• Tuberculosis and Respiratory Diseases
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• v.82 no.3
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• pp.190-193
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• 2019

Inhaled corticosteroids (ICSs) have been widely used as a key medication for asthma control. However, ICSs have been known to cause respiratory infections, such as pneumonia and pulmonary tuberculosis. Consequently, a dilemma exists regarding recommendation of persistent lifetime use of ICSs to mild asthma patients. Short-acting ${\beta}$-agonists (SABAs) have also been widely used for symptom relief. However, SABAs have been reported to increase the risk of asthma-related death, though incidences have been very rare. Consequently, a dilemma exists regarding recommendation of a SABA alone without an ICS or a controller to asthma patients even with very mild disease. In the real world, asthma patients tend to intermittently use ICS and more likely to be dependent on SABA since many patients want immediate relief of their symptoms. Consequently, a dilemma exists regarding the underuse of ICSs but the overuse of SABAs. One strategy for solving the presented dilemma would be identification of patients with asthma who require persistent use of asthma controllers. Such patients, who may be referred to as "persistent controller users," should continuously receive ICSs, even under controlled states of asthma. Another strategy would be a patient-adjusted, symptom-driven, intermittent-to-regular treatment combining low-dose ICS/rapid-onset long-acting ${\beta}$-agonists instead of using a SABA alone or with low-dose ICS for the asthma patients with mild disease. Both of these two strategies could avoid the risky treatment of a SABA alone without an ICS and could reduce the dose of ICS with the maintenance of asthma control.

• Tuberculosis and Respiratory Diseases
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• v.70 no.5
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• pp.416-422
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• 2011

Background: Inhaled corticosteroids (ICSs) are the most essential medication for asthma control. Many reports suggest that the usage of ICSs improves not only the control of asthma symptoms but also prevents exacerbation. We investigated whether increases in ICS prescriptions are associated with decreases in asthma exacerbation in the clinical practice setting. Methods: We retrospectively analyzed the database of adult asthma patients who had visited a tertiary referral hospital, the Asan Medical Center between January 2000 and December 2009. The number of emergency department (ED) visits, admissions, intensive care unit (ICU) care, deaths, and ICS prescriptions were analyzed to evaluate the time trend of asthma exacerbation as a function of the ICS prescription rate during the ten years. Results: The numbers of ED visits, admissions, and episodes of ICU care decreased during the ten years (p<0.001, p=0.033, p=0.001, respectively) while the number of ICS prescriptions increased (p<0.001). We found a correlation between the number of ICS prescriptions and the number of ED visits, admissions, or ICU care. For these outcomes, the correlation coefficients were r=-0.952, p<0.001; r=-0.673, p=0.033; r=-0.948, p<0.001, respectively. Conclusion: The number of ICS prescriptions increased during the past ten years while the number of asthma exacerbations decreased. Our results also showed a negative correlation between the ICS prescription rate and asthma exacerbation in the clinical practice setting. In other words, an increase in ICS prescription may be a major cause of a decrease in asthma exacerbations.

• Proceedings of the Korean Society of Precision Engineering Conference
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• 2008.06a
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• pp.491-492
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• 2008

• Tuberculosis and Respiratory Diseases
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• v.83 no.1
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• pp.42-50
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• 2020

Background: Fractional exhaled nitric oxide (FeNO) is regarded as a potential biomarker for identifying eosinophilic inflammation. We aimed to evaluate the clinical implication of FeNO and its influence on inhaled corticosteroids (ICS) prescription rate in Korean chronic obstructive pulmonary disease (COPD) patients. Methods: FeNO level and its association with clinical features were analyzed. Changes in the prescription rate of ICS before and after FeNO measurement were identified. Results: A total of 160 COPD patients were divided into increased (≥25 parts per billion [ppb], n=74) and normal (<25 ppb, n=86) FeNO groups according to the recommendations from the American Thoracic Society. Compared with the normal FeNO group, the adjusted odds ratio for having history of asthma without wheezing and with wheezing in the increased FeNO group were 2.96 (95% confidence interval [CI], 1.40-6.29) and 4.24 (95% CI, 1.37-13.08), respectively. Only 21 out of 74 patients (28.4%) with increased FeNO prescribed ICS-containing inhaler and 18 of 86 patients (20.9%) with normal FeNO were given ICS-containing inhaler. Previous exacerbation, asthma, and wheezing were the major factors to maintain ICS at normal FeNO level and not to initiate ICS at increased FeNO level. Conclusion: Increased FeNO was associated with the history of asthma irrespective of wheezing. However, FeNO seemed to play a subsidiary role in the use of ICS-containing inhalers in real-world clinics, which was determined with prior exacerbation and clinical features suggesting Th2 inflammation.

• Journal of the Korea Institute of Information Security & Cryptology
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• v.30 no.4
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• pp.745-756
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• 2020

An ICS(industrial control system) is a complex system that safely and efficiently monitors and controls industrial processes such as electric power, water treatment, transportation, automation plants and chemical plants. Because successful cyber attacks targeting ICS can lead to casualties or serious economic losses, it becomes a prime target of hacker groups sponsored by national state. Cyber campaigns such as Stuxnet, Industroyer and TRITON are real examples of successful ICS attacks, and were developed based on the deep knowledge of the target ICS. Therefore, for incident investigation of ICSs, inspectors also need knowledge of control processes and accident investigation techniques specialized for ICSs. Because there is no applicable technology, it is especially necessary to develop techniques and tools for embedded controllers located at cyber and physical boundaries. As the first step in this research, we reviewed logging capability of 4 PLC(Programmable Logic Controller)s widely used in an ICS area, and checked whether selected PLCs generate logs that can be used for digital investigation in the proposed cyber attack scenario.

• JSTS:Journal of Semiconductor Technology and Science
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• v.11 no.3
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• pp.221-228
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• 2011

This paper describes 250-Mb/s fiber optic transmitter and receiver ICs for plastic optical fiber applications using a$ 0.18-{\mu}m$ CMOS technology. Simple signal and light detection schemes are introduced for power reduction in sleep mode. The transmitter converts non-return-to-zero digital data into 650-nm visible-red light signal and the receiver recovers the digital data from the incident light signal through up to 50-m plastic optical fiber. The transmitter and receiver ICs occupy only 0.62 $mm^2$ of area including electrostatic discharge protection diodes and bonding pads. The transmitter IC consumes 23 mA with 20 mA of LED driving currents, and the receiver IC consumes 16 mA with 4 mA of output driving currents at 250 Mb/s of data rate from a 3.3-V supply in active mode. In sleep mode, the transmitter and receiver ICs consume only 25 ${\mu}A$ and 40 ${\mu}A$, respectively.

• Journal of the Korean Society of Safety
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• v.22 no.5
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• pp.27-32
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• 2007

We investigated the damage of the TTL ICs which manufactured five different technologies by artificial microwave. The artificial microwave was rated at a microwave output from 0 to 1000W, at a frequency of 2.45GHz. The microwave power was extracted into a standard rectangular waveguide(WR-340) and TTL ICs were located into the waveguide. TTL ICs were damaged two types. One is breakdown which means no physical damage is done to the system and after a reset the system is going back into function. The other is destruction which means a physical damage of the system so that the system will not recover without a hardware repair. TTL SN74S08N and SN74ALS08N devices get a breakdown and destruction occurred but TTL SN74LS08N, SN74AS08N and 74F08N devices get a destruction occurred. Also destructed TTL ICs were removed their surface and a chip conditions were analyzed by SEM. The SEM analysis of the damaged devices showed onchipwire and bondwire destruction like melting due to thermal effect. The tested results expect to be applied to the fundamental data which interprets the combination mechanism of the semiconductors from artificial microwave environment.

• Journal of the Korea Institute of Information Security & Cryptology
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• v.23 no.2
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• pp.329-337
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• 2013

Cyber threats of the ICS(Industrial Control System) has been researched on the level to the threat to the network service as well as a specific system, even if the extent of damage was not intended. Although some range of "security" just include the protection of systems against the deliberate attacks of terrorists or cyber hackers, often more damage is done by carelessness, and equipment failures than by those deliberate attacks. This paper presented a taxonomy for classifying all abnormal behaviors of ICS, including deliberate attacks, inadvertent mistakes, equipment failures, and software problems. The classification criteria of ICS abnormal behaviors was selected to highlight commonalities and important features of deliberate attacks as well as inadvertent actions.

• Proceedings of the KIPE Conference
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• 2004.07a
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• pp.33-37
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• 2004

Slotless Permanent magnet Brushless DC Motor(PM BLDC) with the characteristics of high speed and high power density has been more widely used in industrial and automatic machine. Generally, PM BLDC meter is necessary that the three Hall-ICs evenly be distributed around the stator circumference in case of the 3 phase motor. The Hall-ICs are set up in this motor to detect the main flux from the rotor. therefore the output signal from Hall-ICs is used to drive a power transistor to control the stator winding current. However, instead of using three Hall-ICs, if only we used one Hall-IC, we estimate information of the others phase in sequence through a revolving rotor. This paper identified the characteristics and performance by using one Hall-IC for the 3 phase PM BLDC whose six stator and two rotor designed.

• Proceedings of the Korean Institute of Intelligent Systems Conference
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• 2004.10a
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• pp.192-196
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• 2004

This paper proposes an alternative observation scheme, T-S fuzzy model based indirect adaptive fuzzy observer. Nonlinear systems are represented by fuzzy models since fuzzy logic systems are universal approximators. In order to estimate the unmeasurable states of a given nonlinear system, T-S fuzzy modeling method is applied to get the dynamics of an observation system. T-S fuzzy system uses the linear combination of the input state variables and the modeling applications of them to various kinds of nonlinear systems can be found. The adaptive fuzzy scheme estimates the parameters comprising the fuzzy model representing the observation system. The proposed indirect adaptive fuzzy observer based on T-S fuzzy model can cope with not only unknown states but also unknown parameters. In the process of deriving adaptive law, the Lyapunov theory and Lipchitz condition are used. To show the performance of the proposed observation method, it is applied to an inverted pendulum on a cart.