• Proceedings of the Acoustical Society of Korea Conference
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• 1998.08a
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• pp.281-286
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• 1998

ETRI에서 개발 중인 대화체 음성언어번역 시스템에 대하여 기술한다. 현재, ETRI는 DAM성언어번역 국제 공동 연구콘서시움인 C-STAR에 핵심참가기관으로 참여하여, 한일, 한영음성언어번역 시스템을 개발하고 있으며 1999년 국제 공동시험을 계획하고 이？. 최근의 연구 진행상황을 간추리면, 먼저 음성인식분야에서 유무성음 및 묵음정보를 미리 추출하여 이를 탐색에 활용하였으며, 음향모델 규모의 설정을 위한 교차 엔트로피 기반 변이음 군집화 알고리즘이 구현되었다. 또한 대상어휘의 확장을 위하여 의사형태소의 개념을 도입하였다. 언어번역분야에서는 이전과 같은 개념기반의 번역을 시도하고 있으며, C-STAR 회원기관과 공동으로 중간언어 규격을 정의하고 있다. 음성합성분야에서는 훈련형 합성기를 개발하여 합성데이타베이스 구축기간을 현저하게 줄였다.

• Molecular & Cellular Toxicology
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• v.5 no.3
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• pp.198-206
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• 2009

Microarray and proteomic expression patterns in response to cadmium exposure were analyzed in human lung epithelial cells. Among 35,000 genes analyzed by cDNA microarray, 228 genes were up-regulated and 99 genes were down-regulated, based on a fold change cut-off value of ${\geq}2$. Combining two-dimensional gel electrophoresis and matrix-assisted laser desorption/ionization-time-of-flight-mass spectrometry (MALDI-ToF-MS), 25 of 629 protein spots showed fold changes in expression ${\geq}2$ (17 up-regulated, 8 down-regulated). After comparing the cDNA microarray and proteomic analyses, only transglutaminase 2, translation elongation factor 1 alpha 1, and glyceraldehyde-3-phosphate dehydrogenase showed overlapping signals in the cDNA microarray and proteomic analyses, whereas the remaining differentially expressed proteins showed large discrepancies with respect to mRNA expression.

• International Journal of Fuzzy Logic and Intelligent Systems
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• v.8 no.2
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• pp.100-104
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• 2008

In this paper, intelligent filtering methodology for masterarm translation signal is proposed. Fidelity and stability are contradicting factors in teleoperation. Human hand trembling filtering is one of the problems in telemanipulation field. During every operation the hand has a certain vibration that can affect the quality of teleoperation, especially in carrying FPD (Flat Panel for Display), nanomanipuation and other precise tasks. It is very important to study the kinesthetic perception of the human and to optimize the teleoperation system accordingly. To cancel out the influence of human's hand vibration the signal from the masterarm should be filtered. One of the feasible solutions is to use an intelligent filter based on fuzzy logic, which is a very flexible instrument. Applying intelligent filtering methodology, we can use some heuristic methods to solve the filtering problem.

• Korean Journal of Environmental Biology
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• v.23 no.2 s.58
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• pp.152-156
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• 2005

Ionizing radiation is a well- known therapy factor for human carcinoma cells. Genotoxic stress mediates cell cycle control, transcription and cellular signaling. In this work, we have used a microarray hybridization approach to characterize the cell type-specific transcriptional response of human carcinoma MCF-7 and HeLa cell line to $\gamma-radiation$, such as 4Gy 4hr. We found that exposure to $\gamma-ray$ alters by at least a $log_2$ factor of 1.0 the expression of known genes. Of the 27 genes affected by irradiation, 11 are down- regulated in MCF-7 cells and 2 genes induced by radiation,15 are repressed in HeLa cells. Many genes were involved in known damage- response pathways for cell cycling, transcription factor and cellular signaling response. However, in MCF-7 cells, we observed gene expression pattern in chromatin, apoptosis, stress, differentiation, cytokine, metabolism, ribosome and calcium. In HeLa cells, it showed clearly the expression changes in adhesion and migration, lysosome, brain, genome instability and translation. These insights reveal new therapy directions for studying the human carcinoma cell response to radiation.

• Journal of the Korean Society of Manufacturing Technology Engineers
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• v.22 no.2
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• pp.192-198
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• 2013

A light-weight enough to be portable yet functionally complete hand-writing machine was designed with hardware assembled and software implemented. The machine simulating human hand-writing not only allows identical massive scriptings on papers in human's proxy, but also offers emotional appearance as if the script was directly hand-written in ink. The features of human writing were independently put together to complete the action of scripting. The writing style could be altered in order to mimic a person's own specific writing style. The present work demonstrates that the assembled hand-writing machine was able to duplicate writing of scripts in almost parallel lines in consistent manner. The machine can be used in the emotional marketing area where seasonal greetings or thank-you cards are to be sent in massive manner. The pen-holding machine can also find an emotional application such as writing a short greeting note on a plastic lid on a disposable coffee cup in coffee-selling stores.

• Proceedings of the IEEK Conference
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• 2000.06d
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• pp.114-117
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• 2000

In this paper, we proposed robust digital image watermarking based on modulation transfer function (MTF) of human visual system (HVS). Using the proposed method, robust watermarking is possible both in common image processing operations such as cropping and lossy compression and in geometrical transforms such as rotation, scaling, and translation, because it can embed watermark and template signal maximally using MTF of HVS. Experimental results show that the proposed watermarking method is more robust to several common image processing operations and geometrical transforms.

• Proceedings of the Korean Society of Life Science Conference
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• 2007.10a
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• pp.118.1-118.1
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• 2007

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• Molecules and Cells
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• v.42 no.10
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• pp.687-692
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• 2019

Transfer RNA-derived small RNAs (tsRNAs) play a role in various cellular processes. Accumulating evidence has revealed that tsRNAs are deeply implicated in human diseases, such as various cancers and neurological disorders, suggesting that tsRNAs should be investigated to develop novel therapeutic intervention. tsRNAs provide more complexity to the physiological role of transfer RNAs by repressing or activating protein synthesis with distinct mechanisms. Here, we highlight the detailed mechanism of tsRNA-mediated dual regulation in protein synthesis and discuss the necessity of novel sequencing technology to learn more about tsRNAs.

• Toxicological Research
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• v.21 no.4
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• pp.347-353
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• 2005

Eukaryotic initiation factor 4E (elF4E) is a key element for cap-dependent protein translation controlled by affinity between elF4E and 4E-binding protein 1 (4E-BP1). Rapamycin can also affect protein translation by regulating 4E-BP1 phosphorylation. Tobacco-specific nitrosamine, 4(N-methyl-N-nitrosamino )-1-(3-pyridyl)-1-butanone (NNK) is a strong lung carcinogen, but its precise lung cancer induction mechanism remains unknown. Relative roles of cap-dependent and -independent protein translation in terms of NNK-induced lung carcinogenesis were elucidated using normal human bronchial epithelial cells. NNK concentrations applied in this study did not decrease cell viability. Addition of NNK restored rapamycin-induced decrease of protein synthesis and rapamycin-induced phosphorylation of 4E-BP1, and increased expression levels of mTOR, ERK1/2, p70S6K, and Raf-1 in a concentration-dependent manner. NNK also caused perturbation of normal cell cycle progression. Taken together, NNK might cause toxicity through the combination of restoration of 4E-BP1 phosphorylation and increase of elF4E as well as mTOR protein expression, interruption of Raf1/ERK as well as the cyclin G-associated p53 network. Our data could be applied towards elucidation of the molecular basis for lung cancer treatment.

• Journal of the Institute of Electronics Engineers of Korea SP
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• v.38 no.5
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• pp.548-555
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• 2001

In this paper, we proposed a HVS(human visual system) model-based digital image watermarking which is not only invariant to rotation and translation but also more robust to lossy compression, cropping, and scaling as compared to the conventional method. Fourier transform and log-polar mapping is used to make the proposed algorithm invariant to rotation and translation, and in addition, watermark energy is embedded maximally based on spatial frequency sensitivity of HVS without the deterioration of the invisibility. As a result, the robustness of watermarking is improved both in general image processing operations such as cropping, low pass filtering, and lossy compression and in geometrical transforms such as rotation, translation, and scaling. And, by disjoint embedding of the watermark and the template without intersection, the deterioration of invisibility and robustness is prevented. Experimental results show that proposed watermarking is about 30~75 [%] more robust af compared to the conventional methods.