• Asian-Australasian Journal of Animal Sciences
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• 제11권1호
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• pp.55-59
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• 1998

To study the effect of induced hypothyroidism on fertility status of male Black Bengal goats, 10 adult healthy mature males were divided into control and treated groups. Hypothyroidism was induced successfully by injecting thiourea subcutaneously initially for 15 days at the rate of 100 mg/kg body weight, followed by 66.7 mg/kg body weight for the subse quent 15 days. This resulted in a decrease (p < 0.01) in plasma tri-iodothyronine, thyroxine and testosterone levels, with increasing duration of thiourea treatment. It also adversely affected semen quality, ejaculate volume, sperm concentration, motility and viability. Live percentage declined to 75% for treated and control remained at 90%. Artificial insemination fo female goats with semen of thiourea-treated goats, resulted in failure of conception. However, females inseminated with semen of male goats of control group showed 100% conception. These observations indicate that, thyroid hormones play a key role in maintaining the normal reproductive processes of male goats.

• 대한본초학회지
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• 제22권1호
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• pp.95-102
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• 2007

Objectives : The aim was to study experimentally the effects of Danggwisaeyeoktang(當歸四逆湯) on the hypothyroidism of rats induced by thiouracil. Methods : Spargue-Dawley rat were separated into three groups. Except normal group, the other two groups were treated with thiouracil 50mg/kg/days for 30 days by oral administration. Among the two group, one group was treated DGSYT extract 0.54g/kg/days for 20 days separately. T3-uptake;, T3, T4, TSH, hematological values, enzyme activity, total cholesterol and Na+ content charge in the Serum of rats were measured after medication of solid extract of DGSYT. Result : As a result of this study, in the serum T3-Uptake and T4 level, hematological values and sodium were increased in DGSYT group compared to controls. The serum TSH, total cholesterol and body weight were decreased in DGSYT group compared to controls. Conclusion : According to the above results, it is suggested that DGSYT is effective to cure hypothyroidism.

• 한국임상약학회지
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• 제30권2호
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• pp.87-91
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• 2020

Background: Levothyroxine is an essential drug for the treatment of hypothyroidism or related diseases. Several studies have reported an association between the effects of levothyroxine treatment and time of administration, which can be inconsistent. Objective: This study was conducted to compare the levels of thyroid-stimulating hormone or free thyroxine between morning and nighttime dosing of levothyroxine. Methods: We reviewed previously reported relevant articles and conducted a meta-analysis. Results: In total, five studies were included in this meta-analysis. Results showed that thyroid-stimulating hormone (standard difference in means [SE]=0.321; 95% confidence interval [CI], -0.016 to 0.657) and free thyroxine (SE= -1.367; 95% CI, -2.943 to 0.210) levels did not differ significantly between morning (before breakfast) and nighttime (before bedtime) administration. Conclusion: This is the first meta-analysis to evaluate the effects of time of administration on levothyroxine levels in patients with hypothyroidism. Based on our results, we suggest considering patients' lifestyles or daily routines when counselling them on the optimal time of administration for levothyroxine.

• 대한한방내과학회지
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• 제15권2호
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• pp.305-317
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• 1994

To study the effect of Kamidaebotang on the hypothyroidism induced by thiourea in SD(Splague Dawley) rats, the weight of thyroid gland, the level of serum $T_3\;and\;T_4$. total cholesterol, hematological changes and histopathological findings were measured. The following results were obtained. 1. Thyroid gland weight of the Kamidaebotang B treated group was significantly increased as compared with that of control group(p<0.05). 2. The level of serum $T_3$ of the Kamidaebotang B treated group was slightly increased as compared with that of control group. But no significant changes appeared between two groups. 3. The level of serum $T_4$ of the Kamidaebotang A, B treated groups were significantly increased as compared with that of control group(p<0.05). 4. Total cholesterol of the Kamidaebotang A, B treated groups were not significant changes as compared with that of control group. 5. Hematological data of the Kamidaebotang A, B treated groups were not significant changes as compared with that of control group. 6. Histopathologically, Kamidaebotang B administration recovered effectly the dystropy, degeneration of thyroid follicle induced by thiourea. From above results, it is suggested that Kamidaebotang B is available to the hypothyroidism induced by thiourea in rats. Therefore, Kamidabotang B seems to be applicable to hypothyroidism in clinical practice.

• 혜화의학회지
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• 제5권1호
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• pp.233-250
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• 1996

In order to determine the effects of Palmijihwangtangs on the hypothyroidism, the biochemical and morphologic effects of PALMIJIHWANGTANGS against 2-thiouracil-induced hypothyroidism in rats were examined. 1. Serum $T_3$ value was significantly incresed by the treatment with PALMIJIHWANGTANG-1, 2 and 3(p<0.05). 2. Serum $T_4$ value was significantly higher in PALMIJIHWANGTANG-1 and PALMIJIIIWANGTANG-2 treated groups than that of control group. In PALMIJIHWANGTANG-3 treated group, serum $T_4$ level was significantly higher and that of control group(p<0.01). 3. Scrum free $T_4$ value was significantly incresed in the PALMIJIHWANGTANG-1 and PALMIJIHWANGTANG-2 treated groups(p<0.05) 4. Total cholesterols was significantly decresed by the treatment with PALMIJIHWANGTANG-1(p<0.05). 5. The treament with the PALMIJIHWANGTANG-1, 2 and 3 resulted in the significantly decrease of serum ALT(p<0.05). 6. Thyroid gland weight was significantly increased in PALMIJIHWANGTANG-3 treated group(p<0.01). 7. Treatment with PALMIJIHWANGTANG-1, 2 and 3 effectively recovered the dystropy and degeneration of follicle in thyroid gland caused by 2-thiouracil. 8. There was no histological and functional lesion observed in the liver after treatment with PALMIJIHWANGTANG-1, 2 and 3. These results suggest that PALMIJIHWANGTANG may be effective in the treatment of hypothyroidism.

• 한국임상수의학회지
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• 제35권1호
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• pp.19-21
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• 2018

A 7-year-old female American cocker spaniel presented with chronic regurgitation and megaesophagus on radiography at a local hospital. Dry and coarse hair coat, tail alopecia, and bradycardia were observed during physical examination. Mild, non-regenerative anemia was indicated by complete blood count (CBC) analysis. Concurrent hypercholesterolemia and hypertriglycemia were indicated by biochemistry tests. Decreased levels of total and free thyroxine (T4) and increased canine thyroid stimulating hormone (cTSH) levels were also detected. Megaesophagus was confirmed by radiographic examination. Based on the results, a diagnosis of hypothyroidism with megaesophagus was made. The patient was initially treated with levothyroxine sodium at a dosage of 0.02 mg/kg twice a day. After two weeks of treatment for hypothyroidism, the dilated esophagus returned to its original size and no further regurgitation was observed. No relapse was observed during two months of follow-up.

• 한국임상수의학회지
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• 제30권6호
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• pp.464-467
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• 2013

6년령의 중성화된 암컷 코카스파니엘이 전신적인 건성지루증으로 내원하였다. 간효소 활성도 증가 및 초음파 상의 stellate pattern에 근거하여 담낭점액종으로 진단되었다. 16개월 동안 담낭점액종에 대한 약물처치가 이루어졌으나 치료반응이 없었다. 호르몬 및 조직병리학 검사를 통하여 갑상선기능저하증이 확인되었다. Levothyroxine 치료 후 피부, 혈청화학 및 초음파상의 이상소견들이 빠르게 회복되었다. 본 증례보고는 담낭점액종과 갑상선기능저하증이 병발한 개에서 갑상선기능저하증에 대한 치료 후 피부병변, 혈정화학 및 초음파상의 연속적인 변화를 기술하고 있다.

• 대한의생명과학회지
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• 제16권1호
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• pp.19-24
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• 2010

We analyzed and compared the concentration of total cholesterol (CHOL), high density lipoprotein (HDL) cholesterol, low density lipoprotein (LDL) cholesterol and triglyceride (TG) in serum and the serum protein electrophoresis fractions of thyroid disease patients. In comparison with the average of reference, our data showed that the average concentration of CHOL, LDL cholesterol and TG in hyperthyroidism patients were decreased significantly, but HDL cholesterol was increased significantly. In hypothyroidism patients, CHOL, HDL cholesterol, LDL cholesterol and TG were all increased significantly. In comparison of the concentration of lipids in each patient to reference range, 28.3% of hyperthyroidism patients showed abnormally low level of total cholesterol. In the patients with hypothyroidism, the percentage of patients showed abnormally high level of CHOL, HDL cholesterol, LDL cholesterol and TG were 37.7%, 10%, 68.8% and 49.1%, respectively. In our studies of serum protein electrophoresis, the average of ${\alpha}_2$-globulin and $\gamma$-globulin in hyperthyroidism patients were increased and $\beta$-globulin was decreased significantly. In hypothyroidism patients, the average of $\gamma$-globulin was increased and $\beta$-globulin was decreased significantly. In comparison of protein fractions of each patient to reference range, 38.3% and 50.0% of hyperthyroidism patients showed abnormally high levels of ${\alpha}_2$-globulin and $\gamma$-globulin, but 73.3% of patients showed abnormally low level of $\beta$-globulin. In hypothyroidism patients, 70.4% of patients were abnormally decreased in $\beta$-globulin and 63.9% of patients were abnormally increased in $\gamma$-globulin. These data suggest that the concentrations of CHOL, HDL cholesterol, LDL cholesterol and TG are not critical data for clinical interpretation of hyperthyroidism, but the levels of them are useful for interpretation of hypothyroidism patients. Our results of serum protein electrophoresis suggest that the concentration of serum protein electrophoresis fractions can be useful to understand the thyroid disease.

• 대한한방내과학회지
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• 제32권3호
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• pp.425-434
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• 2011

Objectives : Hypothyroidism is the most common pathological disease of the endocrine system. Morinda Officinalis Radix has been used in treatment of Yang deficiency. In this study, we investigated the therapeutic effects of Morinda Officinalis Radix on a rat model of hypothyroidism induced by 6-propyl, 2-thiouracil (PTU). Methods : Two-month-old Sprague-Dawley male rats were used with injection of PTU which induced rats into hypo-thyroidism. During 2 weeks, rats were treated with Morinda Officinalis Radix and thyroxine. Body weights were checked every week, the after 4 weeks, biochemical analyses were performed. The levels of T3, T4 and TSH was measured by EILSA. Results : In the Morinda Officinalis Radix group, we could observe the level of T4 significantly increased and TSH level significantly decreased. Conclusions : Morinda Officinalis Radix could help the thyroid to produce thyroid hormones under PTU suppression. There is no harm effect on liver and kidney function, or other metabolism. According to these results it could help to treat hypothyroidism patients and relieve their symptoms.

• Tuberculosis and Respiratory Diseases
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• 제59권3호
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• pp.321-325
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• 2005

저자들은 복수나 심낭액, 심부전의 소견 없이 갑상선기능저하증에 의해 발생한 일측성 흉막액을 진단하고, levothyroxine sodium 치료로 호전을 보인 환자 1예를 경험하였기에 문헌 고찰과 함께 보고하는 바이다.