• 한국초전도학회:학술대회논문집
• /
• v.15
• /
• pp.30-30
• /
• 2005

• Proceedings of the PSK Conference
• /
• 2000.10a
• /
• pp.167.1-167.1
• /
• 2000

• Proceedings of the PSK Conference
• /
• 2003.10b
• /
• pp.177.1-177.1
• /
• 2003

Styrylheterocycles were synthesized as a novel calss of inhibitors on nitric oxide(NO) production. Their inhibitory activities were evaluated using lipopolysaccharid-stimulated RAW264.7 macrophage cells. This series of inhibitors are suggested as lead comounds for the development of potent and selective inhibitors

• Journal of Physiology & Pathology in Korean Medicine
• /
• v.17 no.6
• /
• pp.1519-1523
• /
• 2003

Glehnia littoralis Fr. Schmidt (Umbelliferae) is a short-lived herbaceous species that are mostly distributed throughout East Asia. Although G. littoralis has been regarded as ecologically important one, there is no report on population structure in Korea. Starch gel electrophoresis was used to investigate the allozyme variation and genetic structure of Korean populations of this species. A high level of genetic variation was found in G. littoral is populations. Nine enzymes revealed 18 loci, of which 12 were polymorphic (66.7%). Genetic diversity at the species and population levels were 0.159 and 0.129, respectively. The sexual and asexual reproduction, high fecundity, and colonization process are proposed as possible factors contributing to genetic diversity. An indirect estimate of the number of migrants per generation (Nm = 1.45) indicated that gene flow was not extensive among Korean populations of this species. It is suggested that the ability of vegetation and artificial selection may have played roles in shaping the population structure of this species. we recommend that a desirable conservation population should be included at least 30 plants per population and especially those with high variation.

• Bulletin of the Korean Chemical Society
• /
• v.32 no.4
• /
• pp.1146-1152
• /
• 2011

The discovery of 2'-spirocyclopropyl-ribocytidine (J. Med. Chem. 2010, 53, 8150-8160) as a potent inhibitor of RNA synthesis by NS5B ($IC_{50}=7.3{\mu}M$), the RNA polymerase encoded by hepatitis C Virus (HCV), has led to the synthesis and biological evaluation of several carbocyclic versions of 2'-spiropropyl-nucleosides. The cyclopentenol intermediate 7 was successfully constructed via ring-closing metathesis (RCM) from divinyl 6. Spirocyclopropanation of enone 8 was effected by using (2-chloroethyl)-dimethylsulfonium iodide and potassium tert-butoxide to form the desired intermediate 9. The synthesized nucleoside analogues 21-24 were assayed for their ability to inhibit HCV RNA replication in a subgenomic replicon Huh7 cell line. Among them, the cytosine nucleoside analogue 22 exhibited significant anti-HCV activity ($EC_{50}= 8.2{\mu}M$).

• Journal of the Korean Institute of Electrical and Electronic Material Engineers
• /
• v.25 no.7
• /
• pp.525-530
• /
• 2012

We present the results of a study of the polarizing photovoltaic (PV) effects in an aligned polymer bulk heterojuction PV layer. The fairly uniform in-plane uniaxial alignment of the PV layer with a macroscopic axial orientational order parameter of 0.40 was achieved by means of a simple rubbing technique. Moreover, reflective polarizing PSCs having the aligned PV layers were applied to power-generating reflective type liquid crystal displays (LCDs), which exhibited a maximum contrast ratio of 1.7. These results form a promising foundation for various energy harvesting polarization dependent opto-electrical LCD device applications.

• Proceedings of the IEEK Conference
• /
• 2008.06a
• /
• pp.433-434
• /
• 2008

In this paper, we present an improved design of the conventional ARM7 processor. It is based on the flip-flop to improve the pipeline performance of the processor. Also for improving the performance, the optimization of functional blocks and a multiplier is carried out. According to the experimental results, the maximum delay-time of functional blocks and the execution cycle of a multiplier is reduced by 33% and 2 cycles compared with a conventional design, respectively. Therefore, it leads to improve an operation speed about 30%.

• YAKHAK HOEJI
• /
• v.35 no.6
• /
• pp.515-521
• /
• 1991

A number of 1-ethyl-6-fluoro-1,4-dihydro-4-oxo-7-(4-substitutedcarbamyl-1-piperazinyl) quinoline [or 1,8-naphthyridine]-3-carboxylic acid and their pivaloyloxymethyl esters were prepared. The compounds synthesized were evaluated for antibacterial activity in vitro against Escherichia coli, Bacillus subtilis, Proteus vulgaris, Klebsiella pneumoniae, Staphylococcus aureus and Pseudomonas aeruginosa. Among those 1-ethyl-6-fluoro-1,4-dihydro-4-oxo-7-(4-methylcarbamyl-1-piperazinyl) quinoline-3-carboxylic acid [1] and 1-ethyl-6-fluoro-1,4-dihydro-4-oxo-7-(4-methylcarbamyl-1-piperazinyl)1,8-naphthyridine-3-carboxylic acid [6] showed the most potent in vitro antibacterial activity.

• Bulletin of the Korean Chemical Society
• /
• v.30 no.12
• /
• pp.2989-2992
• /
• 2009

An efficient synthetic route of novel 2′(${\alpha}$)-C-fluoro-2′(${\beta}$)-C-methyl carbocyclic nucleoside analogues is described. The key fluorinated intermediate 7 was prepared from the epoxide intermediate 5 via selective ring-opening of epoxide. Coupling of 7 with nucleosidic bases under the Mitsunobu reactions followed by deprotection afforded the target carbocyclic nucleoside analogues. The synthesized compounds were evaluated as inhibitors of the hepatitis C virus (HCV) in Huh-7 cell line in vitro.

• Asian Pacific Journal of Cancer Prevention
• /
• v.15 no.23
• /
• pp.10085-10089
• /
• 2015

Background: The insulin-like growth factor (IGF) system comprises a group of proteins that play key roles in regulating cell growth, differentiation, and apoptosis in a variety of cellular systems. The aim of this study was to investigate the role of insulin-like growth factor binding protein 3 (IGFBP3) in hepatocellular carcinoma. Materials and Methods: Expression of IGF2, IGFBP3, and PTEN was analyzed by qRT-PCR. Lentivirus vectors were used to overexpress IGFBP3 in hepatocellular carcinoma cell (HCC) lines. The effect of IGFBP3 on proliferation was investigated by MTT and colony formation assays. Results: Expression of IGF2, IGFBP3, and PTEN in several HCC cell lines was lower than in normal cell lines. After 5-aza-2'-deoxycytidine/trichostatin A treatment, significant demethylation of the promoter region of IGFBP3 was observed in HCC cells. Overexpression of IGFBP3 induced apoptosis and reduced colony formation in HUH7 cells. Conclusions: Expression of IGF2, IGFBP3, and PTEN in several HCC cell lines was lower than in normal cell lines. After 5-aza-2'-deoxycytidine/trichostatin A treatment, significant demethylation of the promoter region of IGFBP3 was observed in HCC cells. Overexpression of IGFBP3 induced apoptosis and reduced colony formation in HUH7 cells.