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The Pharmaceutical Society of Korea (대한약학회)
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Efficient Synthesis of 2-Substituted 2,3-Dihydro-4-quinolones as Potential Intermediates for 2-Substituted 1,2,3,4-Tetrahydro-4-quinolone Antitumor Agents

  • Choi Sun (College of Pharmacy, Ewha Womans University) ;
  • Jung Keumn-Yeo (College of Pharmacy, Ewha Womans University) ;
  • Ryu Jae-Sang (College of Pharmacy, Ewha Womans University)
  • Published : 2006.05.01
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Abstract

An efficient method for the synthesis of optically active 2-substituted 2,3-dihydro-4-quinolones has been developed. The key features include the introduction of a chiral side chain and the construction of quinolone skeleton by Mitsunobu alkylation and hydroarylation, respectively.

Keywords

References

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