• Title/Summary/Keyword: Hydroarylation

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Efficient Synthesis of 2-Substituted 2,3-Dihydro-4-quinolones as Potential Intermediates for 2-Substituted 1,2,3,4-Tetrahydro-4-quinolone Antitumor Agents

  • Choi Sun;Jung Keumn-Yeo;Ryu Jae-Sang
    • Archives of Pharmacal Research
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    • v.29 no.5
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    • pp.369-374
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    • 2006

  • An efficient method for the synthesis of optically active 2-substituted 2,3-dihydro-4-quinolones has been developed. The key features include the introduction of a chiral side chain and the construction of quinolone skeleton by Mitsunobu alkylation and hydroarylation, respectively.

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