• Journal of Pharmaceutical Investigation
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• 제30권2호
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• pp.139-143
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• 2000

Gene therapy is becoming a very promising and feasible medical intervention as the understanding of human diseases extends to their molecular levels. Since the first US Food and Drug Administration (FDA)-approved human gene therapy protocol was approved in 1990, over 300 human clinical trial protocols had been approved worldwide so far. Even though some of the domestic gene therapy clinical trials also proved promising and more are awaiting, it should be emphasized that many safety aspects as well as effectiveness aspects should be considered during the development process. Moreover, there seems to be less restricted guidelines from the National Control Authority (NCA) in initiating human clinical trials. This article is intended to suggest some basis and points to consider in the development and evaluation of gene therapy products including antisense oligonucleotides pharmaceuticals.

• 경영정보학연구
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• 제10권3호
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• pp.65-87
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• 2008

지식경영은 조직의 지식 역량을 강화시킴으로써 궁극적으로 조직 경쟁력을 향상시키고자 하는 혁신 패러다임이다. 지식경영을 도입한 조직들은 조직의 지식 역량을 강화시키는 과정에서 나름대로 많은 어려움 들을 겪고 있으며 그 해결 방안을 찾기 위해 많은 노력을 기울이고 있다. 이러한 문제를 효과적으로 해결하기 위한 하나의 접근방법으로 지식경영과 인적자원개발 간의 연계를 고려할 수 있다. 본 연구에서는 지식경 영을 인적자원개발의 주요 영역인 역량 개발 및 경력 개발과 연계하여 운영한 두 개의 사례들을 소개하고, 이 사례들이 포함하고 있는 중요한 원리들을 보다 구조화된 형태로 정립한 모델을 제시하였다. 이 모델은 지식경영과 조직 구성원들의 역량 개발간의 시너지 효과가 창출되는 메커니즘을 제공하는 데 초점을 맞추고 있다. 본 연구의 사례와 모델은 조직의 역량 강화와 지식경영성과 향상에 유용하게 활용될 수 있을 것으로 기대된다.

• Journal of Applied Biological Chemistry
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• 제63권1호
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• pp.103-110
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• 2020

Objective: The objective of our study was to investigate anti-cancer effects of Danggui Liuhuang Decoction extract bioconverted by protease liquid coenzyme of Aspergillus kawachii (DLD-BE), compared to a non-bioconverted DLD extract (DLD-E) and determine the underlying mechanisms. Methods: DLD-E and DLD-BE were evaluated for their ability to modulate these signaling pathways and suppress the proliferation of human colorectal cancer (CRC) cells, HCT-116, LoVo, and HT-29. The anti-cancer effects of DLD-E and DLD-BE were measured by using proliferation and migration assays, cell cycle analysis, Western blots, and real-time PCR. Results: In this study, treatment with DLD-E and DLD-BE at concentrations of 25-100 ㎍/mL inhibited proliferation and migration in human CRC cells. DLD-BE induced apoptotic cell death and decreased COX-2 expression in HT-29 cells. The mechanisms of action included modulation of the AKT and extracellular-signal-regulated kinase signaling cascades along with inhibition of COX-2 expression. The results demonstrate novel anti-cancer mechanisms of DLD-BE against the growth of human CRC cells. Thus, we propose that DLD-BE can be developed as a more potent supplement to inhibit colorectal tumor growth and intestinal inflammation than DLD-E.

• Clinical and Experimental Reproductive Medicine
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• 제23권1호
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• pp.95-102
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• 1996

This study was performed to investigate the effect of human follicular fluid (HFF) on development of mouse embryos, for evaluating the suitability of HFF as a substitutive material of human fetal cord serum in ART program. The various concentrations of HFF were added into the culture medium and the effects of HFF concentrations were examined to identify the optimal concentration of HFF for embryo development. The potency of HFF in improving embryo development was compared to that of other protein supplement. Collected HFFs were classified with the maturity of the containing oocytes; mature, immature, atretic, and then the effects of the classified HFFs on embryo development were examined. Also, HFF was separated into the low (<30,000 Da) and high (>30,000 Da) molecular weight fractions and the effects of the fractions on embryo development were investigated. The highest development rate was found in culture medium supplemented with 20% HFF, bnt this rate was reversely reduced at the concentrations of HFF higher than 20%. The development rates to the blastocyst, hatching blastocyst, attachment and outgrowth cultured in mature HFF was significantly higher than those in immature and atretic HFF, and mean cell number in blastocyst was higher in mature HFF than in immature and atretic HFF. The development rates of mouse embryos according to protein sources were significantly higher in HFF than in fetal cord serum (FCS), maternal serum (MS) and bovine serum albumin (BSA), and mean cell number in blastocyst cultured in HFF was higher than that in FCS, MS and BSA. The development rates of embryo and mean cell number in blastocyst cultured in high molecular weight fraction of HFF were higher than those in low molecular weight fraction, but the results of high molecular weight fraction were lower than those of whole HFF. Therefore, these results indicated that human mature follicular fluid was useful for improving the development of mouse embryos, which suggests a possibility that HFF also may be used efficiently for improving the culture condition in human ART program as a protein supplement.

• 한국컴퓨터정보학회논문지
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• 제29권7호
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• pp.221-229
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• 2024

경제발전 수준이 높아짐에 따라 인적자본에 대한 관심은 더욱 높아지고 있다. 본 연구는 중국의 31개 지역을 대상으로 2002-2019년 기간 지역별 혁신적 인적자본을 추계 비교하고 있다. 본 연구의 혁신적 인적자본은 학력형 인적자본, 논문형 인적자본 그리고 특허형 인적자본으로 구성된다. 특히 본 연구는 기존 연구와 달리 특허형 인적자본과 논문형 인적자본의 가중치를 학력형 인적자본보다 높게 가정하고 있다. 왜냐하면 단순한 학력보다는 특허와 논문이 지역의 혁신역량에 상대적으로 더욱 큰 영향을 초래할 것이기 때문이다. 본 논문의 분석결과는 세 가지로 요약할 수 있다. 첫째, 중국의 지역별 혁신적 인적자본이 지역별 격차를 나타내고 있다. 지역경제발전 수준이 높은 지역일수록 혁신적 인적자본의 수준도 높다. 둘째, 지역별 혁신적 인적자본이 동태적으로 변하고 있다. 셋째, 북경시, 상해시, 광동성, 강소성을 중심으로 지역별 집중 현상이 더욱 가속화되고 있다. 따라서 본 연구결과는 지역경제발전에서 혁신적 인적자본의 역할이 중요함을 강조하고 있다.

• International Journal of Stem Cells
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• 제16권1호
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• pp.16-26
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• 2023

Despite long-term research achievements, the development of cell therapy (CT) products remains challenging. This is because the risks experienced by the subject and therapeutic effects in the clinical trial stage are unclear due to the various uncertainties of CT when administered to humans. Nevertheless, as autologous cell products for systemic administration have recently been approved for marketing, CT product development is accelerating, particularly in the field of unmet medical needs. The human experience of CT remains insufficient compared with other classes of pharmaceuticals, while there are countless products for clinical development. Therefore, for many sponsors, understanding the rationale of human application of an investigational product based on the consensus and improving the ability to apply it appropriately for CT are necessary. Thus, defining the level of evidence for safety and efficacy fundamentally required for initiating the clinical development and preparing it using a reliable method for CT. Furthermore, the expertise should be strengthened in the design of the first-in-human trial, such as the starting dose and dose-escalation plan, based on a sufficiently acceptable rationale. Cultivating development professionals with these skills will increase the opportunity for more candidates to enter the clinical development phase.

• 직업교육연구
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• 제29권3호
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• pp.157-185
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• 2010

이 연구의 목적은 조직의 성과 향상과 개인의 성장을 추구하는 인재개발에서 사이버 기반의 교육 프로그램에 대한 개선과 계속성 여부 등 의사결정에 관련한 유용한 가치 판단을 위하여 필요한 정보를 획득, 기술, 제공하는 과정에서 활용할 수 있는 과정중심 평가준거를 개발하는 데 있었다. 이 연구의 결론은 다음과 같다. 첫째, 문헌고찰 등 이론적 탐색과 내용분석법 적용을 통하여 인재개발 사이버 교육 프로그램의 과정중심 평가준거를 4개 차원, 13개 대영역, 29개 하위영역, 125개 평가문항으로 도출하였다. 둘째, 도출한 평가준거에 대하여 세 차례의 델파이 조사를 통하여 4개 차원, 13개 대영역, 29개 하위영역, 93개 평가문항을 최종 개발하였다. 셋째, 개발된 평가준거의 내용타당도 비율(CVR)은 .31~1.00으로 나타났으며 합의도는 .75이상, 수렴도는 .5이하로 나타나 개발한 평가문항이 타당한 것으로 확인하였다. 이러한 평가문항의 신뢰도 Cronbach's ${\alpha}$는 .980으로 나타나 내적일치도가 만족스러우며 신뢰도는 높은 것으로 나타났다.

• 동남아시아연구
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• 제19권2호
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• pp.173-218
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• 2009

Bring this analysis down to people-centered development perspective and looking through democratization in the Philippines, Thailand and Indonesia, we find similarities and differences among them related with the intensity of conflicts between development and human rights in the process of democratization in line with global transformation. Civil society in the Philippines criticized the developmental path in the Philippines which failed to implement land reform and eradication of poverty under the transition from 'patrimonial oligarchy' to democracy. In Thailand the coalition of military and the royalists had consolidated its power since Sarit military regime, which later paved the way 'hybrid oligarchy' era. Most Thai civil society organizations has regarded their developmental experience rather as 'maldevelopment' which disregarded economic and social rights. It has been especially believed by Thai localists that the stimulation of local markets and the building of autonomic community society will form the alternative economy without going against the conservative banner of nation, religion and king. Thaksin as a populist successfully took advantage of Thai localist ethos in favour of taking the seat of power. He projected himself as a modernizer focused on economic growth and cleaner politics. However Thaksin's procedural legitimacy was overthrown by counterattacking from military-royalist alliance, pretexting that Thaksin caused internal conflicts and lacked morality. Soeharto's New Order regime which can be called 'administrative oligarchy' had an antipathy towards notions of economic and social rights as well as civil and political rights. In spite of the fact that the fall of Soeharto opened the political space for democratic civil society organizations which had long struggled with development aggression and human rights abuses, there have been continuously a strong political and military reaction against human rights activists, NGOs and ethnic minorities such as Aceh and Papua. Nevertheless, Indonesian democracy is more promising than Philippine's and Thai democracy in terms of comparatively less pre-modern legacies.

• 한국생활과학회지
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• 제9권4호
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• pp.405-419
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• 2000

The purpose of this study was to develop a Korean infant-toddler developmental scale and to examine the demographic variables and infant-toddler development. The subjects were 167 mothers who have infant and toddler from 1 to 36 months of age in Seoul, Daejeon, Chungju, Yeasan, and llsan in Korea. The subscales consisted of language development, social and emotional development, physical development, and cognitive development. The significant variables which are influenced the infant-toddler development were age of infant-toddler and age of father.

• 제어로봇시스템학회:학술대회논문집
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• 제어로봇시스템학회 2003년도 ICCAS
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• pp.2022-2026
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• 2003

We define that the end effector is the device which interact environment or objects with contact to execute tasks. Up to now, many researchers developed anthropomorphic robotic hands as end effectors. In this paper, we will discuss a problem on the development of a human-scale and motor-driven anthropomorphic robot hand. In this paper, design concept, actuator and transmission, kinematic design and sensing device are presented. By imitating the physiology of human hands, we devised new metacarpalphalangeal joint and interphalangeal joint suitable for human-size robot hands