• 한국근적외분광분석학회:학술대회논문집
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• 한국근적외분광분석학회 2001년도 NIR-2001
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• pp.1141-1141
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• 2001

The aim of the study was to evaluate the performance of 3 calibration methods, modified partial least squares (MPLS), local PLS (LOCAL) and artificial neural network (ANN) on the prediction of chemical composition of forages, using a large NIR database. The study used forage samples (n=25,977) from Australia, Europe (Belgium, Germany, Italy and Sweden) and North America (Canada and U.S.A) with information relative to moisture, crude protein and neutral detergent fibre content. The spectra of the samples were collected with 10 different Foss NIR Systems instruments, which were either standardized or not standardized to one master instrument. The spectra were trimmed to a wavelength range between 1100 and 2498 nm. Two data sets, one standardized (IVAL) and the other not standardized (SVAL) were used as independent validation sets, but 10% of both sets were omitted and kept for later expansion of the calibration database. The remaining samples were combined into one database (n=21,696), which was split into 75% calibration (CALBASE) and 25% validation (VALBASE). The chemical components in the 3 validation data sets were predicted with each model derived from CALBASE using the calibration database before and after it was expanded with 10% of the samples from IVAL and SVAL data sets. Calibration performance was evaluated using standard error of prediction corrected for bias (SEP(C)), bias, slope and R2. None of the models appeared to be consistently better across all validation sets. VALBASE was predicted well by all models, with smaller SEP(C) and bias values than for IVAL and SVAL. This was not surprising as VALBASE was selected from the calibration database and it had a sample population similar to CALBASE, whereas IVAL and SVAL were completely independent validation sets. In most cases, Local and ANN models, but not modified PLS, showed considerable improvement in the prediction of IVAL and SVAL after the calibration database had been expanded with the 10% samples of IVAL and SVAL reserved for calibration expansion. The effects of sample processing, instrument standardization and differences in reference procedure were partially confounded in the validation sets, so it was not possible to determine which factors were most important. Further work on the development of large databases must address the problems of standardization of instruments, harmonization and standardization of laboratory procedures and even more importantly, the definition of the database population.

• 한국근적외분광분석학회:학술대회논문집
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• 한국근적외분광분석학회 2001년도 NIR-2001
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• pp.1032-1032
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• 2001

Artificial Neural Network (ANN) calibration techniques have been used commercially for agricultural applications since the mid-nineties. Global models, based on transmission data from 850 to 1050 nm, are used routinely to measure protein and moisture in wheat and barley and also moisture in triticale, rye, and oats. These models are currently used commercially in approx. 15 countries throughout the world. Results concerning earlier European ANN models are being published elsewhere. Some of the findings from that study will be discussed here. ANN models have also been developed for coarsely ground samples of compound feed and feed ingredients, again measured in transmission mode from 850 to 1050 nm. The performance of models for pig- and poultry feed will be discussed briefly. These models were developed from a very large data set (more than 20,000 records), and cover a very broad range of finished products. The prediction curves are linear over the entire range for protein, fat moisture, fibre, and starch (measured only on poultry feed), and accuracy is in line with the performance of smaller models based on Partial Least Squares (PLS). A simple bias adjustment is sufficient for calibration transfer across instruments. Recently, we have investigated the possible use of ANN for a different type of NIR spectrometer, based on reflectance data from 1100 to 2500 nm. In one study, based on data for protein, fat, and moisture measured on unground compound feed samples, dedicated ANN models for specific product classes (cattle feed, pig feed, broiler feed, and layers feed) gave moderately better Standard Errors of Prediction (SEP) compared to modified PLS (MPLS). However, if the four product classes were combined into one general calibration model, the performance of the ANN model deteriorated only slightly compared to the class-specific models, while the SEP values for the MPLS predictions doubled. Brix value in molasses is a measure of sugar content. Even with a huge dataset, PLS models were not sufficiently accurate for commercial use. In contrast an ANN model based on the same data improved the accuracy considerably and straightened out non-linearity in the prediction plot. The work of Mr. David Funk (GIPSA, U. S. Department of Agriculture) who has studied the influence of various types of spectral distortions on ANN- and PLS models, thereby providing comparative information on the robustness of these models towards instrument differences, will be discussed. This study was based on data from different classes of North American wheat measured in transmission from 850 to 1050 nm. The distortions studied included the effect of absorbance offset pathlength variation, presence of stray light bandwidth, and wavelength stretch and offset (either individually or combined). It was shown that a global ANN model was much less sensitive to most perturbations than class-specific GIPSA PLS calibrations. It is concluded that ANN models based on large data sets offer substantial advantages over PLS models with respect to accuracy, range of materials that can be handled by a single calibration, stability, transferability, and sensitivity to perturbations.

• 한국근적외분광분석학회:학술대회논문집
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• 한국근적외분광분석학회 2001년도 NIR-2001
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• pp.1121-1121
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• 2001

A previous study (Berzaghi et al., 2001) evaluated the performance of 3 calibration methods, modified partial least squares (MPLS), local PLS (LOCAL) and artificial neural networks (ANN) on the prediction of the chemical composition of forages, using a large NIR database. The study used forage samples (n=25,977) from Australia, Europe (Belgium, Germany, Italy and Sweden) and North America (Canada and U.S.A) with reference values for moisture, crude protein and neutral detergent fibre content. The spectra of the samples were collected using 10 different Foss NIR Systems instruments, only some of which had been standardized to one master instrument. The aim of the present study was to evaluate the behaviour of these different calibration methods when predicting the same samples measured on different instruments. Twenty-two sealed samples of different kind of forages were measured in duplicate on seven instruments (one master and six slaves). Three sets of near infrared spectra (1100 to 2500nm) were created. The first set consisted of the spectra in their original form (unstandardized); the second set was created using a single sample standardization (Clone1); the third was created using a multiple sample procedure (Clone6). WinISI software (Infrasoft International Inc., Port Mathilda, PA, USA) was used to perform both types of standardization, Clone1 is just a photometric offset between a “master” instrument and the “slave” instrument. Clone6 modifies both the X-axis through a wavelength adjustment and the Y-axis through a simple regression wavelength by wavelength. The Clone1 procedure used one sample spectrally close to the centre of the population. The six samples used in Clone 6 were selected to cover the range of spectral variation in the sample set. The remaining fifteen samples were used to evaluate the performances of the different models. The predicted values for dry matter, protein and neutral detergent fibre from the master Instrument were considered as “reference Y values” when computing the statistics RMSEP, SEPC, R, Bias, Slope, mean GH (global Mahalanobis distance) and mean NH (neighbourhood Mahalanobis distance) for the 6 slave instruments. From the results we conclude that i) all the calibration techniques gave satisfactory results after standardization. Without standardization the predicted data from the slaves would have required slope and bias correction to produce acceptable statistics. ii) Standardization reduced the errors for all calibration methods and parameters tested, reducing not only systematic biases but also random errors. iii) Standardization removed slope effects that were significantly different from 1.0 in most of the cases. iv) Clone1 and Clone6 gave similar results except for NDF where Clone6 gave better RMSEP values than Clone1. v) GH and NH were reduced by half even with very large data sets including unstandardized spectra.

• 한국HCI학회:학술대회논문집
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• 한국HCI학회 2006년도 학술대회 1부
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• pp.1031-1036
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• 2006

햅틱 분야는 디스플레이 되는 콘텐츠를 만질 수 있게 촉감을 제공함으로써 의학, 교육, 군사, 방송 분야 등에서 널리 연구되고 있다. 이미 의학 분야에서는 Reachin 사(社)의 복강경 수술 훈련 소프트웨어와 같이 실제 수술 할 때와 같은 힘을 느끼면서 수술 과정을 훈련할 수 있는 제품이 상용화 되어 있다. 그러나 햅틱 분야가 사용자에게 시청각 정보와 더불어 추가적인 촉감을 제공함으로써 보다 실감 있고 자연스러운 상호작용을 제공하는 장점을 가진 것에 비해 아직은 일반 사용자들에게 생소한 분야다. 그 이유 중 하나로 촉감 상호작용이 가능한 콘텐츠의 부재를 들 수 있다. 일반적으로 촉감 콘텐츠는 컴퓨터 그래픽스 모델로 이루어져 있어 일반 그래픽 모델러를 사용하여 콘텐츠를 생성하나 촉감과 관련된 정보는 콘텐츠를 생성하고 나서 파일에 수작업으로 넣어주거나 각각의 어플리케이션마다 직접 프로그램을 해주어야 한다. 이는 그래픽 모델링과 촉감 모델링이 동시에 진행되지 않기 때문에 발생하는 문제로 촉감 콘텐츠를 만드는데 시간이 많이 소요되고 촉감 정보를 추가하는 작업이 직관적이지 못하다. 그래픽 모델링의 경우 눈으로 보면서 콘텐츠를 손으로 조작할 수 있으나 촉감 모델링의 경우 손으로 촉감을 느끼면서 동시에 조작도 해야 하기 때문에 이에 따른 인터페이스가 필요하다. 본 논문에서는 촉감 상호작용이 가능한 촉감 콘텐츠를 직관적으로 생성하고 조작할 수 있게 하는 촉감 모델러를 기술한다. 촉감 모델러에서 사용자는 3 자유도 촉감 장치를 사용하여 3 차원의 콘텐츠를 실시간으로 만져보면서 생성, 조작할 수 있고 촉감 사용자 인터페이스를 통해서 콘텐츠의 표면 촉감 특성을 직관적으로 편집할 수 있다. 촉감 사용자 인터페이스는 마우스로 조작하는 기존의 2차원 그래픽 사용자 인터페이스와는 다르게 3 차원으로 구성되어 있고 촉감 장치로 조작할 수 있는 버튼, 라디오 버튼, 슬라이더, 조이스틱의 구성요소로 이루어져 있다. 사용자는 각각의 구성요소를 조작하여 콘텐츠의 표면 촉감 특성 값을 바꾸고 촉감 사용자 인터페이스의 한 부분을 만져 그 촉감을 실시간으로 느껴봄으로써 직관적으로 특성 값을 정할 수 있다. 또한, XML 기반의 파일 포맷을 제공함으로써 생성된 콘텐츠를 저장할 수 있고 저장된 콘텐츠를 불러오거나 다른 콘텐츠에 추가할 수 있다.

• Asian Pacific Journal of Cancer Prevention
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• 제16권6호
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• pp.2465-2472
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• 2015

Background: The Quality Audit (BQA) program of the Breast Surgeons of Australia and New Zealand (NZ) collects data on early female breast cancer and its treatment. BQA data covered approximately half all early breast cancers diagnosed in NZ during roll-out of the BQA program in 1998-2010. Coverage increased progressively to about 80% by 2008. This is the biggest NZ breast cancer database outside the NZ Cancer Registry and it includes cancer and clinical management data not collected by the Registry. We used these BQA data to compare socio-demographic and cancer characteristics and survivals by ethnicity. Materials and Methods: BQA data for 1998-2010 diagnoses were linked to NZ death records using the National Health Index (NHI) for linking. Live cases were followed up to December $31^{st}$ 2010. Socio-demographic and invasive cancer characteristics and disease-specific survivals were compared by ethnicity. Results: Five-year survivals were 87% for Maori, 84% for Pacific, 91% for other NZ cases and 90% overall. This compared with the 86% survival reported for all female breast cases covered by the NZ Cancer Registry which also included more advanced stages. Patterns of survival by clinical risk factors accorded with patterns expected from the scientific literature. Compared with Other cases, Maori and Pacific women were younger, came from more deprived areas, and had larger cancers with more ductal and fewer lobular histology types. Their cancers were also less likely to have a triple negative phenotype. More of the Pacific women had vascular invasion. Maori women were more likely to reside in areas more remote from regional cancer centres, whereas Pacific women generally lived closer to these centres than Other NZ cases. Conclusions: NZ BQA data indicate previously unreported differences in breast cancer biology by ethnicity. Maori and Pacific women had reduced breast cancer survival compared with Other NZ women, after adjusting for socio-demographic and cancer characteristics. The potential contributions to survival differences of variations in service access, timeliness and quality of care, need to be examined, along with effects of comorbidity and biological factors.

• The Korean Journal of Physiology and Pharmacology
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• 제13권1호
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• pp.61-70
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• 2009

We have examined the effects of certain mutations of the selectivity filter and of the membrane helix M2 on $Ba^{2+}$ blockage of the inward rectifier potassium channel, Kir 2.1. We expressed mutant and wild type murine Kir 2.1 in Chinese hamster ovary(CHO) cells and used the whole cell patch-clamp technique to record $K^+$ currents in the absence and presence of externally applied $Ba^{2+}$. Wild type Kir2.1 was blocked by externally applied $Ba^{2+}$ in a voltage and concentration dependent manner. Mutants of Y145 in the selectivity filter showed little change in the kinetics of $Ba^{2+}$ blockage. The estimated $K_d(0)$ was 108 ${\mu}M$ for Kir2.1 wild type, 124 ${\mu}M$ for a concatameric WT-Y145V dimer, 109 ${\mu}M$ for a WT-Y145L dimer, and 267 ${\mu}M$ for Y145F. Mutant channels T141A and S165L exhibit a reduced affinity together with a large reduction in the rate of blockage. In S165L, blockage proceeds with a double exponential time course, suggestive of more than one blocking site. The double mutation T141A/S165L dramatically reduced affinity for $Ba^{2+}$, also showing two components with very different time courses. Mutants D172K and D172R(lining the central, aqueous cavity of the channel) showed both a decreased affinity to $Ba^{2+}$ and a decrease in the on transition rate constant(${\kappa}_{on}$). These results imply that residues stabilising the cytoplasmic end of the selectivity filter(T141, S165) and in the central cavity(D172) are major determinants of high affinity $Ba^{2+}$ blockage in Kir 2.1.

• 한국통신학회논문지
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• 제31권2A호
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• pp.154-167
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• 2006

IEEE 802.11 무선랜(Wireless LAN)은 다수의 전송속도(transmission rate)를 지원하고 있으며, 채널 상태에 따라 전송속도를 적응적으로 조절함으로써 시스템 성능을 최대화할 수 있다. 지금까지 많은 종류의 전송속도 조절기법들이 제안되어 왔으나 최근까지 대부분의 상용제품에 구현된 기법은 ARF(Automatic Rate Fallback)라는 간단한 open-loop 전송속도 조절기법이다. 이러한 open-loop 전송속도 조절기법의 가장 큰 문제점은 데이터의 충돌현상(collision effect)을 고려하지 않는다는 것이며, 이로 인해 충돌에 의한 다수의 전송실패가 발생할 경우 시스템 성능이 급격히 낮아진다는 문제점이 있다. 이 논문에서는 CARA(Collision-Aware Rate Adaptation)라는 새로운 전송속도 조절기법을 제안하고 있다. CARA는 송신 단말이 채널에러에 의해 발생한 데이터 전송실패를 충돌에 의해 발생한 것과 구분할 수 있도록 적응적으로 CCA(Clear Channel Assessment)와 RTS/CTS(Request-to-Send/Clear-to-Send) 전송을 사용하는 기법이다. 따라서 기존의 open-loop 전송속도 조절기법과 비교할 때, CARA는 보다 정확하게 현재 채널상태에 적합한 전송속도를 선택할 수 있게 된다. 시뮬레이션을 통한 많은 실험결과들로부터 CARA는 채널상태에 관계없이 다른 기법들보다 월등히 높은 성능을 나타낸다는 것을 알 수 있다.

• 한국컴퓨터정보학회논문지
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• 제10권5호
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• pp.161-170
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• 2005

인증서의 유효성을 검증하기 위해 CRL(Certificate Revocation List)dmf 이용할 경우 시간차 문제 때문에 실시간으로 그 유효성을 검증할 수 없으며 OCSP(Online Certificate Status Protocol)를 이용할 경우 규모가 큰 보안시스템에서는 검증서버에 과부하를 주는 문제가 있다. 그리고 IEEE 802. 1x 무선랜 표준에서는 클라이언트가 인증서버로부터 승인받기 전에는 유선랜으로의 접근이 허용되지 않기 때문에 인증서버를 실시간으로 인증할 수 없다. 본 논문에서는 이러한 문제점들을 해결하기 위하여 무선랜에서 통신 내용을 보호하고 통신자 간의 신원을 상호 실시간으로 확인할 수 있는 보안시스템을 설계하였다. 설계된 인증서 검증 프로토콜은 검증 결과의 현재성은 물론 시스템의 높은 안전성과 효율성을 보여주었으며 인증서의 유효성 검증 속도도 시스템의 규모와 상관없이 항상 일정하며 사용자가 신뢰하고 있어야 할 기관의 수도 적고 검증서버의 과부하도 막을 수 있었다. 그리고 고속 고용량과 저속 저용량의 클라이언트에 적합한 사용자 인증 및 키 교환 프로토콜은 실시간 상호 인증은 물론 인증 사실의 공인을 가능하게 하였다.

• 한국HCI학회논문지
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• 제1권2호
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• pp.19-26
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• 2006

가상환경 또는 실제 환경에서 정보를 제공하는 햅틱 인터페이스의 필요성이 점점 증가함에 따라 촉감을 제공하기 위한 다양한 햅틱 장치가 개발되었고 각 장치의 특성과 성능 평가를 위해 기초적인 정신(심리) 물리학적 연구가 수행 되고 있다. 본 논문에서는 여러 가지 햅틱 인터페이스 중 손가락 끝에 부착하는 형태의 새로운 공기 촉감 제시장치(PTI: Pneumatic Tactile Interface)를 제시하고 이 장치의 유용성을 입증하기 위해 localization rate, 시간 분해능, 길이 분해능, 강도의 세기 등의 심리 물리학적 실험(Psychophysical Experiment)의 수행 결과를 제시한다. 공기촉감 시스템은 50개의 출력까지 확장 가능한 공기촉감 하드웨어로 구성되어 있고 손가락 끝에 부착하는 형태로 구성하기 위해 $5{\times}5$의 배열의 디스플레이를 제작하였다. 16명의 피 실험자가 A, B 두 그룹으로 나뉘어 각각 2가지의 심리물리학 실험을 수행하였다. localization rate의 경우 9개의 다른 자극의 위치를 구별하기 위해 $3{\times}3$ 배열로 구성된 밀집된 디스플레이와 확장된 디스플레이로 측정을 수행하여 각각 58.13%, 85.9%의 localization rate를 얻을 수 있었다. 그리고 100번의 반복 실험을 통해 공기촉감제시장치의 길이 분해능을 얻을 수 있었고 자극 강도 실험의 경우, 실제의 강도가 세어짐에 따라 피 실험자들이 느끼는 강도의 척도도 증가하며, 강도가 약해지면 피 실험자들이 느끼는 강도 역시 거의 선형적으로 감소함을 알 수 있었다. 그러나 시간 분해능의 경우에는 시스템을 구성하는 밸브의 성능으로 인해 20ms 이하의 시간 분해능 측정은 제한되었다. 이러한 심리 물리학적 실험을 통하여 개발된 공기촉감 제시장치가 다양한 정보를 전달하는데 충분하다는 결론을 내릴 수 있으며, 향후 연구에서는 제안된 시스템을 사용하는 여러 가지 어플리케이션을 제시할 것이다.

• Asian Pacific Journal of Cancer Prevention
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• 제13권4호
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• pp.1413-1418
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• 2012

Background: Previous studies generally indicate that synchronous bilateral breast cancers (SBBC) have an equivalent or moderately poorer survival compared with unilateral cases. The prognostic characteristics of SBBC would be relevant when planning adjuvant therapies and follow-up medical surveillance. The frequency of SBBC among early breast cancers in clinical settings in Australia and New Zealand was investigated, plus their prognostic significance, using the Breast Cancer Audit Database of the Society of Breast Surgeons of Australia and New Zealand, which covered an estimated 60% of early invasive lesions in those countries. Design: Rate ratios (95% confidence limits) of SBBC were investigated among 35,370 female breast cancer cases by age of woman, histology type, grade, tumour diameter, nodal status, lymphatic/vascular invasion and oestrogen receptor status. Univariate and multivariable disease-specific survival analyses were undertaken. Results: 2.3% of cases were found to be SBBC (i.e., diagnoses occurring within 3 months). The figure increased from 1.4% in women less than 40 years to 4.1% in those aged 80 years or more. Disease-specific survivals did not vary by SBBC status (p=0.206). After adjusting for age, histology type, diameter, grade, nodal status, lymphatic/vascular invasion, and oestrogen receptor status, the relative risk of breast cancer death for SBBC was 1.17 (95% CL: 0.91, 1.51). After adjusting for favourable prognostic factors more common in SBBC cases (i.e., histology type, grade, lymphatic/vascular invasion, and oestrogen receptor status), the relative risk of breast cancer death for SBBC was 1.42 (95% CL: 1.10, 1.82). After adjusting for unfavourable prognostic factors more common in SBBC cases (i.e., older age and large tumour diameter), the relative risk of breast cancer death for SBBC was 0.98 (95% CL: 0.76, 1.26). Conclusions: Results confirm previous findings of an equivalent or moderately poorer survival for SBBC but indicate that SBBC status is likely to be an important prognostic indicator for some cases.