• Journal of the Korean Society for Precision Engineering
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• v.21 no.12
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• pp.182-191
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• 2004

This study is focused on the development of a child human model, which is composed of skin, skeleton, joints and muscle, etc. The dimension of child outer skin is referred to anthropometric data from KRISS (Korea Research Institute of Standards and Science). The positions of joint and mass properties of body segments are calculated from ATB(Articulated Total Body) program, GEBOD. The properties of bones and muscles are obtained by the way of scaling from adult human model. To verify the developed human model, ROM simulation and sled test is conducted. Developed human model can be effectively applied to the evaluation of human injury in crash situation and development of child restraint system. The explicit finite element program $PAM-CRASH^TM$ was used to simulate six-year old child human model.

• Journal of Korea Ship Safrty Technology Authority
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• s.27
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• pp.25-36
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• 2009

Despite the development of the various navigational equipment, such as GPS, ARPA, ECDIS, AIS, VDR, and hull monitoring system, marine accidents are still a leading concern in shipping industry. For all accidents over the reporting period, approximately 60 to 80% of the accidents was involved in human error. It means that in each case, some events which were associated with human error initiated an accident, and those failures of human performance led to the failure to avoid an accident or mitigate it's consequences. However, the improvement and the effort on the maritime human error are still limited in an elementary step. The objective of this paper is to propose a modified Human Factors Analysis and Classification System (HFACS) model in order to analyse the collision accidents of tug-barge ship.

• Journal of Life Science
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• v.32 no.11
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• pp.882-889
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• 2022

Breast cancer anti-estrogen resistance 3 (BCAR3) has been identified as one of the genes that induces anti-estrogen resistance in breast cancer. We have previously reported that BCAR3 activates promoters of c-Jun, activator protein-1, and the serum response element. In this study, we investigated the functional role of BCAR3 in the activation of the estrogen response element (ERE) in normal human breast MCF-12A cells. Transient expression of BCAR3 induced ERE activation, which was further increased by 17β-estradiol treatment but was not blocked by the anti-estrogen tamoxifen. Next, we studied the signaling pathway of BCAR3 leading to ERE activation. BCAR3-mediated ERE activation was inhibited by LY294002 and AZD5363, inhibitors of the phosphatidylinositol (PI) 3-kinase pathway, but not by PD98059 and U0126, inhibitors of the mitogen-activated protein kinase pathway. ERE activation was induced by the catalytic subunit p110α. of PI3-kinase or the active mutant of Akt, and this activation was not further increased by additional BCAR3 transfection. Based on these results, we propose that BCAR3 plays an important role in ERE activation through the PI3-kinase/Akt pathway in human breast MCF-12A cells.

• Proceedings of the Korean Institute of Navigation and Port Research Conference
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• 2015.10a
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• pp.199-201
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• 2015

Nowadays, the issue of maritime safety is an extremely important issue in the maritime industry and Human' Stress is one of the biggest causes of maritime accidents. The purpose of this study was to research and compare the risk marine accidents analysis methods and find the methods which used to analysis data of the human' stress and obtained the relationship between it and the risk of maritime accidents.

• Korean Journal of Veterinary Research
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• v.35 no.1
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• pp.95-105
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• 1995

The human homolog of position specific element of mouse Hoxa-7 was studied using transgene. It contains a 1.1 kb human DNA (HCR)- a homolog to the intergenic region between Hoxa-7 and -9, which directs the position specific expression of Hoxa-7-, tk promoter, LacZ (${\beta}$-galactosidase) gene as a reporter, and polyadenylation signal of SV40 large T antigen. It was injected into the mice embryos, and the resulting transgenic embryos were analysed through PCR as well as genomic Southern blotting with placenta DNA. Out of 20 embryos analysed, two were transgenic. Among them, one transgenic embryo expressed transgene when stained with X-gal. The expression pattern was in analogy to that of the mouse Hoxa-7, showing spatially restricted expression pattern, Since the expression of ${\beta}$-galactosidase is regulated by the upstream human HCR sequence, it implies that the HCR is the plausible position specific regulatory element of human.

• Transactions on Electrical and Electronic Materials
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• v.18 no.2
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• pp.66-69
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• 2017

The internal temperature of human-tissue transfers must be steadily maintained regardless of the external environmental changes. An ice pack and dry ice are the coolants for the transfer containers for which heat-insulating materials such as EPP (expended polypeopylene and EPS (expended polystrene) are used; however, changes of the external temperature/pressure and the melting of the coolants that is due to a long carriage result in changes of the internal temperature, and this makes it difficult to maintain the temperature. Accordingly, the thermoelectric element was used to design/manufacture a transfer container to maintain the internal temperature regardless of the external environmental changes. As a result of the measurement of the changes of the internal temperatures of the manufactured thermoelectric-element container and the EPS container over time, the internal temperature of the EPS container was increased, whereas the internal temperature of the thermoelectric-element container was maintained. The temperature of the distilled water that was poured into the containers indicated a pattern identical to that of the internal temperature.

• Pediatric Gastroenterology, Hepatology & Nutrition
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• v.11 no.sup1
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• pp.117-126
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• 2008

Trace elements compose a very small portion of the body, however they have a variety of essential functions. Various diseases are caused by trace element deficiencies, and sometimes they can be fatal. Long-term TPN is a risk factor of trace element deficiency, and trace elements need to be checked regularly while receiving TPN. It is important to provide sufficient requirements of trace elements regarding the clinical features and the problems of trace element excess or deficiency. Moreover extensive studies to establish the efficiency of examining human hair and nails, recent method to determine the trace elements, are required.

• Korean Institute of Interior Design Journal
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• no.30
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• pp.78-85
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• 2002

Human exists in environment. As environment affects in human movement, human reacts to everything happens in environment especially by the view point of visual continuity and changeability. This study has two purposes. The one is to clarify the visual changeability due to the Human movement from the visual point based on checking the visual field. And the other is to understand the applicable possibility of Philip Thiel's method through the experiment in passing ways. Condition of this study is that colors and figures are affective elements of visual environmental sequence by the Human movement. The Human movement is due to the visual phenomenon. That means it is not limited in Philip Theil's method(Node, District). In particular, the chroma which is checked by the BPA(Basic-Pattern-Area) is the most affective visual environmental element in contemporary shopping mall. Also, everything in visual environment and the movement is connected by the time axis. As an analytical method, the sequence notation devised by Philip Thiel was applied.

• Journal of Fisheries and Marine Sciences Education
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• v.25 no.4
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• pp.898-914
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• 2013

The fusion type human resources, it is a new human resources to scientific and technical information society of the future demands, and means to enjoy life with a creativity and expertise of fusion of various fields, to communicate in consideration of others. Fusion human resource education(STEAM), of "human resources to practice respect and compassion", "human resources equipped with communication skills", "human resources to pursue creativity and innovation" "human resources to understand the knowledge of the fusion to take advantage" in training I have presented to the area of core competence of the 4C 'Creativity"," Communication","Convergence', 'Caring'. In this study, the area of c ore competency for each element by elementary, middle, and high schools around the analysis of the target can be made by each school level to develop a practical program in the sense of basic research is to conduct. The findings are as follows: First, Area of Creativity, communication area, the contents fusion region, as well as care areas, to the detailed item capacity, the design of the class that contains the entire area should be performed. Second, Elementary and secondary school level analysis, design of the class containing the entire region up to capacity detail is required. High school was required study of school full of normal. Third, In general, for STEAM class environment and teaching model was developed by applying operations. Research and methods of teaching a wider variety of form was required. Later in this study is to develop programs and organize. and It intends to become the base to be able to interest and interest in science education by structured around the status of problems that can be found in the life of around themes STEAM.

• Nuclear Engineering and Technology
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• v.52 no.9
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• pp.1983-1989
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• 2020

The human reliability analysis is a method by which, in general terms, the human impact to the safety and risk of a nuclear power plant operation can be modelled, quantified and analysed. It is an indispensable element of the PSA process within the nuclear industry nowadays. The paper herein presents a sensitivity study of the human reliability analysis performed on a real nuclear power plant-specific probabilistic safety assessment model. The analysis is performed on a pre-selected set of post-initiator operator actions. The purpose of the study is to investigate the impact of these operator actions on the plant risk by altering their corresponding human error probabilities in a wide spectrum. The results direct the fact that the future effort should be focused on maintaining the current human reliability level, i.e. not letting it worsen, rather than improving it.