• Sleep Medicine and Psychophysiology
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• v.11 no.1
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• pp.10-16
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• 2004

Sleep is associated with definite changes in respiratory function in normal human beings. During sleep, there is loss of voluntary control of breathing and a decrease in the usual ventilatory response to both low oxygen and high carbon dioxide levels. Especially, rapid eye movement (REM) sleep is a distinct neurophysiological state associated with significant changes in breathing pattern and ventilatory control as compared with both wakefulness and non-rapid eye movement (NREM) sleep. REM sleep is characterized by erratic, shallow breathing with irregularities both in amplitude and frequency owing to marked reduction in intercostal and upper airway muscle activity. These blunted ventilatory responses during sleep are clinically important. They permit marked hypoxemia that occurs during REM sleep in patients with lung or chest wall disease. In addition, sleep-disordered breathing (SDB) is more frequent and longer and hypoventilation is more pronounced during REM sleep. Although apneic episodes are most frequent and severe during REM sleep, most adults spend less than 20 to 25% of total sleep time in REM sleep. It is, therefore, possible for patients to have frequent apneas and hypopneas during REM sleep and still have a normal apnea-hypopnea index if the event-rich REM periods are diluted by event-poor periods of NREM sleep. In this review, we address respiratory physiology according to sleep stage, and the clinical implications of SDB and hypoventilation aggravated during REM sleep.

• Journal of Microbiology and Biotechnology
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• v.22 no.7
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• pp.1029-1033
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• 2012

A number of evidence have been accumulated that the regulation of reversible tyrosine phosphorylation, which can be regulated by the combinatorial activity of protein tyrosine kinases (PTKs) and protein tyrosine phosphatases (PTPs), plays crucial roles in various biological processes including differentiation. There are a total of 107 PTP genes in the human genome, collectively referred to as the "PTPome." In this study, we performed PTP profiling analysis of the HIB-1B cell line, a brown preadipocyte cell line, during brown adipogenesis. Through RT-PCR and real-time PCR, several PTPs showing differential expression pattern during brown adipogenesis were identified. In the case of PTP-RE, it was shown to decrease significantly until 4 days after brown adipogenic differentiation, followed by a dramatic increase at 6 days. The overexpression of PTP-RE led to decreased brown adipogenic differentiation via reducing the tyrosine phosphorylation of the insulin receptor, indicating that PTP-RE functions as a negative regulator at the early stage of brown adipogenesis.

• Proceedings of the Korea Water Resources Association Conference
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• 2012.05a
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• pp.38-38
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• 2012

The East Asia (EA) region including China, Taiwan, Japan, and Korea are especially vulnerable to hydrometerological extremes during the boreal summer (June-September). This study, therefore, pursued an exploratory analysis to improve better understanding of the potential impacts of the two types of PJ patterns on WNP Tropical cyclone (TC) activities and TC-induced extreme moisture fluxes over Korea's five major river basins. This study shows that during positive PJ years, the large-scale atmospheric environments are more favorable for the TC activities than those in negative PJ years. During positive PJ year, it is found that there are weaker wind shear, stronger rising motion, as well as large relative humidity over the Korean peninsula (KP) compared to negative PJ years. As a result, TCs making landfall are more exhibited over the southeastern portions of South Korea. Despite the relatively modest sample size, we expect that insights and results presented here will be useful for developing a critical support system for the effective reduction and mitigation of TC-caused disasters, as well as for water supply management in coupled human and natural systems.

• The Journal of the Korea Contents Association
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• v.17 no.5
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• pp.491-498
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• 2017

This study is to determine the significant effect of white and pink noise on brain. The brain synchronization has been analyzed under the condition of non-noise, white nose and pink noise(male 10, female 10, mean age $23.3{\pm}2.14$). As a result of analysis, pink noise stimulus, alpha, low beta band, and high beta band were significantly decreased than non-noise and white noise. In addition, these brain response pattern significantly increased at frontal lobe and temporal lobe, and dominated on the right hemisphere. This result is considered to be useful of sound design in driving quality of human life on the basis of neuroscience.

• Herbal Formula Science
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• v.29 no.4
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• pp.267-275
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• 2021

Objectives : Previously, we reported that compound K isolated from fermented ginseng by Aspillus oryzae has a wide biochemical and pharmacological effect, including anti-cancer activity in prostate cancer PC-3 cells. Despite these findings, its signaling pathway and gene expression pattern are not clearly understood. Methods : To confirm the gene expression study of treated with compound K in PC-3 cells, a cDNA microarray chip composed of 44K human cDNA probes was used. MTT assay, western blot analysis, propidium iodide staining, and annexin V/propidium iodide staining were analyzed. Results : We confirmed the differences of gene expression profiles. Then, we analyzed with the cell cycle arrest, cell death and cell proliferation related genes using DAVID database. Conclusions : Our finding should be useful for understanding genome-wide expression patterns of compound K-mediated cell cycle arrest toward induction of cell death and be helpful for finding future cancer therapeutic targets for prostate cancer cells.

• Molecules and Cells
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• v.42 no.1
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• pp.1-7
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• 2019

Macrophage is an important innate immune cell that not only initiates inflammatory responses, but also functions in tissue repair and anti-inflammatory responses. Regulating macrophage activity is thus critical to maintain immune homeostasis. Tyro3, Axl, and Mer are integral membrane proteins that constitute TAM family of receptor tyrosine kinases (RTKs). Growing evidence indicates that TAM family receptors play an important role in anti-inflammatory responses through modulating the function of macrophages. First, macrophages can recognize apoptotic bodies through interaction between TAM family receptors expressed on macrophages and their ligands attached to apoptotic bodies. Without TAM signaling, macrophages cannot clear up apoptotic cells, leading to broad inflammation due to over-activation of immune cells. Second, TAM signaling can prevent chronic activation of macrophages by attenuating inflammatory pathways through particular pattern recognition receptors and cytokine receptors. Third, TAM signaling can induce autophagy which is an important mechanism to inhibit NLRP3 inflammasome activation in macrophages. Fourth, TAM signaling can inhibit polarization of M1 macrophages. In this review, we will focus on mechanisms involved in how TAM family of RTKs can modulate function of macrophage associated with anti-inflammatory responses described above. We will also discuss several human diseases related to TAM signaling and potential therapeutic strategies of targeting TAM signaling.

• Journal of Fashion Business
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• v.27 no.4
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• pp.101-114
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• 2023

This study aimed to create globally acceptable Hanbok-inspired work uniforms, by developing practical designs and providing useful resources for incorporating Hanbok characteristics into office attire. First, to establish the elements that the Hanbok work uniform should have, the definition and characteristics of service clothes and preferences for the process of modernization of traditional Hanbok were reviewed through a review of the preceding studies. For the Hanbok work uniform design, a total of 4 pieces, 2 for each male and female, were planned, a schematic diagram was created, and the design was modified after evaluation by fashion design experts. I made a pattern of the modified design with a CAD program, imported it into CLO 3D to produce a virtual costume, and confirmed the final design draft. Work uniform design has symbolism, functionality, and aesthetics as its characteristics. The functionality of the Hanbok work uniform designed in this study is suitable for the season, and it was designed to increase the efficiency of work when worn for a long time. The design was focused on the development of materials and patterns in consideration of comfort and activity. The esthetic nature of hanbok-inspired work clothes was intended to reveal details that could highlight the silhouette of the human body and reflect the beauty of hanbok.

• CELLMED
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• v.14 no.2
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• pp.3.1-3.2
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• 2024

The purpose of this study is to consider the health and well-being of singing, an expression activity of language. There are also many studies in which singing activities have a positive effect on individual quality of life and social activities. Therefore, this study attempted to suggest that more effective singing is being performed by increasing empathy through various expressions of onomatopoeia and mimic words. Love Changbu Taryeong (愛倡夫打令) is Korea's traditional representative Gyeonggi folk song. It is a cheerful and lyrical folk song based on the five scale of Sol-ra-do-re-mi. It sings not only human joy, sorrow, and pleasure, but also natural phenomena and scenes. It is an exciting rhythm based mainly on the Gutgeori jangdan (rhythmic pattern, 12/8) but it is a rhythm that you can feel the sadness in it. In particular, various onomatopoeia and mimic words appear in this song, making you think about the fun of singing and the origin of the language. Therefore, this study attempted to examine that more effective singing is becoming more effective by increasing empathy through various expressions of onomatopoeia and mimic words. You can watch our singing activities on YouTube.(https://youtu.be/IhnBqWiK-3w?si=AAMi2BVes9mPShnr)

• The Journal of the Convergence on Culture Technology
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• v.4 no.2
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• pp.185-189
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• 2018

Today, the incidence of illnesses due to a lack of exercise, such as lack of exercise in the 20s and 30s, 40s menstrual period, and 50s in the fifties, is increasing every year, because of the introduction of new technologies such as smartphone development,And the pattern of life according to it changes conveniently and the amount of activity decreases, and the lack of momentum has a great influence. I would like to study new mixed reality healthcare service products by merging the existing human smartphone with mixed reality. This is not merely showing the numerical value of the momentum by attaching to the human body like the existing healthcare product,And to measure and analyze the amount of exercise to help people to manage their health.

• International Journal of Oral Biology
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• v.39 no.3
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• pp.145-151
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• 2014

During bone remodeling, there is requirement of differentiation of osteoblastic cells. Previously, we identified proteins differentially expressed in soft tissue during bone healing. Of these proteins, we focused the effect of LTF on differentiation of osteoblast. In order to analyze the osteogenic ability of LTF, we treated conditioned media collected from human LTF-stably transfected HEK293T cells into osteoblastic MC3T3-E1. The results showed that the activity and expression of alkaline phosphatase were increased in MC3T3-E1 cells treated with conditioned media containing LTF in dose- and time-dependent manner. At the same time, we observed the significant increase of the expression of osteoblastic genes, such as ALP, BSP, COL1A1, and OCN, and along with matrix mineralization genes, such as DMP1 and DMP2, in LTF conditioned media-treated groups. Moreover, the result of treating recombinant human LTF directly into osteoblastic MC3T3-E1 showed the same pattern of treating conditioned media containing LTF. Our study demonstrated that LTF constitutively enhances osteoblastic differentiation via induction of osteoblastic genes and activation of matrix mineralization in MC3T3-E1 cells.