• Molecules and Cells
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• v.26 no.1
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• pp.5-11
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• 2008

Stalled DNA replication forks activate specific DNA repair mechanism called post-replication repair (PRR) pathways that simply bypass DNA damage. The bypassing of DNA damage by PRR prevents prolonged stalling of DNA replication that could result in double strand breaks (DSBs). Proliferating cell nuclear antigen (PCNA) functions to initiate and choose different bypassing pathways of PRR. In yeast, DNA replication forks stalled by DNA damage induces monoubiquitination of PCNA at K164, which is catalyzed by Rad6/Rad18 complex. PCNA monoubiquitination triggers the replacement of replicative polymerase with special translesion synthesis (TLS) polymerases that are able to replicate past DNA lesions. The PCNA interaction motif and/or the ubiquitin binding motif in most TLS polymerases seem to be important for the regulation of TLS. The TLS pathway is usually error-prone because TLS polymerases have low fidelity and no proofreading activity. PCNA can also be further polyubiquitinated by Ubc13/ Mms2/Rad5 complex, which adds an ubiquitin chain onto monoubiquitinated K164 of PCNA. PCNA polyubiquitination directs a different PRR pathway known as error-free damage avoidance, which uses the newly synthesized sister chromatid as a template to bypass DNA damage presumably through template switching mechanism. Mammalian homologues of all of the yeast PRR proteins have been identified, thus PRR is well conserved throughout evolution. Mutations of some PRR genes are associated with a higher risk for cancers in mice and human patients, strongly supporting the importance of PRR as a tumor suppressor pathway.

• Korean Journal of Human Ecology
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• v.17 no.5
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• pp.975-987
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• 2008

The purpose of this thesis is to conduct a thorough research on shoes of 2000s, understand the changes and analyze the differences and the characteristics of the shoe designs of the past and present in order to predict and indicate the future direction of the women shoe designs. The shoes of the millennium not only kept the old fashioned shapes but also showed futuristic shapes. With the increasing importance of shoes in fashion, shoes with various images were created. As far as the materials are concerned, natural materials and artificial materials were both used. The colors were vivid and the futuristic colors. On the other hand, pastel toned colors and romantic colors were used in many different designs and shapes regardlees of the seasons. Straps and hills differed from the oldies. Heavy decorations were added to strap shoes to form a whole new design and hills show geometrical platforms or the avantgarde like heights. Feminine images overwhelmed the shoe designs of the millennium. To elaborate, Pumps displayed feminine images the most for it showed a high frequency number regardless of the seasons. Shoes are presented in aesthetical perspective rather then functional or practical perspectives that are based on human nature. Cultural, social, environmental and some part religious factors had a great influence on the evolution on the shoes. Especially in the 2000s, future oriented concepts were implemented on shoe designs, resulting a wider range of expressiveness and in the end leading to a more creative shoe designing. Changes in shoe designs could be pointed out in many ways according to the shapes materials, colors, modeling of decorations or also with the diverting trends.

• Journal of the Korea Convergence Society
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• v.9 no.8
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• pp.185-198
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• 2018

This paper was written for the purpose of using as the theoretical basic data of judgment in the situation that there is a growing demand for intelligent design theory to be taught in public schools along with evolution theory. In order to verify the possibility that intelligent design theory, which has little empirical evidence unlike evolutionary theory, could be a scientific theory, what intelligence is and whether the trace of intelligence is actually found in nature was confirmed through literature. If intelligent elements, which are traces of intelligence in nature, are discovered empirically in nature, then intelligent design theory can be recognized as a scientific theory and can also be taught in public schools. The identity and traces of intelligence were found in relevant literature and the traces are found not only in various artificial products derived from human beings such as thinking, knowledge, and civilization, but also in all phenomena of nature. Based on these results, this paper provides a discussion on how the evolutionary theory and intelligent design theory should be handled in the field of school education, as well as how to resolve the conflicts between evolutionary theory and intelligent design theory.

• The Korean Journal of Quaternary Research
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• v.2 no.1
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• pp.51-85
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• 1988

The understanding of the faunal sequence and palaeoenvironment of East Asia since the Late Tertiary depends mainly on the knowledge of Chinese fauna and its environmental changes. The recent Chinese researches including geology, geomorphology, climats fluctuation and loess distribution of this area have provided that the rapid uplifting of Himalayas and Qinghai/Xizang Plateau since the Lower Pleistocene was a main selective factor for the process of environmental changes in this vast territory. Although different concepts of the Plio-Pleistocene boundary have been provided, its boundary can not exceed over 2 mya. Instead of the traditional zoogeographical dicthomy in China, faunal compositions of Pleistocene are divided into three faunal zones. The knowledge of macrofaunal evolution in China are useful to understand the palaeoecology of East Asia. Palaeoenvironment of Korea during the Pleistocene Period can be reconstructed by using the analogy of the current Chinese studies.

• Journal of the Korea Society for Simulation
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• v.21 no.4
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• pp.65-73
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• 2012

Due to the development of technology related to a weapon system and the info-communication, the battle system of a warship has to manage many kinds of human intervention tactics according to the complicated battlefield environment. Therefore, many kinds of studies about M&S(Modeling & Simulation) have been carried out recently. The previous M&S system based on an agent, however, has simply used non-flexible(or fixed) tactics. In this paper, we propose an agent modeling methodology which has reinforcement learning function for spontaneous(active) reaction and generation evolution learning Function using Genetic Algorithm for more proper reaction for warship battle. We experiment with virtual 1:1 warship combat simulation on the west sea so as to test validity of our proposed methodology. We consequently show the possibility of both reinforcement and evolution learning in a warship battle.

• Journal of the Korea Fashion and Costume Design Association
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• v.14 no.2
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• pp.1-10
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• 2012

Clothing design is one of design products for human, the end user and corresponds to artifacts. Sometimes artifacts with one mono module exist, and so does artifacts assembled and combined with multi modules of same shape and size or various shapes and sizes and thus all design products can be understood by modularity concept. The purpose of this study was to make a new suggestion for the clothing design and production of high uniqueness and creativity by reviewing and synthesizing the foundation of clothing modularity concept as the original clothing design figures from the history have shown various modularity concept evolution from mono module to multi module stages. The methods of this study were to identify clothing modularity and analyze the type, evolving direction, and category of clothing modularity, and the value of clothing modularization design through comprehensive literature reviews on topic-related books and theses. The original clothing figures with Significance from the clothing history were analyzed in evolution sequence for application direction and value of clothing modularity in flat pattern. Clothing modularity in ancient clothing figures was classified as three types of the fixed, drapery, and straight lined in evolving direction from clothing of mono module to flat patterned clothing. The direction of clothing modularity was identified as mono- dual-triple-multi into another level of multi modularity after intentional devolution. The categorization of clothing modularity was identified in terms of clothing flat construction, clothing design construction, and clothing form modeling. The value of clothing modularization design using clothing modularity was identified as economical efficiency, convenience, promptitude, adaptability, functionality, and creativity.

• Hwankyungkyoyuk
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• v.20 no.3
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• pp.1-17
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• 2007

The purpose of this study was to establish objectives for ninth grade studies of heredity and evolution in middle school in an attempt to foster students' consciousness of bioethics, and it's additionally intended to develop and apply lesson plans handling different points at issue and to determine the effects of the lesson plans on the bioethics of middle school students. The subjects in this study were 152 ninth graders in a middle school, whose science scores were similar. An experimental group and a control group were made up of 76 students respectively, and a pretest was conducted with test paper developed by this researcher to assess their awareness of bioethics. The experimental group took lessons by using the teaching plans prepared in this study, and the control group received typical education according to the curriculum. And then a posttest was implemented with test paper developed in this study to compare the two groups. In addition their science grades were compared as well. The findings of the study were as follows: First, seven learning objectives were selected from three units related to bioethics in the third-year 8th category of heredity and evolution of middle school. Second, in order to attain the selected learning objectives, four session lesson plans were prepared. Third, the experimental group that studied using by the lesson plans made better progress in bioethics awareness and the gap between the two was statistically significant(t=6.61, p<.001). The former were ahead of the latter in consciousness about species equity(t=7.71, p<.001), the dignity of life (t=3.78, p<.001), human rights(t=2.99, p<.01) and equity among generations(t=2.66, p<.01), but not in awareness of the diversity of species. Fourth, there was no significant gap in science scores between the students studied according to the curriculum and those who received instructions by using the lesson plans developed in the study.

• Journal of the Korean Society of Clothing and Textiles
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• v.35 no.2
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• pp.167-180
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• 2011

The portraits created in the age of Queen Elizabeth I show a very exquisite description about the ruff collar and cuffs representing the notable evolution of periodical costumes from a detailed viewpoint. This thesis analyzes the ruff collar and cuffs of the portraits of Queen Elizabeth I. The method used selects 32 pieces from the portraits of Queen Elizabeth I that are considered excellent depictions of a ruff collar and cuffs, to investigate size, form and decorations. Conclusively, the ruff collar tends to be extremely enlarged and thickened (coinciding with the development of glue) while the cuffs denote the aspect of double cuffs coupled with the turn-back cuffs without a change in size. These traits were widely shown from 1585 to 1587, while after 1588 the ruff cuffs completely disappeared in the portraits of Elizabeth I. At the same time, the change of a ruff collar was remarkable, the collar being in the erect position behind the head (with the use of supporters), of a consistent thickness and decoration of elaborate lace. During the transition period from the $16^{th}$ century to the $17^{th}$ century the earliest change was in cuffs followed by collars. This research is a helpful guide to detect the relatively exact date of portraits not definitively identified in the latter part of the $16^{th}$ century and to observe the microscopic evolution of costumes in the latter part of the $16^{th}$ century.

• Animal Systematics, Evolution and Diversity
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• v.24 no.1
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• pp.25-32
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• 2008

The Gold-spotted pond frog, Rana plancyi chosenica, designated as a vulnerable species by IUCN Red list. This species is a typical example facing local population threats and extinction due to human activities in South Korea. A strategic conservation plan for this endangered species is urgently needed. In order to provide information for future conservation planning, accurate information on the genetic diversity and taxonomic status is needed for the establishment of conservation units for this species. In this study, we used a molecular genetic approach using the mitochondrial cytochrome b gene and control region sequences to find the genetic diversity of gold-spotted pond frogs within South Korea. We sequenced the mitochondrial DNA cytochrome b gene and control region of 77 individuals from 11 populations in South Korea, and one from Chongqing, China. A total of 15 cytochrome b gene haplotypes and 34 control region haplotypes were identified from Korean gold-spotted pond frogs. Mean sequence diversity among Korean gold-spotted pond frogs was 0.31% (0.0-0.8%) and 0.51% (0.0-1.0%), respectively. Most Korean populations had at least one unique haplotype for each locus. The Taean, Ansan and Cheongwon populations had no haplotypes shared with other populations. There was a sequence divergence between Korean and Chinese gold-spotted pond frogs (1.3% for cyt b; 2.9% for control region). Analysis of genetic distances and phylogenetic trees based on both cytochrome b and control region sequences indicate that the Korean gold-spotted pond frog are genetically differentiated from those in China.

• Nano
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• v.13 no.11
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• pp.1850126.1-1850126.10
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• 2018

Flexible strain sensors, as the core member of the family of smart electronic devices, along with reasonable sensing range and sensitivity plus low cost, have rose a huge consumer market and also immense interests in fundamental studies and technological applications, especially in the field of biomimetic robots movement detection and human health condition monitoring. In this paper, we propose a new flexible strain sensor based on thick CVD graphene film and its low-cost fabrication strategy by using the commercial adhesive tape as flexible substrate. The tensile tests in a strain range of ~30% were implemented, and a gage factor of 30 was achieved under high strain condition. The optical microscopic observation with different strains showed the evolution of cracks in graphene film. Together with commonly used platelet overlap theory and percolation network theory for sensor resistance modeling, we established an overlap destructive resistance model to analyze the sensing mechanism of our devices, which fitted the experimental data very well. The finding of difference of fitting parameters in small and large strain ranges revealed the multiple stage feature of graphene crack evolution. The resistance fallback phenomenon due to the viscoelasticity of flexible substrate was analyzed. Our flexible strain sensor with low cost and simple fabrication process exhibits great potential for commercial applications.