• The Korean Journal of Physiology
• /
• 제27권1호
• /
• pp.93-105
• /
• 1993

The present study was performed to investigate the properties of ionic currents elicited by voltage pulses in the unfertilized eggs of mouse and hamster by using the whole cell voltage clamp techniques and to find out if there are any differences in properties between eggs of the two rodents. In addition, the modulatory effect of G proteins and protein kinase C (PKC) on the ionic channels were observed. The inward current in hamster eggs was shown to be due to $Ca^{2+}\;current\;(i_{ca})$). The current voltage relations of these currents in hamster egg were analogous to those in mouse eggs. The amplitude of $i_{ca}$ in the hamster egg was larger than that in the mouse egg ($-3.12{\pm}1.07\;nA\;vs.\;-1.71{\pm}0.71\;nA,\;mean{\pm}\;SD$). These results suggest that the $Ca^{2+}$ channels in both kinds of eggs have similar channel properties but their density, and/or conduct ance per unit area is higher in hamster eggs than in mouse eggs. Outward currents in eggs of both mouse and hamster were carried by $K^+$. In hamster eggs, they appeared to comprise at least two components; a transient outward component ($i_{to}$) and a steady state component ($i_{\infty}.$ The $i_{to}$ was found to be dependent on intracellular $Ca^{2+}$ concentration; whereas on the other hand $i_{\infty}\;was\;Ca^{2+}$-independent. $Ca^{2+}$ currents were increased in eggs treated with GTP (or $GTP{\gamma}S$) or fluoroaluminate ($AIF_4^-$). In the hamster egg these increments were antagonized by GDP (or $GDP{\beta}S$) application. In contrast to the enhancement of $i_{ca},\;i_k$ was reduced following GTP (or $GTP{\gamma}S$) perfusion in mouse eggs. The transient component ($i_{to}$) in hamster eggs was increased by adding GTP but decreased by phorbol ester, TPA or dioctanoyl glycerol (DOG). Simultaneous application of $GTP{\gamma}S$ and DOG suppressed $i_{to}$ more effectively than a single application or DOG or TPA. From the above results, we have shown that ionic currents elicited by voltage pulses existed in the unfertilized eggs of mouse and hamster. There are at least two types of currents, $i_{ca}\;and\;i_k$ in mouse eggs, while three types, $i_{ca},\;Ca^{2+}$-dependent $i_k$ and $Ca^{2+}$-independent $i_k$ exist in hamster eggs. ionic channels in these eggs may be regulated either directly by GTP and PKC or indirectly by the substances linked with GTP and PKC.

• 한국위성정보통신학회논문지
• /
• 제1권2호
• /
• pp.83-88
• /
• 2006

이동통신을 비롯하여 많은 무선통신 시스템에서 사용자들의 멀티미디어 정보에 대한 수용가 증가함에 따라 채널의 용량을 늘리기 위한 여러 가지 방법들이 시도되고 있다. 그러나 현실적으로 여러 가지 제약에 의하여 사용할 수 있는 채널의 숫자와 용량이 제한되어 있다. 이러한 상황을 해결하여 좀 더 크고 많은 채널을 얻기 위한 여러 가지 방법들이 소개되었고 현재에도 연구되고 있다. 이 논문에서는 위성 DMB시스템을 기반으로 하여 제시된 여러 가지 방법 중 계층변조 방식을 이용하여 채널의 용량 및 그에 따른 성능을 분석하도록 한다. 특정 환경에서 사용자 수 증가에 의한 성능분석 및 계층면조 방식과 기존의 방법을 비교 분석하도록 한다.

• 한국물환경학회지
• /
• 제21권6호
• /
• pp.682-686
• /
• 2005

Recently some urban areas have been flooded due to heavy storm rainfalls. Though major causes of these floodings may be attributed to localized heavy rainfalls, other factors are related to urban flooding including deficiency of storm sewer network capacity, change of surface runoff due to covered open channels, and operational problems of storm drainage pump stations. In this study, hydrologic and hydraulic analysis of Sutak basin in Guri city were carried out to evaluate flooding problems occurred during the heavy storm in July, 2001. ArcView, a world most widely used GIS tool, was used to extract required data for the hydrologic analysis including basin characteristics data, concentration times, channel routing data, land use data, soil distribution data and SCS runoff curve number generation from digital maps. HEC-HMS, a GIS-based runoff simulation model, was successfully used to simulate the flood inflow hydrograph to Sutak pumping station.

• Journal of Communications and Networks
• /
• 제13권3호
• /
• pp.221-231
• /
• 2011

A joint multipath routing algorithm and channel allocation and scheduling for wireless multihop and multichannel systems is discussed. In packet transmission, distribution of packets to multiroutes makes it possible to reduce the transmission cost of the channels. Cross-layer cooperation of routing, channel allocation, and scheduling is an effective method of packet distribution. As a framework for the cooperation, we propose a multiroute distance vector routing (MDVR) scheme. In the MDVR scheme, the routing table is logically placed in between the routing and link layers, and the table plays the role of a service access point between these two layers. To evaluate the performance of MDVR, simulation is performed in a multichannel, multihop environment. The simulation results show that the MDVR framework can be efficiently implemented in the form of a distributed routing algorithm. It is also shown that in MDVR, the system-wise channel efficiency is almost 25% higher than that in a conventional single-route routing approach.

• International Journal of Aeronautical and Space Sciences
• /
• 제9권1호
• /
• pp.66-75
• /
• 2008

In this work, we explore the feasibility of roll-pitch-yaw integrated autopilots for high angle-of-attack missiles. An investigation of the aerodynamic characteristics of a surface-to-air missile is presented, which reveals the strong effects of cross coupling between the longitudinal and lateral dynamics. Robust control techniques based on $H_{\infty}$ synthesis are employed to design roll-pitch-yaw integrated autopilots. The performance of the proposed roll-pitch-yaw integrated controller is tested in high-fidelity nonlinear five-degree-of-freedom simulations accounting for kinematic cross-coupling effects between the lateral and longitudinal channels. Against nonlinearity and cross-coupling effects of the missile dynamics, the integrated controller demonstrates superior performance when compared with the controller designed in a decoupled manner.

• 한국지반공학회:학술대회논문집
• /
• 한국지반공학회 1992년도 폐기물 매립지의 공학적 특성과 개량기술
• /
• pp.33-66
• /
• 1992

Recently, waste landfills built on seashores have been increased because of the easy availability of broad area near the urban communities. To evaluate the performance of the marine clay landfill liner numerical contaminant transport analyses are performed by selecting the typical section of a waste landfill built on seashores and using hydraulic conductivity data obtained from the site. Also, the laboratory electrical resistivity test and the in-situ corrosion test are performed in order to analyze the influence of the soil and leachates composing the landfills on the construct ion materials. From the results of contaminant transport analyses, it is shown that the leachates can be migrated faster through narrow pervious channels than the wide homogeneous pervious tedium and the importance of good quality barriers to prevent the contaminant migration is recognized. In the laboratory electrical resistivity test all the earth materials except the cover soils saturated with distilled water have small resistivities, which shows a high potential of corrosivity of soils composing landfills. However, the degree of corrosion of specimens buried in the landfills was not so severe except the zinc and carbon steel specimens. This apparently conflict results present the necessity of the investigation of other major factors and the long term in-situ corrosion test.

• Bulletin of the Korean Chemical Society
• /
• 제24권9호
• /
• pp.1339-1344
• /
• 2003

Flow field-flow fractionation (FlFFF) is a technology to separate the molecules by size in an open channel. Molecules with different size have different diffusivities and are located vertically in different positions when passing through an open channel. In this study, hollow fiber membranes instead of conventional rectangular channels have been used as materials for the open channel and this change would decrease the cost of manufacturing. FlFFF is a useful technique to characterize the biopolymeric materials. Retention time, diffusion coefficients and Stokes radius of analysis can be calculated from the related simple equations. Hollow-fiber flow field-flow fractionation (HF-FlFFF) has been used for the characterization and separation of protein mixture in a phosphate buffer solution and has demonstrated the potential to be developed into a disposable FlFFF channel. The important indexes for the analytical separation are selectivity, resolution and plate height. The optimized separation condition for protein mixture of Ovalbumin, Alcohol dehydrogenase, Apoferritin and Thyroglobulin is ${\dot V}_{out}/{\dot V}_{rad}=0.65/0.85\;mL/min$.

• 대한원격탐사학회지
• /
• 제34권6_1호
• /
• pp.847-855
• /
• 2018

GMTI는 항공기에 탑재되어 지상에 움직이는 표적을 탐지하는 레이다 기능으로 군사적으로 널리 활용되고 있다. 본 논문에서는 GMTI 신호처리 방법을 제시하고, 구축된 항공용 GMTI 시스템으로부터 획득한 GMTI용 2채널 합/차 원시데이터를 이용하여 GMTI 신호처리 결과를 검증하였다.

• 생명과학회지
• /
• 제32권2호
• /
• pp.175-188
• /
• 2022

혈관과 섬유증 기관들의 평활근과 세포외기질에 대한 릴랙신의 조절기능이 입증되어왔다. 본 총설에서는 저항성 소동맥과 방광을 포함한 섬유증 기관들의 세포외기질에 작용하는 릴랙신의 다양한 기전들을 고찰한다. 릴랙신은 혈관 평활근육의 수축을 억제하고, 콜라겐과 같은 세포외기질의 구성성분들을 감소키켜 혈관벽의 수동적 신전성을 증가시킴으로써, 혈관확장을 유도한다. 릴랙신이 동맥의 혈관확장을 유도하는 주된 세포기전은 RXFP1/PI3K의 활성화, Akt 인산화 및 eNOS 활성화를 통한 내피세포-의존성 산화질소의 생성에 의해 매개된다. 추가적으로, 릴랙신은 또한 다른 대체경로들을 작동하여 신장과 장간막 동맥의 혈관확장을 증가시킨다. 신장 소동맥에서, 릴랙신은 내피세포의 MMPs 및 EtB 수용체의 활성화와 VEGF 및 PlGF의 생성을 촉진하여, 평활근의 수축성과 콜라겐의 침착을 억제함으로써 혈관확장을 초래한다. 이와 달리, 장간막 소동맥에서, 릴랙신은 bradykinin (BK)-유도 이완을 시간-의존적으로 증강시킨다. BK-매개 이완의 신속 증가는 IK_Ca 이온통로와 뒤이은 EDH 유발에 의존하는 반면, BK에 의한 지속적 이완은 COX 활성과 PGI₂에 의존한다. 릴랙신의 항섬유화 효과는 염증유발 면역세포의 침투, endothelial-to-mesenchymal transition (EndMT) 및 근섬유아세포의 분화와 활성을 억제하여 매개된다. 릴랙신은 또한 근섬유아세포 내 NOS/NO/cGMP/PKG-1 경로를 활성화하여, TGF-β1-유도 ERK1/2 및 Smad2/3 신호의 활성과 ECM 콜라겐의 침착을 억제한다.

• Journal of Korean Neurosurgical Society
• /
• 제29권11호
• /
• pp.1429-1436
• /
• 2000

Objectives : This study was performed in cultured rat hippocampal neurons to investigate the acute electrophysiological features of ionotropic glutamate receptors which act as a major excitatory neurotransmitter in mammalian brain. Method : Glutamate receptor agonists were applied into the bath solution embedding in whole-cell patch-clamp recording of single hippocampal neuron. Results : In voltage-clamped at -60mV and the presence of 1mmol $Mg^{2+}$, extracellulary applied NMDA did not induce any inward current. Both the elimination of $Mg^{2+}$ and addition of glycine in bath, however, elicited a NMDAinduced inward current. $Mg^{2+}$ block current was increased gradually in more negative potentials from -30mV, showing a negative slope in I-V plot with $Mg^{2+}$. Glutamate-induced current represented an outward rectification. A non-NMDA receptor component occupied about 40% of glutamate-induced current in the voltage range of -80mV to +60mV. Conclusion : Present study suggests that glutamate activates acutely the non-NMDA receptors which induces an inward current in the level of resting membrane potential. This makes the membrane potential increase and can activate the NMDA receptors that permit calcium influx against $Mg^{2+}$ block. At the depolarized state of neuron, there may be recovery mechanisms of membrane potential to repolarize irrespective of voltage-dependent potassium channels in the hippocampal neurons.