• Title/Summary/Keyword: Human research subjects

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Evaluation of Fruits and Vegetables Intake for Prevention of Chronic Disease in Korean Adults Aged 30 Years and Over: Using the Third Korea National Health and Nutrition Examination Survey (KNHANES III), 2005 (만성질병 예방 측면에서 본 30세 이상 한국 성인의 과일과 채소 섭취 평가: 2005년 국민건강영양조사 자료를 이용하여)

  • Kwon, Jung-Hyun;Shim, Jae-Eun;Park, Min-Kyung;Paik, Hee-Young
    • Journal of Nutrition and Health
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    • v.42 no.2
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    • pp.146-157
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    • 2009
  • Korean diet is high in plant foods but also high in salted vegetables. World Cancer Research Fund (WCRF) recommends consumption of fruits and vegetables excluding salted vegetables for prevention cancer. This study aimed to analyze relations between intakes of salted and non-salted vegetables and socioeconomic factors, providing a data for targeted groups in promotion of fruits and vegetables consumption. Dietary and socioeconomic status data of the 5,400 subjects over 30 years of age from the 2005 Korea National Health and Nutrition Examination Survey (KNHANESIII) were used. Dietary intake data from KNHANESIII was obtained by one day 24-hour recall method. Mean daily intakes of salted vegetables, non-salted vegetables and fruits of subjects were 151 g, 237 g, and 71 g respectively. Mean daily intake of salted vegetables was significantly higher in men than women for daily amount (173 g vs. 133 g) as well as percentage of total food intake (9.9% vs. 9.6%). Subjects living in rural area consumed more salted vegetables. Salted vegetables as percent of total food were lower in subjects with higher education levels (p < 0.001). Intakes of non-salted vegetables were significantly affected by age and gender. Intake levels of fruit were significantly higher in younger groups, in females, and subjects with higher income and education levels (p < 0.05). Average intake of fruits and non-salted vegetables was 307 g, lower than WCRF recommended level of 400 g for personal guideline. Intake of salted vegetables was positively correlated with sodium intake (Pearson's correlation coefficient, r = 0.43) but less so with potassium (r = 0.16) and other micronutrients intake (r < 0.1). On the other hand, non-salted vegetables had higher correlations with potassium (r = 0.45), carotene (r = 0.38), vitamin A (r = 0.37), iron (r = 0.34) and low for sodium (r = 0.13). Fruits intake was highly correlated with vitamin C intake (r = 0.46). Proportion of subjects satisfying WCRF personal guideline of fruits and non-salted vegetables was 25.7%. Results of this study indicate that intake of salted vegetable is considerably high among Koreans, and it is highly correlated with sodium intake and less so with other micronutrients.

Prediction of Postural Sagging Observed During Driving in Korean Male Drivers (한국인 남성 운전자의 운전 자세에서 발생하는 몸통 처짐 현상에 관한 예측 모델 연구)

  • Oh, Youngtaek;Jung, Eui S.;Park, Sungjoon;Jeong, Seong Wook
    • Journal of Korean Institute of Industrial Engineers
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    • v.34 no.1
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    • pp.57-65
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    • 2008
  • In the vehicle design, the research on driving posture has stood out as one of the important issues. Recently, the research on 3D human modeling focused on more exact implementation of real driving posture. However, prediction of driving posture through the 3D human modeling fail to reflect on the model the phenomenon called sagging, which refers to the retraction or shrinking of the torso while driving. 30 male subjects participated in the experiment where total subjects were divided into four groups according to height percentile(under 50%ile, 51%ile to 75%ile, 76%ile to 95%ile, over 95%ile). The independent variables were seat back angle(4 levels) and seat pan angle(2 levels). The dependent variable was capacity or the degree of retraction of the torso. First this study measured the sagging capacity by using a paired T-test between erect and retracted posture. Secondly it was tried to find out significant anthropometric variables that were statistically correlated by the analysis of correlation. Finally, a prediction model was derived which explains the capacity of sagging.

Effect of a 12-week weight management program on the clinical characteristics and dietary intake of the young obese and the contributing factors to the successful weight loss

  • Lee, AeJin;Jeon, Kyeong Jin;Kim, Hye-Kyeong;Han, Sung Nim
    • Nutrition Research and Practice
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    • v.8 no.5
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    • pp.571-579
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    • 2014
  • BACKGROUND/OBJECTIVES: The objectives were to investigate the effect of a 12-wk intervention with behavioral modification on clinical characteristics and dietary intakes of young and otherwise healthy obese and to identify factors for successful weight loss. The goal was to lose 0.5 kg per week by reducing 300-500 kcal/day and by increasing physical activities. SUBJECTS AND METHODS: Forty four obese subjects (BMI > 25) and 19 normal weight subjects (BMI 18.5-23) finished the 12-week intervention. Obese subjects participated in 5 group educations and 6 individual counseling sessions. Normal weight subjects attended 6 individual counseling sessions for evaluations of dietary intake and exercise pattern. Anthropometric and clinical characteristics and 3-day dietary records were evaluated at baseline and week12. RESULTS: Weight and serum triglyceride and free fatty acid concentrations in obese group decreased significantly with intervention. Intakes of energy, fat, and cholesterol decreased significantly in the obese. Active participation, realistic weight loss goal setting, and weight gain after high school graduation not during childhood were identified as key factors for successful weight loss. CONCLUSIONS: The 12-week intervention with behavioral modification resulted in reduced energy and fat intakes and led to significant weight loss and improvements of clinical characteristics in the obese. The finding that those who became obese during childhood lost less weight indicates the importance of 'early' intervention.

Evaluation of Chromosomal Alteration in Electrical Workers Occupationally Exposed to Low Frequency of Electro Magnetic Field (EMFs) in Coimbatore Population, India

  • Balamuralikrishnan, Balasubramanian;Balachandar, Vellingiri;Kumar, Shanmugam Suresh;Stalin, Nattan;Varsha, Prakash;Devi, Subramaniam Mohana;Arun, Meyyazhagan;Manikantan, Pappuswamy;Venkatesan, Chinnakulandhai;Sasikala, Keshavarao;Dharwadkar, Shahnaz N.
    • Asian Pacific Journal of Cancer Prevention
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    • v.13 no.6
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    • pp.2961-2966
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    • 2012
  • Extremely low frequency electro magnetic fields (EMFs) have been classified as possibly carcinogenic to humans by the International Agency for Research on Cancer. An increased number of chromosomal alterations in peripheral lymphocytes are correlated with elevated incidence of cancer. The aim of the present study was to assess occupationally induced chromosomal damage in EMF workers exposed to low levels of radiation. We used conventional metaphase chromosome aberration (CA) analysis and the micronucleus (MN) assay as biological indicators of non ionizing radiation exposure. In the present study totally 70 subjects were selected including 50 exposed and 20 controls. Informed written consent was obtained from all participants and the study was performed in accordance with the Declaration of Helsinki and the approval of the local ethical committee. A higher degree of CA and MN was observed in exposed subjects compared to controls, the frequency of CA being significantly enhanced with long years of exposure (P<0.05). Moreover increase in CA and MN with age was noted in both exposed subjects and controls, but was significantly greater in the former. The results of this study demonstrated that a significant induction of cytogenetic damage in peripheral lymphocytes of workers occupationally exposed to EMFs in electric transformer and distribution stations. In conclusion, our findings suggest that EMFs possess genotoxic capability, as measured by CA and MN assays; CA analysis appeared more sensitive than other cytogenetic end-points. It can be concluded that chronic occupational exposure to EMFs may lead to an increased risk of genetic damage among electrical workers.

Analysis of Research Papers Published in the Korean Parent-Child Health Journal (1998-2009) (부모.자녀건강학회지 논문분석 (창간호-2009))

  • Park, Hye-Sook;Oh, Jin-A
    • Korean Parent-Child Health Journal
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    • v.14 no.1
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    • pp.1-8
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    • 2011
  • Purpose: This study was aimed to classify the major subjects and theme and to analyze the data collection and analysis method in research papers published in the Korean Parent-Child Health Journal of the Academic Society of Parent-Child Health since 1998. Methods: A total 152 studies published from the first edition to volume 12, number 2 were reviewed using structured analysis criteria developed by researchers; research type, research design, research subjects, research theme, data collection and analysis method. Research theme was founded 4 nursing domains. Data collection and analysis method of papers were limited to quantitative and qualitative researches. Results: One hundred papers conducted quantitative research; 79.0% used survey design. Most of the data collection and analysis method in quantitative research were self-reported questionnaire (69.4%) and parametric statistics respectively. The research subjects of sixty three papers were parent with well or child. The common domain studies was human related concepts such as raring. Conclusion: The findings of this study suggest that published studies have been improved and diversified, however, detailed and clear evaluation tool that assess study process and method should be developed as a way to further improve the quality of published papers in the Korean Parent-Child Health Journal.

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A Survey on the Current Status of Human Research Protection Program Settlement and Subject Protection Activities in Korea (국내 임상시험 및 대상자 보호프로그램 도입 현황과 안전관 리체계에 대한 설문조사 연구)

  • Park, Sinyoung;Cho, Su Jin;Seo, Kyung Jeong;Kim, Jin Seok
    • The Journal of KAIRB
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    • v.3 no.2
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    • pp.28-36
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    • 2021
  • Purpose: The purpose of this study is to assess the status of the Human research Protection Program (HRPP) within a hospital or a research institute in Korea. Methods: Survey was conducted during June 12th-21th 2019. Survey was distributed to the members of Korean Association of IRB (KAIRB) through each IRB office. Descriptive statistics were performed using SPSS ver. 26. Results: A total of 86 people responded, and 75 (87.0%) answered that they have perceived the HRPP. Seventy out of 86 respondents (81.4%) were conducting internal audit, several institutions were operated simultaneously the other form of audits such as IRB audit, system audit. Regarding the management of Suspected Unexpected Serious Adverse Reaction (SUSAR), 62.8% answered that they have regulation that can decide to suspend the study when there is a risk to subject safety. Among the respondents, 66.3% performed 'Help desk.' Conclusion: In this study, we assessed the current status of HRPP operation at each research institution based on Ministry of Food and Drug Safety (MFDS) HRPP guidelines. The HRPP accredited institution operated the subject protection activities according to this program, and even if the HRPP was not officially operated, the related activities were conducted focusing on the cases that could have a significant impact on the safety of research subjects. In order to ensure the quality of domestic clinical trials and to stably establish the HRPP, efforts at the individual institution level will be required.

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An Analysis of Major Maritime Casualty from Bridge Resource Manage

  • Kim, Thi Thu Lan;Jeong, Jae-Yong;Jeong, Jung-Sik
    • Proceedings of the Korean Institute of Navigation and Port Research Conference
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    • 2011.11a
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    • pp.13-15
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    • 2011
  • This report represents analysis of the maritime casualty in terms of Bridge Resource Management. We evaluate the attitudes and knowledge of bridge officer regarding human factors issues that have been identified as causal to mishaps in high-risk situations. So to reduce human errors our goal is to establish effective officer resource management (ORM) program which is based on all subjects for cadets in IMO model course. In harmonization with STCW(The International Convention on Standards of training, Certification and Watch-keeping for Seafarers), as the result, the curriculumss in the maritime education institutions is surveyed to improve our education system and then reduce the human errors by mariners at sea.

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A comparison of two differential methods for nutrition education in elementary school: lecture- and experience-based learning program

  • Jung, Lan-Hee;Choi, Jeong-Hwa;Bang, Hyun-Mi;Shin, Jun-Ho;Heo, Young-Ran
    • Nutrition Research and Practice
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    • v.9 no.1
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    • pp.87-91
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    • 2015
  • BACKGROUND/OBJECTIVES: This research was conducted to compare lecture- and experience-based methods of nutritional education as well as provide fundamental data for developing an effective nutritional education program in elementary schools. SUBJECTS/METHODS: A total of 110 students in three elementary schools in Jeollanam-do were recruited and randomly distributed in lecture- and experience-based groups. The effects of education on students' dietary knowledge, dietary behaviors, and dietary habits were analyzed using a pre/post-test. RESULTS: Lecture- and experience-based methods did not significantly alter total scores for dietary knowledge in any group, although lecture-based method led to improvement for some detailed questions. In the experience-based group, subjects showed significant alteration of dietary behaviors, whereas lecture-based method showed alteration of dietary habits. CONCLUSIONS: These outcomes suggest that lecture- and experience-based methods led to differential improvement of students' dietary habits, behaviors, and knowledge. To obtain better nutritional education results, both lectures and experiential activities need to be considered.

Circulating microRNA expression profiling in young obese Korean women

  • Choi, Won Hee;Ahn, Jiyun;Um, Min Young;Jung, Chang Hwa;Jung, Sung Eun;Ha, Tae Youl
    • Nutrition Research and Practice
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    • v.14 no.4
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    • pp.412-422
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    • 2020
  • BACKGROUND/OBJECTIVES: This study investigates correlations between circulating microRNAs (miRNAs) and obesity-related parameters among young women (aged 20-30 years old) in Korea. SUBJECTS/METHODS: We analyzed TaqMan low density arrays (TLDAs) of circulating miRNAs in 9 lean (body mass index [BMI] < 25 kg/㎡) and 15 obese (BMI > 25 kg/㎡) women. We also performed gene ontology (GO) analyses of the biological functions of predicted miRNA target genes, and clustered the results using the database for annotation, visualization and integrated discovery. RESULTS: The TLDA cards contain 754 human miRNAs; of these, the levels of 8 circulating miRNAs significantly declined (> 2-fold) in obese subjects compared with those in lean subjects, including miR-1227, miR-144-5p, miR-192, miR-320, miR-320b, miR-484, miR-324-3p, and miR-378. Among them, miR-484 and miR-378 displayed the most significant inverse correlations with BMI (miR-484, r = -0.5484, P = 0.0056; miR-378, r = -0.5538, P = 0.0050) and visceral fat content (miR-484, r = -0.6141, P = 0.0014; miR-378, r = -0.6090, P = 0.0017). GO analysis indicated that genes targeted by miR-484 and miR-378 had major roles in carbohydrate and lipid metabolism. CONCLUSION: Our result showed the differentially expressed circulating miRNAs in obese subjects compared to lean subjects. Although the mechanistic study to reveal the causal role of miRNAs remains, these miRNAs may be novel biomarkers for obesity.

A Research on Actual Status of Dietary Compliance of the Subjects with type 2 Diabetes mellitus in Daejeon (대전지역 제 2형 당뇨병 환자의 식사요법 실천 실태 조사 연구)

  • Wang, Soo-Gyoung;Park, Sun-Hee
    • Korean Journal of Human Ecology
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    • v.18 no.1
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    • pp.211-221
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    • 2009
  • The study investigated medical treatment features of patients with type 2 diabetes mellitus, their further complications, levels of diet therapy education and the status of dietary compliance. The subjects were patients who came to oriental medicine clinics in Daejon. The percentage of male was 37.5% and female was 62.7% in the subject group's sex distribution. The outbreak of the disease was most common in the age of 50's. Also 40% of the subjects had been suffering for more than 5 years. 35.7% of men and 53.7% of women had family history. All the subjects had further complications, among them hypertension was the most common. Kidney, hepatic, vascular heart diseases were followed. 85.3% of the subjects answered they already had educations about diet therapy. Those educations were given in the public health center, general and private hospitals. 32% of subjects were not practicing diet therapy. The difficulties with which patients can be faced when they take dietary education were exchange(?exchanging?) food and calculating calories. Most of the subjects tend to overlook the importance of dietary habits and show low understanding to diet therapy, which leads to low participation rate of diabetes patients. Based on these results, therefore, we can conclude that diet therapy education to the patients should be more organized and easily practicable for them. To develop educational methods which can draw patients' attention and also be more effective is the most important task.