• The Journal of Natural Sciences
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• v.15 no.1
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• pp.79-88
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• 2005

There are five isoforms of thiol peroxidase in yeast. Each isoform was named after its subcellular localization such as cytoplasmic TPx I, cTPx II, cTPx III, mitochondrial TPx (mTPx), and nuclear TPx (nTPx). Recently, we reported that unlike other TPx null mutants, cTPx IInull mutant showed a slow-growth phenotype. This observation suggests that cTPx II might be involved in yeast cell growth. In this study, for a first step toward to investigate the physiological function of cTPx II in yeast, we have identified a novel interaction between cTPx II and various proteins by using the yeast two-hybrid system.

• Genomics & Informatics
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• v.16 no.4
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• pp.29.1-29.5
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• 2018

Hybrid capture-based targeted sequencing is being used increasingly for genomic variant profiling in tumor patients. Unique molecular index (UMI) technology has recently been developed and helps to increase the accuracy of variant calling by minimizing polymerase chain reaction biases and sequencing errors. However, UMI-adopted targeted sequencing data analysis is slightly different from the methods for other types of omics data, and its pipeline for variant calling is still being optimized in various study groups for their own purposes. Due to this provincial usage of tools, our group built an analysis pipeline for global application to many studies of targeted sequencing generated with different methods. First, we generated hybrid capture-based data using genomic DNA extracted from tumor tissues of colorectal cancer patients. Sequencing libraries were prepared and pooled together, and an 8-plexed capture library was processed to the enrichment step before 150-bp paired-end sequencing with Illumina HiSeq series. For the analysis, we evaluated several published tools. We focused mainly on the compatibility of the input and output of each tool. Finally, our laboratory built an analysis pipeline specialized for UMI-adopted data. Through this pipeline, we were able to estimate even on-target rates and filtered consensus reads for more accurate variant calling. These results suggest the potential of our analysis pipeline in the precise examination of the quality and efficiency of conducted experiments.

• Journal of Information Management
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• v.33 no.1
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• pp.1-17
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• 2002

This study examined several recommendation techniques to construct an effective book recommender system in a library. Experiments revealed that a hybrid recommendation technique is more effective than either collaborative filtering or content-based filtering technique in recommending books to be borrowed in an academic library setting. The recommendation technique based on association rule turned out the lowest in performance.

• Journal of the Korean Society for Library and Information Science
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• v.42 no.3
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• pp.189-205
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• 2008

The roles of librarians have been changing with the paradigm shift of libraries. The paradigm of libraries has shifted from a traditional information management-centered way to a hybrid approach emphasizing a balance between collection and access. This study analyzed the internal and external changes of libraries to create Blue Ocean of special libraries by using the SWOT analysis. and adopted ERCR analysis for the reasonable management of libraries. The findings of this study indicate that the scope of role played by librarians belonging to special libraries shall be diversified from their traditional library activities in order to adapt themselves to changes in time. The Blue Ocean Strategy can be successfully developed only if the activities of libraries have been changed so that they are closely related to those activities for which such affiliate organizations are expected to carry out.

• Journal of Korean Library and Information Science Society
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• v.32 no.4
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• pp.77-98
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• 2001

As the role of a library has changed to the integrated management system of knowledge, the library needs new information retrieval tools. The purpose of this study is to propose a method and principle of the Korean-English semantic thesaurus construction for a knowledge management system. The method and principle is as follows; 1) in collecting terminology, I included not only internal documents but external documents on the web as a source for the descriptors extraction. 2) conceptual descriptors are more needed than semantic ones. I also proposed the necessity of the authority files for complement. 3) I proposed the appropriate scale of the descriptors to be 15,000 in a thesaurus. And 4) I proposed a hybrid method that used both a manual and an automatic process in establishing the relationship.

• Journal of the Korean Society for Library and Information Science
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• v.39 no.3
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• pp.75-91
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• 2005

The popularization of the internet has produced an explosion in amount of the information. The importance of web personalization is being more and more increased. The personalization is realized by learning user's interest. User's interest is changing continuously and rapidly. We use user's profile to represent user's interest. User's profile is updated to reflect the change of user's interest. In this paper we present an adaptive learning algorithm that can be used to reflect user's interest that is changing with time. We propose the User's profile model. With this profile user's interest is learned based on user's feedback. This approach has applied to develop hybrid recommendation system.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.9 no.6
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• pp.1795-1799
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• 2008

The heterogeneous nuclear ribonucleoprotein K (hnRNP K) is a component of hnRNP complexes. This protein binds strongly to cytidine-rich RNA/DNA sequences. It is a nucleocytoplasmic shuttling protein. To investigate the functions of hnRNP K, I searched for hnRNP K-interacting proteins in HeLa cDNA library using a yeast two-hybrid screening system. One of the cDNA clones is identical to human hnRNP E1 (poly(rC) binding protein 1) cDNA (GenBank accession number XM_031585). In this study, hnRNP K is shown to specifically interact with hnRNP E1 in yeast two-hybrid system and in vitro biochemical assay.

• Journal of the Korean Society for Library and Information Science
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• v.41 no.3
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• pp.81-102
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• 2007

The purpose of this study is to examine the ISO/DIS 11620 : 2007(library performance indicators) in terms of structures, objectives, and BSC, and to apply the selected performance indicators to the digital library services for the case of 'B' University in Korea. Standardization of library statistics and of qualify or performance measures for libraries is carried on within ISO in the frame of the TC46/SC8/WG4. While the first edition of ISO 11620 grouped the indicators as to service areas, the ISO/DIS 11620:2007 uses the structure of the balanced scorecard(BSC). For the study, 44 performance indicators are grouped into traditional, hybrid. and digital libraries according to the characteristics of them. Ten selected Performance indicators, which are classified into digital libraries, are verified for the applicability.

• Journal of the Korean Society for Library and Information Science
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• v.57 no.1
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• pp.23-44
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• 2023

The word library(図書館) is a Japanese translation of the Western library or Bibliothek in the mid-Meiji period. This word has been accepted in Chinese(图书馆), Taiwan(圖書館), Korea(도서관), and Vietnam(Dđồ thư quán), which are Chinese-speaking countries. If so, when and who first introduced the term library to Japan and China? In Japan, the enlightenment thinker Fukuzawa's 『Seiyo Jijo, 1866』 is regarded as the first document to introduce the Western library, and in China, the article published in 『Qing Yi Bao, 1896』 by the reformed thinker Liang Qichao referred to as the first example. Therefore, this study traced and demonstrated the time and person in which the word library appeared, focusing on modern dictionaries, books, translations, papers, and newspaper articles that were introduced in both countries. As a result, the theory of the introduction to Fukuzawa in 1866 is wrong because Western libraries are described in various terms in many diaries and dictionaries, including Motoki's 『An English Japanese Dictionary of the Spoken Language, 1814』. Also, in China, the theory of introduction of Liang Qichao in 1896 is not true because the term library first appeared in Ryu Jeong-dam's 『A Dictionary of Loan Words and Hybrid Words in Chinese, 1884』. In the same context, it is necessary to trace and argue the history of the first use of the term library in Korea and the name of the first library in Korea established by the Busan Branch of the Japan Hongdo Association in 1901.

• Journal of Korean Society of Industrial and Systems Engineering
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• v.29 no.3
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• pp.62-69
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• 2006

Vehicle routing problem with time windows is determined each vehicle route in order to minimize the transportation costs. All delivery points in geography have various time restriction in camparision with the basic vehicle routing problem. Vechicle routing problem with time windows is known to be NP-hard, and it needs a lot of computing time to get the optimal solution, so that heuristics are more frequently developed than optimal algorithms. This study aims to develop a heuristic method which combines guided local search with a tabu search in order to minimize the transportation costs for the vehicle routing assignment and uses ILOG programming library to solve. The computational tests were performed using the benchmark problems.