• Genomics & Informatics
• /
• v.2 no.3
• /
• pp.134-141
• /
• 2004

Hepatocellular carcinoma (HCC) is one of the most common malignancies worldwide and a typical hypervascular tumor. Therefore, it is important to find factors related to angiogenesis in the process of HCC malignancy. In order to find angiogenesis-related factors in HCC, we used combined methods of in silico prediction and an experimental assay. We analyzed 1457 genes extracted from cDNA microarray of HCC patients by text-mining, sequence similarity search and domain analysis. As a result, we predicted that 16 genes were likely to be involved in angiogenesis and then the effects of these genes were confirmed by hypoxia response element(HRE)-luciferase assay. For instant, we classified osteopontin into a potent angiogenic factor and coagulation factor XII into a significant anti­angiogenic factor. Collectively, we suggest that using a combination of in silico prediction and experimental approaches, we can identify HCC-specific angiogenesis­related factors effectively and rapidly.

• ETRI Journal
• /
• v.36 no.3
• /
• pp.479-489
• /
• 2014

This paper presents a model-based image steganography method based on Watson's visual model. Model-based steganography assumes a model for cover image statistics. This approach, however, has some weaknesses, including perceptual detectability. We propose to use Watson's visual model to improve perceptual undetectability of model-based steganography. The proposed method prevents visually perceptible changes during embedding. First, the maximum acceptable change in each discrete cosine transform coefficient is extracted based on Watson's visual model. Then, a model is fitted to a low-precision histogram of such coefficients and the message bits are encoded to this model. Finally, the encoded message bits are embedded in those coefficients whose maximum possible changes are visually imperceptible. Experimental results show that changes resulting from the proposed method are perceptually undetectable, whereas model-based steganography retains perceptually detectable changes. This perceptual undetectability is achieved while the perceptual quality - based on the structural similarity measure - and the security - based on two steganalysis methods - do not show any significant changes.

• Journal of Fashion Business
• /
• v.20 no.3
• /
• pp.68-88
• /
• 2016

The purpose of this research is to investigate the characteristics of Chinese minority women's waistbands, in view of their lifestyle, costume, and symbolism. The research method combined literature research and case study. In the case study, this research targeted the secondary data of a total of 215 pieces from books, articles and the internet. A total of 5 pieces per each representative women's waistband of 43 minorities, excluding those who did not wear a waistband, we collected. We then quantitatively analyzed the form and decoration of the waistbands. As a result of considering the form, the waistbands of Chinese minorities per region were closely related to the costumes, mainly showing high similarity in respect to color and decoration. Moreover, the decorations of the waistbands were most often made from their own area's special products, such as silver, bronze, cotton, and linen, amongst other. The form and decoration of the Chinese minority women's waistbands were all connected with functionality, aesthetic impression, and symbolism, which can be said to be an important part of understanding Chinese minority costume culture. This research contributes to the development and preservation of Chinese minorities' costume culture by considering and analyzing unique costume factors besides giving excellent fashion design ideas for contemporary fashion.

• Proceedings of the Korean Society for Bioinformatics Conference
• /
• 2005.09a
• /
• pp.249-255
• /
• 2005

Angiotensin-converting enzyme (ACE) is primarily responsible for human hypertension. Current ACE drugs show serious cough and angiodema health problems due to the un-specific activity of the drug to ACE protein. The availability of ACE crystal structure (1UZF) provided the plausible biological orientation of inhibitors to ACE active site (C-domain). Three-dimensional quantitative structure-activity relationship (3D-QSAR) models have been constructed using the comparative molecula. field analysis (CoMFA) and comparative molecular similarity indices analysis (CoMSIA) for a series of 28 ACE inhibitors. Alignment for CoMFA obtained by docking ligands to 1UZF protein using FlexX program showed better statistical model as compared to superposition of corresponding atoms. The statistical parameters indicate reasonable models for both CoMFA (q$^2$ = 0.530, r$^2$ = 0.998) and CoMSIA (q$^2$= 0.518, r$^2$ = 0.990). The 3D-QSAR analyses provide valuable information for the design of ACE inhibitors with potent activity towards C-domain of ACE. The group substitutions involving the phenyl ring and carbon chain at the propionyl and sulfonyl moieties of captopril are essential for specific activity to ACE.

• Proceedings of the Korean Society for Bioinformatics Conference
• /
• 2005.09a
• /
• pp.388-391
• /
• 2005

The Protein Structural and Functional Conservation need a common language for data definition. With the help of common language provided by Protein Ontology the high level of sequence and functional conservation can be extended to all organisms with the likelihood that proteins that carry out core biological processes will again be probable orthologues. The structural and functional conservation in these proteins presents both opportunities and challenges. The main opportunity lies in the possibility of automated transfer of protein data annotations from experimentally traceable model organisms to a less traceable organism based on protein sequence similarity. Such information can be used to improve human health or agriculture. The challenge lies in using a common language to transfer protein data annotations among different species of organisms. First step in achieving this huge challenge is producing a structured, precisely defined common vocabulary using Protein Ontology. The Protein Ontology described in this paper covers the sequence, structure and biological roles of Protein Complexes in any organism.

• Journal of the Korean Society of Costume
• /
• v.61 no.5
• /
• pp.21-33
• /
• 2011

The aim of this study is to identify the formative feature of the Chippendale style of the 18th century and to understand the aesthetic feature of the Chippendale style applied in the modern fashion. This is significant in that new possibilities are proposed in fashion design in more holistic and multifaceted views by comparing and delving into the fashion vis-a-vis other fields in a bigger scope of the formative art. The Chippendale style furniture is a combination of various styles of different eras and regions such as Gothic and Chinese style based on the Rococo style. Today, It is regarded in fashion as a composite design of heterogeneous elements or very curvy decorative design. The Chippendale style of this kind is classified into the Rococo style, Gothic style and Chinese style. Depending on each classification, formative features including curves, asymmetry, decorativeness, geometrical feature, exoticism, compositeness and graceness were derived. In comparative studies, fashion and furniture of the Chippendale style have the similarity in formative features but there were some differences in the expressive method. This study analyzed the formative features of the Chippendale style represented in furniture and the modern fashion based on the Rococo-revival design in the modern fashion starting from 2000.

• The Korean Journal of Emergency Medical Services
• /
• v.7 no.1
• /
• pp.179-198
• /
• 2003

If see disaster administration system of our country, start in terms of is coping by countermeasure after four immediately after disaster occurrence many problems blessing with a sons by tribe and so on of link nature between formation, disaster administration complete charge utensil's absence, disaster charge manpower and budget be indicated and join. If examine improvement way accordingly, is as following ; Necessity of synthetic disaster administration system, Fire fighting formation's independence guarantee, Integration of fire fighting connection similarity business, Disaster administration's permanent establishment complete charge utensil's necessity, Disaster administration midautumn complete charge utensil at a metropolitan autonomous fire fighting system reorganization, Role division of labor between center and local government, Disaster administration professional human strength positivity, Disaster administration information system construction practical use, Equipment and improvement of budget state, Education public information for safety culture consciousness fixing, Internationalization of fire fighting business, globalization propulsion, Structure, member of rescue confrontation system and efficiency. Fire fighting environment is changing greatly, and fire fighting must become center to correspond to do confrontation that do one thing troble when produce disaster.

• The Korean Journal of Ecology
• /
• v.15 no.4
• /
• pp.329-335
• /
• 1992

Bionomics of diplopodes was studid near chongyongchi in the chiri mountains from sept. 1990 to dec. 1991 by surveying 10 sample sites at 12 occasions. During this period 13 species of diplopodes from 11 genera, 8 families, and 6 orders were collected. Species were more diversed under quercus mongolica followed by quercus serrata and pinus densiflora sp. epenerchodus koreanus bifidus, and e. k. koreanus were found in all sample sites and these 6 species have been reported to be distributed throughout south korea. yamasinaium sp., riukiaria semicirculalis, parafontaria koreanus, and sicotanus eurygaster were found only under quercus mongolica community and postulated to be related to diet meanwhile other enviromental factors such as temperature, soil ph, and altitude should be taken into consideration. Species diversity index was higher at altitude 700m followed by at 900m, 1, 000m, 800m, 600m, 500m, 1, 100m, 400m, 300m, and 1, 200m in discending order likely due to the enviromental factors such as climatic and edaphic affects, disturbance by human, and degree of floral diversity. Species similarity index was highest 0.78 between altitude 500m and 600m sample sites could be grouped into 3, namely first 300m, 400m, second 500m, 600m, 700m, 1, 000m, 800m, 900m, and third 1, 100m, 1, 200m.

• Journal of the Korean housing association
• /
• v.5 no.2
• /
• pp.99-108
• /
• 1994

The purpose of this study was to present basic data for better space plan of the apartment housing. It attempted to examine the possession and space usage of furniture and housing goods in three type floor plan. It also studied in relation to socidemographic variables and physical variables. The major findings were as follows :1) Housewife age, educational level, family income, number of family members were affected variables to the possession of housing goods and furniture except furniture possession to housewife age.2) It appeared similarity in the furnishing of housing goods and furniture in case of same floor plan.3) Generally, the space of living room was used often in furnishing of furniture and housing goods. 4) Linear arrangement of sofa set and corner arrangement of Anbang furniture are a tendency to get a effective space for activities in living room.5) The size of floor plan space was the most powerful variable to explain the possession and space usage of housing goods and furniture.6) The scarce of space result in pressing the household living space hard. The storage space should be planned and chosen after consideration of human factors according to the tastes, character of the users, and the space factors according to the composition of unit plan and the size of each living space. In case of the small size plan, particularly, it needed to the Built-in furniture as a effective method.

• Interdisciplinary Bio Central
• /
• v.4 no.4
• /
• pp.11.1-11.8
• /
• 2012

Genes that are indispensable for survival are referred to as essential gene. Due to the momentous significance of these genes for cellular activity they can be selected potentially as drug targets. Here in this study, an essential gene for Streptococcus suis was predicted using coherent statistical analysis and powerful genome comparison computational method. At first the whole genome protein scatter plot was generated and subsequently, on the basis of statistical significance, a reference genome was chosen. The parameters set forth for selecting the reference genome was that the genome of the query (Streptococcus suis) and subject must fall in the same genus and yet they must vary to a good degree. Streptococcus pneumoniae was found to be suitable as the reference genome. A whole genome comparison was performed for the reference (Streptococcus pneumoniae) and the query genome (Streptococcus suis) and 14 conserved proteins from them were subjected to a screen for potential essential gene property. Among those 14 only one essential gene was found to be with impressive similarity score between reference and query. The essential gene encodes for a type of 'Clp protease'. Clp proteases play major roles in degrading misfolded proteins. Results found here should help formulating a drug against Strptococcus suis which is responsible for mild to severe clinical conditions in human. However, like many other computational studies, the study has to be validated furthermore through in vitro assays for concrete proof.