• 동의생리병리학회지
• /
• 제32권3호
• /
• pp.178-183
• /
• 2018

Pruritus is the most prominent symptom of atopic dermatitis and other skin diseases. It is not easily improved and is a major factor that threatens the quality of life of patients and their families. The purpose of this study was to evaluate the effect of HyungGae-Water, which was bath preparation made from Korean medicine herbs, for children and adolescents suffering pruritus. The participants were 50 boys and girls aged from 2 to 15 years old. The HyungGae-Water was used once a day for 6 weeks, and we were followed up three times every two weeks. Of 50 participants enrolled, 47 completed the study. The outcome variables were dermatology quality of life scales in children, pruritus VAS, and investigator global assessment (IGA). The results of the study show that the dermatology quality of life is significantly improved and the VAS of pruritus has meaningful changes. In the IGA, moderate or severe improvement was observed in 48.9% and slight improvement in 17%. There were seven suspected or less relevant adverse events using HyungGae-Water. The present results suggest that the HyungGae-Water has alleviating effect for the pruritus in children and adolescents.

• Bulletin of the Korean Chemical Society
• /
• 제15권9호
• /
• pp.786-791
• /
• 1994

A simple and rapid sample pretreatment process necessary for determination of metal oxides in water was proposed. Samples were injected into the continuous-flow tube installed inside the microwave oven and the treated samples were cooled before entered to the Ion Chromatography (IC) or Inductively Coupled Plasma (ICP). By coupling this microwave digestion system with IC or ICP, a fully automatic analytical procedures may be easily established. In this study, two different types of digestion methods were considered; the open tubing method (OTM) and the restraint tubing method (RTM). The RTM was proved to be 3 times faster in digestion period and 10 times higher in detection range than the OTM. Validation of proposed sample digestion system was carried out by using an ICP. The results showed that both of continuous-flow methods, the OTM and the RTM were comparable in accuracies with the conventional batch-type vessel digestion method.

• Geomechanics and Engineering
• /
• 제12권5호
• /
• pp.771-783
• /
• 2017

Using a transparent fracture replica with aperture size and water-cement ratio (w/c), the factors affecting the penetration behavior of rock grouting were investigated through laboratory experiments. In addition, the waterproof efficiency was estimated by the reduction of water outflow through the fractures after the grout curing process. Penetration behavior shows that grout penetration patterns present similarly radial forms in all experimental cases; however, velocity of grout penetration showed clear differences according to the aperture sizes and water-cement ratio. It can be seen that the waterproof efficiency increased as the aperture size and w/c decreased. During grout injection or curing processes, air bubbles formed and bleeding occurred, both of which affected the waterproof ability of the grouting. These two phenomena can significantly prevent the successful performance of rock grouting in field-scale underground spaces, especially at deep depth conditions. Our research can provide a foundation for improving and optimizing the innovative techniques of rock grouting.

• Geomechanics and Engineering
• /
• 제30권2호
• /
• pp.211-218
• /
• 2022

This study characterizes Proctor and geophysical properties in a broad range of grading and fines contents. The results show that soil index properties such as uniformity and fines plasticity control the optimum water content and peak dry unit trends, as well as elastic wave velocity. The capillary pressure at a degree of saturation less than S = 20% plays a critical role in determining the shear wave velocity for poorly graded sandy soils. The reduction in electrical resistivity with a higher water content becomes pronounced as the water phase is connected A parallel set of compaction and geophysical properties of sand-kaolinite mixtures reveal that the threshold boundaries computed from soil index properties adequately capture the transitions from sand-controlled to kaolinite-controlled behavior. In the transitional fines fraction zone between F_F ≈ 20 and 40%, either sand or kaolinite or both sand and kaolinite could dominate the geophysical properties and all other properties associated with soil compaction behavior. Overall, the compaction and geophysical data gathered in this study can be used to gain a first-order approximation of the degree of compaction in the field and produce degree of compaction maps as a function of water content and fines fraction.

• 한국식품영양학회지
• /
• 제29권1호
• /
• pp.1-11
• /
• 2016

To enhance the physiological activities of roasted coffee (RC), 30 kinds of green coffee beans (GCB) with different cultivating areas and varieties were fermented with Monascus ruber mycelium (MR) by solid-state culture. After the dried MR-fermented GCB was subjected medium roasting, each RC was extracted with hot-water. Among the hot-water extracts, the highest yield was the hot-water extract of RC from MR-fermented Indonesia Mandheling GCB (15.5%). However, the hot-water extract of RC from MR-fermented Ethiopia Sidamo GCB showed significantly higher polyphenolic contents (3.08 mg GAE/100 mg) and ABTS free radical scavenging activity (25.41 mg AEAC/100 mg). Meanwhile, the hot-water extract of RC from MR-fermented Vietnam Robusta GCB showed not only the effective inhibition of $TNF-{\alpha}$ level (73.7% inhibition of LPS-stimulated control) from LPS-stimulated RAW 264.7 cells but also significant inhibition of lipogenesis (63.5% inhibition of lipid differentiation control) in 3T3-L1 pre-adipose cells. In conclusion, these results suggest that roasted coffees from Ethiopia Sidamo and Vietnam Robusta green coffee beans fermented with Monascus ruber mycelium using solid-state culture could have industrial applications as functional coffee beverages.

• Geomechanics and Engineering
• /
• 제37권3호
• /
• pp.253-262
• /
• 2024

Dynamic properties are pivotal in soil analysis, yet their experimental determination is hampered by complex methodologies and the need for costly equipment. This study aims to predict dynamic soil properties using static properties that are relatively easier to obtain, employing machine learning techniques. The static properties considered include soil cohesion, friction angle, water content, specific gravity, and compressional strength. In contrast, the dynamic properties of interest are the velocities of compressional and shear waves. Data for this study are sourced from 26 boreholes, as detailed in a geotechnical investigation report database, comprising a total of 130 data points. An importance analysis, grounded in the random forest algorithm, is conducted to evaluate the significance of each dynamic property. This analysis informs the prediction of dynamic properties, prioritizing those static properties identified as most influential. The efficacy of these predictions is quantified using the coefficient of determination, which indicated exceptionally high reliability, with values reaching 0.99 in both training and testing phases when all input properties are considered. The conventional method is used for predicting dynamic properties through Standard Penetration Test (SPT) and compared the outcomes with this technique. The error ratio has decreased by approximately 0.95, thereby validating its reliability. This research marks a significant advancement in the indirect estimation of the relationship between static and dynamic soil properties through the application of machine learning techniques.

• Geomechanics and Engineering
• /
• 제38권2호
• /
• pp.205-214
• /
• 2024

Permafrost refers to the condition where the ground is frozen. It is crucial to review and evaluate the ground's characteristics before construction. In this study, electrical resistivity surveying is chosen as the investigative technique to apply and illustrate the results on the state of permafrost ground and to summarize its applicability. Field experiments are conducted in the Yeoncheon area of South Korea, which has a freezing index of 522.6°C·days. The target area is categorized into two ground conditions: the first where the original ground freezes, and the second involves excavating the original ground up to a depth of 3 meters, backfilling it, and then artificially injecting fluid. Thus, frozen ground conditions are simulated under both natural and artificial circumstances. Electrical resistivity surveys are performed under both above-freezing and sub-zero temperature conditions, with the experiments conducted at sub-zero temperatures revealing relatively more high-resistivity zones due to the temperature conditions. In this area, the distribution of soil moisture content is also investigated using the Time Domain Reflectometry (TDR) technique. It is observed that the ground into which water is artificially injected had a relatively higher moisture content, although the difference is minor. Finally, a 3D map of the target ground is constructed based on the measured electrical resistivity values, and through this, the distribution of porosity, a crucial design parameter, is also depicted. This research demonstrates that the electrical resistivity technique can effectively evaluate the state of frozen and unfrozen ground and further suggests that it can detailed extract the characteristics of the target ground.

• 대한환경공학회지
• /
• 제27권5호
• /
• pp.461-467
• /
• 2005

내분비계장애물질로 분류된 phthalate esters의 제거방법에 대해 연구하였다. 상수처리조건에서 회분식으로 제거실험을 한 결과 응집침전은 $26.6{\sim}33.8%$, 오존산화에서는 $10{\sim}15%$ 제거효율을 나타내었다. 상수처리조건에서 활성탄 흡착에 의해 효과적으로 제거되는 것으로 나타났고 연속공정에서 EBCT를 10분 운전했을 때 원수의 phthalate esters농도가 $100\;{\mu}g/L$일 경우 WHO 및 US EPA 먹는 물 기준 달성이 가능한 것으로 나타났다. Pilot plant 실험결과 응집침전공정에서 $32{\sim}44%$, 사여과 공정에서는 $6{\sim}10%$, 오존산화공정에서 $8{\sim}10%$의 제거효율을 보였으며 활성탄 흡착공정을 거친 후에는 4가지 물질(DEP, DBP, BBP 및 DEHP)모두 검출되지 않았다. 실제 고도처리 정수장에서의 공정별 phthalate esters 제거율은 응집침전 공정에서 $29{\sim}76%$ 정도 제거되었고 모래여과 공정에서 $3{\sim}29%$, 오존산화 공정에서 $17{\sim}22%$ 제거되었으며, 활성탄 처리 후에는 4가지 물질 모두 검출되지 않았다.

• 한국식품과학회지
• /
• 제53권1호
• /
• pp.46-54
• /
• 2021

본 연구에서는 아스파라거스 부산물인 줄기와 뿌리 추출물의 루틴 및 총폴리페놀 함량, DPPH 및 ABTS radical 소거능, xanthine oxidase 및 MMP-9 저해활성, 간세포 보호효과를 분석하였다. 루틴과 총폴리페놀 함량은 아스파라거스 줄기 열수 추출물 31.74 mg/g과 20.14 mg GAE/g으로 가장 많았으며, ABTS radical 및 DPPH radical 소거능은 페놀성 화합물의 함량이 상대적으로 높은 줄기 열수 추출물에서 IC50 값이 각각 541.1±21.0, 649.5±6.6 ㎍/mL이였으며, 아스파라거스 추출물에 존재하는 페놀성 화합물과 radical 소거능과의 연관성을 시사하였다. Xanthine oxidase 저해활성은 아스파라거스 뿌리 열수추출물이 200 ㎍/mL 농도에서 43.68%의 저해활성을 보였다. HepG2 간세포는 아스파라거스 모든 추출물에서 세포독성이 없는 것으로 나타났으나, RAW 264.7 대식세포의 경우 아스파라거스 줄기 열수 및 20% 에탄올 추출물 200 ㎍/mL 농도에서 각각 90.18, 84.14%로 생존률이 유의하게 감소하는 것으로 나타났다. MMP-9 발현량은 아스파라거스 추출물 처리구에서 전반적으로 감소하였고, 특히 줄기 추출물 처리구에서 MSU 처리구와 비교하여 유의하게 감소하는 경향을 보였다. HepG2 간세포에 3% 에탄올을 처리하여 간독성을 유발하여 GGT, AST 및 LDH 활성을 측정한 결과 아스파라거스 줄기 20% 에탄올 추출물이 가장 우수한 것으로 나타났다. 이 결과를 토대로 아스파라거스 줄기 및 뿌리는 총 폴리페놀과 루틴이 다량 함유되어 있어 생리활성 소재로써 개발 가치가 높을 것으로 판단되며, 추가적인 in vivo 생리활성평가를 통해 활용방안 모색이 필요할 것으로 판단된다.

• 한국식품저장유통학회지
• /
• 제22권3호
• /
• pp.428-436
• /
• 2015

본 연구에서는 추출방법을 달리하여 블루베리 열수추출물들간의 항산화 활성 차이를 비교하였다. Autoclave를 이용한 가압가열추출(AE), 오븐을 이용한 추출(OE), 끓인 증류수에 혼합 후 sonication한 추출(HWSE), 끓인 증류수에 산을 첨가한 후 sonication한 추출(HWASE) 및 15분간 끓여 추출(BE) 등의 방법으로 추출물을 제조하고, 총 폴리페놀, 플라보노이드 및 안토시아닌 함량을 확인하고 ABTS, alkyl 및 DPPH radical 소거능 실험과 $Fe^{2+}$ ion chelating 활성을 확인하였다. 총 폴리페놀 및 플라보노이드 함량 모두 AE에서 각각 $3.47{\pm}0.16mg\;GAE/g$ 및 $1.59{\pm}0.19mg\;RE/g$으로 가장 높은 값을 나타냈다. 한편 이와는 반대로 총 안토시아닌 함량은 AE가 가장 낮은 함량을 나타냈으며, HWSE(5.29 mg/g) 에서 가장 높은 함량을 나타냈다. ABTS와 alkyl radical 소거능 측정 결과, AE가 가장 우수한 소거능을 나타냈으며, DPPH radical 소거능 실험에서는 AE와 더불어 안토시아닌 함량이 가장 높은 HWSE이 우수한 활성을 나타냈다. $Fe^{2+}$ ion chelating 활성 측정 실험에서는 모든 추출물이 유의적 차이 없이 높은 활성을 나타냈다. 또한 SOD activity 측정 실험에서 AE가 가장 우수한 활성을 나타냈으며, $H_2O_2$에 의해 유도된 세포독성 또한 AE가 가장 효과적으로 억제시켰다. 이상의 결과를 토대로 추출 조건에 따른 항산화 활성 차이를 수율 대비로 비교하였을 때, 가장 낮은 활성을 나타냈던 HWASE에 대비하여 AE는 ABTS radical scavenging activity 1.90배, alkyl radical scavenging activity 2.32배, DPPH radical scavenging activity 1.72배, SOD assay 1.65배, $H_2O_2$에 의해 유도된 세포독성에 대한 보호효능 1.84배의 우수한 항산화 활성을 나타냈다.