한 유전모수 추정)

  • Lee, Ki-Hwan;Koo, Yang-Mo;Kim, Jung-Il;Song, Chi-Eun;Jeoung, Yeoung-Ho;Noh, Jae-Kwang;Ha, Yu-Na;Cha, Dae-Hyeop;Son, Ji-Hyun;Park, Byong-Ho;Lee, Jae-Gu;Lee, Jung-Gyu;Lee, Ji-Hong;Do, Chang-Hee;Choi, Tae-Jeong
    • Journal of agriculture & life science
    • /
    • v.51 no.6
    • /
    • pp.89-105
    • /
    • 2017
  • This study utilized 32,312 records of 17 linear type and 10 conformation traits(including final scores) of Hanwoo cows in the KAIA(Korea Animal Improvement Association) ('09~'10), with 60,556 animals in the pedigree file. Traits included stature, body length, strength, body depth, angularity, shank thickness, rump angle, rump length, pin bone width, thigh thickness, udder volume, teat length, teat placement, foot angle, hock angle, rear leg back view, body balance, breed characteristic, head development, forequarter quality, back line, rump, thigh development, udder development, leg line, and final score. Genetic and residual(co) variances were estimated using bi-trait pairwise analyses with EM-REML algorithm. Herd-year-classifier, year at classification, and calving stage were considered as fixed effects with classification months as a covariate. The heritability estimates ranged from 0.03(teat placement) to 0.42(body length). Rump length had the highest positive genetic correlation with pin bone width(0.96). Moreover, stature, body length, strength, and body depth had the highest positive genetic correlations with rump length, pin bone width, and thigh thickness(0.81-0.94). Stature, body length, strength, body depth, rump length, pin bone width, and thigh thickness traits also had high positive genetic correlations.

A Study on the Efficient Utilization of Spatial Data for Heat Mapping with Remote Sensing and Simulation (원격탐사 및 시뮬레이션의 열지도 구축을 위한 공간정보 활용 효율화 연구)

  • Cho, Young-Il;Yoon, Donghyeon;Lim, Youngshin;Lee, Moung-Jin
    • Korean Journal of Remote Sensing
    • /
    • v.36 no.6_1
    • /
    • pp.1421-1434
    • /
    • 2020
  • The frequency and intensity of heatwaves have been increasing due to climate change. Since urban areas are more severely damaged by heatwaves as they act in combination with the urban heat island phenomenon, every possible preparation for such heat threats is required. Many overseas local governments build heat maps using a variety of spatial information to prepare for and counteract heatwaves, and prepare heatwave measures suitable for each region with different spatial characteristics within a relevant city. Building a heat map is a first and important step to prepare for heatwaves. The cases of heat map construction and thermal environment analysis involve various area distributions from urban units with a large area to local units with a small area. The method of constructing a heat map varies from a method utilizing remote sensing to a method using simulation, but there is no standard for using differentiated spatial information according to spatial scale, so each researcher constructs a heat map and analyzes the thermal environment based on different methods. For the above reason, spatial information standards required for building a heat map according to the analysis scale should be established. To this end, this study examined spatial information, analysis methodology, and final findings related to Korean and oversea analysis studies of heatwaves and urban thermal environments to suggest ways to improve the utilization efficiency of spatial information used to build urban heat maps. As a result of the analysis, it was found that spatial, temporal, and spectral resolutions, as basic resolutions, are necessary to construct a heat map using remote sensing in the use of spatial information. In the use of simulations, it was found that the type of weather data and spatial resolution, which are input condition information for simulation implementation, differ according to the size of analysis target areas. Therefore, when constructing a heat map using remote sensing, spatial, spectral, and temporal resolution should be considered; and in the case of using simulations, the spatial resolution, which is an input condition for simulation implementation, and the conditions of weather information to be inputted, should be considered in advance. As a result of understanding the types of monitoring elements for heatwave analysis, 19 types of elements were identified such as land cover, urban spatial characteristics, buildings, topography, vegetation, and shadows, and it was found that there are differences in the types of the elements by spatial scale. This study is expected to help give direction to relevant studies in terms of the use of spatial information suitable for the size of target areas, and setting monitoring elements, when analyzing heatwaves.