• 한국컴퓨터그래픽스학회논문지
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• 제11권4호
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• pp.21-27
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• 2005

본 논문에서는 연속된 모션 프레임의 효과적인 단순화를 매우 효율적으로 수행시킬 수 있는 점진적 모션 (progressive motion) 기법을 제안하고 실험 결과를 설명한다. 제안된 점진적 모션 기법에서는 효과적인 단순화를 위하여 인접한 두 모션간의 차이를 측정하는 수식을 정의하고 모션 LOD (level of detail)를 효율적으로 처리하기 위하여 모션 차이가 최소인 두 모션을 차례대로 병합하고 역으로 병합된 모션을 분해하는 기법을 사용하였다. 이 방법은 모션 편집 등에서 매우 빠른 속도로 모션 LOD를 제공하며 임의의 캐릭터의 실시간 시뮬레이션에서 효과적인 단순화 기법으로 적용될 수 있는 잠재력을 가지고 있다.

• 대한예방의학회:학술대회논문집
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• 대한예방의학회 1996년도 제48차 추계 학술대회 연제집
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• pp.417-418
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• 1996

• 한국환경성돌연변이발암원학회:학술대회논문집
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• 한국환경성돌연변이발암원학회 2004년도 춘계학술대회
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• pp.98-98
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• 2004

• Asian Pacific Journal of Cancer Prevention
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• 제13권7호
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• pp.3247-3252
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• 2012

Aim: We conducted a prospective study in an Chinese population to detect associations of GSTM, GSTT and GSTP polymorphisms with hepatocellular carcinoma (HCC), and analyze roles in determining survival outcome. Methods: A prospective follow-up study was conducted with 476 HCC patients and 481 controls collected from May 2005 to May 2007. All patients were followed up until the end of Dec. 2011. GSTM1, GSTT1 and GSTP1 genotyping were performed by PCR-CTPP methods. Results: Null GSTM1 carriers had a 1.64 fold risk of HCC compared with non-null genotype, while GSTP1 Val/Val carriers had a 93% increased risk over the GSTP1 IIe/IIe genotype. The median follow-up time for the 476 patients was 34.2 months (range: 1 to 78 months). Individuals with null GSTM1 genotype had better survival of HCC than non-null genotype carriers (HR=0.71, 95%CI=0.45-0.95). Similarly, GSTP1 Val/Val genotypes had significant better survival than the GSTP1 IIe/IIe genotype (HR=0.34, 95%CI=0.18-0.65). Individuals carrying null GSTM1 and GSTP1 Val/Val who received chemotherapy had lower risk of death from HCC than those without chemotherapy. Conclusion: This study indicated carriage of null GSTM1 and GSTP1 Val/Val genotypes to have roles in susceptibility to and survival from HCC.

• 전기화학회지
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• 제5권4호
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• pp.173-177
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• 2002

Electrochemical characteristics of a graphite/lithium and a $LiCoO_2/lithium$ half cell and a $graphite/LiCoO_2$ full cell were analyzed using a GCSOC (gradual control test of the state of charge) technique. The IIE (initial intercalation coulombic efficiency), which represents lithium intercalation property of the electrode material, and the $lIC_s$ (initial irreversible capacity by the surface), which represents irreversible reaction between the electrode surface and the electrolyte were obtained from the GCSOC analysis. Linear-fittable capacity ranges of IIE of graphite and $LiCoO_2$ electrodes were 370 and 150 mAh/g, respectively, based on material weight. The value of lIE for graphite and $LiCoO_2$ electrodes were $93-94\%$ and $94-95\%$, respectively. The value of IICs for graphite and $LiCoO_2$ electrodes were 15-17 mAh/g and 0.3-1.7 mAh/g, respectively. The value of IIE for $graphite/LiCoO_2$ full cell, used GX25 and DJG311 as a graphite, was $89-90\%$ that lower than that for the half cells. Parameters of IIE and IICs can also be used to represent not only half cell but also full cell.

• Radiation Oncology Journal
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• 제5권2호
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• pp.97-104
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• 1987

1970년부터 1980년까지 연세대학교 치료방사선과에서 방사선치료 받은 비강 및 부비동에 발생한 NHL환자 15예를 대상으로 후향성 분석을 하여 다음과 같은 결과를 얻었다. 1. 병기분포는 13예가 IE 2예가 IIE였고 TNM병기에 따르면 7예가 국소병변이 진행된 T3, T4 환자였다. 2. Overall 5년 생존율을 $25\%$, IE는 $28\%$, IIE는 $0\%$였다. 3. 병기별 치료실패율은 T1, T2는 $33\%(2/6),\; T3,\;T_4는\;86\%(6/7),\;IIE$에서는 $100\%(2/2)$였다. 4. 방사선 조사량이 55Gy 이상인 경우 $100\%$의 완전 관해율을 보였으며 55Gy이하인 경우 $73\%$의 완전 관해율을 보였다. 5. 비강 및 부비동의 NHL의 Ann Arbor병기 분류와 함께 TNM 병기도 예후에 중요한 요인이 될 것 같다. 6. 국소병변이 진행된 병기 T3, T4와 IIE 환자에서는 화학요법제의 병용치료가 필요할 것 같다.

• Food Science and Biotechnology
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• 제15권4호
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• pp.534-542
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• 2006

The effects of ethanol fractions of three different rice grain extracts, Jakwangchalbyeo, Hwasunchalbyeo, and Ilpumbyeo, on apoptotic cell death in the rat hepatoma H4IIE cell line were investigated using the MTT [3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide] cell viability assay. One hundred mg/mL Jakwangchalbyeo extract significantly reduced cell viability to 69.5, 57.2, and 46.1% within 24, 48, and 72 hr, respectively. Fluorescence-activated cell sorting (FACS) analyses were also performed to characterize the cell death pattern caused by treatment with the rice grain extracts. Apoptotic cell death was clearly observed with time after treatment with the Jakwangchalbyeo extract. In Western blotting analysis, degradation of the 116 kDa poly-ADP-ribose polymerase (PARP) molecule was observed with concomitant formation of an 89 kDa product 24, 48, and 72 hr after treating cells with the Jakwangchalbyeo extract. This indicates that an apoptotic process caused cell death in these cells. In conclusion, red-pericarp Jakwangchalbyeo extract induced apoptotic cell death in H4IIE cells to a larger extent than the other rice extracts.

• 한국발생생물학회지:발생과생식
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• 제27권2호
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• pp.77-89
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• 2023

Metformin is the most widely used anti-diabetic drug that helps maintain normal blood glucose levels primarily by suppressing hepatic gluconeogenesis in type II diabetic patients. We previously found that metformin induces apoptotic death in H4IIE rat hepatocellular carcinoma cells. Despite its anti-diabetic roles, the effect of metformin on hepatic de novo lipogenesis (DNL) remains unclear. We investigated the effect of metformin on hepatic DNL and apoptotic cell death in H4IIE cells. Metformin treatment stimulated glucose consumption, lactate production, intracellular fat accumulation, and the expressions of lipogenic proteins. It also stimulated apoptosis but reduced autophagic responses. These metformin-induced changes were clearly reversed by compound C, an inhibitor of AMP-activated protein kinase (AMPK). Interestingly, metformin massively increased the production of reactive oxygen species (ROS), which was completely blocked by compound C. Metformin also stimulated the phosphorylation of p38 mitogen-activated protein kinase (p38MAPK). Finally, inhibition of p38MAPK mimicked the effects of compound C, and suppressed the metformin-induced fat accumulation and apoptosis. Taken together, metformin stimulates dysregulated glucose metabolism, intracellular fat accumulation, and apoptosis. Our findings suggest that metformin induces excessive glucose-induced DNL, oxidative stress by ROS generation, activation of AMPK and p38MAPK, suppression of autophagy, and ultimately apoptosis.

• 제어로봇시스템학회:학술대회논문집
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• 제어로봇시스템학회 2003년도 ICCAS
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• pp.1278-1282
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• 2003

A new interacting multiple model (IMM) method using intelligent input estimation (IIE) is proposed to track a maneuvering target. In the proposed method, the acceleration level for each sub-model is determined by IIE-the estimation of the unknown acceleration input by a fuzzy system using the relation between maneuvering filter residual and non-maneuvering one. The genetic algorithm (GA) is utilized to optimize a fuzzy system for a sub-model within a fixed range of acceleration input. Then, multiple models are composed of these fuzzy systems, which are optimized for different ranges of acceleration input. In computer simulation for an incoming ballistic missile, the tracking performance of the proposed method is compared with those of the input estimation (IE) technique and the adaptive interacting multiple model (AIMM) method.

• 대한산업공학회지
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• 제38권1호
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• pp.67-73
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• 2012

Identification of meaningful patterns and trends in large volumes of text data is an important task in various research areas. In the present study we crawled the keywords from the abstracts in IIE Transactions, one of the representative journals in the field of Industrial Engineering from 1969 to 2011. We applied low-dimensional embedding method, clustering analysis, association rule, and social network analysis to find meaningful associative patterns of key words frequently appeared in the paper.