• Bulletin of the Korean Chemical Society
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• 제25권6호
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• pp.878-880
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• 2004

Revered-phase LC-electrospray ionization mass spectrometry was used to selectively determine enalapril from plasma with minimal sample preparation. Detection limit of the method was 1 ng/mL. Precision (within day and between days) and accuracy of the method at various concentrations were acceptable. The analytical technique was used for pharmacokinetic studies after administration of enalapril to human test subjects.

• 대한자기공명의과학회:학술대회논문집
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• 대한자기공명의과학회 2002년도 제7차 학술대회 초록집
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• pp.109-109
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• 2002

Purpose： The aim of the study is to see the representation patterns of human visual cortex by perceiving some geometrical shapes. Method： 3 humans as subjects for the fMRI experiment. A classical block or box car design was used as experimental paradigm. 3 different types of fan shapes and concentric circles were presented.

• The Korean Journal of Physiology
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• 제4권2호
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• pp.37-44
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• 1970

Human body volumes were calculated from the measurments of body height and body weight. Equations Suited to express the relations of height, weight, and surface area to show the body volume were derived from the body volume measurements by means of underwater. weighing method. Underwater body weights were corrected for the residual volume of long obtained by the Rahn's three breath method. Underwater weighing was performed on 173 male subjects aged between 13 and 51 years. Subjects were divided into 4 age groups, namely, 13-16 years group of 47 subjects, 16-19 years group of 46 subjects, adult group aged between 22 and 38 years comprising 45 subjects, and middle-aged group (40-51 years) of 35 subjects. The group division was made on .the basis of physical growth and development. The following results were obtained. 1. Body height (H, cm), body weight (W, kg), body surface area $S,\; m^{2})$, and body volume (V, liter.) interrelated closely. V/S showed a high correlation with W/H and the coefficient of correlation was r=0.97 irrespective of age group differences of the subjects. The coefficients of correlation between V/S and W/H in the total mate subjects as a single group was r=1.983. Subsequently the following regression equation was obtained. V = S X (54.84 W/H + 14.08) The agreement of body volume values obtained by the calculation and underwater weighing in the total subject group was better than that of the separate age group division. 2. The calculated values of body volume were: 40.4 l (euiqvalent to the body density value of 1.0562 kg/1) in 13-16 years group; 52.0 l (equivalent to density value of 1.0723 kg/l) in 16-19 years group; 55.3 l (equivalent to density value of 1.0570 kg/l) In the adult group; and 54. 0 l (equivalent to density value of 1.074 kg/l) in the middle-age group. The mean deviation of calculated from the measured volume value ranged between ${\pm}0.55$ and ${\pm}0.81$ liters. 3. The correlation between V/S and mean skinfold thickness of 4 sites (arm, back, iliac and chest) was high, namely, the coefficient of correlation was r=0.656. The coefficients of correlation between V./S and the $R\"{o}hrer$ index ranged between r=0.668 and r=0.810 affected by the difference in group age of the subject. The body volume (V) alone correlated poorly than V/S with mean skinfold thickness (r=0.606) and the $R\"{o}hrer$ index (r ranged between 0.274 and 0.588).

• 동의생리병리학회지
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• 제23권2호
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• pp.294-300
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• 2009

Nowadays, as the era of aging is developing remarkably fast, conventional disease treatments such as surgery or emergency therapy are now being substituted to 'health promotion' and 'health prevention through whole-life management. Recently, many oriental medicine colleges are teaching subjects related to Yangsaeng and Gigong. However, detail investigation about the exact education situation and correlation between among subjects has not been performed yet. Thus, in this research, I collected data about each oriental medicine college's Yangsaeng/Gigong-related subjects' prevalence and management situation through the analysis of 'National Education Report about Korea's Oriental Medicine Colleges' and direct investigation, First, I analyzed oriental medicine colleges' education object. Among 11 basic medicine subjects, there were 2 subjects related to Yangsaeng and Gigong. And among 13 clinical medicine subjects, there were 7 subjects related to Yangsaeng and Gigong. In these subjects, the word 'Yangsaeng' was used for 14 times. The word 'Gigong' was used for 5 times and the words 'natural medicine' and 'alternative medicine' were used for 4 times. Total class hours related to Yangsaeng and Gigong were 19.6 hours (practice classes were 4.6 hours). Each class of subjects had 'study objects'. Study objects were categorized into A (Essential) and B (Recommendation) Items. There were44 A items and 23 B items. Among 11 oriental medicine colleges all over Korea, 10 classes related to Yangsaeng and Gigong existed in 9colleges. 7 classes were included in pre-OM course and 3 classes were included in major-OM course. 6 classes were taught only for one semester and 4 classes were taught for 2 semesters. 6 classes were single unit and 4 classes were 2-units sunjects. 3 classes were held 3 hours a week. 6 classes were held 2 hours a week and one class was held an hour per week. In conclusion, each oriental medicine college should focus on the education and research about Yangsaeng and Gigong. To achieve this object, systemic regulation and specialized human resources should also be made.

• 한국문헌정보학회지
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• 제31권4호
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• pp.53-81
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• 1997

본 연구는 학생들의 창의성 함양을 위하여 정보교과목과 타 교과목들을 통합적으로 교수학습 하는 것이 필요한 이유를 심리학과 신경과학의 이론을 연구함으로써 밝히고 있다. 창의성이란 마음이나 두뇌의 내부에 이미 존재하는 정보와 외부에서 입수하는 정보를 통합하는 과정에서 생긴다. 이것이 곧 사람이 생각하는 것 또는 인간정보처리라고 말하는 것이다. 창의성이 정보통합의 과정에서 생기는 것이라면 학교수업에서 이 원리를 활용하여 학생들의 창의성 함을 도모해야 할 것이다. 다양한 정보자료의 활용을 기본 바탕으로 하는 정보교과목을 정규 교과목으로 가르치되. 타 교과목들과 병행하여 교수/학습함으로써 학생들의 마음 또는 두뇌가 두 가지 이상의 교과목의 정보를 통합하는 경험을 하도록 할 수 있는 것이다. 정보교과목과 타 교과목의 통합적 교수/학습을 실시하는 것은 최종적으로는 각각의 교과목 담당자들이 주도적 역할을 해야 하는 것이므로 사서교사와 일반교과목 담당교사들을 대상으로 통합적 교수/학습의 실시에 대한 의견과 이러한 교육의 실시를 위하여 필요한 환경을 설문조사 하였다. 이들은 학생들의 창의성 함양을 위한 통합적 교수/학습에 기본적으로 긍정적 견해를 가지고 있으며 교수/학습의 대상자인 학생들도 통합적 교수학습의 실시에 필요한 조건을 갖추고 있다는 것이 밝혀졌다. 그러나 일반교과목 담당교사는 물론 사서교사들까지도 정보교과목과 타 교과목의 통합적 교수/학습에 대하여 그 내용이나 방법 효과 등의 지식이 매우 부족하며 또 학교도서관은 통합적 교수/학습의 실시에 필요한 준비가 되어 있지 않은 것으로 판명되었다. 조사결과에 따라 필자는 사서교사 양성기관인 대학의 문헌정보학 교육과정에 정보교과목과 타 교과목의 통합적 교수/학습에 대한 내용을 포함시키는 것이 선결 과제이며. 학교도서관은 이러한 교수/학습을 실시하는데 필요한 자료를 충실히 갖추어서 창의성 함양에 도움이 되는 교육이 이루어질 수 있도록 해야 한다는 제안을 하였다.

• 한국의류산업학회지
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• 제1권4호
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• pp.376-386
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• 1999

The purpose of this study was to determine the physiological responses and the Subjective sensations of the human subjects when 10 human subjects(5 males and 5 females) were tested with selected ensembles, including the uniforms of students, industrial and bank workers. For the study, garment material and design were selected, which was mostly used in Taegu area by the survey. Thermal manikin and the human subject tests were performed. The results were as follows: 1. There was no significant difference among skin temperature of head by season and among that of breast and back by all variables, however, there was a significant difference among that of belly by gender and that of thigh and shank by season. In addition, there was no significant difference among rectal temperature by gender and season, but there was a significant difference by uniform. 2. Mean skin temperature of male subjects was significantly higher than that of female subjects. Specially in lower environmental condition, the difference got larger. 3. There was a significant difference among purse rate of subjects by uniform, but there was no significant difference among those by gender and season. There were no significant difference among maximum and minimum blood pressure by gender, uniform, and season. 4. There was a significant difference in temperature of chest among gender and uniform, and there was no significant difference in temperature of back by season. In addition, There was a significant difference in humidity of back by uniform and season but there were no significant difference in that by gender. 5. There was a significant difference in humidity sensation by gender, comfort sensation by uniform and season, but there was no significant difference thermal sensation by uniform and season. 6. For the result of regression analysis, we got the regression equations as follows: Clo=1.810 Thickness+0.525, Clo=0.475 weight+0.863.

• Journal of Periodontal and Implant Science
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• 제31권2호
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• pp.401-420
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• 2001

A novel glucanhydrolase from a mutant of Lipomyces starkeyi(KSM 22)has been shown effective in hydrolysis of mutan, reduction of mutan formation by Streptococcus mutans and removal pre-formed sucrose-dependent adherent microbial film and Lipomyces starkeyi KSM 22 dextranase has been strongly bound to hydroxyapatitie. These in vitro properties of Lipomyces starkeyi KSM 22 dextranase are desirable for its application as a dental plaque control agent. This study was performed to determine oral hygiene benefits and safety of dextranase(Lipomyces starkeyi KSM 22 dextranase)-containing mouthwash in human experimental gingivitis. This 3-week clinical trial was placebo-controlled double-blind design evaluating 1U/ml dextranase mouthwash and 0.12% chlorhexidine mouthwash. A total 39 systemically healthy subjects, who had moderate levels of plaque and gingivitis were included. At baseline, 1, 2 and 3 weeks, subjects were scored for plaque(Silness and $L{\ddot{o}e$ plaque index and plaque severity index), gingivitis($L{\ddot{o}e$ and Silness gingival index), and at baseline and 3 weeks of experiment, subjects were scored for plaque(Turesky-Quingley-Hein's plaque index and plaque severity index), tooth stain(Area and severity index system by Lang et al). Additionally, oral mucosal examinations were performed and subjects questioned for adverse symptoms. Two weeks after pre-experiment examinations and a professional prophylaxis, the subjects provided with allocated mousewash and instructed to use 20-ml volumes for 30s twice dailywithout toothbrushing. All the groups showed significant increase in plaque accumulation since 1 week of experiment. During 3 weeks' period, the dextranase group showed the least increase in plaque accumulation of Silness and $L{\ddot{o}e$ plaque index, compared to the chlorhexidine and placebo groups, but chlorhexidine group showed the least increase inplaque accumulation of Turesky-Quingley-Hein's plaque index. As for gingival inflammation, all the groups showed significant increase during 3 weeks of experiment. The dextranase group also showed the least increase in gingival index score, compared to the chlorhexidine as well as the placebo groups. Whereas the tooth stain was increased significantly in the chlorhexidine group, compared to the baseline score and the placebo group since 3 weeks of mouthrinsing. It was significantly increased after 3 weeks in the dextranase group, still less severe than the chlorhexidine group. As for the oral side effect, the dextranase group showed less tongue accumulation, bad taste, compared to the chlorhexidine group. From these results, mouthrinsing with Lipomyces starkeyi KSM 22 dextranase was comparable to 0.12% chlorhexidine mouthwashin inhibition of plaque accumulation and gingival inflammation and local side effects were if anything less frequent and less intense than chlorhexidine, in human experimental gingivitis. All data had provided positive evidence for Lipomyces starkeyi KSM 22 dextranase as an antiplaque agent and suggested that further development of dextranase formulations for plaque control are warranted.

• Journal of Acupuncture Research
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• 제26권5호
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• pp.19-28
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• 2009

Objectives : We tried to investigate the effects of Panax Ginseng Radix pharmacopuncture and Zizyphi Spinosi Semen pharmacopuncture on human body with the Heart Rate Variability (HRV) in adult man. As well as we tried to investigate how safe Panax Ginseng Radix and Zizyphi Spinosi Semen pharmacopuncture on the the human being. Methods : We investigated on 44 healthy volunteers consisted of 16 subjects in Panax Ginseng Radix pharmacopuncture group, 13 subjects in Zizyphi Spinosi Semen pharmacopuncture group and 15 subjects in Normal Saline. We ruled out subjects who wasn't stable by rest, with in the limit of normal heart beat(60-120cycle/min). Study form was a randomized, clinical trial. Each group was injected Panax Ginseng Radix pharmacopuncture, Zizyphi Spinosi Semen pharmacopuncture and Normal Saline $0.2m{\ell}$ at $GB_{21}$(Kyonjong). We measured HRV on 7 times : before and after injection per 5 minutes during 30 minutes. The SPSS 13.0 for windows was used to analyze the data by the paired t-test(in the group) and Anova test(among the groups) were used to verify the result. Results : 1. After Panax Ginseng Radix pharmacopuncture injection, SDNN was significantly high, pNN50 was significantly low, Ln(TP) was significantly high, Ln(VLF) was significantly high, Ln(LF) was significantly high at 30 minutes. 2. After Zizyphi Spinosi Semen pharmacopuncture injection, Complexity was significantly low, Ln(VLF) was significantly high at 30 minutes. 3. HRV-index made a significant difference between the Zizyphi Spinosi Semen pharmacopuncture and normal saline at 5 minutes(p=0.02). 4. There wasn's any pain the injected region and whole body, rubefaction, uredo, nausea, vomiting, colic, headache, dizziness within 24 hours. Measured data and mean value of Mean-HRV was within normal range. Conclusions : The results suggested that and Panax Ginseng Radix pharmacopuncture in healthy adult man tended to activate the vagus nervous system within normal range.

• 한국의류산업학회지
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• 제9권1호
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• pp.89-95
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• 2007

The purposes of this study were to investigate the names and locations of beauty-related high schools, and to examine the cources and subjects of beauty-related high schools according to types of high schools. Data were obtained from 8 beauty-related high schools, which consisted of 2 schools for each beauty-related high schools types and permitted the investigation of their curriculum. The findings of this study were as follows: First, These were about 30 beauty-related high schools that were mostly industrial high schools, located in Busan and Kyungsang Province, and almost used "Beauty" or "Aesthetics" as the name of department. Second, the rates of common and professional courses of business high schools and industrial high schools were similar to those suggested from the Ministry of Education and Human Resources. But for specialized high schools and integrated high schools, the rate of these courses were not in accord with those of the Ministry of Education and Human Resources. Third, The credit hour of special study in beauty-related high schools largest in hair care, followed by skin care and makeup courses. But nail and foot care were established only 2-3 beauty-related high schools. Fourth, The number of subjects of special study were largest in specialty high school. Industrial high schools offered the least number of subjects of special study. Fifth, as a result of making a comparative analysis of their subjects of special study, eight high schools offered hair care, skin care, public health and makeup courses, which had the same or similar titles. The independence titles were established nail care and foot care. The others titles were established actual training, food and nutrition, digital image processing, accounts theory, coordinatin.

• Molecular & Cellular Toxicology
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• 제4권1호
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• pp.5-10
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• 2008

The effect of obesity on the drug-metabolizing enzymes remains an important issue for clinician since obesity is a world wide epidemic problem. However, little is known about the effects of obesity on flavincontaining monooxygenase (FMO) production and activity. We show here for the first time that in vivo FMO activity determined by urinary ranitidine (RA) metabolites ratio in human, was higher in subjects with a high body mass index (BMI, kg/$m^2$, 21.97-30.32) than in those with an intermediate BMI (range 19.38-21.83). Moreover, there was a significant correlation between FMO activity and BMI in 209 subjects. In high fat diet-induced obese mice, we also observed that the hepatic expression of FMO (225% of lean mice) and the activity measured by the RA Noxidation rate ($513{\pm}58.1$ vs. $349{\pm}66.0$ pmol/hr per mg protein) were significantly higher than in lean mice fed a control diet. Unknown factors rather than leptin or insulin appeared to regulate the hepatic FMO production. Thus, FMO activity may be increased in obese or overweight individuals. Moreover, the regulation of FMO activity in subjects with morbid obesity, with or without complications and its clinical implications, should be investigated further.