• Neonatal Medicine
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• v.18 no.1
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• pp.96-103
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• 2011

Purpose: Although infants with bronchopulmonary dysplasia (BPD) are at risk of developing secondary pulmonary hypertension (PH), which is associated with significant morbidity and mortality, little has been reported about the incidence, clinical course and prognosis of PH secondary to BPD in premature infants. This study was done to investigate the incidence, risk factors, clinical course, and the ultimate prognosis of PH developed secondary to BPD in very low birth weight infants (<1,500 g). Methods: Medical records of very low birth weight infant (VLBWI) admitted to Samsung Medical Center NICU from January 2000 to July 2007 were reviewed retrospectively. BPD was defined by Jobe's classification. The diagnosis of pulmonary hypertension was established as velocity of tricuspid valve regurgitation (TR) ${\geq}$3 m/s and a flattening of the intraventricular septum by conducting Doppler echocardiography. Results: The incidence of pulmonary hypertension was 6% in VLBWI with BPD and it developed in moderate to severe BPD. The diagnosis of pulmonary hypertension was made on postnatal 133 days (range 40-224 days) and the risk factors related to developing pulmonary hypertension were severe BPD, small for gestational age and outborn infants. The mortality rate was 57% and especially higher in severe BPD (70%). The time to recovery spent 3 months (range 1-10 months) in survived patients. Conclusion: Based on the results of this research, pulmonary hypertension secondary to BPD in VLBWI related to severity of BPD and had a poor prognosis. We expect that regular long-term echocardiography may be helpful in treating reversible in VLBWI with moderate to severe BPD.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.17 no.11
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• pp.236-247
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• 2016

The purpose of this study was to examine the effects of health program s on hypertension in a public health center located in Y-si. Most interesting were the effects on hypertension-related knowledge, self-care behavior, quality of life, and physiological parameters for hypertensive patients. Nonequivalent control group pretest-posttest design was employed. A total of 48 patients with hypertension living in Y-si were assigned to either the experimental group (n=23) or the control group (n=25). The experimental group was provided with an 8-week health program on hypertension between August 31 and October 23 in 2015. Data were analyzed with SPSS/WIN 21.0 using descriptive statistics, ${\chi}^2$-test, Fisher's exact test, and t-test. The result indicated a significant difference between the experimental group and the control group with respect to the scores of hypertension-related knowledge (t=-3.76, p<.001), self-care behavior (t=-3.33, p=.002), physiological parameters, including systolic blood pressure (t=6.27, p<.001) and diastolic blood pressure (t=4.70, p<.001), total cholesterol levels (t=3.08, p=.003), and Abdominal circumference (t=2.52, p=.015). We conclude that the self-group program on hypertension has a significant effect on the change of hypertension-related knowledge and self-care behavior for hypertensive patients.

• The Korean Journal of Physiology and Pharmacology
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• v.22 no.4
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• pp.447-456
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• 2018

Angiotensin-(1-9) [Ang-(1-9)], generated from Ang I by Ang II converting enzyme 2, has been reported to have protective effects on cardiac and vascular remodeling. However, there is no report about the effect of Ang-(1-9) on pulmonary hypertension. The aim of the present study is to investigate whether Ang-(1-9) improves pulmonary vascular remodeling in monocrotaline (MCT)-induced pulmonary hypertensive rats. Sprague-Dawley rats received Ang-(1-9) ($576{\mu}g/kg/day$) or saline via osmotic mini-pumps for 3 weeks. Three days after implantation of osmotic mini-pumps, 50 mg/kg MCT or vehicle were subcutaneously injected. MCT caused increases in right ventricular weight and systolic pressure, which were reduced by co-administration of Ang-(1-9). Ang-(1-9) also attenuated endothelial damage and medial hypertrophy of pulmonary arterioles as well as pulmonary fibrosis induced by MCT. The protective effects of Ang-(1-9) against pulmonary hypertension were inhibited by Ang type 2 receptor ($AT_2R$) blocker, but not by Mas receptor blocker. Additionally, the levels of LDH and inflammatory cytokines, such as $TNF-{\alpha}$, MCP-1, $IL-1{\beta}$, and IL-6, in plasma were lower in Ang-(1-9) co-treated MCT group than in vehicle-treated MCT group. Changes in expressions of apoptosis-related proteins such as Bax, Bcl2, Caspase-3 and -9 in the lung tissue of MCT rats were attenuated by the treatment with Ang-(1-9). These results indicate that Ang-(1-9) improves MCT-induced pulmonary hypertension by decreasing apoptosis and inflammatory reaction via $AT_2R$.

• Proceedings of The Korean Society of Health Promotion Conference
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• 2009.10a
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• pp.247-248
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• 2009

• The Journal of Korean Society for School & Community Health Education
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• v.17 no.3
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• pp.87-101
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• 2016

Objectives: This study was for analysis the educational needs of personnels who works for hypertension and diabetes centers in community in order to serve as the basis for the development of the future educational programs. Methods: To analyze the educational needs of personnels who wokrs for hypertension and diabetes centers in community, a survey based on CompHP core competencies framework for health promotion was conducted in September 2016. 102 personnels were answered to the online questionnaires and collected data were analyzed through SPSS. Results: The highest point of educational needs was 'how to use verbal and non-verbal effective communication skills' among 46 core competencies for health promotion and 'self-management practical skills for hypertension and diabetes patients'. There were some differences of educational needs between leaders and general staff members of centers. Most wanted educational subjects of leaders are 'contribute to the development and dissemination of health promotion evaluation and research process', and 'use evaluation findings to refine and improve health promotion action'. On the other hand, most general staff members of centers wanted 'use effective communication skills including written, verbal, non-verbal, and listening skills' and 'facilitate the development of personal skills that will maintain and improve health. Conclusions: Evidence-based and long-term educational programs should be developed for personnels who works for hypertension and diabetes centers in community.

• Journal of Preventive Medicine and Public Health
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• v.36 no.3
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• pp.289-297
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• 2003

Objectives : The main objectives of this study are to identify the factors associated with hypertension control and to determine the influencing factors associated with antihypertensive therapy. Methods : The study was conducted on 107 subjects who participated in the 1999 and 2002 Gwacheon Study and who had had uncontrolled hypertension (systolic$\geq$140 or diastolic$\geq$ 90mmHg) in 1999, We compared the characteristics of the controlled and uncontrolled hypertensive group and investigated the characteristics of those taking antihypertensive medication. Univariate associations between hypertension control and its characteristics and the association between antihypertension treatment and its characteristics were tested with $x^2$-test. We also peformed logistic regression analysis. Results : The participants who had their blood pressure checked within 6 months before their first measurement and those who had taken the antihypertensive medication showed significantly better hypertension control during the follow-up. The multivariate analysis showed that baseline antihypertensive therapy was the most important determinant factor of hypertension control during the follow-up. Socioeconomic level and life style did not affect hypertension control when controlled by the treatment variable in this study. The factors associated with antihypertensive therapy at follow-up were previous antihypertensive therapy, old age, and high educational level. Conclusions : Those who received antihypertensive therapy and those who had their blood pressure re-checked within 6 months both showed well controlled hypertension. The subjects with high educational level complied well with the antihypertensive regimen, but those in their forties did not.

• Nutrition Research and Practice
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• v.14 no.1
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• pp.76-84
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• 2020

BACKGROUND/OBJECTIVES: Few epidemiological studies examined the association between fried food intake and hypertension. This study examined whether fried food intake was associated with higher prevalence of prehypertension and hypertension combined in a cross-sectional study of the Filipino Women's Diet and Health Study (FiLWHEL). SUBJECTS/METHODS: This study included a total of 428 women aged 20-57 years who have ever been married to Korean men. Prehypertension was defined as 120 - < 140 mmHg of SBP or 80 - < 90 mmHg of DBP and hypertension as SBP ≥ 140 mmHg or DBP ≥ 90 mmHg. Fried food intake was assessed using one-day 24-hour recall. Fried foods were categorized into total, deep/shallow and pan/stir fried foods. The odds ratio (OR)s and 95% confidence interval (CI)s were calculated using multivariate logistic regression. RESULTS: The prevalence of prehypertension and hypertension combined was 41.36% in this population. High fried food intake was associated with high prevalence of prehypertension and hypertension combined. The odds of having prehypertension and hypertension was higher in the 3rd tertile of fried food intake among fried food consumers compared to non-fried food consumers (OR = 2.46, 95% CI = 1.24, 4.87; P for trend = 0.004). Separate analysis for types of frying showed that deep and shallow fried food intake was associated with prevalence of prehypertension and hypertension combined for comparing the 3rd tertile vs. non-fried food consumers (OR = 2.93; 95% CI = 1.57-5.47; P for trend = < 0.001). CONCLUSIONS: This study showed the evidence that high fried food intake was significantly associated with high prevalence of prehypertension and hypertension combined among Filipino women married to Korean men.

• Biomedical Science Letters
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• v.18 no.4
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• pp.377-383
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• 2012

Recent genome-wide association studies (GWAS) have identified a number of common variants associated with blood pressure homeostasis and hypertension in population. In the previous study, single nucleotide polymorphisms (SNPs) in the SLC4A4 gene have been reported to be associated with hypertension in Han Chinese population. We aimed to confirm whether the genetic variation of SLC4A4 gene influence the susceptibility to blood pressure and hypertension in Korean population. We genotyped variants in or near SLC4A4 in a population-based cohort including 7,551 unrelated Korean from Ansan and Ansung. Here, we performed association analysis to elucidate the possible relations of genetic polymorphisms in SLC4A4 gene with blood pressure traits. By examining genotype data of a total of 7,551 subjects in the Korean Association REsource (KARE) study, we discovered the SLC4A4 gene polymorphisms are associated with blood pressure and hypertension. The common and highest significant polymorphism was rs6846301 (${\beta}$=0.839, additive P=0.032) with systolic blood pressure (SBP), rs6846301 (${\beta}$=0.588, additive P=0.027) with diastolic blood pressure (DBP), and rs6846301 (OR=1.23, CI: 1.09~1.40, additive $P=1.2{\times}10^{-3}$) with hypertension. Furthermore, the SNP rs6846301 was consistently associated with both blood pressure and hypertension. Consequently, we found statistically significant SNPs in SLC4A4 gene that are associated with both blood pressure and hypertension traits. In addition, these results suggest that the individuals with the minor alleles of the SNP in the SLC4A4 gene may be more susceptible to the development of hypertension in the Korean population.

• Korean Journal of Health Education and Promotion
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• v.23 no.4
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• pp.13-28
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• 2006

Objectives: This study used the characteristics of the knowledge discovery and data mining algorithms to develop hypertension predictive model for hypertension management using the Korea National Health Insurance Corporation database(the insureds' screening and health care benefit data). Methods: This study validated the predictive power of data mining algorithms by comparing the performance of logistic regression, decision tree, and ensemble technique. On the basis of internal and external validation, it was found that the model performance of logistic regression method was the best among the above three techniques. Results: Major results of logistic regression analysis suggested that the probability of hypertension was: - lower for the female(compared with the male)(OR=0.834) - higher for the persons whose ages were 60 or above(compared with below 40)(OR=4.628) - higher for obese persons(compared with normal persons)(OR= 2.103) - higher for the persons with high level of glucose(compared with normal persons)(OR=1.086) - higher for the persons who had family history of hypertension(compared with the persons who had not)(OR=1.512) - higher for the persons who periodically drank alcohol(compared with the persons who did not)$(OR=1.037{\sim}1.291)$ Conclusions: This study produced several factors affecting the outbreak of hypertension using screening. It is considered to be a contributing factor towards the nation's building of a Hypertension Management System in the near future by bringing forth representative results on the rise and care of hypertension.

• The Journal of Internal Korean Medicine
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• v.12 no.1
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• pp.114-122
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• 1991

Hypertension is not the name of disease but that of syndrome, about which the record of causes and treatments did not exist in the classics. So I surveyed the oriental medical category of hypertension in the classics and studied on the causes and principal acupuncture points of treatment in the modern literature. And a result, I came to the following conclusion. 1. According to the category of hypertension in oriental medicine way, WIND(風), FIRE(火), PHLEGM(痰) were the evoked causes of hypertension. And the greater oart of hypertension's line in the classics was related to DIZZINESS(眩暈), APOPLEXY(中風), WIND OF THE LIVER(肝風). 2. There were exceedingly various causes such as inheritance, mind, emotion, change of nerve, other disease, etc. 3. In the treatment of acupuncture and moxibustion, there were Zusanli(足三里), Quchi(曲池), Fengchi(風池), Baihui(自會), Hegu(合谷), Sanyinjiao(三陰交), Taichong(太衝) which, 7 acupuncture points, showed high ratio. 4. According to the evoked causes, the major acupuncture points became to be different as follow; FIRE(火) : Neiguan(內關 ; P6) WIND(風) : Fengchi (風池 ; G20), Yanglingquan (陽陵泉 ; G34), Taichong(太衝 ; Liv3) PHLEGM(痰) : Zusanli(足三里 ; S36); Sanyinjiao(三陰交 ; Sp6). Basing on the Literature research, I have studied hypertension. I found that there were objective studies on the causes. But I couldn't find any objective study on the category of hypertension in oriental medicine way and the treatment of acupuncture and moxibustion. So I think that more profound study on the category and the interrelation between the acupuncture points of treatment and its dis tribution of the 14 meridians deserves to be continued from now on.