1 |
Ben-Batalla, I., Schultze, A., Wroblewski, M., Erdmann, R., Heuser, M., Waizenegger, J.S., Riecken, K., Binder, M., Schewe, D., Sawall, S., et al. (2013). Axl, a prognostic and therapeutic target in acute myeloid leukemia mediates paracrine crosstalk of leukemia cells with bone marrow stroma. Blood 122, 2443-2452.
DOI
|
2 |
Caberoy, N.B., Alvarado, G., Bigcas, J.L., and Li, W. (2012). Galectin-3 is a new MerTK-specific eat-me signal. J. Cell Physiol. 227, 401-407.
DOI
|
3 |
Caberoy, N.B., Zhou, Y., and Li, W. (2010). Tubby and tubby-like protein 1 are new MerTK ligands for phagocytosis. EMBO J. 29, 3898-3910.
DOI
|
4 |
Camenisch, T.D., Koller, B.H., Earp, H.S., and Matsushima, G.K. (1999). A novel receptor tyrosine kinase, Mer, inhibits TNF- production and lipopolysaccharide-induced endotoxic shock. J. Immunol. 162, 3498-3503.
|
5 |
Caraux, A., Lu, Q., Fernandez, N., Riou, S., Di Santo, J.P., Raulet, D.H., and Roth, C. (2006). Natural killer cell differentiation driven by Tyro3 receptor tyrosine kinases. Nat. Immunol. 7, 747-754.
DOI
|
6 |
Carrera Silva, E.A., Chan, P.Y., Joannas, L., Errasti, A.E., Gagliani, N., Bosurgi, L., Jabbour, M., Perry, A., Smith-Chakmakova, F., Mucida, D., et al. (2013). T cell-derived protein S engages TAM receptor signaling in dendritic cells to control the magnitude of the immune response. Immunity 39, 160-170.
DOI
|
7 |
Castellano, F., Montcourrier, P., and Chavrier, P. (2000). Membrane recruitment of Rac1 triggers phagocytosis. J. Cell Sci. 113, 2955-2961.
DOI
|
8 |
Fourgeaud, L., Traves, P.G., Tufail, Y., Leal-Bailey, H., Lew, E.D., Burrola, P.G., Callaway, P., Zagorska, A., Rothlin, C.V., Nimmerjahn, A., et al. (2016). TAM receptors regulate multiple features of microglial physiology. Nature 532, 240-244.
DOI
|
9 |
Nakahira, K., Haspel, J.A., Rathinam, V.A., Lee, S.J., Dolinay, T., Lam, H.C., Englert, J.A., Rabinovitch, M., Cernadas, M., and Kim, H.P. (2011). Autophagy proteins regulate innate immune responses by inhibiting the release of mitochondrial DNA mediated by the NALP3 inflammasome. Nat. Immunol. 12, 222-230.
DOI
|
10 |
O'Bryan, J.P., Frye, R.A., Cogswell, P.C., Neubauer, A., Kitch, B., Prokop, C., Espinosa, R., Beau, M.M.L., Earp, H.S., and Liu, E.T. (1991). Axl, a transforming gene isolated from primary human myeloid leukemia cells, encodes a novel receptor tyrosine kinase. Mol. Cell Biol. 11, 5016-5031.
DOI
|
11 |
Paolino, M., Choidas, A., Wallner, S., Pranjic, B., Uribesalgo, I., Loeser, S., Jamieson, A.M., Langdon, W.Y., Ikeda, F., Fededa, J.P., et al. (2014). The E3 ligase Cbl-b and TAM receptors regulate cancer metastasis via natural killer cells. Nature 507, 508-512.
DOI
|
12 |
Prasad, D., Rothlin, C.V., Burrola, P., Burstyn-Cohen, T., Lu, Q., de Frutos, P.G., and Lemke, G. (2006). TAM receptor function in the retinal pigment epithelium. Mol. Cell Neurosci. 33, 96-108.
DOI
|
13 |
Robinson, D.R., Wu, Y.M., and Lin, S.F. (2000). The protein tyrosine kinase family of the human genome. Oncogene 19, 5548-5557.
DOI
|
14 |
Rothlin, C.V., Carrera-Silva, E.A., Bosurgi, L., and Ghosh, S. (2015). TAM receptor signaling in immune homeostasis. Annu. Rev. Immunol. 33, 355-391.
DOI
|
15 |
Rothlin, C.V., Ghosh, S., Zuniga, E.I., Oldstone, M.B., and Lemke, G. (2007). TAM receptors are pleiotropic inhibitors of the innate immune response. Cell 131, 1124-1136.
DOI
|
16 |
Sheridan, C. (2013). First Axl inhibitor enters clinical trials. Nat. Biotechnol. 31, 775-756.
DOI
|
17 |
Gruber, R.C., Ray, A.K., Johndrow, C.T., Guzik, H., Burek, D., de Frutos, P.G., and Shafit-Zagardo, B. (2014). Targeted GAS6 delivery to the CNS protects axons from damage during experimental autoimmune encephalomyelitis. J. Neurosci. 34, 16320-16335.
DOI
|
18 |
Gjerdrum, C., Tiron, C., Hoiby, T., Stefansson, I., Haugen, H., Sandal, T., Collett, K., Li, S., McCormack, E., Gjertsen, B.T., et al. (2010). Axl is an essential epithelial-to-mesenchymal transition-induced regulator of breast cancer metastasis and patient survival. Proc. Natl. Acad. Sci. USA 107, 1124-1129.
DOI
|
19 |
Graham, D.K., Dawson, T.L., Mullaney, D.L., Snodgrass, H.R., and Earp, H.S. (1994). Cloning and mRNA expression analysis of a novel human protooncogene, c-mer. Cell Growth Differ. 5, 647-657.
|
20 |
Grivennikov, S.I., Greten, F.R., and Karin, M. (2010). Immunity, inflammation, and cancer. Cell 140, 883-899.
DOI
|
21 |
Hafizi, S., and Dahlback, B. (2006). Gas6 and protein S. Vitamin Kdependent ligands for the Axl receptor tyrosine kinase subfamily. FEBS J. 273, 5231-5244.
DOI
|
22 |
Sasaki, T., Knyazev, P.G., Clout, N.J., Cheburkin, Y., Gohring, W., Ullrich, A., Timpl, R., and Hohenester, E. (2006). Structural basis for Gas6-Axl signalling. EMBO J. 25, 80-87.
DOI
|
23 |
Han, J., Bae, J., Choi, C.Y., Choi, S.P., Kang, H.S., Jo, E.K., and Lee, M.S. (2016). Autophagy induced by AXL receptor tyrosine kinase alleviates acute liver injury via inhibition of NLRP3 inflammasome activation in mice. Autophagy 12, 2326-2343.
DOI
|
24 |
Hirschi, K.M., Chapman, S., Hall, P., Ostergar, A., Winden, D.R., Reynolds, P.R., and Arroyo, J.A. (2018). Gas6 protein induces invasion and reduces inflammatory cytokines in oral squamous cell carcinoma. J. Oral. Pathol. Med. 47, 748-754.
DOI
|
25 |
Huang, M., Rigby, A.C., Morelli, X., Grant, M.A., Huang, G., Furie, B., and Furie, B.C. (2003). Structural basis of membrane binding by Gla domains of vitamin K-dependent proteins. Nat. Struct. Biol. 10, 751-756.
DOI
|
26 |
Jung, M. (2004). Expression profiling of IL-10-regulated genes in human monocytes and peripheral blood mononuclear cells from psoriatic patients during IL-10 therapy. Eur. J. Immunol. 34, 481-493.
DOI
|
27 |
Klionsky, D.J., and Emr, S.D. (2000). Autophagy as a regulated pathway of cellular degradation. Science 290, 1717-1721.
DOI
|
28 |
Shibata, T., Ismailoglu, U.B., Kittan, N.A., Moreira, A.P., Coelho, A.L., Chupp, G.L., Kunkel, S.L., Lukacs, N.W., Hogaboam, C.M. (2014). Role of growth arrest-specific gene 6 in the development of fungal allergic airway disease in mice. Am. J. Respir. Cell Mol. Biol. 51, 615-625.
DOI
|
29 |
Smiley, S.T., Stitt, T.N., and Grusby, M.J. (1997). Cross-linking of protein S bound to lymphocytes promotes aggregation and inhibits proliferation. Cell Immunol. 181,120-126.
DOI
|
30 |
Schroder, K., and Tschopp, J. (2010). The inflammasomes. Cell 140, 821-832.
DOI
|
31 |
Scott, R.S. (2001). Phagocytosis and clearance of apoptotic cells is mediated by MER. Nature 411, 207-211.
DOI
|
32 |
Lemke, G., and Burstyn-Cohen, T. (2010). TAM receptors and the clearance of apoptotic cells. Ann. NY Acad. Sci. 1209, 23-29.
DOI
|
33 |
Segawa, K. (2014). Caspase-mediated cleavage of phospholipid flippase for apoptotic phosphatidylserine exposure. Science 344, 1164-1168.
DOI
|
34 |
Lai, C., Gore, M., and Lemke, G. (1994). Structure, expression, and activity of Tyro 3, a neural adhesion-related receptor tyrosine kinase. Oncogene 9, 2567-2578.
|
35 |
Lawrence, T., and Natoli, G. (2011). Transcriptional regulation of macrophage polarization: enabling diversity with identity. Nat. Rev. Immunol. 11, 750-761.
DOI
|
36 |
Lew, E.D., Oh, J., Burrola, P.G., Lax, I., Zagorska, A., Traves, P.G., Schlessinger, J., and Lemke, G. (2014). Differential TAM receptor-ligand-phospholipid interactions delimit differential TAM bioactivities. Elife, 3, e03385.
DOI
|
37 |
Lewis, C.E., and Pollard, J.W. (2006). Distinct role of macrophages in different tumor microenvironments. Cancer Res. 66, 605-612.
DOI
|
38 |
Linger, R.M., Cohen, R.A., Cummings, C.T., Sather, S., Migdall-Wilson, J., Middleton, D.H., Lu, X., Baron, A.E., Franklin W.A., Merrick, D.T., et al. (2013). Mer or Axl receptor tyrosine kinase inhibition promotes apoptosis, blocks growth and enhances chemosensitivity of human non-small cell lung cancer. Oncogene 32, 3420-3431.
DOI
|
39 |
Linger, R.M., Keating, A.K., Earp, H.S., and Graham, D.K. (2008). TAM receptor tyrosine kinases: biologic functions, signaling, and potential therapeutic targeting in human cancer. Adv. Cancer Res. 100, 35-83.
DOI
|
40 |
Lingnau, M., Hoflich, C., Volk, H.D., Sabat, R., and Docke, W.D. (2007). Interleukin-10 enhances the CD14-dependent phagocytosis of bacteria and apoptotic cells by human monocytes. Hum. Immunol. 68, 730-738.
DOI
|
41 |
Sosic, D., Richardson, J.A., Yu, K., Ornitz, D.M., and Olson, E.N. (2003). Twist regulates cytokine gene expression through a negative feedback loop that represses activity. Cell 112, 169-180.
DOI
|
42 |
Sharif, M. N., Sosic, D., Rothlin, C.V., Kelly, E., Lemke, G., Olson, E.N., and Ivashkiv, L.B. (2006). Twist mediates suppression of inflammation by type I IFNs and Axl. J. Exp. Med. 203, 1891-1901.
DOI
|
43 |
Sica, A., and Bronte, V. (2007). Altered macrophage differentiation and immune dysfunction in tumor development. J. Clin. Invest. 117, 1155-1166.
DOI
|
44 |
Solinas, G., Germano, G., Mantovani, A., and Allavena P. (2009) Tumor-associated macrophages (TAM) as major players of the cancer-related inflammation. J. Leukoc. Biol. 86, 1065-1073.
DOI
|
45 |
Stitt, T.N. (1995). The anticoagulation factor protein S and its relative, Gas6, are ligands for the Tyro 3/Axl family of receptor tyrosine kinases. Cell 80, 661-670.
DOI
|
46 |
Medzhitov, R. (2009). Approaching the asymptote: 20 years later. Immunity 30, 766-775.
DOI
|
47 |
Loges, S., Schmidt, T., Tjwa, M., Van Geyte, K., Lievens, D., Lutgens, E., and Luttun, A. (2010). Malignant cells fuel tumor growth by educating infiltrating leukocytes to produce the mitogen Gas6. Blood 115, 2264-2273.
DOI
|
48 |
Lu, Q., and Lemke, G. (2001). Homeostatic regulation of the immune system by receptor tyrosine kinases of the Tyro 3 family. Science 293, 306-311.
DOI
|
49 |
Lu, Q., Gore, M., Zhang, Q., Camenisch, T., Boast, S., Casagranda, F., and Earp, H.S. (1999). Tyro-3 family receptors are essential regulators of mammalian spermatogenesis. Nature 398, 723-728.
DOI
|
50 |
Mills, C.D. (2012). M1 and M2 macrophages: oracles of health and disease. Crit. Rev. Immunol. 32, 463-488.
DOI
|
51 |
Mills, C.D., and Ley, K. (2014). M1 and M2 macrophages: the chicken and the egg of immunity. J. Innate. Immun. 6, 716-726.
DOI
|
52 |
Mills, C.D., Kincaid, K., Alt, J.M., Heilman, M.J., and Hill, A.M. (2000). M-1/M-2 macrophages and the Th1/Th2 paradigm. J. Immunol. 164, 6166-6173.
DOI
|
53 |
Mosser, D.M., and Edwards, J.P. (2008). Exploring the full spectrum of macrophage activation. Nat. Rev. Immunol. 8, 958-969.
DOI
|
54 |
Alciato, F., Sainaghi, P.P., Sola, D., Castello, L., and Avanzi, G.C. (2010). TNF-alpha, IL-6, and IL-1 expression is inhibited by Gas6 in monocytes/macrophages. J. Leukoc. Biol. 87, 869-875.
DOI
|
55 |
Behrens, E.M., Gadue, P., Gong, S.Y., Garrett, S., Stein, P.L., and Cohen, P.L. (2003). The mer receptor tyrosine kinase: expression and function suggest a role in innate immunity. Eur. J. Immunol. 33, 2160-2167.
DOI
|
56 |
Ubil, E., Caskey, L., Holtzhausen, A., Hunter, D., Story, C., and Earp, H.S. (2018). Tumor-secreted Pros1 inhibits macrophage M1 polarization to reduce antitumor immune response. J. Clin. Invest. 128, 2356-2369.
DOI
|
57 |
Stutz, A., Golenbock, D.T., and Latz, E. (2009). Inflammasomes: too big to miss. J. Clin. Invest. 119, 3502-3511.
DOI
|
58 |
Takeuchi, O., and Akira, S. (2010). Pattern recognition receptors and inflammation. Cell 140, 805-820.
DOI
|
59 |
Todt, J.C., Hu, B., and Curtis, J.L. (2004). The receptor tyrosine kinase MerTK activates phospholipase C gamma2 during recognition of apoptotic thymocytes by murine macrophages. J. Leukoc. Biol. 75, 705-713.
DOI
|
60 |
Wu, G., Ma, Z., Cheng, Y., Hu, W., Deng, C., Jiang, S., Li, T., Chen, F., Yang, Y. (2018). Targeting Gas6/TAM in cancer cells and tumor microenvironment. Mol. Cancer 17, 20.
DOI
|
61 |
Wu, Y., Singh, S., Georgescu, M.M., and Birge, R.B. (2005). A role for Mer tyrosine kinase in alphavbeta5 integrin mediated phagocytosis of apoptotic cells. J. Cell Sci. 118, 539-553.
DOI
|
62 |
Zhang, L., DeBerge, M., Wang, J., Dangi, A., Zhang, X., Schroth, S., Zhang, Z., Thorp, E.B., and Luo, X. (2018). Receptor tyrosine kinase MerTK suppresses an allogenic type I IFN response to promote transplant tolerance. Am. J. Transplant. [In press] Available at: https://doi.org/10.1111/ajt.15087
DOI
|
63 |
Zhou, R., Yazdi, A.S., Menu, P., and Tschopp, J. (2011). A role for mitochondria in NLRP3 inflammasome activation. Nature 469, 221-225.
DOI
|
64 |
Nagata, K., Ohashi, K., Nakano, T., Arita, H., Zong, C., Hanafusa, H., and Mizuno, K. (1996). Identification of the product of growth arrest-specific gene 6 as a common ligand for Axl, Sky, and Mer receptor tyrosine kinases. J. Biol. Chem. 271, 30022-30027.
DOI
|