• 제목/요약/키워드: Human Subjects

검색결과 3,198건 처리시간 0.026초

Evaluation of Chromosomal Alteration in Electrical Workers Occupationally Exposed to Low Frequency of Electro Magnetic Field (EMFs) in Coimbatore Population, India

  • Balamuralikrishnan, Balasubramanian;Balachandar, Vellingiri;Kumar, Shanmugam Suresh;Stalin, Nattan;Varsha, Prakash;Devi, Subramaniam Mohana;Arun, Meyyazhagan;Manikantan, Pappuswamy;Venkatesan, Chinnakulandhai;Sasikala, Keshavarao;Dharwadkar, Shahnaz N.
    • Asian Pacific Journal of Cancer Prevention
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    • 제13권6호
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    • pp.2961-2966
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    • 2012
  • Extremely low frequency electro magnetic fields (EMFs) have been classified as possibly carcinogenic to humans by the International Agency for Research on Cancer. An increased number of chromosomal alterations in peripheral lymphocytes are correlated with elevated incidence of cancer. The aim of the present study was to assess occupationally induced chromosomal damage in EMF workers exposed to low levels of radiation. We used conventional metaphase chromosome aberration (CA) analysis and the micronucleus (MN) assay as biological indicators of non ionizing radiation exposure. In the present study totally 70 subjects were selected including 50 exposed and 20 controls. Informed written consent was obtained from all participants and the study was performed in accordance with the Declaration of Helsinki and the approval of the local ethical committee. A higher degree of CA and MN was observed in exposed subjects compared to controls, the frequency of CA being significantly enhanced with long years of exposure (P<0.05). Moreover increase in CA and MN with age was noted in both exposed subjects and controls, but was significantly greater in the former. The results of this study demonstrated that a significant induction of cytogenetic damage in peripheral lymphocytes of workers occupationally exposed to EMFs in electric transformer and distribution stations. In conclusion, our findings suggest that EMFs possess genotoxic capability, as measured by CA and MN assays; CA analysis appeared more sensitive than other cytogenetic end-points. It can be concluded that chronic occupational exposure to EMFs may lead to an increased risk of genetic damage among electrical workers.

슬랙스 맞음새 평가를 위한 하반신 체형 유형화에 관한 연구 (A Study on the Classification of Lower Body Shape Type for Fit Evaluation of Slacks)

  • 김선영;남윤자
    • 패션비즈니스
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    • 제20권2호
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    • pp.181-196
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    • 2016
  • This study intended to suggest criteria for selection of subjects by lower body shape types necessary for evaluating slacks. For this, the characteristics were examined by lower body parts which would influence the fit of slacks on 3D human body shape data of the front and sides of the lower body for lower body shaping. The frequency of subjects by lower body shape types and the boundary points for discrimination of each type were suggested so that they could be available in selecting subjects. Using the data from Size Korea(2004), indirect measurement values measured on the front and sides of the lower body among 3D human body shape data of 175 subjects were analyzed. Their height, waist, and hip circumference fell under the range of standard deviation based on the mean of women aged 18~24 years, and then lower body shaping was conducted by combining the front and side shapes of the lower body. The front of the lower body was classified into four sections: average waist/average hip type(F1), average waist/narrow hip tyle(F2), narrow waist/narrow hip type(F3) and narrow waist/wide hip type(F4) and the sides of the lower body were divided into four sections: average abdomen/average hip type(S1), flat abdomen/average hip type(S2), average abdomen/protrude hip type(S3)and round abdomen/flat hip type(S4), and thus total 16 lower body types were created by cross analysis. Besides, discriminant analysis suggested the boundary points for each shape type of the front and sides of the lower body as a criterion for deciding lower body shape type of each subject

일부 여대생의 영양섭취와 손목 골밀도와의 상관성 (Correlation between Nutrient Intakes and Bone Mineral Density in Carpus of Female University Students)

  • 최유진;임룻;라선화;최미경
    • 대한영양사협회학술지
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    • 제12권1호
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    • pp.10-17
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    • 2006
  • The purpose of this study was to examine the correlation between nutrient intakes and bone mineral density in female university students. A total 27 female university students were measured the anthropometric characteristics, dietary intake and the bone mineral density of carpus using DEXA. The average age, height, weight, % body fat, WHR, and BMI of the subjects were 22.7 years, 161.5 cm, 57.0 kg, 29.9%, 0.8, 21.8 kg/$m^2$, respectively. Bone mineral density of ultradis and distal carpus as T-value were -1.5 and -0.4, respectively. The daily energy intake of the subjects was 1589.0kcal. And the intakes of energy, calcium, iron, zinc, vitamin $B_2$, and folic acid did not meet the Korean RDAs. The daily total food intake of the subjects was 1011.0g and food intake from cereals and vegetables was high. The major food groups of mineral intake were vegetables/cereals/milks/fishes for calcium, cereals/meat/vegetables/fishes for phosphorus, cereals/vegetables/meats for iron, seasonings/vegetables/cereals for sodium, vegetables/cereals/seasonings for potassium, and cereals/meats for zinc. The body weight and body mass index were significantly positive correlated to the bone mineral density of average carpus, respectively. The intakes of animal calcium and vitamin $B_2$ were significantly negative correlated to the bone mineral density of average carpus, respectively. In conclusion, bone mineral density in carpus and nutrient intakes of some female university students were low. Therefore, health management and the study on relation between bone mineral density in various site and long-term intakes of nutrients in many subjects are required.

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MTHFR Polymorphism and Folate Status of Korean Women of Childbearing Age

  • Choi, Jeong-Hwa;Kim, Hee-Ah;Lim, Hyeon-Sook
    • Nutritional Sciences
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    • 제9권1호
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    • pp.35-41
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    • 2006
  • It should be concerned to the women with mutated genotype of methylenetetrahydrofolate reductase (MTHFR), C677T or A1298C, since they need more folate than those with wild genotypes. In this study, we evaluated the folate status of Korean women of childbearing age according to their MTHFR polymorpiysm. Dietary folate intakes, plasma and erythrocyte folate concentrations, plasma homocysteine concentrations, and urinary excretions of para-aminobenzoylglutamate (pABG) and para-acetoamidobenzoylglutamate (ApABG) of twenty-five subjects aged between 19 and 35 years old were determined Folate intakes seemed to be inadequate, being only three-quarters of the Korean RDA of folate. More than one-quarter of the subjects was exposed to folate deficiency risk as determined by erythrocyte folate concentration and almost one-quarter of the subjects showed hyperhomocysteinemia, although they had normal plasma folate concentrations. Urinary excretions of pABG and ApABG seemed to be low and ApABG constituted more than $85\%$ of total folate catabolites. There were no significant differences in dietary folate intakes, plasma concentrations of folate and homocysteine, and urinary excretions of pABG and ApABG among the geneotypes of both C677T and A1298C. However, the subjects with 1298AC genotype had significantly lower erythrocyte folate concentration than those with 1298AA. Erythrocyte folate concentration showed an inverse relationship with plasma homocysteine concentration and positive relationships with urinary excretions of pABG and ApABG. The results of this study imply that mutations of 677C$\rightarrow$T and 1298A$\rightarrow$C in the study were not associated with decreased plasma folate and raised plasma homocysteine concentrations. A1298C polymorphism night be, however, more influential on erythrocyte folate concentration than C677T polymorphism, and urinary excretions of folate catabolites, pABG and ApABG, might be reliable indexes of folate nutritional status like plasma homocysteine concentrations.

남자대학생의 외모관리 인식 및 행동 분석 -헤어.피부.미용성형.패션.몸매관리를 중심으로 - (The Analysis on Appearance Management of Male College Students: Focused on Management of Hair, Skin, Cosmetic Surgery, Fashion and Body Shape)

  • 김영숙;박진영
    • 한국생활과학회지
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    • 제18권1호
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    • pp.259-273
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    • 2009
  • The goal of this study is to analyze male college students' awareness and behaviors toward appearance management, and expenditure for appearance management. Male subjects' appearance management behaviors were focused on hair, skin, cosmetic surgery, fashion and body shape. A chi-square test, t-test, one-way ANOVA, Pearson's correlation analysis, multiple regression analysis were used. The major findings were as follows: (1) The mean of male college students' 'awareness toward appearance management' is 30.01(out of a possible 50). (2) The variables that significantly influenced their awareness toward appearance management are 'an allowance amount per month' and 'household income'. (3) Subjects' most preferred behavior is a variable of 'fashion care' in the appearance management(29.9%). (4) Appearance management behavior is different, according to demographic variables and awareness toward appearance management. (5) The mean of 'monthly expenditure for appearance management' is 247,194won. Consequently, the study shows that there is a most significant relation of 'awareness toward appearance management' to 'expenditure for appearance management'

음향진동장치에 의한 인체의 스트레스 저감효과 (The Effect of Stress Reduction of Human Body by the Vibroacoustic Equipment)

  • 문덕홍;김영완;강화중;최명수
    • 대한기계학회:학술대회논문집
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    • 대한기계학회 2007년도 춘계학술대회A
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    • pp.1063-1068
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    • 2007
  • 개인마다 소음, 음악과 음향진동 자극에 대한 인체의 반응은 상당한 차이가 발생하는 것을 고려하여 뇌파 파워의 상대적인 비율로 비교.고찰하였다. 우선 강한 소음 자극에 대한 뇌파의 변화는 긴장과 스트레스 증가를 의미하는 베타파의 증가 및 긴장완화와 안정을 의미하는 알파파의 감소를 보였고, 좋은 자극에 대해서는 그 반대의 효과를 보였다. 즉, 좋은 자극에 의한 스트레스저감의 효과가 있음을 확인하였다. 자극 후의 변화에서는 좋은 자극시와 마찬가지로 대체로 알파파가 증가하는 경향이 있지만 이와 반대의 경우도 발생하고있어 이 역시 개인차가 있음을 알았다.

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이중양면편 스포츠용 소재의 착용쾌적성 평가 (Wear Comfort of Double Jersey for Sports Wear)

  • 정수경;홍경희
    • 한국생활과학회지
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    • 제12권2호
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    • pp.253-263
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    • 2003
  • The purposes of this study were to find out an evaluation scale that could predict wear comfort and to investigate the effect of the skin-contacting fiber type on the subjective sensation and microclimate. Sensorial evaluation was basically followed by the Human Perception Analysis (HPA) interviewing 144 consumers. Sixteen female subjects were participated in the sleeve wear test with and without wearing vapor permeable water repellent outerwear. Experimental sleeves were constructed using the same double knit by turning inside out to control other material effects except the skin-contacting fiber type, hence each different side of double knit, cotton side and the cotton/polypropylene blend side, was next to skin in each trial of the experiment. As results, it was noted that the term representing a combined feeling of thermal and wetness sensation, and muggy appeared to be a powerful language to measure perceptual responses of human subject among five dimensions of evaluation. although the ordinary users did not use the term very often. As for the comfort properties of double knits, it seemed that subjects slightly more preferred polypropylene/cotton blend to cotton as the skin-contacting fiber type when they wore outerwear and their skin were covered with sweat, although the result was rot statistically significant and need to be confirmed under higher work load.

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인체에서 식품의 기능성 확인을 위한 최신의 분석 방법 (New paradigm for human intervention study in functional food development)

  • 김지연;김민서;정세원;권오란
    • 식품과학과 산업
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    • 제51권1호
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    • pp.8-15
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    • 2018
  • Functional food research has been struggling to demonstrate their beneficial effects in human, however, the physiological changes in humans who are in the target for functional food are very subtle and long term. In addition, it is difficult to obtain significant beneficial effect because of the necessity of using relatively healthy subjects. Relatively healthy subjects are homeostatic, and most of the biomarkers maintain a certain level under the "normal" or "resting" state. Moreover, due to wide inter-individual variation, it is difficult to detect significant changes. To address this problem, research has been actively conducted to identify the efficacy of natural products using 'omics' and 'bioinformatics' technology. In this review, we would like to introduce the human intervention studies applied homeostatic challenge model.

A Study on Sensibility Measurement Method

  • Kwon, Kyu-Sik;Kim, Sun-Woong
    • 한국감성과학회:학술대회논문집
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    • 한국감성과학회 2000년도 춘계 학술대회 및 국제 감성공학 심포지움 논문집 Proceeding of the 2000 Spring Conference of KOSES and International Sensibility Ergonomics Symposium
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    • pp.426-430
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    • 2000
  • This study is about the human sensibility measurement method. Researches on human sensibility measurement have been performed in many aspects. However, due to the subtlety and intricacy of human sensibility, it has been difficult to exactly measure human sensibility.At present, Semantic Differential(SD) method is most widely used to quantify human sensibility. In SD method, complicate human sensibility is represented on a scale with equal interval or equal ratio. However, this method has a critical problem in that human sensibility cannot be expressed with equal interval or equal ratio.In order to complement SD method and represent human sensibilities appropriately, we proposed an alternative method using the chroma-scale with saturation that had not equal interval or ratio. In experiment, proposed method shown that subjects understood a new scale easily and they could express their sensibilities on a new scale without any limitation. As a result, the chroma-scale can be used not only for measuring consumer's preference but also for evaluating or selecting sensibility words.

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전북지역 성인의 녹차 및 녹차관련 제품에 대한 기호도와 이용실태에 관한 연구 (The Preference and Utilization of Green Tea and its Products of Adults in Chonbuk Area)

  • 양향숙;노정옥
    • 대한가정학회지
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    • 제44권9호
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    • pp.21-29
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    • 2006
  • The purpose of this study was to investigate the preferences and utilization of green tea and its products for adults living in Chonbuk area. Self-administered questionnaires were collected from 388 (117 male, 271 female) subjects. who were classified into 5 groups by age. Data were analysed by chi-square and ANOVA. The results can be summarized as follows. On the investigation of preferences, there was a significant difference between and among the age groups(p<.001). More than 20% of the subjects in the $20{\sim}29$ years group preferred coffee and juice. A half of the elderly over 60 years preferred a kind of green tea. The frequency of green tea drinking was not significantly influenced by age. Drinking green tea less than once a day was replied by 59.0% of the subject of whom 44.3% drank the green tea at home. and 42.0% got information about green tea from TV or radio. Regarding the satisfaction with products using green tea, 62.6% of the subjects responded only 'mediocre.' The brown rice-green tea was marked to be the highest in terms of recognition among all kinds of products. The green tea-related products were rated higher by the elder group. In conclusion, future research should focus on the development of green tea and its products in accordance with the consumption pattern in each age group.