• Tuberculosis and Respiratory Diseases
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• v.40 no.2
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• pp.147-152
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• 1993

Background: There is evidence that platelet is activated in chronic obstructive pulmonary disease and activated platelet with injured endothelium contribute to the pathogenesis of pulmonary hypertension, prognostic factor of chronic obstructive pulmonary disease. So, we have investigated platelet function further in chronic obstructive pulmonary disease and effect of platelet activation on pulmonary hypertension. Method: We studied platelet aggregation ratio and alpha-granule products such as platelet factor 4(PF4) and beta-thromboglobulin (${\beta}$-TG) in control subjects and COPD without and with pulmonary hypertension subjects. Result: 1) The platelet aggregation ratio (PAR) was $0.99{\pm}0.04$ in control subjects, $0.98{\pm}0.05$ in COPD without pulmonary hypertension subjects and $0.89{\pm}0.08$ in COPD with pulmonary hypertension subjects. The platelet aggregation ratio of COPD subjects was tend to decrease than that of control subjects and the ratio of COPD with pulmonary hypertension subjects was significantly lower than that of control subjects. 2) The platelet factor 4 (PF4, IU/ml) was $4.7{\pm}1.2$ in control subjects, $18.6{\pm}4.9$ in COPD without pulmonary hypertension subjects and $57.2{\pm}12.7$ in COPD with pulmonary hypertension subjects. The level of COPD subjects was significantly higher than that of control subjects and the level of COPD with pulmonary hypertension subjects was significantly higher than that of COPD without pulmonary hypertension subjects. 3) The beta-thromboglobulin (${\beta}$-TG, IU/ml) was $34.4{\pm}5.8$ in control subjects, $80.4{\pm}18.1$ in COPD without pulmonary hypertension subjects and $93.0{\pm}14.0$ in COPD with pulmonary hypertension subjects. The level of COPD subjects was significantly higher than that of conrtrol subjects and the level of COPD with pulmonary hypertension subjects was tend to increase than that of COPD without pulmonary hypertension subjects. 4) There was no correlation between the clinical parameters and PAR, PF4 and ${\beta}$-TG but there was significant correlation among PAR, PF4 and ${\beta}$-TG. Conclusion: The platelet is activated in chronic obstructive pulmonary disease and the platelet of COPD with pulmonary hypertension is tend to be activated more than that of COPD without pulmonary hypertension. So, activated platelet may involve in the pathogenesis and maintenance of pulmonary hypertension in COPD subjects and modulation of platelet activity that might reduce pulmonary hypertension needs to be determined.

• The Korean Journal of Physiology and Pharmacology
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• v.4 no.2
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• pp.143-147
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• 2000

The present study was aimed at investigating whether there are changes in the expression of nitric oxide synthase (NOS) in relation with the unclipping-induced fall of blood pressure in two-kidney, one clip (2K1C) hypertension. Male Sprague-Dawley rats were made 2K1C hypertensive by clipping the left renal artery for four weeks. Sham-clipped rats served as control. The expression of endothelial constitutive (ec) NOS proteins and tissue levels of NO metabolites were determined in the kidney. Systolic blood pressure was significantly increased in clipped rats compared with that in the control. The development of hypertension was associated with decreases in the expression of ecNOS proteins and tissue levels of NO metabolites in the clipped kidney. The blood pressure at twenty-four hours after removal of the renal arterial clip fell to the control level. Accordingly, in the unclipped kidney, the expression of ecNOS proteins and tissue contents of NO metabolites were increased to the control level. The contralateral kidney was not affected by the development or reversal of hypertension. It is suggested that an enhanced expression of ecNOS in the unclipped kidney is an important component in the reversal of renovascular hypertension.

• Journal of Korean Medical Ki-Gong Academy
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• v.9 no.1
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• pp.1-48
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• 2006

This is a paper on the validity of Extra Gigong Therapy(EGT) on Hypertension patients. We've treated hypertension patients EGT, used IEMD for analysis, so that come to these conclusions. 1. Average value of treatment group was 4.215, this is higher than one of control group. They had differences up to the standard. 2. Hypertension patients are divided into EGT treated group(treatment group) and non-treated one(control group). 3. Light stomach meridian has differences in treatment group and no differences in control group before and after EGT. That means EGT is effective. So does Spleen meridian. 4. With 12 meridians' electric potential values, we come to conclusion that EGT is likely to do hypertension patients good, especially on the point of view of liver, kidney, stomach and spleen meridian pathways. And bibliographies back up in this conclusion. 5. We classified hypertension patients into 4 factors: that is a spiritual factor, a physical factor, an eating factor and a circulation factor. Among these, a physical factor was seen of high frequency. There is a close connection between a physical factor and liver, kidney, spleen meridian pathways. The consequence was that subjects are suburban residents in the prime of time who had overworked.

• Journal of Society of Preventive Korean Medicine
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• v.13 no.3
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• pp.43-53
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• 2009

Objective : The purpose of this study was to investigate the prevalence and the relationship between hypertension and the grades of 'Yang-Saeng'(health promotion methods in oriental medicine) in hypertension group and control group of Hong-Cheon county in Korea. Methods : To accomplish the purpose, we analyzed the Hong-Cheon survey data which was collected from 1,739 subjects from october 1. 2006 to October 20. 2006. Results : Hypertension group marked lower mentality score($21.0{\pm}3.7$) than that of control group($21.8{\pm}3.2$). (p<0.05) Hypertension group marked higher grades in the other Yang-Saeng categories{Eating($31.6{\pm}5.0$ ; $29.9{\pm}4.9$), Daily life($31.5{\pm}4.3$ ; $30.6{\pm}4.2$), Seasonal life($29.1{\pm}3.4$ ; $28.3{\pm}3.1$), Sexual behavior($13.9{\pm}2.3$ ; $13.5{\pm}2.1$)}. (p<0.05) Conclusion : The result of this study suggest that mental program could be needed more during operating health promotion program for hypertension group.

• KSII Transactions on Internet and Information Systems (TIIS)
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• v.16 no.1
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• pp.173-187
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• 2022

Recent studies have focused on self-management of hypertension using smart devices (cellular phones, tablets, watches). It has proven to be an effective tool for early detection and control of high Blood Pressure (BP) without affecting patients' daily routines. This systematic review surveys the existing self-monitoring systems, evaluate their effectiveness and compares the different approaches. We investigated the current systems in terms of various attributes, including methods used, sample size, type of investigation, inputs/ outputs, rate of success in controlling BP, group of users with higher response rate and beneficiaries, acceptability, and adherence to the system. We identified some limitations, shortcomings, and gaps in the research conducted recently studying the impact of mobile technology on managing hypertension. These shortcomings can generate future research opportunities and enable it to become more realistic and adaptive. We recommended including more observable factors and human behaviors that affect BP. Furthermore, we suggested that vital monitoring/logging and medication tuning are insufficient to improve hypertension control. There is also a need to observe and alter patient behavior and lifestyles.

• Asian Pacific Journal of Cancer Prevention
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• v.13 no.11
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• pp.5829-5834
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• 2012

Background: Breast cancer is the most common cancer in women worldwide. Although different metabolic factors have been implicated in breast cancer development, the relationship between hypertension and breast cancer has not been elucidated. Aim: To evaluate hypertension as a risk factor for breast cancer in Chilean women of low and middle socio-economic status. Methods: We conducted an age-matched (1:1) case-control study in 3 hospitals in Santiago, Chile. Breast cancer cases (n=170) were histopathologically confirmed. Controls had been classified as Breast Imaging Reporting and Data System I (negative) or II (benign findings) within 6 months of recruitment. Blood pressure was measured using a mercury sphygmomanometer and standardized procedures. We used 2 hypertension cut-off points: blood pressures of ${\geq}140/90$ mmHg and ${\geq}130/85$ mmHg. Fasting insulin and glucose levels were assessed, and anthropometric, sociodemographic, and behavioral information were collected. Odds ratios and 95% confidence intervals were estimated for the entire sample and restricted to postmenopausal women using multivariable conditional logistic regression models. Results: Hypertension (${\geq}140/90$ mmHg) was significantly higher in cases (37.1%) than controls (17.1%) for the entire sample and in postmenopausal pairs (44.0% compared to 23.8%). In crude and adjusted models, hypertensive women had a 4-fold increased risk of breast cancer (adjusted odds ratio: 4.2; 95% confidence interval: 1.8; 9.6) compared to non-hypertensive women in the entire sample. We found a similar association in the postmenopausal group (adjusted odds ratio: 2.8; 95% confidence interval: 1.1; 7.4). A significant effect was also observed when hypertension was defined as blood pressure of ${\geq}130/85$ mmHg. Conclusion: A significant association was found between hypertension and breast cancer over the entire sample and when restricted to postmenopausal women. Hypertension is highly prevalent in Latin America and may be a modifiable risk factor for breast cancer; therefore, a small association between hypertension and breast cancer may have broad implications.

• Journal of muscle and joint health
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• v.23 no.1
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• pp.49-60
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• 2016

Purpose: The purpose of this study was to examine the effects of hypertension health school program performed in a public health center located in Y-si. Most interesting were the effects on hypertension-related knowledge, self-efficacy, self-care behavior and physiological parameters for hypertensive patients. Methods: Nonequivalent control group pretest-posttest design was employed. 45 patients with hypertension living in Y-si were assigned into an experimental group (n=23) or a control group (n=22). Experimental group was provided with the 8-weeks hypertension health school program from April 7 to May 20 in 2014. Data were analyzed with SPSS/WIN 21.0 using descriptive statistics, $x^2$-test, Fisher's exact test and t-test. Results: The result indicated a significant difference between the experimental group and control group in the scores of hypertension-related knowledge (t=-10.97, p<.001), self-efficacy (t=-4.56, p<.001), self-care behavior (t=-407, p<.001), physiological parameters including systolic blood pressure (t=2.18, p=.032) and diastolic blood pressure (t=2.74, p=.008) and cholesterol levels (t=5.04, p<.001). Conclusion: The conclusion of this study is that the hypertension self-help group program has a significant effect on the change of hypertension-related knowledge, self-efficacy and self-care behavior for hypertensive patients.

• Asian Pacific Journal of Cancer Prevention
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• v.14 no.12
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• pp.7685-7692
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• 2013

Background: Management of hypertension and diabetes in cancer survivors is an important issue; however, not much is known about the level of management of such chronic disease in Korea. This study therefore assessed the prevalence, awareness, control, and treatment of hypertension and diabetes in Korean cancer survivors compared to non-cancer survivors. Materials and Methods: A cross-sectional design was employed, wherein data were obtained from standardized questionnaires completed by 943 cancer survivors and 41,233 non-cancer survivors who participated in the Fourth and Fifth Korea National Health and Nutrition Examination Surveys (2007-2011). We calculated adjusted proportions for prevalence and management of hypertension and diabetes in non-cancer survivors and cancer survivors. We also assessed the associated factors with prevalence and management of cancer survivors. Results: Cancer survivors are more likely than the general population to have higher prevalence, awareness, treatment, and control of hypertension. However, diabetic management was not significantly higher in cancer survivors than in non-cancer survivors, despite their having a higher prevalence. Several factors, such as, age, drinking, years since cancer diagnosis, self-perceived health status, and specific cancer types were found to affect to management of hypertension and diabetes. Conclusions: These data suggest that cancer survivors appear to be better than non-cancer survivors at management of hypertension, but not diabetes. There is a need for healthcare providers to recognize the importance of long-term chronic disease management for cancer survivors and for the care model to be shared between primary care physicians and oncologists.

• Health Policy and Management
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• v.25 no.2
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• pp.90-96
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• 2015

Background: This study aimed to research on how adherence and blood control could make a difference when it comes to develop complications. Methods: The study's subjects were 255,916 patients who were newly diagnosed with hypertension in 2009 using data collected by National Health Insurance Cooperation. Patients are considered as a group under adherence if visit days and prescription days are more than 300 days. Patients are considered to have successfully controled their hypertension based on actual value measured by National Health Insurance Cooperation and the study takes a look at whether they were diagnosed with complications of cerebrocardiovascular disease in 2012. Chi-square test and logistic regression was used to analyze. Results: Patients who were able to control their hypertension show 0.80 times chance of developing cerebrovascular disease, and 0.89 times chance of developing cardiocerebrovascular disease. The group of adherence shows lower chance of developing complication in general than the group of non-adherence. Conclusion: The study revealed that hypertension's constant treatment could control the blood pressure and prevent complications. It is important that encourages patients to effort for persistent treatment for reducing complication.

• Journal of Digital Convergence
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• v.11 no.11
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• pp.509-519
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• 2013

The purpose of this study was to identify the factors related to awareness, treatment, and control of hypertension in Korea using data from the 4th KNHANES. The analytical technique employed multivariate logistic regression analysis and the major findings of this research are as follows. First, awareness of hypertension was positively associated with age, occupation, self-rated health, Body Mass Index, and health examination since 2 years ago, in both males and females. Second, treatment of hypertension was positively associated with age, self-rated health, Body Mass Index, and health examination since 2 years ago, in both males and females. Third, control of hypertension was positively associated with age, self-rated health, Body Mass Index, and health examination since 2 years ago, in both males and females. Finally, the results of analysis suggest that the government should especially focus on the vulnerable group and continue to strengthen effective efforts for improving awareness, treatment, and control of hypertension.