• 제목/요약/키워드: Human Development

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경기 혁신교육지구 사업의 발전방향과 특성화(전문계)고 프로그램적용 방안연구 (A study on applying specialized vocational high schools program and development of Gyeonggi innovative education project)

  • 장은영;유형진
    • 한국실천공학교육학회논문지
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    • 제3권1호
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    • pp.1-8
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    • 2011
  • 본 논문 새로운 경기도 교육청에서 선도하여 시행하고 있는 경기 혁신 교육지구 사업에 관하여 문제점과 발전방향을 고찰하였다. 특히 현재 직면한 특성화고등학교의 여러 가지 문제점을 인식하고 특성화고등학교의 경쟁력을 높이는 방안으로 프로그램의 내용과 수준을 살펴보았으며 교육혁신지구 사업의 장단점을 분석하여 향후 발전방안을 모색하기도 하였다. 선행 연구 분석결과 지원대상과 특성화고의 취업지원이 미치지 못하는 부분이 발생 하였으며 일반계 초 중등학교에 전반에 걸쳐 지원 되므로 특성화고(전문계)에서 필요로 하는 하드웨어 기반보다는 보편적 교육복지로 초등학교, 중학교, 일반고에서 원하는 감성적 소프웨어적인 지원이 보다 많은 것을 알 수 있었다. 이에 특성화고 학부모와 교사 학생에 대한 설문지 조사 분석결과 대체로 만족한 평가를 받았지만 균형적인 지원을 요구하는 교사가 증가하고 교육효과를 의심하는 학생도 있고 일부 학부모는 주민입장에서 교육보다는 지역 발전을 요구하는 경우도 설문조사에 포함되어 아직까지 학부모 교사 학생들이 혼선을 가지고 있었다. 이러한 문제점을 해소하기 위해서는 지역교육공동체 구축을 내실화하고 행 재정지원 에서 교육청과 지자체가 적극적으로 공교육 혁신을 이루기 위한 신뢰와 믿음으로 대규모 시설사업에서 탈피하여 특성화고 학교실정에 맞는 프로그램이 지원이 될 수 있도록 지역혁신교육협의체에 지역특성화고 교사를 포함한 전문가 교사운영위원회를 설치 참석시켜 현장의 요구를 반영시킬 수 있어야 하겠다. 지역의 인적 물적 인프라 활용한 계획으로 초빙강사인력풀 구축 하여 혁신프로그램을 수행하는 교사에게 제공하여 교육의 질을 높이고. 학생의 선택권을 넓혀 우수 타 학교 프로그램에 참여 기회를 주도록 개선방안을 모색하여야 할 것이다.

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Identification of LEF1 as a Susceptibility Locus for Kawasaki Disease in Patients Younger than 6 Months of Age

  • Kim, Hea-Ji;Yun, Sin Weon;Yu, Jeong Jin;Yoon, Kyung Lim;Lee, Kyung-Yil;Kil, Hong-Ryang;Kim, Gi Beom;Han, Myung-Ki;Song, Min Seob;Lee, Hyoung Doo;Ha, Kee Soo;Sohn, Sejung;Ebata, Ryota;Hamada, Hiromichi;Suzuki, Hiroyuki;Kamatani, Yoichiro;Kubo, Michiaki;Ito, Kaoru;Onouchi, Yoshihiro;Hong, Young Mi;Jang, Gi Young;Lee, Jong-Keuk;The Korean Kawasaki Disease Genetics Consortium
    • Genomics & Informatics
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    • 제16권2호
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    • pp.36-41
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    • 2018
  • Kawasaki disease (KD) is an acute febrile vasculitis predominately affecting infants and children. The dominant incidence age of KD is from 6 months to 5 years of age, and the incidence is unusual in those younger than 6 months and older than 5 years of age. We tried to identify genetic variants specifically associated with KD in patients younger than 6 months or older than 5 years of age. We performed an age-stratified genome-wide association study using the Illumina HumanOmni1-Quad BeadChip data (296 cases vs. 1,000 controls) and a replication study (1,360 cases vs. 3,553 controls) in the Korean population. Among 26 candidate single nucleotide polymorphisms (SNPs) tested in replication study, only a rare nonsynonymous SNP (rs4365796: c.1106C>T, p.Thr369Met) in the lymphoid enhancer binding factor 1 (LEF1) gene was very significantly associated with KD in patients younger than 6 months of age (odds ratio [OR], 3.07; $p_{combined}=1.10{\times}10^{-5}$), whereas no association of the same SNP was observed in any other age group of KD patients. The same SNP (rs4365796) in the LEF1 gene showed the same direction of risk effect in Japanese KD patients younger than 6 months of age, although the effect was not statistically significant (OR, 1.42; p = 0.397). This result indicates that the LEF1 gene may play an important role as a susceptibility gene specifically affecting KD patients younger than 6 months of age.

청소년대상 인쇄매체 성교육자료분석 (A Study on the Analysis of Sexual Health Education for Korean Adolescents)

  • 양순옥;임미림
    • 한국보건간호학회지
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    • 제12권2호
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    • pp.27-47
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    • 1998
  • The Purpose of this study is to offer basic data when the new printed media for sex education are developed, by grasping the problem through analyzing the data of the printed media for sex education that are produced by the government and composed of relatively inclusive contents. The subjects of analyzed data were 10 printed media books connected with sex education. This study focused on analysis for the printed media. therefore the method of analysis used effectively for the study of the mass media was used. The SAS program was used for analyzing the frequency of data and processing with percentage. The result of this study is as follows. 1. The subject of sex education that the printed media intend for was classfied the data for students and for teachers and the general. 2. According to the result of analyzing the writers of the printed media for sex education, classified by occupation, research workers accounted for $30.2\%$ as 23 persons, and the rest were distributed as 19 professors $(25\%)$, 13 teachers $(17.2\%)$, 10 workers in related institutions of various kinds $(13.1\%)$, 6 doctors $(10.6\%)$ and 3 writers $(3.9\%)$. Examing the organization of writers of the printed media for sex education for students, it was composed of sequence as research workers $30.5\%$. workers in related institutions of various kinds $19.6\%$, teachers $19.5\%$, professors $13\%$, doctors $10.8\%$ and writers $6.5\%$. And that of writers of the printed media for sex education for teachers and the general was shown as professors $43.2\%$ (13 persons), research workers $30.1\%$ (9 persons), teachers $13.2\%$ (4 persons) and doctors $10.2\%$ (3 persons). 3. Seeing the result of analyzing for the printed media, classified by themes, it was shown as 314.1 pages $(28.5\%)$ in a field of development of men, 195.9 pages $(17.6\%)$ in a field of sex-health, 141.7 pages $(12.9\%)$ in a field of relationship. 74.1 pages $(6.7\%)$ in a field of a sex act. 51.7 pages $(4.6\%)$ in a field of a personnal technology and 313.4 pages $(28.4\%)$ in the others. As are suit of the analysis classified by themes about the printed media for sex education for students, it was distributed as the content about sexual abuse $12.3\%$ (60.2 pages), the anatomical physiology of reproduction $12.1\%$ (59.3 pages). a friendship $8.5\%$ (41.6 pages). the reproduction $7.2\%$ (35.5 pages). a sexual disease $6.8\%$ (33.2 pages) and the puberty $4.3\%$ (20.9 pages). Examing the result of the analysis about contents classified by themes of the printed media for sex education for teachers and the general. it was indicated as 67.1 pages $(10.9\%)$ on the 'puberty', 37.9 pages $(6.2\%)$ on the anatomical physiology of reproduction, 36.6 pages ($6.0\%$ on a sexual disease, 23.2 pages $(3.8\%)$ on dating, 21.7 pages $(3.5\%)$ on a human sexual reaction. 21.0 pages $(3.4\%)$ on a sexual role. 20.1 pages $(3.3\%)$ of the reproduction. The suggestion according to the upper result is as follows. 1. It is needed to expand the range of analysis into the data. besides the printed media. into the data for sex education using such media as a video. a slide, a CD-ROM, on internet, etc. 2. It is necessary to develop the ideal program for sex education of teenagers and analyze the effect. on the basis of analyzing data about data sex education. 3. It is needed that practice workers for nursing or teachers for nursing as well as workers in educational field or medical experts participate in producing data for sex education.

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최근국제항공보안대책(最近國際航空保安対策)의 제간제(諸間題) -특히 법적측면(法的測面)을 중심(中心)으로- (Some New Problems of International Aviation Security- Considerations Forcused on its Legal Aspects)

  • 최완식
    • 항공우주정책ㆍ법학회지
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    • 제5권
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    • pp.53-75
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    • 1993
  • This article is concerned with the comment on "Some New Problems of International Aviation Security-Considerations Forcused on its Legal Aspects". Ever since 1970, in addition to the problem of failure to accept the Tokyo, Hague and Montreal Conventions, there has been also the problem of parties to them, failing to comply with their obligations under the respective treaties, in the form especially of nominal penalties or the lack of any effort to prosecute after blank refusals to extradite. There have also been cases of prolonged detention of aircraft, passengers and hostages. In this regard, all three conventions contain identical clauses which submit disputes between two or more contracting States concerning the interpretation or application of the respective conventions to arbitration or failing agreement on the organization of the arbitration, to the International Court of Justice. To the extent to which contracting States have not contracted out of this undertaking, as I fear they are expressly allowed to do, this promision can be used by contracting States to ensure compliance. But to date, this avenue does not appear to have been used. From this point of view, it may be worth mentioning that there appears to be an alarming trend towards the view that the defeat of terrorism is such an overriding imperative that all means of doing so become, in international law, automatically lawful. In addition, in as far as aviation security is concerned, as in fact it has long been suggested, what is required is the "application of the strictest security measures by all concerned."In this regard, mention should be made of Annex 17 to the Chicago Convention on Security-Safeguarding International Civil Aviation against Acts of Unlawful Intereference. ICAO has, moreover, compiled, for restricted distribution, a Security Manual for Safeguarding Civil Aviation Against Acts of Unlawful Interference, which is highly useful. In this regard, it may well be argued that, unless States members of ICAO notify the ICAO Council of their inability to comply with opecific standards in Annex 17 or any of the related Annexes in accordance with Article 38 of the 1944 Chicago Convention on International Civil Aviation, their failure to do so can involve State responsibility and, if damage were to insure, their liability. The same applies to breaches of any other treaty obligation. I hope to demonstrate that although modes of international violence may change, their underlying characteristics remain broadly similar, necessitating not simply the adoption of an adequate body of domestic legislation, firm in its content and fairly administered, but also an international network of communication, of cooperation and of coordination of policies. Afurther legal instrument is now being developed by the Legal Committee of ICAO with respect to unlawful acts at International airports. These instruments, however, are not very effective, because of the absence of universal acceptance and the deficiency I have already pointed out. Therefore, States, airports and international airlines have to concentrate on prevention. If the development of policies is important at the international level, it is equally important in the domestic setting. For example, the recent experiences of France have prompted many changes in the State's legislation and in its policies towards terrorism, with higher penalties for terrorist offences and incentives which encourage accused terrorists to pass informations to the authorities. And our government has to tighten furthermore security measures. Particularly, in the case an unarmed hijacker who boards having no instrument in his possession with which to promote the hoax, a plaintiff-passenger would be hard-pressed to show that the airline was negligent in screening the hijacker prior to boarding. In light of the airline's duty to exercise a high degree of care to provide for the safety of all the passengers on board, an acquiescence to a hijacker's demands on the part of the air carrier could constitute a breach of duty only when it is clearly shown that the carrier's employees knew or plainly should have known that the hijacker was unarmed. The general opinion is that the legal oystem could be sufficient, provided that the political will is there to use and apply it effectively. All agreed that the main responsibility for security has to be borne by the governments. A state that supports aviation terrorism is responsible for violation of International Aviation Law. Generally speaking, terrorism is a violation of international law. It violates the sovereign rights of states, and the human rights of the individuals. We have to contribute more to the creation of a general consensus amongst all states about the need to combat the threat of aviation terrorism. I think that aviation terrorism as becoming an ever more serious issue, has to be solved by internationally agreed and closely co - ordinated measures.

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역사소재 기반 디지털게임의 발전과정 및 기획요소 연구 - 동.서양 5개국의 역사소재 게임을 중심으로 (Development of Digital Games Based on Historical Material and its Design Components - With History Based Games of 5 Countries)

  • 문만기;김태용
    • 방송공학회논문지
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    • 제12권5호
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    • pp.460-479
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    • 2007
  • 문화가 산업의 영역으로 들어온 이후 세계 각국에서는 자국의 문화콘텐츠를 다양한 매체를 통하여 교육적 또는 상업적 목적으로 활용하기 위한 노력을 해 왔으며, 다양한 문화 및 역사가 이 분야의 주요 배경 및 소재로 인식되면서 역사학 등을 전공하는 많은 학자들의 역할도 증가되고 있는 추세이다. 그 중 에서도 특히 게임분야는 관객이 직접 참여하여 스토리텔링을 완성해 간다는 인터페이스 특성상 문화전파와 학습효과가 매우 높은 매체로 인식되고 있다. 이러한 측면에서 인간의 단순한 놀이로 인식되고 있는 디지털게임에서 현재 세계 각국이 제작하여 전 세계에 전파하는 역사게임의 소재 및 세계관등을 비교 분석하는 것은 매우 중요한 일이다. 본 논문은 1980년부터 2005년까지 한국에서 서비스된 약 70여 편의 역사소재게임 중 대표적 제작 및 보급 국가인 한국, 미국, 일본, 대만, 독일, 총 5개국의 역사소재 게임 68편을 무작위로 선정하여 각국이 제작한 게임의 배경시대 및 기획의도 등을 분석하고 역사원형이 게임 시나리오 및 세계관, 배경으로 등장하는 사례를 비교하여 각국이 선호하는 시대와 장르 및 문제점을 도출하여 향후 우리의 발전적인 역사소재게임의 기회방안을 제시하였다. 역사게임에 적용된 세계관 및 등장인물 분석에서는 각국의 역사게임에 적용된 실존인물, 실제역사 및 역사소설로 나누어 비교하였으며, 그 결과 총68편 중 실존인물을 게임에 적용한 사례는 총 8편으로 전체의 11.8%에 해당하였다. 또한, 과거의 실제 역사 및 배경을 게임의 소재로 적용한 사례는 37편으로 전체의 54.4%를 차지한 것으로 조사되었다. 각국이 선호하는 역사게임의 주 소재는 인물보다는 실제의 배경이 주무대가 된다는 것을 알 수 있었으며, 한국은 고대 고구려를 중심으로 한 삼국시대, 미국은 1,2차 세계대전, 독립전쟁, 일본은 중세 일본 전국시대, 독일은 고대 유럽역사 등 각 국이 선호하는 역사적 배경은 그 나라가 역사적으로 자랑스럽게 생각하는 역사적 시점이 역사게임의 주 배경이 된다는 결과를 얻었다 게임의 주 배경이 되는 시대로서는 고대가 37편으로 54.4%를 차지하여 각국에서 제일 선호되는 시대로 조사되었으며 그 다음은 근 현대가 18편으로 26.47%, 중세 7편 10.3%, 선사시대 5편 7.35%, 상고시대가 1편으로 1.47%로 나타나 고대 중세, 근 현대 순으로 선호하는 것으로 나타났다.

판교테크노벨리의 지속가능한 혁신 클러스터 영향요인에 관한 통합연구 (Integrated Study on the Factors Influencing Sustainable Innovation Cluster of Pangyo Techno Valley)

  • 박정선;박상혁;홍성신
    • 벤처창업연구
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    • 제15권1호
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    • pp.71-94
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    • 2020
  • 우리나라의 혁신클러스터 정책은 지역균형발전을 목표로 2005년부터 본격적으로 추진되었다. 본 연구는 판교테크노밸리를 사례로 혁신클러스터 입주기업의 지속가능성에 영향을 미치는 요인을 조사하는 것을 목적으로 한다. 판교테크노밸리는 중앙정부 보다는 지자체(경기도)의 주도하에 건립되었고 '한국의 실리콘밸리', '아시아 실리콘밸리' 등으로 불리며 대표성이 커지고 있다. 성장하고 있는 판교테크노밸리는 2016년 대비 2017년에 입주기업 수가 감소하는 현상이 발생하였고, 2019년을 기점으로 판교테크노밸리의 비즈니스 생태계가 변할 수 있는 이슈(기업의 입지 이전 가능 이슈)가 발생하기 때문이다. 본 논문에서는 영향 요인을 조사하기 위해 양적 및 질적 연구를 통합하여 진행하였다. 설문조사를 기반으로 양적연구를 진행하고 인터뷰를 통한 질적 연구를 적용하였다. 양적 연구에서는 판교테크노밸리의 지속가능성에 영향을 주는 요인을 조사하였고, 질적 연구에서는 양적 연구결과에 대한 구체적인 이유와 추가적인 요인을 조사하였다. 양적 연구결과 기업내부여건변화, 인적·물적 인프라, 협력 및 시너지, 입주 형태 범주에서 지속가능성에 대한 영향력을 발휘하는 요인들이 나타났다. 영향력에 대한 구체적 이유는 질적 연구과정에선 나타났다. 지자체의 지원 범주는 양적 연구에서 의미있는 요인이 나타나지 않았다. 추가적으로 질적 연구를 통해 지속가능성에 영향을 가장 크게 발휘하는 범주로 '판교테크노밸리의 좋은 이미지'가 제시되었다. 판교테크노밸리 내 협력네트워크 활성화에 대해서는 기업들이 수동적인 자세를 취하고 있으며 지자체의 역할을 기대하고 있는 것으로 나타났다. 따라서 본 논문에서는 판교테크노밸리가 지속가능하기 위한 방안으로 현실적인 방안과 이상적인 방안을 함께 제시하였다.

1920년대 소비에트 구성주의 패션에 관한 연구 (A Study on Soviet Constructive Fashion in 1920s)

  • 조윤경;금기숙
    • 복식
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    • 제36권
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    • pp.183-203
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    • 1998
  • The wave of Avant-garde swept away all in the unique social background so called 'October Revolution' and the early 1900 Russian society which was able to absorb and accept anything. The Russian avant-garde has been affected by the Cubism and the Futurism those had peculiarly appeared in the early twentieth century, spreaded out to three spheres: the Suprematism, the Rayonism and the Constructivism. The Russian Constructivism has appeared in this background, concretely and ideally ex-pressed the ideology of the revolution into the artistic form and made an huge influence to the whole Russian society. The Constructivist like Tatlin, naum Gabo, Pevaner, Rodchenko, Stepanova, Popova and Exter gave great effect on the Soviet Constructive fashion design in 1920's after the Revolution. The Soviet costume in 1920s hold in common the characteristicss of the Constructive graphic as it is, geometrical and abstractive form, energetic and motility. In fashion design, these graphic qualities have been showed as the application of geometrical form and architectural image, physical distortion and transformation. And in textile design, the simple, dynamical presentation has been appeared. We can classify the Soviet costume at this time into three occasions. The first term is from late 1910 th mid 1920, and it is altered from folk costume design to modern one. With Lamanova as the first on the list, using the folk mitif, the Constructive expression of simple form has been gradually revealed in design. Designers like Makarova, Pribylskaia and Mukhina produced the plane, simple chemise style with the decoration of the Russian traditional motif. From early to late 1920 is the second term, and it is at the pick of the most active processing of the Constructive design. Not only at the costume in daily life but also at the theatrical costume and textile, the con-structive design has been represented all avail-able fields. Many Constructivists including Stepanova, Popova, Exter and Rodchenko took part in the textile design and costume design so as to evlvo their aesthetic concept. The third term is from late 1920 to early 1930. The socialistic realism has dominated over the whole culture and art, the revolutionary dynamic motif has been presented also in textile design. The formative features of Soviet Constructive fashion design are; silhouette, from, motif, color and fabric. The first, the silhouette : a straight rectangular silhouetted has been expressed through the whole period and a volumed one with distorted human body shape has introduced in the theatrical costume design. The second, the form: many lengthened rectangular forms have been made at beginnings, but to the middle period, geometrical, architectural forms have been more showed and there are energy and movement in design. At the last period, only a partial feature-division has been seen. The third, the motif; no pattern or ethnic motif has been partly used at beginnings, a figure like circle, tri-angle has gradually appeared in textile design. At latter period, a real-existent motif like an airplane has been represented with graphing and simplicity. The fourth, the color ; because of insufficient dyeing, neutral color like black or grey color has been mainly covered, but after middle term, a primary color or pastel tone has been seen, contrast of the fabric; without much development of textile industry after the Revolution, thick and durable fabrics have been the main stream, but as time had going to the last period, fabrics such as linen, cotton, velvet and silk have been varously choesn. At the theatrical costume, new materials like plastics and metals that were able to accentuate the form. The pursuit of popularity, simplicity and functionalism that the basic concept of Constructive fashion is one of the "beauty" which has been searching in modern fashion. And now we can appreciate how innovative and epochal this Soviet Constructive fashion movement was.ement was.

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세신 추출물의 Streptococcus mutans에 대한 성장, 산생성, 부착 및 비수용성 글루칸 합성억제에 미치는 영향 (Effect of Asarum sieboldii Extracts on the Growth, Acid Production, Adhesion, and Insoluble Glucan Synthesis of Streptococcus mutans)

  • 유현희;서세정;김연환;이흥수;김강주;전병훈;유용욱
    • 동의생리병리학회지
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    • 제17권3호
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    • pp.666-671
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    • 2003
  • 치아우식 예방제를 개발하기 위해 천연물인 세신을 메탄올, 물로 추출하여 S. mutans의 성장과 산 생성 억제, S-HA에 부착 억제, 비수용성 글루칸 합성 효과를 측정하고 다음과 같은 결과를 얻었다. S. mutans의 성장억제율이 세신 추출물은 넣지 않은 대조군에 비해 10, 100, 1,000, 2,000 μg/ml 농도에서 메탄올 추출물은 각각 9%, 14%, 34%, 53%, 물추출물은 4%, 8%, 17%, 21%를 나타내어, 100 μg/ml이상 농도에서 S. mutans의 성장억제 효과가 유의적으로 있었고(p<0.01), S. mutans의 산 생성량은 대조군에 pH는 3.76, 메탄올 추출물은 10, 100, 1,000, 2,000 μg/ml 농도에서 각각 3.91, 4.21, 4.74, 5.36, 물 추출물은 3.75, 3.97, 4.66, 5.15를 나타내어, 100μg/ml 이상 농도에서 S. mutans의 산 생성억제 효과가 유의적으로 있었다(p<0.05). 또 S-HA에 S. mutans 부착 억제율이 대조군에 비해 메탄올 추출물은 10, 100, 1,000, 2,000 μg/ml 농도에서 각각 56%, 61%, 63%, 96%, 물 추출물은 51%, 74%, 81%, 98%로 부착억제 효과가 유의적으로 있었으며(p<0.05), 10μg/ml 농도에서도 50% 이상의 S. mutans의 hydroxyapatite bead 부착억제 효과가 있었고, GTFase에 의한 비수용성 글루칸 정량 실험을 한 결과 대조군에 비해 메탄올 추출물은 10, 100, 1,000, 2,000 g/ml 농도에서 각각 4%, 18%, 75%, 99%, 물 추출물은 8%, 32%, 73%, 99%의 합성억제 효과가 있었고(p<0.05), 2,000 μg/ml 농도에서는 비수용성 글루칸 합성이 거의 이루어지지 않는 것으로 나타났다. 이상의 결과를 토대로 하여 볼 때, 세신은 S. mutans의 살균 작용과 유기산의 생성 억제 보다는, S. mutans의 치아표면에의 부착과 비수용성 글루칸 합성 억제에 관여하여, 항치아우식 효과를 기대할 수 있을 것으로 보인다.

Genome-Wide Analysis of DNA Methylation before- and after Exercise in the Thoroughbred Horse with MeDIP-Seq

  • Gim, Jeong-An;Hong, Chang Pyo;Kim, Dae-Soo;Moon, Jae-Woo;Choi, Yuri;Eo, Jungwoo;Kwon, Yun-Jeong;Lee, Ja-Rang;Jung, Yi-Deun;Bae, Jin-Han;Choi, Bong-Hwan;Ko, Junsu;Song, Sanghoon;Ahn, Kung;Ha, Hong-Seok;Yang, Young Mok;Lee, Hak-Kyo;Park, Kyung-Do;Do, Kyoung-Tag;Han, Kyudong;Yi, Joo Mi;Cha, Hee-Jae;Ayarpadikannan, Selvam;Cho, Byung-Wook;Bhak, Jong;Kim, Heui-Soo
    • Molecules and Cells
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    • 제38권3호
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    • pp.210-220
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    • 2015
  • Athletic performance is an important criteria used for the selection of superior horses. However, little is known about exercise-related epigenetic processes in the horse. DNA methylation is a key mechanism for regulating gene expression in response to environmental changes. We carried out comparative genomic analysis of genome-wide DNA methylation profiles in the blood samples of two different thoroughbred horses before and after exercise by methylated-DNA immunoprecipitation sequencing (MeDIP-Seq). Differentially methylated regions (DMRs) in the pre-and post-exercise blood samples of superior and inferior horses were identified. Exercise altered the methylation patterns. After 30 min of exercise, 596 genes were hypomethy-lated and 715 genes were hypermethylated in the superior horse, whereas in the inferior horse, 868 genes were hypomethylated and 794 genes were hypermethylated. These genes were analyzed based on gene ontology (GO) annotations and the exercise-related pathway patterns in the two horses were compared. After exercise, gene regions related to cell division and adhesion were hypermethylated in the superior horse, whereas regions related to cell signaling and transport were hypermethylated in the inferior horse. Analysis of the distribution of methylated CpG islands confirmed the hypomethylation in the gene-body methylation regions after exercise. The methylation patterns of transposable elements also changed after exercise. Long interspersed nuclear elements (LINEs) showed abundance of DMRs. Collectively, our results serve as a basis to study exercise-based reprogramming of epigenetic traits.

우리나라 독일광부(獨逸鑛夫) 지원자(志願者)에 대(對)한 건강상태(健康狀態)에 관(關)한 조사연구(調査硏究) (A Study on Health Status of the 1,559 Korean Applicants Applying for the Coal Miners in West Germany during the Year of 1972 and 1973)

  • 전현숙;최삼섭
    • Journal of Preventive Medicine and Public Health
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    • 제7권2호
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    • pp.383-393
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    • 1974
  • The importance of the health care for the miners not only concerns the productivity of the enterprises but also as a fundamental human right, it has to be secured and protected by the society and the government. The Korean coal miners began to find their works at overseas since 1963 when the Korean government selected and dispatched its miners to West Germany. As years go by, the demand and the supply of the coal miners, the program of the coal miners health care became the important tasks to be solved and the further studies and research were necessary to support these tasks achievement. The writers made a statistical analysis on health status of the 1,559 Korean applicants applying for the coal miners in West Germany during the year of 1972 and 1973 by the using of the data of physical examination which were directed by the Korea Overseas Development Cooperation. The standard of physical examination which was applied for coal miners applying the jobs in West Germany was authorized by the Government Office of Labor in 1967. The results are as following; 1. The applicants were from the various provinces throughout Korea; Gang Weon 50.2%, Jeon-Nam 16.8%, Chung-Nam 13.7%, Gyeong-Nam 10.5%, City of Seoul 5.4%, and others 3.7%. 2. The ages of the applicants were from 20 to 44. The age group of 25-29(36.3%) and of 30-34(55.2%) together occupied the 91.5 per cent of the total applicants. 3. Among the 1,559 applicants 52.1 per cent passed the physical examinations. The tendency were shown that as the age increased, the passing rate decreased, and the married applicnts had lower passing rates compared to the unmarried applicants. 4. The height of the applicants averaged $168.4{\pm}4.74(cm)$ and the weight averaged $61.3{\pm}5.65(kg)$. 5. The average vision of the left eye of the applicants was $0.92{\pm}0.23$ and the right eye was $0.91{\pm}0.30$. 6. The mean value of the systolic blood pressure of the applicants was $145{\pm}13(mmHg)$ and the diastolic blood pressure was $85{\pm}8(mmHg)$. 7. Fifteen hundred and fifty-nine applicants were taken chest X-ray and 17.2 per cent were found abonrmal. For each 1,000 applicants, 46 Pulmonary calcification and fibrosis, 45 chronic bronchitis, 27 pleural thickening and adhesion, 20 pulmonary tuburculosis, 11 anomalies of the rib, 10 pulmonary infiltration and 21 others diseases were found. 8. Lumber X-ray examination showed that 23.9 per cent (372 applicants) were found abnormal. For each 1,000 applicants, 77 osteoarthritis, 56 lumbarization, 15 fracture of vertebrae, 15 spondyloarthritis, 14 deformity of vertebrae, 13 spina bifida, 12 sacralization, 12 spondylolysis, and 5 others diseases were found. 9. In total, 47.9 per cent of 1,559 applicants failed the physical examinations, and the main causes for the failure were shown to be 7.1% of anomalies of spine, 6.3% of osteoarthritis, 4.7% of pulmonary calcification and fibrosis, 4.6% of chronic brochitis, 3.6% of hypertension (only), 3.4% of fracture of vertebrae. 3.1% of underweight(under 57.0kg), 2.0% of spondyloarthritis, 2.0% oe pulmonary tuberculosis, 1.7% of pleurisy, 1.0% of spina bifida, 1.5% of syphilis, 1.5% of color blindess, and 1.0% of underheight(under 160.0cm).

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