• Journal of Life Science
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• v.33 no.6
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• pp.490-497
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• 2023

Pregnant women may need to take medications to treat preexisting diseases or diseases that develop during pregnancy. However, some drugs may be fetotoxic and lead to, for example, teratogenicity and growth retardation. Predicting the fetotoxicity of drugs is thus important for the health of the mother and fetus. The fetotoxicity of many drugs has not been established because various challenges hinder the ability of researchers to determine their fetotoxicity. The need exists for in silico-based fetotoxicity assessment models, as they can modernize the testing paradigm, improve predictability, and reduce the use of animals and the costs of fetotoxicity testing. In this study, we collected data on the fetotoxicity of drugs and constructed fetotoxicity prediction models based on various machine learning algorithms. We optimized the models for more precise predictions by tuning the hyperparameters. We then performed quantitative performance evaluations. The results indicated that the constructed machine learning-based models had high performance (AUROC >0.85, AUPR >0.9) in fetotoxicity prediction. We also analyzed the feature importance of our model's predictions, which could be leveraged to identify the specific features of drugs that are strongly associated with fetotoxicity. The proposed model can be used to prescreen drugs and drug candidates at a lower cost and in less time. It provides a predictive score for fetotoxicity risk, which may be beneficial in the design of studies on fetotoxicity in human pregnancy.

• Journal of The Korean Association of Information Education
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• v.15 no.3
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• pp.413-423
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• 2011

Programming education has the favorable influence on creative logical thinking and problem-solving ability of students. However programming has not been actively taught at the elementary schools. One of the causes is the lack of systematic curriculum. In this paper, we design the curriculum for 'Understanding of Information Processing' in revised ICT educational guidelines using the educational programming language Scratch. We propose curriculum that consists of 4 lessons for 1st and 2nd graders, 5 lessons for 3rd and 4th graders, and 6 lessons for 5th and 6th graders to lesson the cognitive load, and present the instruction plans. Selected group of experts verified our proposed curriculum and instruction plans. According to verification results, we can conclude that almost the area including the targets, educational factors, learning content, amount of learning, instruction plans are appropriate. The curriculum proposed in this paper can help the elementary students learn programming efficiently, and develop their logical thinking, problem-solving ability, creativity, and information processing ability.

• The Journal of Korean Academy of Orthopedic Manual Physical Therapy
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• v.28 no.3
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• pp.79-87
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• 2022

Background: The purpose of this study was to examine the effect of transcranial direct current stimulation (tDCS) on the pain and balance of patients who receive total knee arthroplasty (TKA). Methods: This study subjects were 24 patients in Hospital T, located in Daegu, South Korea who received TKA after being diagnosed with degenerative arthritis. The subjects were randomly divided into and experimental group and a control group, with each group including 12 patients. Both group received superfical thermal therapy, interferential current therapy (ICT), and continue passive motion (CPM), which are conventional knee therapy on the knee joint. The experimental group received the tDCS treatment three times a week for three weeks, from October 1st to October 20th. The visual analogue scale and Wii Balance Board system were used to measure the pain and balancing ability, respectively, of both groups. In the statistical result analysis, to compare about pre and post test difference in each groups was accomplished. Statistical analysis of independent t-test and paired t-test were conducted using SPSS version 23.0. Results: After three weeks of intervation, there were significantly difference in balance ability in pre and post test in the tDCS group. VAS decreased significantly in both groups(p<.05), There was a significantly difference in pain, balance ability in the tDCS group compared to the sham group. Conclusion: These results indicate that applying tDCS together with conventional knee joint therapy for TKA patients is effective in promoting the patients' recovery.

• Journal of the Korean Data and Information Science Society
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• v.14 no.2
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• pp.223-235
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• 2003

Using internet, most of students are still exposed to unreasonable commercial information and even tend to consumptive behaviors. Various programs have been mobilized to keep it with a blockade system against the noxious information. But guidance is more instructive than blockade in respect of education. Thus, the focus of this study is to induce and motivate their self-directed learning activities with internet guide contents. We develope a learning guidance material as one of the information platforms. Furthermore, we consider the availability of such learning guidance materials through interview and observation. We find that easy and meaningful internet access and utilizing environment influence the children's self-directed learning ability.

• The Mathematical Education
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• v.52 no.4
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• pp.465-481
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• 2013

In this study, 27 pre-service teachers presented virtual mathematics instruction to develop his/her own teaching practice ability. I found several attributes in their virtual mathematics instruction such as connecting contents, asking justification, encouraging students' communication, representing variously, and using ICT etc. These will be the characteristics of the future mathematics class. When peer pre-service teachers assess presenter's instruction quantitatively, there are differences in the results between expert and pre-service teachers. Pre-service teachers didn't find the elements of student self assessment or group assessment and communication activities at the virtual instruction. When they assess peers' virtual instruction qualitatively, the results are specific or new ones compared with the quantitative assessment elements. Thus I suggested some implications for the mathematics pre-service teachers' virtual instruction in the view of teacher education.

• Journal of Korea Technology Innovation Society
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• v.4 no.1
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• pp.64-78
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• 2001

The 21st century is characterized by knowledge-based economy or society. The most important features of this knowledge society are the close relationship between science and technology, and the birth of science-based technologies or industries. Bioindustry which is the core area in this era is a representative science-based industry(SBI). In SBIs including BT(biotechnology) and ICT(information and communication technology), the creation of scientific knowledge and the ability to capitalize on that are very important. The United States leadership in research across the spectrum of science and technology is the result of the success in both achieving high level of research and capitalizing on that enabled them to grow. Capitalization is the process that transforms the results of research into practical concrete national benefits. It is such a dynamic process that cant be clearly modeled. In this study, we propose the dynamic capitalization process for innovation of SBIs in terms of the fuel and engine and analyse our potential.

• Journal of The Korean Association of Information Education
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• v.15 no.4
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• pp.543-550
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• 2011

STEAM education is a topic-based curriculum to integrate the concepts into other subjects such as science, technology, engineering, art and mathematics in order to improve the students' interesting, understanding, integrated thinking and problem solving ability. In this paper, we designed STEAM curriculum in the form of Project-based Learning and developed the material for elementary students. We also developed the android-based application through searching for a utilization of IT simulation for enhancement the students' Project-based Learning effect.

• Journal of Information Technology Applications and Management
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• v.9 no.1
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• pp.111-126
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• 2002

The purpose of this research is to study the effectiveness of applying Information technology to education, so-called education informatization. Education informatiantion consists of building information infrastructure, educational course operation and improvement of the teacher's ICT ( Information and Communication Technology) ability to consolidate and teach educational information development and diffusion. In this study, we've studied the effects of the use of IT on the improvement of student's class Participation and understanding level, We set the hypotheses and tested them. A method of teaching and learning using IT influences the degree of class participation. Educational courses and a method of teaching and learning have been proved to affect the understanding of a lecture. Also, we validated the educational effectiveness on the educational course and class teaching by setting WIS (Weighted least square) on the IT utilization time.

• International Journal of Advanced Culture Technology
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• v.6 no.4
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• pp.309-316
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• 2018

The main purpose of this study is to understand how cognitive factors influence the way people interact with information/information systems, by conducting comprehensive and in-depth literature reviews and a theoretical synthesis of related research. Adaptive systems have been built around an individual user's characteristics, such as interests, preferences, knowledge and goals. Individual differences in the ability to use new information and communication technology have been an important issue in all fields. Performance differences in utilizing new information and communication technology are sufficiently predictable that we can begin to coordinate them. Therefore, it is necessary to understand cognitive mechanisms to explain differences between individuals as well as the levels of performance. The theoretical synthesis from this study can be applied to design intelligent (i.e., human friendly) systems in our everyday lives. Further research should explore optimization design for user, by integrating user's individual traits (such as emotion and intent) and system modules to improve the interactions of human-system in data-driven environments.

• International Journal of Internet, Broadcasting and Communication
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• v.13 no.2
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• pp.112-119
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• 2021

In the Fourth Industrial Revolution and the foundation of software and hardware technologies through ICT, the technology to analyze the principles of information processing activities is the ability to implement programming. In this study, to improve the programming academic performance of electronics majors, firstly, we presented an effective teaching method in order to promote employment in the programming field by improving problem-solving skills and logical thinking skills in the programming field that electronics majors do not prefer. Secondly, we plan to promote intelligence informatization by converging intelligence information technology into the existing electronics industry by developing software utilization skills through programming curriculum that reflects the specificity and reality of electronics. Lastly, as computer programmers, we would like to expand creative talent education by developing learners' capabilities to cultivate smart talents who have both hardware and software capabilities.