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Improvement of Megaesophagus after Treatment of Concurrent Hypothyroidism

  • Ko, Gyeong-Bin (Department of Internal Medicine, College of Veterinary Medicine, Chonnam National University) ;
  • Kim, Joonyoung (Department of Internal Medicine, College of Veterinary Medicine, Chonnam National University) ;
  • Choi, Hyeong-Il (Department of Internal Medicine, College of Veterinary Medicine, Chonnam National University) ;
  • Moon, Min-Young (Department of Internal Medicine, College of Veterinary Medicine, Chonnam National University) ;
  • Suh, Guk-Hyun (Department of Internal Medicine, College of Veterinary Medicine, Chonnam National University) ;
  • Kim, Ha-Jung (Department of Internal Medicine, College of Veterinary Medicine, Chonnam National University)
  • Received : 2017.11.13
  • Accepted : 2018.02.14
  • Published : 2018.02.28

Abstract

A 7-year-old female American cocker spaniel presented with chronic regurgitation and megaesophagus on radiography at a local hospital. Dry and coarse hair coat, tail alopecia, and bradycardia were observed during physical examination. Mild, non-regenerative anemia was indicated by complete blood count (CBC) analysis. Concurrent hypercholesterolemia and hypertriglycemia were indicated by biochemistry tests. Decreased levels of total and free thyroxine (T4) and increased canine thyroid stimulating hormone (cTSH) levels were also detected. Megaesophagus was confirmed by radiographic examination. Based on the results, a diagnosis of hypothyroidism with megaesophagus was made. The patient was initially treated with levothyroxine sodium at a dosage of 0.02 mg/kg twice a day. After two weeks of treatment for hypothyroidism, the dilated esophagus returned to its original size and no further regurgitation was observed. No relapse was observed during two months of follow-up.

Keywords

References

  1. Miller J, Popiel J, Che mo ska-Soyta A. Humoral and Cellular Immune Response in Canine Hypothyroidism. J Comp Path 2015; 153: 28-37. https://doi.org/10.1016/j.jcpa.2015.03.003
  2. Pancotto TE, Rossmeisl JH Jr, Huckle WR, Inzana KD, Zimmerman KL. Evaluation of endothelin-1 and MMPs-2,-9,-14 in cerebrospinal fluid as indirect indicators of bloodbrain barrier dysfunction in chronic canine hypothyroidism. Res Vet Sci 2016; 105: 115-120. https://doi.org/10.1016/j.rvsc.2016.01.021
  3. Giza EG, P onek M, Nicpon JM, Wrzosek MA. Electrodiagnostic studies in presumptive primary hypothyroidism and polyneuropathy in dogs with reevaluation during hormone replacement therapy. Giza et al. Acta Vet Scand 2016; 58:32.
  4. Kumar KS, Srikala D. Hypothyroid associated megaesophagus in dogs: four years (2009-2013) study in Hyderabad, India. J Adv Vet Anim Res 2015; 2: 221-224. https://doi.org/10.5455/javar.2015.b69
  5. Kanemoto Y, Fukushima K, Kanemoto H, Ohno K, Tsujimoto H. Long-term management of a dog with idiopathic megaesophagus and recurrent aspiration pneumonia by use of an indwelling esophagostomy tube for suction of esophageal content and esophagogastric tube feeding. J Vet Med Sci 2017; 79: 188-191. https://doi.org/10.1292/jvms.16-0374
  6. Manning K, Birkenheuer AJ, Briley J, Montgomery SA, Harris J, Vanone SL, Gookin JL. Intermittent At-Home Suctioning of Esophageal Content for Prevention of Recurrent Aspiration Pneumonia in 4 Dogs with Megaesophagus. J Vet Intern Med 2016; 30: 1715-1719. https://doi.org/10.1111/jvim.14527
  7. Voorbij AM, Leegwater PA, Buijtels JJ, Daminet S, Kooistra HS. Central Hypothyroidism in Miniature Schnauzers. J Vet Intern Med 2016; 30: 85-91. https://doi.org/10.1111/jvim.13818