• Animal cells and systems
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• v.12 no.4
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• pp.203-209
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• 2008

Berberine, an isoquinoline alkaloid found in Coptidis Rhizoma(goldenthread) extract, has multiple pharmacological effects such as anti-inflammatory, antimicrobial and anti-ischemic effects. In the present study, we examined the effects of berberine on neuronal survival and differentiation in a hippocampal precursor cell line and in the memory deficient rat model. Berberine increased in a dose dependent manner the survival of hippocampal precursor cells as well as differentiated cells. In addition, berberine promoted neuronal differentiation of hippocampal precursor cells. In the memory deficient rat model induced by stereotaxic injection of ibotenic acid into entorhinal cortex(Ibo model), hippocampal cells were increased about 2.7 fold in the pyramidal layer of CA1 region and about 2 fold in the dentate gyrus by administration of berberine after 2 weeks of ibotenic acid injection. Furthermore, neuronal cells immunoreactive to calbindin were increased in the hippocampus and entorhinal cortex area by administration of berberine. Taken together, these results suggest that berberine has neuroprotective effect in the Ibo model rat brain by promoting the neuronal survival and differentiation.

• The Journal of Korean Institute of Electromagnetic Engineering and Science
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• v.13 no.6
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• pp.538-545
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• 2002

In the orthogonal frequency division multiplexing (OFDM) system, the nonlinear distortion in the high power amplifier(HPA) degrades the system performance because of the high peak-to-average power ratio (PAPR). In this paper, a semi-analytical method is newly proposed for the performance evaluation of the nonlinearly distorted OFDM communication system. In the proposed method, at first, the probability density function (pdf) of the PAPR is generated by computer simulation. Then, mean and variance of the non-linear distortion noise process are computed. Next, the overall BER is found by the analytical method. When the equivalent SSPA model is applied in case of the QPSK/16-QAM and AWGN channel, the BER is calculated for the variation of the IBO(input back-off) and PAPR parameter. It is shown that the results by proposed method are very similar to those of the conventional Monte-Carlo method. The computation time can be considerably reduced than the conventional method that depends on the magnitudes of BER and IBO.

• The Journal of Korean Institute of Electromagnetic Engineering and Science
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• v.16 no.4 s.95
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• pp.389-396
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• 2005

In this paper, we propose a pre-distortion method using the NLMS(Normalized Least Mean Square) algorithm to cope with hish PAPR(Peak to Average Power Ratio) problem in OFDM communication system. This proposed scheme estimates the distortion characteristics of HPA, and changes the characteristic against the distortion. Therefore, it can be shown that the adaptive characteristic of the NLMS pre-distorter is good to track the various nonlinear characteristic of HPA, even though HPA characteristic is changed by temperature variation or aging. From the performance analysis, SNR efficiency of NLMS pre-distorter is about $0.5\;\cal{dB}$ less than that of common numerical non-adaptive pre-distorter, when IBO(Input Back Off) is $0\;\cal{dB}$. However, the NLMS pre-distorter is better than the common numerical pre-distorter, because these two pre-distorters have similar performance in higher than $3\;\cal{dB}$ IBO, and the NLMS pre-distorter maintains the constant performance even though characteristic of HPA is changed.

• The Journal of Korean Institute of Electromagnetic Engineering and Science
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• v.19 no.12
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• pp.1303-1312
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• 2008

Satellite WiBro system has high PAPR characteristics in addition to the nonlinear characteristics of the power amplifier. These characteristics reduce amplifying efficiency of the power amplifier and also cause high error rate and interference with adjacent channels. This paper proposed satellite WiBro based system to reduce input signal's IBO of TWTA remarkably by adapting simultaneously PAPR reduction techniques, active-constellation extension technique and pre-distortion technique.

• The Journal of Korean Institute of Electromagnetic Engineering and Science
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• v.15 no.11
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• pp.1026-1033
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• 2004

Clipping is a simple and convenient PAPR reduction method to prevent the high-speed OFDM communication system from the nonlinear distortion. However, it inherently produces clip noise so that BER performance can be degraded. Clipping noise can be divided into in-band and out-of-band clipping noise. In this paper, we study the clipping effect on the forward link of the OFDM-FDMA system. BER performance of OFDM-FDMA system using clipping method is theoretically analyzed. We also investigate the BER performance of the clipped OFDM-FDMA signal through the HPA. From the simulation results it can be quantified how much the BER performance of OFDM-FDMA system is degraded by the clipping method. From the study results, we can choose the appropriate IBO value and CR(clip ratio) to get the desired BER performance.

• The Journal of Korean Institute of Communications and Information Sciences
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• v.29 no.2A
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• pp.166-173
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• 2004

Satellite communication system uses a high non-linear HPA(high power amplifiers) in the earth station and satellite transponder. Therefore, it is important to consider the nonlinear effect of HPA on the communication system. In this paper, we find the variation of power spectrum density by nonlinearity HPA and the change of harmonic component according to IBO (input back-off). When the BPSK is used for satellite communication system, we analyze BER performance including the external co-channel interference (CCI) and the adjacent channel interference (ACI) resulting from the HPA nonlinearity. BER degrades as ACI magnitude grows up when the uplink SNR, uplink SIR (signal to co-channel interference power ratio) and downlink SIR are constant at some level. In case there is only non-linear HPA in the satellite, it is shown that BER considerably depends on the ACI magnitude ACI. When there are two non-linear HPAs in the both earth station and satellite, much BER degradation results from the CCI and ACI.

• The Journal of Korean Institute of Communications and Information Sciences
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• v.28 no.7C
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• pp.678-687
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• 2003

8SQAM(8-state Superposed Quadrature Amplitude Modulation) being a new modem technique for use in power and bandwidth limited digital communication system generates output signals which have a mか and continuous phase transition and a reduced envelope fluctuation by keeping correlation between amplitudes and phases of two subsequent symbols. Also, 8SQAM signal is free of inter-symbol interference(ISI), and has a compact power spectrum. Accordingly 8SQAM, as compared with a conventional 8PSK, is influenced a little by inter-modulation(IM), inter-symbol interference(ISI) and adjacent channel interference(ACI) in a nonlinearly amplified multi-channel(SCPC-FDMA) environment. In this paper, the performance of 8SQAM system in a nonlinearly amplified multi-channel interference environment is analyzed via computer simulation The simulation result shows that 8SQAM outperforms 8PSK with roll-off value of $\alpha$ = 0.3 by 2.7dB in CNR to maintain BER=1$\times$10$^{-4}$ when input back-off(IBO) of HPA is 1dB and channel space is 41.7% of the data bit rate(i.e., spectral efficiency = 2.40b/s/Hz).

• The Journal of Korean Institute of Communications and Information Sciences
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• v.28 no.7C
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• pp.669-677
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• 2003

A new Modem technique - 8SQAM(8-state Superposed Quadrature Amplitude Modulation) - for use in power and bandwidth limited digital communication system is proposed. 8SQAM is free of inter-symbol interference(ISI) and generates output signals which have a smooth and continuous phase transition and a reduced envelope fluctuation by keeping correlation between amplitudes and phases of two subsequent symbols. Accordingly, 8SQAM, as compared with a conventional 8PSK, is influenced a little by ISI and inter-modulation(IM) caused by nonlinear distortions. In this paper, the performance of the 8SQAM system, in a nonlinearly amplified channel impaired by additive white Gaussian noise(AWGN), ISI and IM, is analyzed via computer simulation. The simulation result shows that 8SQAM outperforms 8PSK with roll-off value of $\alpha$=0.25 by 2.5dB in CNR to maintain BER=1$\times$10$^{-4}$ when input back-off(IBO) of HPA is 3dB.

• Journal of The Korean Association For Science Education
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• v.18 no.4
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• pp.485-491
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• 1998

In this study, the achievement of Korean biology gifted-students was compared with that of International Biology Olympiad(IBO) participants to explore international achievement level of biology and to suggest the need of teaching program for biology gifted-students. Korean thirty gifted-students were selected through test by Korean Biology Olympiad Committee. They examined theoretical test two times in January and March. 1998. Theoretical part consisted of eight domains as follows; cell biology. anatomy and physiology of plants, anatomy and physiology of animals, ethology. genetics and evolution, ecology, systematics, and microbiology. As a result, Korean biology gifted-students had lower achievement than IBO participants in eight domains. and especially much lower achievement in ethology and systematics. Though thirty Korean gifted-students were found to had much lower achievement than lBO participants, four higher rankers of them are in prospect of winning bronze medals. Thus, it is necessary to develope an appropriate teaching program for biology gifted-students with theoretical lectures and inquiry activities.

• Proceedings of the Korean Society of Broadcast Engineers Conference
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• 2002.11a
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• pp.3-8
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• 2002

A new Modem technique - 8-state Superposed QAM(8SQAM) - for use in power and bandwidth limited digital communication system is proposed. The premodulation baseband signal of the 8SQAM system is a double-interval(2Ts) raised cosine pulse superposed with weighted single-interval(Ts) raised cosine pulse. The performance of the 8SQAM, in a nonlinearly amplified multi-channel environment with additive white Gaussian noise(AWGN), inter-symbol interference(ISI), inter-modulation(IM) and adjacent channel interference(ACI), is analyzed via computer simulation. The simulation result shows that the 8SQAM outperforms 8PSK by about 1.6㏈ at BER=$1\times10^{-4}$ when HPA IBO is 1㏈ and channel Spacing, ${\Delta}F$ is 0.417fb.