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Efficient Synthesis of 2-Substituted 2,3-Dihydro-4-quinolones as Potential Intermediates for 2-Substituted 1,2,3,4-Tetrahydro-4-quinolone Antitumor Agents  

Choi Sun (College of Pharmacy, Ewha Womans University)
Jung Keumn-Yeo (College of Pharmacy, Ewha Womans University)
Ryu Jae-Sang (College of Pharmacy, Ewha Womans University)
Publication Information
Archives of Pharmacal Research / v.29, no.5, 2006 , pp. 369-374 More about this Journal
Abstract
An efficient method for the synthesis of optically active 2-substituted 2,3-dihydro-4-quinolones has been developed. The key features include the introduction of a chiral side chain and the construction of quinolone skeleton by Mitsunobu alkylation and hydroarylation, respectively.
Keywords
2,3-Dihydro-4-quinolone; 1,2,3,4-Tetrahydro-4-quinolone; Hydroarylation; Mitsunobu; $PtCl_4$; Antitumor agent;
Citations & Related Records
Times Cited By KSCI : 1  (Citation Analysis)
Times Cited By Web Of Science : 3  (Related Records In Web of Science)
Times Cited By SCOPUS : 4
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