• Biomedical Science Letters
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• v.24 no.1
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• pp.23-29
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• 2018

Abdominal obesity is considered as one of the most risky factors governing the development of metabolic diseases. Here we identify that human chitinase 3-like 1 (CHI3L1, also called YKL-40 in human) single nucleotide polymorphism (SNP), rs883125, is associated with abdominal obesity in Korean women. Korean women subjects with the rs883125 G/G or C/G genotype present higher waist-hip ratio than subjects with C/C genotype suggesting that human subjects who G nucleotide substitution at the rs883125 tended to more accumulate intra-abdominal fat at the abdominal cavity. In addition, Chi3l1 gene expression is increased in adipose tissue from obese mice and pro-inflammatory cytokine enhances Chi3l1 expression in adipocytes, indicating that Chi3l1 is greatly related with obesity and obesity-induced pro-inflammatory responses. Taken together, the minor allele of rs883125 is associated with a higher prevalence of abdominal obesity in Korean women. These findings suggest that genotype of rs883125 can be a biomarker of incident abdominal obesity and abdominal obesity-related metabolic diseases.

• The Research Journal of the Costume Culture
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• v.2 no.1
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• pp.29-38
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• 1994

This research has been to perform with various methods of measurement of human body. As experiment methods, performed the body measurement method with Martin's measurer, took pictures for he observation of body gesture and body shape, and applied the cross-section measurement method of each body part for the making of body pivot. In the making of body pivot. used several sheets of styroform, and attached some gypsum power on the surface of the body pivot for he body silhouette of body. Eventhough, there were not enough subjects for this study, these methods will be continuously conducted with enough subjects, there will be to develop the body measurement method for Korean women, and will find to solve a suitable manufacturing body and the study of body for Korean women.

• Korean Journal of Human Ecology
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• v.20 no.5
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• pp.885-896
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• 2011

This research is intended to examine adult children's experiences with parental bereavement and the effect of the experiences on family relationships and their lives. In order to describe the subjects' experiences as they are and understand their meaning and essence, data was analyzed using the Colaizzi method, an approach to phenomenology as a qualitative research methods. The findings showed that subjects suffered from the loss of parents; however, they recovered from their conditions after an ancestor worshiping service. In addition, they took heavy responsibility for a survived parent after bereavement and experienced changes in the roles of family members. In conclusion, experience with parental bereavement caused adult children to reflect on themselves, to discuss the essence of life, and to change the attitudes of their life from a future-oriented perspective to a here-and-now perspective.

• Molecular & Cellular Toxicology
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• v.4 no.1
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• pp.5-10
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• 2008

The effect of obesity on the drug-metabolizing enzymes remains an important issue for clinician since obesity is a world wide epidemic problem. However, little is known about the effects of obesity on flavincontaining monooxygenase (FMO) production and activity. We show here for the first time that in vivo FMO activity determined by urinary ranitidine (RA) metabolites ratio in human, was higher in subjects with a high body mass index (BMI, kg/$m^2$, 21.97-30.32) than in those with an intermediate BMI (range 19.38-21.83). Moreover, there was a significant correlation between FMO activity and BMI in 209 subjects. In high fat diet-induced obese mice, we also observed that the hepatic expression of FMO (225% of lean mice) and the activity measured by the RA Noxidation rate ($513{\pm}58.1$ vs. $349{\pm}66.0$ pmol/hr per mg protein) were significantly higher than in lean mice fed a control diet. Unknown factors rather than leptin or insulin appeared to regulate the hepatic FMO production. Thus, FMO activity may be increased in obese or overweight individuals. Moreover, the regulation of FMO activity in subjects with morbid obesity, with or without complications and its clinical implications, should be investigated further.

• ETRI Journal
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• v.44 no.3
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• pp.426-437
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• 2022

To understand the multilateral characteristics of human behavior and physiological markers related to physical, emotional, and environmental states, extensive lifelog data collection in a real-world environment is essential. Here, we propose a data collection method using multimodal mobile sensing and present a long-term dataset from 22 subjects and 616 days of experimental sessions. The dataset contains over 10 000 hours of data, including physiological, data such as photoplethysmography, electrodermal activity, and skin temperature in addition to the multivariate behavioral data. Furthermore, it consists of 10 372 user labels with emotional states and 590 days of sleep quality data. To demonstrate feasibility, human activity recognition was applied on the sensor data using a convolutional neural network-based deep learning model with 92.78% recognition accuracy. From the activity recognition result, we extracted the daily behavior pattern and discovered five representative models by applying spectral clustering. This demonstrates that the dataset contributed toward understanding human behavior using multimodal data accumulated throughout daily lives under natural conditions.

• Journal of the Korean Society of Safety
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• v.23 no.3
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• pp.65-70
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• 2008

Electroencephalogram(EEG) would be the most objective psychophysiological research technique on human errors though few research has been taken yet. This study aimed to get characteristics of human error while committing simple Odd-Ball tasks by utilizing the power spectrum technique of EEG data. Each experiment was composed of 3 tasks with different rules, and three young undergraduate students participated in this study as paid subjects. The result showed that subject and the interaction of subject and task factors were statistically significant on variation of power of $\alpha$ and $\beta$ bands which implied there would exist groups with homogeneity in their response. And though the variation of band powers due to task factors were not so great as to get statistical significance, it implied that the task requiring decoding process would be more strange to human beings than the task merely requiring psychological recall process.

• Fashion & Textile Research Journal
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• v.16 no.1
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• pp.167-174
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• 2014

The physical properties of textile materials and thermal physiological responses of the human subjects were evaluated with 4 different types of the army combat uniforms including US, German, Korean and general uniforms for this study. 8 male adults were used as the human subjects and the tests were done in the environmental chamber that was $25{\pm}0.1^{\circ}C$ of temperature, $65{\pm}5%$ of relative humidity and below 0.3 m/sec of air velocity. The test protocol consisted the rest period for 20 min., the exercise period for 20 min., the rest period for 20 min., the exercise period under wind condition for 20 min., and the recovery period for 20 min. The human subjects walked with 4.5 km/hr for 10 min., ran 7.5 km/hr for 10 min. during the first exercise period and walked and ran with the same speeds under 3.5 m/sec of the air velocity that simulated outdoor condition during the second exercise period. The test results of the study were as follows; The wind condition affected the skin and microclimate temperature of the human subjects lower compared to without wind condition, but had insignificant effect on the humidity control. The low air permeability of Korean uniform caused blocking the elimination of the humidity from the body and the regulation of body temperature. However, Korean uniforms could be the excellent one with the designs considering the ventilation of the uniforms and the textile fabrics with better air permeability.

• Journal of Acupuncture Research
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• v.30 no.4
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• pp.1-14
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• 2013

Objectives : The purpose of this study is to investigate the effects of Sa-Am spleen-tonifying acupuncture on radial pulse in healthy human subjects. Methods : Forty healthy human subjects participated in this study, divided into acupuncture group and control group. Radial pulse was measured by 3 dimensional pulse imaging system(DMP-3000) before, right after, 30 minutes after and 60 minutes after acupuncture in the acupuncture group. The subjects in the control group didn't received acupuncture but took a rest and then the radial pulse was measured at the same time points as the acupuncture group. The parameters were analyzed by gender, measuring location, and measuring time point. However the time related parameters exceptionally were analyzed without distinction of measuring location. Results : 1. T, variance of period, T2/T, T4/T, (T-T4)/T, T4/(T-T4), and W significantly changed after acupuncture. 2. Pressure, amplitude of H1, amplitude of H2, Amplitude of H4 and pulse energy significantly changed after acupuncture. 3. Pulse area, systolic pulse area and diastolic pulse area significantly changed after acupuncture. 4. Elasticity, AIx and AIx/HR significantly changed after acupuncture. Conclusions : The effect of Sa-Am spleen-tonifying acupuncture in healthy human may be observed on time, amplitude, pulse area and augmentation index. Further studies on the effects of Sa-Am acupuncture using radial pulse are needed.

• Safety and Health at Work
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• v.2 no.4
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• pp.355-364
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• 2011

Objectives: Though sulfur dioxide (SO2) is used widely at workplaces, itseffects on humans are not known. Thresholds are reportedwithout reference to gender or age and occupational exposure limits are basedon effects on lung functioning, although localized effects in the upper airways can be expected. This study's aim is to determine thresholds with respect to age and gender and suggests a new approach to risk assessment using breathing reflexes presumably triggered by trigeminal receptors in the upper airways. Methods: Odor thresholds were determined by the ascending method of limits in groups stratified by age and gender. Subjects rated intensities of different olfactory and trigeminal perceptions at different concentrations of $SO_2$. During the presentation of the concentrations, breathing movements were measured by respiratory inductive plethysmography. Results: Neither age nor gender effects were observed for odor threshold. Only ratings of nasal irritation were influenced bygender. A benchmark dose analysis on relative respiratory depth revealed a 10%-deviation from baseline at about 25.27 mg/$m^3$. Conclusion: The proposed new approach to risk assessment appearsto be sustainable. We discuss whether a 10%-deviation of breathingdepth is relevant.

• ETRI Journal
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• v.28 no.1
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• pp.111-114
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• 2006

An alternative human interface enabling people with severe motor disabilities to control an assistive system is presented. Since this interface relies on the biosignals originating from the contraction of muscles on the face during particular movements, even individuals with a paralyzed limb can use it with ease. For real-world application, a dedicated hardware module employing a general-purpose digital signal processor was implemented and its validity tested on an electrically powered wheelchair. Furthermore, an additional attempt to reduce error rates to a minimum for stable operation was also made based on the entropy information inherent in the signals during the classification phase. In the experiments, most of the five participating subjects could control the target system at their own will, and thus it is found that the proposed interface can be considered a potential alternative for the interaction of the severely disabled with electronic systems.