• Journal of the Ergonomics Society of Korea
• /
• v.17 no.1
• /
• pp.91-102
• /
• 1998

History of the Sensibility Ergonomics is explained. Concepts, definition, and research methods on the human sensibility are proposed for systematic applications of human sensibility studies to product and environment developments. Sensibility Ergonomics was born in socio-technological environments where consumers required aesthetic and satisfactory products in addition to useful and usable ones, and manufactures were trying to develop consumer-oriented, user-friendly products. Sensibility Ergonomics is defined as "multi-disciplinary and inter-disciplinary processes for developing products and environment as usable, comfortable and satisfactory with the information on human sensibility." Human sensibility is functionally defined as "feelings generated when perceived sensory and information stimuli are reflected from memory which has been accumulated through personal experiences." Human sensibility is affected by at least three factors: personal, social, and cultural. Consumers evaluate products in three aspects : functional, sensorial, and cultural sensibilities. Human sensibility is personal, dynamic, and ambiguous. It is generated reflectively and intuitively against external stimuli. No Physiological responses are accompanied, and one cannot control his/her sensibility. However, the sensibility affects the decision making or behavior of the person. To understand the human sensibility many inter-disciplinary methods should be used instead of one-variable approach. Micro-scopic studies such as Questionnaire, interview, behavioral analysis, and psychophysiological experiments can be performed. In addition, social and cultural studies are essential to understand an individual's sensibility. Results of sensibility studies can be applied to setup new interactions between human and machine through sensible(or affective) human-machine (computer) interfaces. Human-oriented and user-friendly products can be made with the information on human sensibility.

• Archives of Pharmacal Research
• /
• v.21 no.1
• /
• pp.35-40
• /
• 1998

Human cytochrome P450 4F2 shows high regioselectivity in hydroxylation of stearic acid and leukotriene $ B_4.$ As a first step of its regulation study, human cytochrome P450 4F2 genomic DNA was isolated from liver of a person who was administered clofibrate for 10 years. From Southern hybridization, restriction enzyme digestion and sequencing experiments, isolated genomic DNA fragment was found to contain around 32 Kb DNA and more than 20 Kb of $5^I$ end regulatory region. Sequences of the structural gene region revealed exon 1 and exon 2. Further regulation studies would elucidate the feedback mechanisms of the oxidative degradation of fatty acids, inflammatory response and the clearance of leukotriene B4 in the liver. Furthermore, regulation study of this gene could explain the species difference in responses to peroxisome proliferator and help in the safety evaluation of peroxisome proliferating chemicals to human being.

• Fibers and Polymers
• /
• v.7 no.4
• /
• pp.446-449
• /
• 2006

The purpose of this study was to evaluate the comfort of PET clothing treated by UV. The physiological responses of the human body were investigated. Mean skin temperature and physiological signals such as Electroencephalogram (EEG), and heart rate (Electrocardiogram, (ECG)) were examined for 20 minutes during stable wearing conditions. Mean skin temperature was measured every two seconds using Ramanathan's method. Physiological responses were measured using Biopac MP100 series and analyzed using the software, Acqknowledge 3.5.2. Psychological effects were analyzed every five minutes. Comfort of untreated PET clothing decreased with the passage of time. Compared with PET clothing untreated, treated for 30 minutes, and treated for 90 minutes, the analysis of EEG showed that PET clothing treated for 90 minutes was the most comfortable after 20 minutes. In addition, the interval of the heart rate shown on the ECG was the highest in PET clothing treated for 90 minutes. Skin temperature was the lowest in PET treated for 90 minutes. We thus conclude that suitable UV irradiation would improve comfort.

• Tuberculosis and Respiratory Diseases
• /
• v.79 no.4
• /
• pp.207-213
• /
• 2016

Chronic obstructive pulmonary disease (COPD) encompasses several clinical syndromes, most notably emphysema and chronic bronchitis. Most of the current treatments fail to attenuate severity and progression of the disease, thereby requiring better mechanistic understandings of pathogenesis to develop disease-modifying therapeutics. A number of theories on COPD pathogenesis have been promulgated wherein an increase in protease burden from chronic inflammation, exaggerated production of reactive oxygen species and the resulting oxidant injury, or superfluous cell death responses caused by enhanced cellular injury/damage were proposed as the culprit. These hypotheses are not mutually exclusive and together likely represent the multifaceted biological processes involved in COPD pathogenesis. Recent studies demonstrate that mitochondria are involved in innate immune signaling that plays important roles in cigarette smoke-induced inflammasome activation, pulmonary inflammation and tissue remodeling responses. These responses are reviewed herein and synthesized into a view of COPD pathogenesis whereby mitochondria play a central role.

• Journal of the Korean Institute of Illuminating and Electrical Installation Engineers
• /
• v.27 no.8
• /
• pp.42-50
• /
• 2013

The reactionary responses to control human standing dynamics were estimated under the assumption that postural complexity mainly occurs in the mid-sagittal plane. During the experiment, the subject was exposed to continuous horizontal perturbation. The ankle and hip joint rotations of the subject mainly contributed to maintaining standing postural control. The designed mobile platform generated anterior/posterior (AP) motion. Non-predictive random translation was used as input for the system. The mean acceleration generated by the platform was measured as $0.44m/s^2$. The measured data were analyzed in the frequency domain by the coherence function and the frequency response function to estimate its dynamic responses. The significant correlation found between the input and output of the postural control system. The frequency response function revealed prominent resonant peaks within its frequency spectrum and magnitude. Subjects behaved as a non-rigid two link inverted pendulum. The analyzed data are consistent with the outcome hypothesized for this study.

• Transactions of the Korean Society for Noise and Vibration Engineering
• /
• v.13 no.9
• /
• pp.713-719
• /
• 2003

This paper introduces attempts to obtain the ‘representative’ characteristics of the mechanical impedance of seated Korean subjects under vertical vibration. Individual responses of driving-point mechanical impedance obtained from forty one Korean subjects are illustrated. Four kinds of vibration levels and three different sitting postures are selected to collect the responses of each subject. Those individual responses are used to estimate the ‘mean’ mechanical impedance, which may be expected to be a representative model to Korean subjects. Several interesting features of the estimated mechanical impedance are suggested and compared to those of ISO/DIS 5982.

• IMMUNE NETWORK
• /
• v.21 no.1
• /
• pp.1.1-1.16
• /
• 2021

The emergence of a new severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic has become a significant health concern worldwide. Undoubtedly, a better understanding of the innate and adaptive immune responses against SARS-CoV-2 and its relationship with the coronavirus disease 2019 (COVID-19) pathogenesis will be the sole basis for developing and applying therapeutics. This review will summarize the published results that relate to innate immune responses against infections with human coronaviruses including SARS-CoV-1 and SARS-CoV-2 in both humans and animal models. The topics encompass the innate immune sensing of the virus to the dysregulation of various innate immune cells during infection and disease progression.

• Journal of the Ergonomics Society of Korea
• /
• v.5 no.2
• /
• pp.33-36
• /
• 1986

Compatiblity is a very generalized concept that has substantial applicablity to various aspects of human factors. It refers to the spatial movement, or conceptual relationships of stimuli and of responses, individually or in combination, which are consistent with human expectations. In this paper, first, several remarks which should be considered in designing the visual display and control of automobile are considered. Also, two advanced designs of visual display and control are suggested based on the compatibility principles.

• 제어로봇시스템학회:학술대회논문집
• /
• 2004.08a
• /
• pp.1776-1780
• /
• 2004

In this paper, we propose the new emotion model and the robot behavior decision model based on proposed emotion model. As like in human, emotions are hierarchicalized in four levels (momentary emotions, mood, attitude, and personality) and are determined from the robot behavior and human responses. They are combined with motivation (which is determined from the external stimuli) to determine the robot behavior.

• Progress in Medical Physics
• /
• v.5 no.2
• /
• pp.77-85
• /
• 1994

In this paper, the vibration response characteristics of individual's subjective are studied to whole-body and hand-arm induced vibration. For defining limits of vibration exposure to human, experimental data are investigated in a set of vibration criteria specified in ISO Standard 2631. Instrumentation requirements for evaluation of the responses of humans to vibration according to these criteria are discribed.