• Title/Summary/Keyword: IL- 6

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Evaluation of Web Sites on Treatment of Childhood and Adolescent Obesity (국내 인터넷 웹사이트에 소개된 소아 및 청소년 비만치료의 실태 및 문제점)

  • Shin, Sang Won;Kim, Eun Young;Rho, Young Il;Yang, Eun Seok;Park, Sang Kee;Park, Young Bong;Moon, Kyung Rye
    • Pediatric Gastroenterology, Hepatology & Nutrition
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    • v.8 no.1
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    • pp.49-55
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    • 2005
  • Purpose: The purpose of this study was to evaluate the quality and problems of Web sites for management of childhood and adolescent obesity. Methods: We evaluated 203 Web sites identified from the search engine, Korean Yahoo, using the word of 'childhood and adolescent obesity'. 203 Web sites were classified according to medical institutions, health information Web sites, beauty shops. etc. We surveyed whether childhood and adolescent obesity distinguished with adult obesity was considered, or not. and researched the unique managements of childhood and adolescent obesity including the cardinal treatment. Results: Of the 203 Web sites, 157(77.3%) provided detailed information about treatment of obesity, 46(22.7%) provided only simple information about one. The sites providing detailed information were composed of 52.2% of oriental medicine clinics, 35.0% of clinic & hospitals including pediatric hospitals. Distribution of the sites about management of childhood and adolescent obesity distinguished with adult's one was only 23% of oriental medicine clinics, but 93% of childrens hospitals. Conclusion: Without considering the speciality of childhood obesity, inaccurate information are distributing on internet web sites. It is necessary for concern and development of advertizing system on the internet distributing accurate information about treatment of childhood obesity.

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Evaluation of Heavy Metal Contamination in Streams within Samsanjeil and Sambong Cu Mining Area (삼산제일.삼봉 동광산 주변 수계의 중금속 오염도 평가)

  • Kim, Soon-Oh;Jung, Young-Il;Cho, Hyen-Goo
    • Journal of the Mineralogical Society of Korea
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    • v.19 no.3 s.49
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    • pp.171-187
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    • 2006
  • The status of heavy metal contamination was investigated using chemical analyses of stream waters and sediments obtained from Samsanjeil and Sambong Cu mining area in Goseong-gun, Gyeongsangnam-do. In addition, the degree and the environmental risk of heavy metal contamination in stream sediments was assessed through pollution index (Pl) and danger index (DI) based on total digestion by aqua regia and fractionation of heavy metal contaminants by sequential extraction, respectively. Not only the degree of heavy metal contamination was significantly higher in Samsanjeil area than in Sambong area, but its environmental risk was also revealed much more serious in Samsanjeil area than in Sambong area. The differences in status and level of contamination and environmental risk between both two mining areas may be attributed to existence of contamination source and geology. Acid mine drainage is continuously discharged and flows into the stream in Samsanjeil mining area, and it makes the heavy metal contamination in the stream more deteriorated than in Sambong mining area in which acid mine drainage is not produced. In addition, the geology of Samsanjeil mining area is mainly comprised of andesitic rocks including a small amount of calcite and having lower pH buffering capacity fer acid mine drainage, and it is likely that the heavy metal contamination cannot be naturally attenuated in streams. On the contrary, the main geology of Sambong mining area consists of pyroclastic sedimentary Goseong formation containing a high content of carbonates, particularly calcite, and it seems that these carbonates of high pH buffering capacity prevent the heavy metal contamination from proceeding downstream in stream within that area.

Inhibition effect against elastase, collagenase, hyaluronidase and anti-oxidant activity of thinning Green ball apple (그린볼 사과(Green ball apple; Malus pumila Mill.) 적과의 항산화 및 elastase, collagenase, hyaluronidase 저해 효과)

  • Go, Yu-Jin;Kim, Ye-Eun;Kim, Hyun-Nam;Lee, Eun-Ho;Cho, Eun-Bi;Sultanov, Akhmadjon;Kwon, Soon-Il;Cho, Young-Je
    • Journal of Applied Biological Chemistry
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    • v.63 no.1
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    • pp.43-50
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    • 2020
  • In this study, the anti-oxidative, health functional, and beauty food activities of water and ethanol extracts from newly bred Ruby S apple (Malus pumila Mill.). The results of measuring the 1,1-diphenyl-2-picrylhydrazyl radical scavenging activity by treating the phenolic compound with thinning green ball apple at a concentration of 50-200 ㎍/mL showed that the water and ethanol extracts at a concentration of 200 ㎍/mL showed 94.69 and 92.24%, respectively. 2,2'-Azinobis-(3-ethylbenzothiazoline-6-sulfonic acid) radical scavenging activities showed 100.30 and 99.16%, respectively, in 200 ㎍/mL of water and ethanol extracts. The water and ethanol extracts of Green ball showed antioxidant protection factor of 1.76 PF 1.76, respectively. The water and ethanol extracts showed 101.46 and 99.64% anti-oxidative effect on thiobarbituric acid reactive substances at phenolic concentration of 200 ㎍/mL. The water and ethanol extracts showed 33.28 and 32.14% hyaluronidase inhibition, respectively, at phenolic concentration of 150 ㎍/mL. The water and ethanol extracts showed 47.33 and 40.92% elastase inhibition and 46.19 and 65.58% collagenase inhibition at phenolic concentration of 200 ㎍/mL, respectively. About these experiments, thinning Green ball apple was found to exhibit anti-oxidation activity as well as hyaluronidase, elastase and collagenase inhibitory activities. Therefore, thinning Green ball apple can be considered a potential sources for new functional materials.

Studies on the Flowering and Maturity in Sesame (Sesamum indicum L.) II. Capsule-Setting Habit by Different Plant Types (참깨의 개화 등숙에 관한 연구 II. 참깨의 초형에 따른 착삭습성)

  • Jung-Il Lee;;Eung-Ryong Son
    • KOREAN JOURNAL OF CROP SCIENCE
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    • v.29 no.4
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    • pp.376-385
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    • 1984
  • The habit of anthesis and maturity of sesame were investigated as a basic research for the improvement of high-yielding varieties and cultural practices. Eight different plant types were identified using typical cultivars among gene pool grown in Korea. Non-branching, Monocapsule, Bicarpels quadriloculi (NMB) type showed higher ratio for capsule setting compared with Non-branching, Monocapsule, Quadricarpels octoloculi (NMQ) type. Non-branching, Tricapsules, Quadricarpels octoloculi(NTQ) type presented lower ratio for capsule setting than non-branching, tricapsules, bicarpels quadriloculi(NTB) type. The number of flowers by flower setting position was the highest on lower part, intermediate on middle part, and the lowest on higher part in NMB and NTB type. However, the number of flowers was the highest on middle part, intermediate on lower part, and lowest on higher part in NMQ and NTQ type. BMB type appeared to have the highest ratio for capsule setting when compared with the other plant types. BTB type with many flowers and capsules exhibited higher percentage for capsule setting than BTQ type with lowest capsule setting percentage. Capsule setting percentage of branch appeared to be lower than that of main stern in the branching type. The branching type had more flowers and capsules than non-branching type. Tricapsules type had more flowers and capsules per plant than monocapsule type, and bicarpels quadriloculi type had more than quadricarpels octoloculi type. However, capsule setting ratio in non-branching type was higher than in branching type. The ratio was higher in monocapsule type than in tricapsules type. Bicarpels quadriloculi type had higher ratio of capsule setting than quadricapels octoloculi type. Number of capsules per plant and capsule setting ratio are supposed to be dominated by shape of capsule (number of carpels and loculi), not by branching or number of capsules per axil. The order of number of capsules per plant was as follows; BTB, BMB, NTB, BTQ, BMQ, NTQ, NMQ, and NMB types. However, the order of capsule setting ratio was as follows: BMB, NMB, NTB, NTQ, NMQ, BMQ, BTB, BTQ types. Consequently, branching, tricapsules, bicarpels quadriloculi(BTB) type was considered as a sourse of breeding for high yielding varieties by introducing the genes govering BMB type with one capsule per axil which has high capsule setting ability.

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Studies on Ichthyophthirius multifiliis Fouquet, 1876 in Freshwater Fishes II. Experimental Infection and Development of I. multifiliis (담수산 백점충(Ichthyophthirius multifiliis)에 관한 연구 II. 백점충의 인위 감염 및 어체내 충체 발달상)

  • Ji, Bo-Young;Kim, Ki-Hong;Park, Soo-Il;Kim, Yi-Cheong
    • Journal of fish pathology
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    • v.11 no.1
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    • pp.51-60
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    • 1998
  • Concerned to the lyfe cycle of Ichthyophthirius multifiliis, the experimental infection and development of the parasites were studied in the several freshwater cultured fishes. Opitimum conditions for the propagation of the parasite by serial passage with the rainbow trout fry was observed. Visiable white spots were examined in the body surface, fins and gills of the healthy fries, and a stable infection has been maintained for 2 months in the experimental system (Temperature: $18{\pm}1^{\circ}C$ DO: 7-7.5 ppm; pH: $7{\pm}0.2$). Induction conditions for artificial infection of the parasite by interms of the host fishes, stages of the parasites, and rearing temperature regimes was investigated. Rainbow trout fries showed a positive infection which was resulted from exposure of theront at $18^{\circ}C$. The rainbow trout fries induced white spots on the body surface at 3-7 days exposure to the theronts at $18^{\circ}C$. It was found that exposure of the rainbow trout fries exposed to 1,000 theronts per fish (10 theront/ml) for 45-60 minutes at $18^{\circ}C$ would consistently produce infection. Perfect infection (100%) was induced when the fries were exposed to 1,500 theront per fish (15 theront/ml) under laboratory condition. Development of I. multifiliis in the rainbow trout was observed for 7 days postexposure (PE). The parasite increased in average diameter from $54{\mu}m$ on the 1st day PE to $426{\mu}m$ on the 7th day PE. In the initial infestation period, the parasites were found on the gill epithelium, and on the 3rd day PE they invaded into the basal part of the gill filament adjacent to the major blood vessels, particularly the afferent vessels. Morphological change of buccal apparatus were observed on the 2nd day PE. Contractile vacuoles were more prominent on the 4th day PE, and they had notable changes on the 7th day PE.

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Enzymatic Assessment of $2-Hydroxyethyl-{\beta}-undecenate$ Purified from Cumin (Cuminum cymium L.) Seed for Anti-periodontitis (Cumin(Cuminum cymium L.) seed로부터 정제한 $2-hydroxyethyl-{\beta}-undecenate$의 항치주염 효과의 효소학적 평가)

  • Ryu, Il-Hwan;Kang, Eun-Ju;Lee, Kap-Sang;Park, Chung-Soon
    • Korean Journal of Food Science and Technology
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    • v.39 no.6
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    • pp.669-675
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    • 2007
  • The present study was conducted to explore the anti-inflammatory action of $2-hydroxyethyl-{\beta}-undecenate$ (HPS) purified from Cumin (Cuminum cymium L.) seed against periodontitis. From the study in which human leukocyte was employed to detect the inhibiting effects of 5-lipokygenase and cyclooxygenase, enzymes generating carriers of infection like $LTB_4$ and PGs, as well as of collagenase and elastase, organ-destroying enzymes, following conclusions could be drawn: HPS was found to inhibit leukotrien $B_4$ biosynthesis by stimulating more than 97% of human polymorphonuclear leukocyte (PMNL) with addition of $5\;{\times}\;10^{-2}\;M$ when $IC_{50}$ was set at $2\;{\times}\;10^{-4}\;M$. Ninety-two percent of enzyme activation turned out to be inhibited when $5\;{\times}\;10^{-2}\;M$ was added in a test to prove inhibiting effects of HPS against activation of PMNL 5-lipoxygenase from homogeneous humans and purified 5-lipoxygenase on the market. Besides, $IC_{50}$ for enzyme activation was valued at $2.5\;{\times}\;10^{-4}\;M$, while the value of $IC_{50}$ for purified 5-lipoxygenase was $2.3\;{\times}\;10^{-4}\;M$. The $IC_{50}$ values of COX-activated leukocyte and purified collagenase were $5.1\;{\times}\;10^{-4}\;M$ and $2.3\;{\times}\;10^{-4}\;M$, respectively. Moreover, the value of $IC_{50}$ for activation of leukocyte collagenase was $2\;{\times}\;10^{-3}\;M$, whereas that for purified collagenase was $5\;{\times}\;10^{-2}\;M$. In case of leukocyte elastase, addition of $5\;{\times}\;10^{-2}\;M$ inhibited its activation by 66%. In case of purified one, however, activation of enzyme was inhibited by 25% with addition of $5\;{\times}\;10^{-2}\;M$. Furthermore, the $IC_{50}$ value for activation of leukocyte elastase was revealed to be $7.5\;{\times}\;10^{-3}\;M$. From the virulence test with human gingiva cell, it was shown that, on the second day of cultivation, 47.83% of the cell had been activated when HPS was added by $5\;{\times}\;10^{-2}\;M$. Even the addition of HPS by $1\;{\times}\;10^{-2}\;M$ featured 68.53% of cell activation, suggesting relatively strong toxicity of the substance against gingiva cell.

Forage Productivity and Feed Value in Triple Cropping Systems with Winter Forage Crops-Silage Corn-Summer Oat Cultivation at Paddy Field in Southern Region of Korea (남부지역 논에서 사료맥류-사료용 옥수수-하파귀리 삼모작 시 조사료 생산성 및 사료가치)

  • Song, Tae-Hwa;Park, Tae-Il;Kang, Hyeon-Jong;Park, Hyong-Ho;Han, Ouk-Kyu;Cho, Sang-Kyun;Oh, Young-Jin;Jang, Yun-Woo;Roh, Jae-Hwan;Park, Kwang-Geun
    • Journal of The Korean Society of Grassland and Forage Science
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    • v.34 no.2
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    • pp.87-93
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    • 2014
  • Multiple cropping system is an important agricultural system in Korea, which is significant to increase forage yield and promote agricultural economic development. This experiment was carried out to develop triple cropping systems (winter cereals crop for forage - silage corn - summer oats) for maximum year-around forage production at paddy field in southern region. We also to select a winter forage crop to determine corn planting time, and to examine the forage productivity and feed value of summer cultivated oat, which was planted after corn cultivation. When winter cereal crops for forages are harvested in accordance with and corn planter, the fresh yield and dry matter yield of rye were 32.0 ton/ha and 5.8 ton/ha, respectively, showing higher yielding compared to other winter crops. Corn silage as summer crop was showed the fresh yield and dry matter yield of 72.1 ton/ha and 20.2 ton/ha, respectively. In the feed value, crude protein and TDN contents were 7.4% and 69.3%, respectively. They was showed higher productivity and feed value. The heading date of High-speed oat was October 10, and its fresh yield and dry matter yield were 37.6 ton/ha and 8.0 ton/ha, respectively. As a feed value, crude protein and TDN content was 11.4% and 59.1%, respectively. Therefore, triple cropping systems for the production of forage all throughout the year are possible with the introduction of summer oats in the southern region, and rye could be the most suitable winter forage crops for triple cropping systems.

Enhancement of Immunomodulatory Activities of Low Molecular Weight Fucoidan Isolated from Hizikia fusiforme (톳 유래 저분자 푸코이단의 면역활성 증진)

  • Ha, Ji-Hye;Kwon, Min-Chul;Han, Jae-Gun;Jin, Ling;Jeong, Hyang Suk;Choi, Geun-Pyo;Park, Uk-Yeon;You, Sang-Guan;Lee, Hyeon-Yong
    • Korean Journal of Food Science and Technology
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    • v.40 no.5
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    • pp.545-550
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    • 2008
  • The anticancer and immunomodulatory activities of low molecular weight (Mw 11 kDa) fucoidan isolated from Hizikia fusiforme (H. fusiforme) via the ultrasonification extraction process were assessed in this study. Low molecular weight fucoidan improved the growth of human B and T cells, up to approximately 40% as compared to the controls (untreated) and 30% for commercially available fucoidan (Mw 150 kDa). IL-6 and TNF-$\alpha$ were secreted from human B cells at levels of $7.8\times10^{-4}$ pg/mL and $7.2\times10^{-4}$ pg/mL, respectively, and these levels were higher than the levels measured in the controls and with other high molecular weight fucoidan. It was also determined that the cytokine from human B and T cells cultivated with added fucoidan enhanced the growth of human NK cells. The fucoidan isolated from H. fusiforme showed low cytotoxicity, approximately 19%, after the addition of 1.0 mg/mL, the highest tested concentration. The growth of human lung cancer cells (A549) and human breast cancer cells (MCF-7) were inhibited by 69.8% and 83.3%, respectively. These results demonstrated that the low molecular weight fucoidan isolated from H. fusiforme has potential as a new functional food component that evidences immunomodulatory activities and anticancer activity. One of the primary positive features of this fucoidan is that low molecular weight polysaccharides can be readily handled during processing.

High Forage Yielding and Good Silage Quality of a New Barley (Hordeum vulgare L.) Cultivar 'Dachung' (조사료 수량이 높고 사일리지 품질이 우수한 청보리 신품종 '다청')

  • Park, Jong-Ho;Cheong, Young-Keun;Kim, Kyong-Ho;Park, Tae-Il;Kim, Yang-Kil;Park, Hyoung-Ho;Park, Jong-Chul;Gang, Cheon-Sik;Song, Tae-Hwa;Han, Ouk-Kyu;Yun, Geon-Sig;Hong, Ki-Heung;Bae, Jeong-Suk;Song, Jae-Ki;Oh, Young-Jin
    • Journal of The Korean Society of Grassland and Forage Science
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    • v.37 no.4
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    • pp.301-307
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    • 2017
  • A new barley(Hordeum vulgare L.) cultivar 'Dachung' having high forage yielding and good silage quality was developed at National Institute of Crop Science, RDA in 2015. This cultivar was derived from a cross of the 'Sunwoo' and 'Keunalbori1ho' in 2002. And it's promising line showed both high yield and lodging resistance through the preliminary and advanced yield trials(PYT, AYT) at Iksan from 2010 to 2012. It was designated as the 'Iksan479'. 'Iksan479' was conducted to regional yield trials(RYT) in six locations around Korea for three years from 2013 to 2015. And it was released as the name of 'Dachung'. It has erect plant type, growth habit of IV and green leaf. In the paddy field its heading date was April 24 and maturing date was May 26, same day with 'Youngyang'. Plant height of 'Dachung' was 99cm. Dachung's spikes per $m^2$ was 625. It has high rate of leaf blades, resistance to BaYMV(Barley Yellow Mosiac Virus) and better winter hardiness than that of 'Youngyang'. The average dry matter of 'Dachung' was about $11.9ton\;ha^{-1}$ in paddy field. And average feed quality of 'Dachung' was 9.0% of crude protein content, 31.3% of ADF (Acid Detergent Fiber), 54.4% of NDF (Neutral Detergent Fiber), 64.0% of TDN (Total Digestible Nutrients). 'Dachung' had grade I of silage quality. This cultivar would be suitable for the area above the daily minimum temperature of $-8^{\circ}C$ in January in Korean peninsula.

Trend and Further Research of Rice Quality Evaluation (쌀의 품질평가 현황과 금후 연구방향)

  • Son, Jong-Rok;Kim, Jae-Hyun;Lee, Jung-Il;Youn, Young-Hwan;Kim, Jae-Kyu;Hwang, Hung-Goo;Moon, Hun-Pal
    • KOREAN JOURNAL OF CROP SCIENCE
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    • v.47
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    • pp.33-54
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    • 2002
  • Rice quality is much dependent on the pre-and post harvest management. There are many parameters which influence rice or cooked rice qualitys such as cultivars, climate, soil, harvest time, drying, milling, storage, safety, nutritive value, taste, marketing, eating, cooking conditions, and each nations' food culture. Thus, vice evaluation might not be carried out by only some parameters. Physicochemical evaluation of rice deals with amy-lose content, gelatinizing property, and its relation with taste. The amylose content of good vice in Korea is defined at 17 to 20%. Other parameters considered are as follows; ratio of protein body-1 per total protein amount in relation to taste, and oleic/linoleic acid ratio in relation to storage safety. The rice higher Mg/K ratio is considered as high quality. The optimum value is over 1.5 to 1.6. It was reported that the contents of oligosaccharide, glutamic acid or its derivatives and its proportionalities have high corelation with the taste of rice. Major aromatic compounds in rice have been known as hexanal, acetone, pentanal, butanal, octanal, and heptanal. Recently, it was found that muco-polysaccharides are solubilized during cooking. Cooked rice surface is coated by the muco-polysaccharide. The muco-polysaccharide aye contributing to the consistency and collecting free amino acids and vitamins. Thus, these parameters might be regarded as important items for quality and taste evaluation of rice. Ingredients of rice related with the taste are not confined to the total rice grain. In the internal kernel, starch is main component but nitrogen and mineral compounds are localized at the external kernel. The ingredients related with taste are contained in 91 to 86% part of the outside kernel. For safety that is considered an important evaluation item of rice quality, each residual tolerance limit for agricultural chemicals must be adopted in our country. During drying, rice quality can decline by the reasons of high drying temperature, overdrying, and rapid drying. These result in cracked grain or decolored kernel. Intrinsic enzymes react partially during the rice storage. Because of these enzymes, starch, lipid, or protein can be slowly degraded, resulting in the decline of appearance quality, occurrence of aging aroma, and increased hardness of cooked rice. Milling conditions concerned with quality are paddy quality, milling method, and milling machines. To produce high quality rice, head rice must contain over three fourths of the normal rice kernels, and broken, damaged, colored, and immature kernels must be eliminated. In addition to milling equipment, color sorter and length grader must be installed for the production of such rice. Head rice was examined using the 45 brand rices circulating in Korea, Japan, America, Australia, and China. It was found that the head rice rate of brand rice in our country was approximately 57.4% and 80-86% in foreign countries. In order to develop a rice quality evaluation system, evaluation of technics must be further developed : more detailed measure of qualities, search for taste-related components, creation and grade classification of quality evaluation factors at each management stage of treatment after harvest, evaluation of rice as food material as well as for rice cooking, and method development for simple evaluation and establishment of equation for palatability. On policy concerns, the following must be conducted : development of price discrimination in conformity to rice cultivar and grade under the basis of quality evaluation method, fixation of head rice branding, and introduction of low temperature circulation.