• Clinical and Experimental Pediatrics
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• 제61권3호
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• pp.71-77
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• 2018

Purpose: Small for gestational age (SGA) is confusingly defined as birth weight (BW) either below 3rd percentile or 10th percentile for infants. This study aimed to compare postnatal catch-up growth between SGA groups according to different definitions. Methods: Data of 129 infants born with BW below the 10th percentile and admitted to Korea University Anam Hospital and Ansan Hospital were retrospectively reviewed. Height and weight were measured at 6, 12, and 24 months. Results were compared between group A (BW: <3rd percentile) and group B (BW: 3rd-10th percentile). Results: Group A included 66 infants and group B included 63. At age 6 months (n=122), 62.9% of group A and 71.7% (P=0.303) of group B showed catch-up growth in weight. At 6 months (n=69), 55.9% of group A and 80.0% of group B (P<0.05) showed catch-up growth in height. At 12 months (n=106), 58.5% of group A, and 75.5% (P=0.062) of group B showed catch-up growth in weight. At 12 months (n=75), 52.8% of group A and 64.1% of group B (P=0.320) showed catch-up growth in height. Up to age 24 months, 66.7%/80.0% in group A and 63.6%/80.0% in group B showed catch-up growth in weight/height. Conclusion: Despite different definitions, there were no significant differences between the two SGA groups in postnatal catch-up growth up to age 24 months, except for height at 6 months. Compared to infants with appropriate catch-up growth, low gestational age and BW were risk factors for failed catch-up growth at 6 months.

• Preventive Nutrition and Food Science
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• 제20권2호
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• pp.126-132
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• 2015

This study investigated the anti-amnesic effect of fermented Ganoderma lucidum water extracts (GW) on scopolamine- induced memory impairment in rats. GW were fermented by the lactic acid bacterium Bifidobacterium bifidum (FGWB), followed by Lactobacillus sakei LI033 (FGWBL). To induce amnesia, scopolamine (1 mg/kg) was intraperitoneally injected into rats 30 min before the behavioral tests. Step-through latencies of rats treated with primary fermented extracts (300 mg/kg, FGWB) and secondary fermented extracts (300 mg/kg, FGWBL) were significantly longer than those of rats treated with GW (300 mg/kg) in the retention trial of the multiple trial passive avoidance test. In the Morris water maze task, FGWBL significantly shortened escape latencies in training trials. Furthermore, swimming times within the target zone during the probe trial with FGWBL were significantly higher than the GW and FGWB treatments. In addition, acetylcholinesterase activities were lower in the brains of scopolamine-treated rats treated with FGWBL. These results suggest that FGWBL could be useful to enhance learning memory and cognitive function via cholinergic dysfunction.

• 폴리머
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• 제38권2호
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• pp.205-212
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• 2014

본 연구에서는 폴리에테르설폰(polyethersulfone, PES)을 연소배가스에 포함된 수증기를 분리 및 회수하기 위한 고분자 분리막 소재로 사용하기 위해 다양한 물리 화학적 표면개질 방법을 사용하여 PES 평막 표면의 친수성을 향상시키고자 하였다. 균일한 PES 평막을 제조한 후 친수성 향상을 위한 개질 방법으로 산처리, 블렌딩 및 플라즈마 처리를 통해 표면개질을 하였고, 표면 특성을 비교하였다. PES 평막 표면의 특성 변화는 ATR-FTIR, XPS, SEM 및 접촉각 측정을 통해 관찰하였다. 황산을 이용한 산처리 방법과 양친매성 고분자를 이용한 블렌딩 방법에 의해 개질된 PES 평막에서는 접촉각의 변화가 크지 않았다. Ar 플라즈마 처리를 한 경우, 플라스마 처리 시간이 증가함에 따라 PES 표면의 친수성이 크게 증가하는 것을 확인할 수 있었다. 본 결과를 통해 다양한 표면개질 방법 중 플라즈마 방법을 적용하여 PES 표면을 처리하는 것이 PES 막 표면의 친수성 향상에 가장 효과적임을 확인하였다.

• 한국실천공학교육학회논문지
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• 제2권2호
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• pp.10-15
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• 2010

산업체가 필요로 하는 인력의 양성을 위하여 대학에서는 공학교육의 질을 향상시키는 다양한 노력이 이뤄지고 있다. 유공압기초실습은 그러한 노력의 일환인 공학교육 인증과목으로, 자동화가 요구되는 모든 산업 분야에서 폭넓게 사용되고 있는 공압기기의 구성과 원리를 이해하고, 전기시퀀스회로의 프로그래밍과 공압시스템의 응용 설계능력 배양을 교과목 목표로 하고 있다. 본 교과목은 주당 3시간의 수업을 통하여 이론과 실습을 병행해야 하는데 실제 학생들에게 많은 내용을 전달하기에는 시간적인 여유가 절대적으로 부족하다. 이로 인하여 단편적인 전문지식 전달 강의로 진행 될 수밖에 없으며 산업체와 연계된 교육 또한 어려운 실정이다. 본 논문에서는 이에 대한 해결방법으로 E러닝을 통한 보완학습을 제시하고 있다. 한 학기 동안 유공압기초실습교과목의 오프라인 수업과 E러닝을 병행하고, 수업에 참여한 학생들을 대상으로 설문을 실시하여 보완학습에 대한 효과를 분석하였다. 그리고 추후 필요한 연구에 대해서도 제시하였다.

• 한국건축시공학회지
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• 제10권5호
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• pp.1-10
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• 2010

지역 경제가 침체됨에 따라 각종 정책은 거대한 건축산업을 활성화를 위해 제시되고 있지만, 건설산업은 여러 요인들이 복합 작용하므로 목적에 모두 부합하는 것은 어렵다. 본 연구는 부산지역 전문인들을 대상으로 인터뷰 및 설문조사를 실시하여 현지 건설 시장의 경기침체의 원인을 찾을 수 있었다. 주요 결과는 다음과 같다. 첫째, 원가절감 및 현실적인 마스터 플랜은 재개발 주택계획을 위한 해결책으로 필요하다. 둘째, 지역 건설산업을 고려하지 않은 수도권 중심의 정책 문제는 규제 완화가 필요하다. 마지막으로, 건설사업타당성 분석에 대한 낮은 인식과 전문인력 부족 문제는 교육을 통한 인력양성이 필요하다. 본 연구결과는 지역건설의 활성화 개선에 도움이 될 것이며, 전문인들의 인식 차이를 고려할 수 있는 계기가 될 것이다.

• Journal of Information Processing Systems
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• 제16권2호
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• pp.246-260
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• 2020

IT Service Management (ITSM) achieves consolidated management for the IT services supporting the acquisition system, and no outside connections can be established with such ITSM. Issues pertaining to the D2B can be addressed to System Q&A or a Call Center for problem-solving. In other words, internal staff can take the necessary measures for problems by directly connecting with ITSM. Currently, diverse innovative technologies are being used in electronics and ubiquitous computing environments. This allows us to create a better world by providing the backbone for remarkable development in our human society in the fields of electronics, devices, computer science, and engineering. Following the expansion of IT services in the military acquisition sector such as Defense Electronic Procurement, military export/import support system, etc., customers' dependence on IT for conducting business with the military or related companies is increasing, including the military's dependence on the same technology for services to the public. Nonetheless, issues pertaining to the simplified/integrated management of complex IT service management systems, including slow system recovery, lack of integrated customer service window, and insufficient information sharing, have become the priority problems that IT managers are required to solve. Therefore, this study conducted research on the integrated management of IT services provided by Korea's national defense acquisition system, which was developed based on the existing system IT Infrastructure Library (ITIL) v2, and investigated the level of satisfaction with services with focus on ensuring that it can be used for understanding the necessity of the system and its advancement in the future.

• The Korean Journal of Physiology and Pharmacology
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• 제4권2호
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• pp.99-104
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• 2000

We investigated the action of NOS inhibitors on NOS in rats. Both of nitric oxide synthase inhibitors, $N^G$-monomethyl-L-arginine $(L-NMMA,\;3\;{\mu}M)$ or $N^G$-nitro-L-arginine methylester $(L-NAME,\;30\;{\mu}M),$ augmented phenylephrine $(PE,\;10^{-7}\;M)-induced$ contraction which was inhibited by acetylcholine (ACh) in rat thoracic aorta. This augmentation by L-NAME or L-NMMA was attenuated with the treatment of NO precursor, arginine. ACh, however, decreased the augmentation induced by L-NMMA, but not by L-NAME. Superoxide dismutase (SOD, 50 u/ml) potentiated an inhibitory effect of ACh on the PE $(10^{-7}\;M)-induced$ contraction. It has been known that platelet activating factor itself induces iNOS. Platelet activating factor $(PAF,\;10^{-7}\;M)$ inhibited PE $(10^{-7}\;M)-induced$ contraction. Pretreatment with L-NMMA (30 mM) or L-NAME (30 mM) significantly blocked the inhibitory action of PAF on PE-induced contraction. L-NMMA (100 mM) or L-NAME (100 mM) reduced nerve conduction velocity (NCV) relevant to nNOS in rat sciatic nerve. ACh attenuated the reduction of NCV by L-NMMA-, but not by L-NAME-induced reduction of NCV. These results suggest that L-NMMA and/or L-NAME have different action on three types of NOS in rats.

• 한국응용약물학회:학술대회논문집
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• 한국응용약물학회 2004년도 Annual Meeting of KSAP : New Drug Development from Natural Products
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• pp.3-10
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• 2004

Oxidative stress is a constant threat to all living organisms and an immense repertoire of cellular defense systems is being employed by most pro- and eukaryotic systems to eliminate or to attenuate oxidative stress. Ischemia and reperfusion is characterized by both a significant oxidative stress and characteristic changes in the antioxidant defense. Heme oxigenase-l (HO-l) is up-regulated by various stimuli including oxidative stress so that it is thought to participate in general cellular defense mechanisms against ischemic injury in mammalian cells. Higenamine, an active ingredient of Aconite tuber, has been shown to have antioxidant activity along with inhibitory action of inducible nitric oxide synthase (iNOS) expression in various cells. In the present study, we investigated whether higenamine and related analogs protect cells from oxidative cellular injuries by modulating antioxidant enzymes, such as HO-l, MnSOD etc. R-form of YS-51 was the most potent inducer of HO-l in bovine endothelial cells, which inhibited apoptotic cell death by H$_2$O$_2$. HO-1 induction by YS 51 was mediated by PI3 kinase activation in which PKA- as well as PKG pathway is considered as important regulators. YS-51 also induced Mn-SOD mRNA expression by activating c-jun N-terminal kinase in endothelial cells and Hela cells. In ROS 17/2.1 cells, higenamine and enetiomers of related compounds inhibited iNOS expression by cytokine mixtures. Taken together, higenamine and related compounds can be developed as possible protective agents from oxidative cell injury or death.

• 한국재료학회지
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• 제13권2호
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• pp.115-119
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• 2003

The thick film type sensor having Pt/Na Super Ionic Conductor(NASICON) solid electrolyte/Pt/$Na_2$$SO_4$/Pt catalyst system for $SO_2$gas was fabricated by screen-print method. The phase of Na Super Ionic Conductor solid electrolyte sintered at different temperature of 1050, 1150,$ 1250^{\circ}C$ and for different time of 1.5, 2.5, 3.5 hr were investigated by XRD. The Electromotive Force variation of the sensor with $SO_2$concentrations and operating temperatures were investigated. The major phase of Na Super Ionic Conductor film sintered at 115$0^{\circ}C$ for 3.5 hr was sodium zirconium silicon phosphate($Na_3$Zr$_2$$Si_2$PO$_{12}$). The Nernst's slope of Na Super Ionic Conductor sensor for $SO_2$gas with the variation of concentration from 10 to 100 ppm was 167.14 ㎷/decade at the operating temperature of $500 ^{\circ}C$. The increase of oxygen partial pressure was not affected to the variation of Nernst's slope.e.

• 한국압력기기공학회 논문집
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• 제15권2호
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• pp.19-30
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• 2019

In this study, to evaluate conservatism of various fatigue life evaluation procedures, fatigue tests were conducted using compact tension (CT) specimens with a round notch, made of A516 Gr.70 carbon steel and A240 TP304 stainless steel, under load-controlled cyclic condition. Experimental fatigue failure cycles were measured and compared with predicted fatigue lives using two different life evaluation methods; (1) Design-By-Analysis (DBA) procedure given in ASME B&PV Code, Sec. III, Div. 1, Subsec. NB-3200 and (2) structural stress-based approach provided in ASME B&PV Code, Sec. VIII, Div. 2, Part 5. To predict fatigue failure cycles, three-dimensional elastic finite element analysis was conducted. Fatigue lives were predicted by both design fatigue curve given in ASME B&PV Code, Sec. III, Div. 1, Appendices and best-fit fatigue curve suggested in NUREG/CR-6815 for the DBA procedure. Finally, fatigue lives evaluated by various methods were compared with test results, and then conservatism between each evaluation procedure was discussed.