• 해양환경안전학회지
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• 제12권1호
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• pp.39-45
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• 2006

항공기와 자동차의 운전을 중심으로 알코올이 인간의 행동과 수행도에 미치는 연구가 많이 이루어져 왔으며 이를 통해 선박의 당직 전 및 당직 중의 음주는 이어지는 행동에 큰 영향을 미친다고 할 수 있다. 본 연구에서는 승선 중 음주 실태를 파악하기 위하여, 선택형 앙케트를 교육중인 사관들에게 배포하여 118명으로부터 얻어진 결과를 조사하였다. 알코올 의존도에 관한 자가진단결과에 따르면, 조사대상자의 27% 이상이 알코올 남용 증세를 나타내었다. 또한, 승선 중 음주 현황 및 인식에 관한 사항을 정리하여, 선박운항 시뮬레이터를 이용한 음주 운항 시나리오를 마련하였으며, 알코올이 선박운항능력에 미치는 영향을 알아보았다. 실험결과를 분석한 결과, 알코올의 섭취가 선박운항능력을 다소 저하시키는 것으로 나타났다. 이러한 분석결과는 앞으로 선박운항자의 피로에 의한 해양사고 발생을 근본적으로 줄이기 위한 기초자료로 활용할 수 있을 것이다.

• Journal of Preventive Medicine and Public Health
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• 제30권3호
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• pp.518-529
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• 1997

1,281 male subjects who had been examined more than 3 times for regular check-up in one human dock center of the university hospital were studied between 1990-1995, to evaluate the effect of health counselling with life style and $\gamma-GTP$ value between 1054 normal group without intervention and 227 abnormal group with intervention, ages from 30 to 69 years old. Total mean value of $\gamma-GTP$ was $45.7{\pm}40.7$ unit with highest $\gamma-GTP$ value in age group 50-59 on initial examination. Total abnormal rate was 17.7% with the highest abnormal rate of 18.6% in age group 50-59. Initially, the value of $\gamma-GTP$ was significantly different according to the degree of alcohol intake, relative weight and smoking in normal group(p<0.01) not in abnormal group. In conclusion, the value of $\gamma-GTP$ were significantly increasing in normal group without intervention and significantly decreasing in abnormal group with intervention(p<0.05), which suggests the effect of health counselling, such as the recommendation to change the health behaviour.

• Advances in aircraft and spacecraft science
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• 제3권1호
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• pp.61-75
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• 2016

Climate changes brought on by human interventions have proved to be more devastating than predicted during the recent decades. Recognition of seriousness of the situation has led regulatory organisations to impose strict targets on allowable carbon dioxide emissions from automotive vehicles. As a possible solution, it has been proposed that Fibre Metal Laminate (FML) system is used to reduce the weight of future vehicles. To facilitate this investigation, FML based on steel and self-reinforced polypropylene was stamp formed into dome shapes under different blank holder forces (BHFs) at room temperature and its forming behaviour analysed. An open-die configuration was used in a hydraulic press so that a 3D photogrammetric measurement system (ARAMIS) could capture real-time surface strains. This paper presents findings on strain evolutions at different points along and at $45^{\circ}$ to fibre directions of circular FML blank, through various stages of forming. It was found initiation and rate of deformation varied with distance from the pole, that the mode of deformations range from biaxial stretching at the pole to drawing towards flange region, at decreasing magnitudes away from the pole in general. More uniform strain distribution was observed for the FML compared to that of plain steel and the most significant effects of BHF were its influence on forming depth and level of strain reached before failure.

• Asian Pacific Journal of Cancer Prevention
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• 제17권8호
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• pp.4019-4023
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• 2016

Background: Colorectal cancer (CRC) or bowel cancer is one of the most important cancer diseases, needing serious attention. The cell surface receptor gene human epidermal growth factor receptor (EGFR) may have an important role in provoking CRC. In this pharmaceutical era, it is always attempted to identify plant-based drugs for cancer, which will have less side effects for human body, unlike the chemically synthesized marketed drugs having serious side effects. So, in this study the authors tried to assess the activity of two important plant compounds, ferulic acid (FA) and p-coumaric acid (pCA), on CRC. Materials and Methods: FA and pCA were tested for their cytotoxic effects on the human CRC cell line HCT 15 and also checked for the level of gene expression of EGFR by real time PCR analysis. Positive results were confirmed by in silico molecular docking studies using Discovery Studio (DS) 4.0. The drug parallel features of the same compounds were also assessed in silico. Results: Cytotoxicity experiments revealed that both the compounds were efficient in killing CRC cells on a controlled concentration basis. In addition, EGFR expression was down-regulated in the presence of the compounds. Docking studies unveiled that both the compounds were able to inhibit EGFR at its active site. Pharmacokinetic analysis of these compounds opened up their drug like behaviour. Conclusions: The findings of this study emphasize the importance of plant compounds for targeting diseases like CRC.

• 대한의용생체공학회:의공학회지
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• 제19권5호
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• pp.495-502
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• 1998

Y.C. Fung[1]에 의한 연조직의 점탄성에 관한 수학적 모델이론 (Fung's Quasi-linear vlscoelastic theory)을 이용하여 인간의 인두조직의 점탄성(vlscoelatlcity)특성을 측정하기 위하여 반복성하중(cyclic load) ,응력완화 (tensile stress relaxation), incremental load, 그리고 일축성인장 (uniaxial tensile) 시험 등을 실시하였다. 실험적으로 측정한 인두조직의 점탄성특성이 이미 조사된 다른 조직의 점탄성특성과 정량적으로 비교되었다. 인두조직의 점탄성특성의 정량화를 위하여 Y.C.Fung의 수학적 모델이 적용되었는데 응력완화(tensile stress relaxation) 시험 측정결과로부터 도출된 표준화된 응력완화(reduced stress relaxation)함수 G(t)와 일축성인장(uniaxial tensile)시험에서 도출된 탄성반응(elastic response)함수 5(t)를 이용하여 시간에 따른 응력의 궤적을 산출하여 이를 반복성 하중(cyclic load)실험에서 측정된 결과와 비교, 분석하였다. 이러한 인두조직의 점탄성특성에 관한 연구결과는 향후 유한요소를 이용한 인두의 생체역학적 모델의 기본 데이터로 이용될 수 있다.

• Coupled systems mechanics
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• 제8권2호
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• pp.169-184
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• 2019

This research work presents a study that aims to assess the dynamic structural behaviour and also investigate the human comfort levels of a reinforced concrete building, when subjected to nondeterministic wind dynamic loadings, considering the effect of masonry infills on the global stiffness of the structural model. In general, the masonry fills most of the empty areas within the structural frames of the buildings. Although these masonry infills present structural stiffness, the common practice of engineers is to adopt them as static loads, disregarding the effect of the masonry infills on the global stiffness of the structural system. This way, in this study a numerical model based on sixteen-storey reinforced concrete building with 48 m high and dimensions of $14.20m{\times}15m$ was analysed. This way, static, modal and dynamic analyses were carried out in order to simulate the structural model based on two different strategies: no masonry infills and masonry infills simulated by shell finite elements. In this investigation, the wind action is considered as a nondeterministic process with unstable properties and also random characteristics. The fluctuating parcel of the wind is decomposed into a finite number of harmonic functions proportional to the structure resonant frequency with phase angles randomly determined. The nondeterministic dynamic analysis clearly demonstrates the relevance of a more realistic numerical modelling of the masonry infills, due to the modifications on the global structural stiffness of the building. The maximum displacements and peak accelerations values were reduced when the effect of the masonry infills (structural stiffness) were considered in the dynamic analysis. Finally, it can be concluded that the human comfort evaluation of the sixteen-storey reinforced concrete building can be altered in a favourable way to design.

• 정보보호학회논문지
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• 제26권4호
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• pp.903-910
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• 2016

터치스크린 기반 스마트 기기가 널리 보급 되면서 모바일 환경을 위한 주요 인증 메커니즘으로 그래픽 패스워드 기법 중 하나인 패턴 락 시스템이 등장했다. 사용자가 잠금 해제를 위하여 패턴 락을 사용한 후의 남아있는 패턴 모양의 흔적은 스머지 공격에 취약하다. 이러한 스머지 공격에 대응하기 위하여 TinyLock을 포함한 다양한 패턴 락이 제안되었다. 본 논문에서는 스머지 공격이 발생할 수 있는 환경에서 획득한 스머지 패턴 이미지를 이용하여 기계 학습을 통한 자동화된 스머지 공격의 유효성에 대하여 실험하고 안드로이드 패턴 락과 TinyLock의 안전성에 대하여 비교 분석하였다. 자동화된 스머지 공격에서 높은 공격 성공률을 보였으며 기존에 많이 사용되고 있는 안드로이드 패턴 락이 TinyLock보다 더 안전하지 않음을 검증하였다.

• KSBB Journal
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• 제16권3호
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• pp.237-240
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• 2001

본 연구에서는 keratinocytes 세포를 이용하여 VEGF가 세포의 증식, MMP-2 및 plasmin 분비에 미치는 영향을 조사하였다. 그 결과 VEGF는 keratinocytes의 세포증식을 약 2.5배 상승시켜 내피세포 뿐반 아니라 상피세포에서도 강력한 mitogen임을 확인하였으며 submaximal effect를 보이는 농도는 10 ng/mL이었다. VEGF의 농도 증가에 따른 MMP-2의 분비에 미치는 효과 역시 10 ng/mL에서 최대 효과를 나타냈으며 VEGF 처리 후 1시간만에 확인 가능한 MMP-2 밴드가 나타났다. 한편, MMP-2의 분비 증가와 함께 plasmin의 분비 증가가 수반되는지를 확인한 결과 VEGF를 첨가했을 때 약 3배 정도 plasmin의 분비량이 증가함을 알 수 었었다. 이러한 결과는 VEGF의 성장촉진 효과와 관련자어 볼 때 MMP-2와 plasmin이 keratinocytes 세포의 성장과 이동에 부분적으로 관여할 것임을 시사하고 있다.

• 한국생활과학회지
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• 제10권1호
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• pp.113-126
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• 2001

The purpose of this study was to investigate clothing behavior and ornaments wear of university students. The subject of this study consists of 241 college students who were attended in Kongju National University. SPSSWIN Program was utilized to calculated frequency(N), mean value(M) and standard deviation(SD) for statistical analysis. Differences among the populations were examined through T-test, F-test, $x^2$-test. The results of this study were as follow : 1. Clothing behavior of university students had significant difference according to sex, grade. In general, female students showed higher score than did male students in clothing interest, clothing conformity, self-estimation about clothing, clothing dependence, clothing aesthetic, clothing modesty, A first-year students had high tendency in clothing interest. 2. The wear of ornaments had significant difference according to variables. Buying the ornaments, most of students sot information in show window and emphasized on design. Male students wanted to have the ornaments of shoes, watch, hat & necklet, but female students wanted to have the ornaments of shoes, earring, necklet & hairpin. 3. Clothing behavior has Influenced university students' ornaments wear. The university students who appeared to be interested in clothes were apparently influenced by peers when selecting ornaments. Ornaments were usually bought in the department store, while belts were among the most popular choices. Students who stressed color when purchasing ornaments showed a high level of interest in and dependence on clothes. On the basic of these results, we can conclude that university students' taste in clothing behavior and use of ornaments wear depend on several different factors. Therefore, it is possible to outline the shift in clothing attitudes during adolescence. In order to understand university students' behaviour concerning clothes, much guidance and various studies on the subject are much recommended.

• KIEAE Journal
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• 제15권2호
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• pp.27-35
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• 2015

Purpose: Healthcare is on the whole a personal and critical service that consumer's use, whereas hospitalization is as a rule painful, because nature nurtures and Sun Light Luminosity for healthcare settings is considered healing. The performance and design of climate responsive buildings such as AKU requires a detailed study of attributes of climate both at micro as well as macro level. The therapeutic value of contact with nature through window view, greenery and landscape is calculated there. Method: A two prong strategy is been devised for this article, at micro level three typical morphologies are analysed by creating same environment of neighboring building on sun shading chart, radiation and temperature range. Since the analysis of local climate helps to determine the design strategies for hospital Healing Environment which is suitable for Karachi climate; in order to track the macro climatic behaviour, a considerable analysis of psychometrics chart for AKU Karachi are designed on Climate Consultant (CC) and analysed by Machine Learning. Climate Consultant proposes different design strategies suitable for Karachi. And on the other hand time wise illumination sources for clinical area which are then measured on psychrometric chart- according to singular space: multi patient admission, secondly: acute ambulatory ward, and tertiary: multi windowed space according to the mushrabiyah and sky light pattern. Result: Our findings support the hypothesis that windowed wall is 75-80% more healing wall; an accelerated evidence was found for healing at macro level if the form of the hospital is designed according to the climatologically preferences, whereas at micro level: the light resource becomes the staff attentiveness determinant. In Conclusion evidence was provided that the actual form of luminosity results consequently in satisfaction while light entering from several set of windows and other sources might be valued if design according to the healing environment. The data added on the sun shading chart to calculate rays entraining into space in patient room equal to 124416.21 Watts/ meter $m^2$ is calculated as precise healing rate-and is confirmed by questionnaire from patients belonging from each clinical stage having different illnesses.