• Title/Summary/Keyword: Human health risk

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Roles of Malaysian Online Newspapers in the Construction of Public Opinion on Rare Earth Risks

  • Hasan, Nik Norma Nik;Dauda, Sharafa
    • Asian Journal for Public Opinion Research
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    • v.8 no.4
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    • pp.432-452
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    • 2020
  • This study explored the representation of risks from the controversial Lynas rare earth refining as a risk event by five Malaysian online mainstream and alternative newspapers using qualitative content analysis. The aim is to uncover the role of the news media in the social amplification and attenuation of risks within the literature evidence as those roles are still uncertain. Content analysis is used to explore the online newspapers' roles guided by the Social Amplification of Risk Framework (SARF). The representations typified environmental, financial, health, occupational, property, radioactive, and technological risks and established connections between four risk types (environmental, financial, radioactive, and health risks). Radioactive risk was repeatedly associated with other risks, suggesting that the volume and information flow focused on radioactive risk as a key ingredient for amplification. This connection shows that the nature of the relationship between risks is multidimensional, contradicting the unidirectional type found in previous studies. Alternative online newspapers amplified and attenuated more risks, thus, providing more diverse coverage than mainstream sources. Consequently, this study provides evidence that risk representation from rare earth refining in a digital news environment is multidimensional and intensified or weakened in a multi-layered pattern. The stakeholders are engaged in a contestation by positioning their narratives to oppose or support their interests, which are amplified or attenuated by the online newspapers as social amplification stations.

Risk Assessment of Dioxin in Japan

  • Kurokawa, Yuji
    • Toxicological Research
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    • v.17
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    • pp.25-35
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    • 2001
  • In 1990, Tolerable Daily Intake (TDI) of 10 pg TCDD/kg/day for dioxins based on carcinogenicity and reproductive toxicity was determined by WHO/EURO, that resulted in the establishment of TDIs in other countries. In Japan, Ministry of Health and Welfare and Environment Agency, respectively established the TDI of 10 pg TCDD/kg/day and Health Risk Assessment Index of 5 pg TCDD/kg/day in 1996. Accumulation of new scientific data, especially by molecular toxicology since 1990, resulted in the reevaluation of TDI by WHO-ECEH and IPCS in May, 1998. At this meeting, it was stressed that \circled1 toxic effects of dioxin is mediated through Ah-receptor in both animals and humans, \circled2 use of ebody burdeni concept is better than the use of traditional NOAEL/UF approach, \circled3 inclusion of coplanar PCBs in the TDI by the use of new WHO-TEF. LOAELs (0.16~200 ng TCDD/kg/day) obtained from reproductive toxicity and immunotoxicity in rats, and neurobehavioral toxicity and induction of endometriosis in rhesus monkeys are calculated to be the body burden of 10~50 ng TCDD/kg that is 14~37 pg TEQ/kg/day as human daily intake. Finally TDI of 1~4 pg TEQ/kg/day was established by applying the UF of 10. In Japan, reproductive toxicity and immunotoxicity in rats were used to obtain LOAELs (100~200 ng TCDD/kg/day). Finally TDI of 4 pg TEQ/kg/day was established in June 1999 by applying the UF of 10 to human daily intake of 43.6 pg TEQ/kg/day which corresponds to the body burden of 86 ng TCDD/kg.

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Avoidable Burden of Risk Factors for Serious Road Traffic Crashes in Iran: A Modeling Study

  • Shadmani, Fatemeh Khosravi;Mansori, Kamyar;Karami, Manoochehr;Zayeri, Farid;Shadman, Reza Khosravi;Hanis, Shiva Mansouri;Soori, Hamid
    • Journal of Preventive Medicine and Public Health
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    • v.50 no.2
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    • pp.83-90
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    • 2017
  • Objectives: The aim of this study was to model the avoidable burden of the risk factors of road traffic crashes in Iran and to prioritize interventions to reduce that burden. Methods: The prevalence and the effect size of the risk factors were obtained from data documented by the traffic police of Iran in 2013. The effect size was estimated using an ordinal regression model. The potential impact fraction index was applied to calculate the avoidable burden in order to prioritize interventions. This index was calculated for theoretical, plausible, and feasible minimum risk level scenarios. The joint effects of the risk factors were then estimated for all the scenarios. Results: The highest avoidable burdens in the theoretical, plausible, and feasible minimum risk level scenarios for the non-use of child restraints on urban roads were 52.25, 28.63, and 46.67, respectively. In contrast, the value of this index for speeding was 76.24, 37.00, and 62.23, respectively, for rural roads. Conclusions: On the basis of the different scenarios considered in this research, we suggest focusing on future interventions to decrease the prevalence of speeding, the non-use of child restraints, the use of cell phones while driving, and helmet disuse, and the laws related to these items should be considered seriously.

CHEMOPREVENTIVE EFFECT OF GINKGO BILOBA EXTRACT: ESTROGENIC AND ANTIESTROGENIC POTENTIALS IN HUMAN BREAST CANCER CELL LINES

  • Oh, Seung-Min;Chung, Kyu-Hyuck
    • Proceedings of the Korean Society of Toxicology Conference
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    • 2001.10a
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    • pp.162-162
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    • 2001
  • Phytoestrogens produced naturally by either plants or their seeds are three main classes of phytoestrogens: isoflavone, lignan and coumestan. Phytoestrogens can have both agonist and antagonist action of estrogenic activity. It is believed that phytoestrogens with agonist and antagonist action of estrogenic activity may reduce the risk of breast cancer, in addition to may reduce the risk of osteoporesis by therapeutic agent of breast cancer.(omitted)

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Risk Assessment on Carcinogenic Pesticides of Vegetables in Korea (채소류 중 발암성 농약의 위해성 평가)

  • Yoon, Jae-Hong;Chung, Yong;Shin, Dong-Chun;Lee, Jong-Tae
    • Journal of Preventive Medicine and Public Health
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    • v.32 no.2
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    • pp.155-161
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    • 1999
  • Objectio ostinato the carcinogenic risks from the ingestion of some carcinogenic pesticides (CPs) in vegetables sampled at a local agricultural product market in Seoul. Methods: After applying a hazard identification step, we selected four pesticides, such as DDT, dieldrin, folpet, and heptachlor epoxide, for this risk assessment. Concentrations of each pesticide were measured from randomly sampled vegetables. In order to estimate the human exposure levels, we combined the concentration of pesticides in the vegetables with consumption rate of those vegetables. Three scenarios were hypothesized for human exposure assessment. Scenario I was the most conservative which supposed the undetected CPs would be the detection limit values. Scenario II was assumed that the undetected CPs would be a half of the detection limit values, and finally scenario III merely considered only values greater than the detection limit values. We finally presented the estimated carcinogenic risks on the basis of the traditional risk assessment procedure suggested by U.S. EPA. Results: Pesticides including DDT, dieldrin, folpet and heptachlor epoxide were detected in 9 samples (6%) in the range of $0.0006\sim0.09ppm$. The daily intake levels of carcinogenic pesticides were estimated in the range of $0.0009\sim0.0079{\mu}g/day$. As we expected, excess cancer risks based on scenario I was also the highest $(1.1\times10^{-8}\sim5.5\times10^{-5})$. Conclusions: We found that the estimated risks from the pesticides we investigated were not serious. We, however, propose that a continuos monitoring is needed to make sure for the protection of public health.

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Permeation Characteristics of Hazardous Substances in Tattoo Dye using Franz Diffusion Cells (Franz Diffusion Cell을 이용한 문신용 염료 내 유해물질의 피부 투과특성 연구)

  • Park, Kyo-Hyun;Jung, Se-Hoon;Shin, Ho-Sang;Kim, Bae-Hwan
    • Journal of Environmental Health Sciences
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    • v.42 no.1
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    • pp.61-70
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    • 2016
  • Objectives: The purpose of this study is to determine the exposure risk to tattoo components by analyzing skin absorption using the in vitro method. Tattoos are commonly used for cosmetic purposes, and the skin of not only the operator but of the people who are undergoing the cosmetic procedure is continuously exposed to hazardous chemicals. Methods: Skin permeation risk determination was conducted by the in vitro Franz diffusion cell method according to the ingredient types of tattoo dyes, such as volatile organic compounds (VOCs), non-volatile organic compounds and heavy metals, using hairless mouse full skin and human cadaver epidermis. Results: The major components with good skin penetration for each type of tattoo dye ingredient were clarified. Among the tatto dye ingredients, 1,2-Dichlorobenzene, Zn, Al, Pb and Ti showed good skin penetration. Most of the skin transmission rates were higher in hairless mouse full skin than in human cadaver epidermis. Conclusion: A possible exposure risk to hazardous substances in tattoo dyes was confirmed from this study. These results are expected to provide a positive contribution to the establishment of management regulations for tattoo dyes.

Emerging Zoonoses: the "One Health Approach"

  • Rabozzi, Giulia;Bonizzi, Luigi;Crespi, Eleonora;Somaruga, Chiara;Sokooti, Maryam;Tabibi, Ramin;Vellere, Francesca;Brambilla, Gabri;Colosio, Claudio
    • Safety and Health at Work
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    • v.3 no.1
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    • pp.77-83
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    • 2012
  • Zoonoses represent a public health risk recently pointed out by the spreading of previously unknown human infectious diseases emerging from animal reservoirs such as severe acute respiratory syndrome and avian influenza caused by H5N1-virus. These outbreaks have shown that animal breeding activities can pose a significant public health risk. Until now, the risk of zoonoses has probably been underestimated, particularly in occupational settings. The emergence or re-emergence of bacterial (Mycobacterium bovis and Brucella spp) or viral (hepatitis E virus) infections shows that zoonoses should be considered as emerging risks in agricultural and animal breeding and should be addressed by specific preventive interventions. Close cooperation and interaction between veterinarians, occupational health physicians and public health operators is necessary, for a worldwide strategy to expand interdisciplinary collaborations and communications in all aspects of health care for humans, animals and the environment. This is what the One Health Approach was intended to be.

Pregnant and Childbearing-age Women's Knowledge and Awareness of Human Mercury Exposure Risks in Korea (우리나라 임신부와 가임기 여성의 인체 수은 노출 위험 인식과 지식)

  • Kim, Yu-Mi;Seo, Jeong-Wook;Choi, Sung-Yong;Woo, Kuck-Hyeun;Oh, Inbo;Kim, Yangho;Kim, Byoung-Gwon;Hong, Young-Seoub
    • Journal of Environmental Health Sciences
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    • v.43 no.6
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    • pp.447-456
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    • 2017
  • Objectives: Pregnant women and those of childbearing age are a well-known sensitive population for human mercury exposure. Therefore, this study was conducted to reveal and enrich basic information for effective risk communication to reduce the adverse health effects of mercury exposure. Methods: A self-administered questionnaire survey was conducted among 432 women aged 19-44 years, recruited conveniently from three different regions (Busan, Ulsan, and Gumi City). Questionnaires were developed by referring to the existing literature and through expert meetings. They consisted of questions on knowledge and awareness of mercury exposure risks, health information literacy, and relevant information. Results: The rank of perceived mercury health risk score was 5 out of 16 environmental risk factors, and 41.7% of participants thought that even a very little mercury could lead to an adverse health effect. Although 90.3% of participants had knowledge that childbearing age women must pay attention to fish intake, only 38.9% of participants knew the national fish intake guidelines for pregnant women. Conclusions: Although risk perception and knowledge of pregnancy-specific features of mercury were relatively high, the national fish intake guidelines were still not well recognized. It could be an effective strategy to provide evidence-based and targeted information articulated by professionals using internet based communication channels.

Association between Relative Preference for Vegetables and Meat and Cancer Incidence in Korean Adults: A Nationwide Population-based Retrospective Cohort Study (채소 및 육류 섭취의 상대적인 선호도와 암 발생의 연관성: 국민건강보험공단 국민건강정보자료 활용)

  • Yie, Ga-Eun;Kim, An Na;Cho, Hyun Jeong;Kang, Minji;Moon, Sungji;Kim, Inah;Ko, Kwang-Pil;Lee, Jung Eun;Park, Sue K.
    • Korean Journal of Community Nutrition
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    • v.26 no.3
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    • pp.211-227
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    • 2021
  • Objectives: We aimed to examine the association between the relative preference for vegetables and meat and cancer incidence, in a population-based retrospective cohort in Korea. Methods: We included 10,148,131 participants (5,794,124 men; 4,354,007 women) who underwent national health screening between 2004 and 2005 from the National Health Information Database of the National Health Insurance Service (NHIS-NHID). Participants were asked whether they preferred consuming 1) vegetables more often, 2) both vegetables and meat or 3) meat more often. Participants were followed up to Dec. 31, 2017. All cancer and eighteen common cancer cases were identified through the code from the International Classification of Diseases, 10th revision. We estimated sex-specific relative risks and 95% confidence intervals, adjusting for age, body mass index, alcohol consumption, smoking, physical activity, and income level. Results: During an average follow-up of 12.4 years, 714,170 cancer cases were documented. In men, consuming meat more often was associated with lower risk of esophageal, liver, and stomach cancers, but higher risk of lung and kidney cancers. Consuming both vegetables and meat was associated with higher risk of prostate cancer, but with lower risk of esophageal, liver, and stomach cancers in men. In women, consuming meat more often was associated with a higher risk of colorectal cancer and breast, endometrial, and cervical cancers diagnosed before the age of 50. Consuming both vegetables and meat was associated with lower risk of liver cancer in women. Conclusions: Our study suggests a potential link between vegetable and meat intake and cancer incidence in the Korean population. Further investigation on the association between the intake of specific types of vegetables and meat and cancer risk in Korean prospective cohort studies is needed.

Meningococcal Disease and Quadrivalent MenACWY-CRM Vaccine (Menveo®)

  • Tsai, Theodore F.
    • Pediatric Infection and Vaccine
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    • v.19 no.3
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    • pp.89-110
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    • 2012
  • Meningococcal Disease, manifesting as meningitis and septicemia, is a life-threatening bacterial infection that results in significant morbidity and mortality, particularly in childhood. Its epidemic potential and limited opportunities for clinical intervention due to its rapid course present unique public health and clinical challenges. Incidence is highest in infants and young children, with a secondary peak of risk in adolescents. Approximately 10% of cases are fatal and survivors can be left with serious and permanent sequelae including amputations, hearing loss and cognitive impairment. Transmission is only from human-to-human, by infected respiratory tract secretions or saliva and therefore crowding poses a tremendously elevated risk for disease development. Military recruits and university students are at high risk due to the high carriage rate in adolescents, their behavior patterns and close contact. Menveo$^{(R)}$ (Novartis Vaccines and Diagnostics), a novel quadrivalent meningococcal conjugate vaccine directed against meningococcal serogroups A, C, W-135 and Y, has been shown to be immunogenic and well tolerated in all age groups and was recently licensed for use in Korea. Recent cases and deaths among military recruits drew public attention to their elevated risk and the Korean government has recommended vaccination of all new military recruits. Many Korean students seek to attend school, university, or language institutes in countries where routine meningococcal vaccination is required - clinicians should be aware of such requirements to ensure that students are vaccinated prior to arrival in the destination country.

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