• Natural Product Sciences
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• v.17 no.3
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• pp.216-220
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• 2011

Activation of hepatic stellate cells (HSCs) characterized by increased proliferation and extracellular matrix deposition is identified as the major pathological feature of hepatic cirrhosis. Therefore, suppression of HSC activation has been proposed as an important antifibrotic therapeutic strategy. In the present study, we investigated the antiproliferative activity of root barks of Ulmus davidiana var. japonica (Ulmaceae) by employing HSC-T6 hepatic stellate cells as an in vitro assay system. Further investigation of the n-hexane and $CHCl_3$ fractions of root barks of U. davidiana var japonica led to the isolation of six triterpenoids: friedelin (1), epifridelanol (2), oleanolic acid (3), maslinic acid (4), ${\beta}$-amyrin (5) and ${\alpha}$-amyrin (6), together with ${\beta}$-sitosterol (7) and daucosterol (8). Among these compounds, 2, 3 and 4 significantly inhibited HSC proliferation. In addition, 4 inhibited HSC proliferation in time- and concentration-related manners, via a partially direct toxic effect, as assessed by morphological changes and release of lactate dehydrogenase.

• Smart Structures and Systems
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• v.3 no.1
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• pp.51-68
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• 2007

High-strength concrete (HSC) is becoming increasingly attractive for various construction projects since it offers a multitude of benefits over normal-strength concrete (NSC). Unfortunately, current design provisions for shear capacity of RC slender beams are generally based on data developed for NSC members having a compressive strength of up to 50 MPa, with limited recommendations on the use of HSC. The failure of HSC beams is noticeably different than that of NSC beams since the transition zone between the cement paste and aggregates is much denser in HSC. Thus, unlike NSC beams in which micro-cracks propagate around aggregates, providing significant aggregate interlock, micro-cracks in HSC are trans-granular, resulting in relatively smoother fracture surfaces, thereby inhibiting aggregate interlock as a shear transfer mechanism and reducing the influence of compressive strength on the ultimate shear strength of HSC beams. In this study, a new approach based on genetic algorithms (GAs) was used to predict the shear capacity of both NSC and HSC slender beams without shear reinforcement. Shear capacity predictions of the GA model were compared to calculations of four other commonly used methods: the ACI method, CSA method, Eurocode-2, and Zsutty's equation. A parametric study was conducted to evaluate the ability of the GA model to capture the effect of basic shear design parameters on the behaviour of reinforced concrete (RC) beams under shear loading. The parameters investigated include compressivestrength, amount of longitudinal reinforcement, and beam's depth. It was found that the GA model provided more accurate evaluation of shear capacity compared to that of the other common methods and better captured the influence of the significant shear design parameters. Therefore, the GA model offers an attractive user-friendly alternative to conventional shear design methods.

• Natural Product Sciences
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• v.14 no.2
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• pp.118-121
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• 2008

Manassantin B, a dilignan isolated from Saururus chinensis, significantly inhibited proliferation in HSC-T6 cells in concentration- and time-dependent manners. In addition, treatment of HSC-T6 cells with manassantin B changed cell morphology from flattened myofibroblastic membranous morphology, representing activation state, to slender shape, representing quiescent state. Furthermore, manassantin B effectively reduced collagen content in HSC-T6 cells. These results suggested that manassantin B exerted antifibrotic activity in HSCT6 cells, in part, via inhibition of cell proliferation and decrease of collagen production.

• 한국가시화정보학회:학술대회논문집
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• 2002.11a
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• pp.35-38
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• 2002

Variations of temperature and velocity fields in a Hele-Shaw Convection Cell (HSC) were measured using a holographic interferometry and PIV technique with varying Rayleigh number. Experimental results show a steady flow pattern at low Rayleigh numbers and a time-dependent periodic flow at high Rayleigh numbers. Two different measurement methods of holographic interferometry, double-exposure method and real-time method, were employed to measure the temperature field variations of HSC convective flow. In the double-exposure method, unwanted waves can be eliminated and reconstruction images are clear, but transient flow structure cannot be observed clearly. On the other hand, transient flow can be observed and reconstructed well using the real-time method. PIV results show that flow inside the HSC is periodic and the oscillating state is well matched with the temperature field results. The holographic interferometry and PIV techniques employed in this study are useful for analyzing the unsteady convective thermal fluid flows.

• Structural Engineering and Mechanics
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• v.73 no.1
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• pp.17-25
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• 2020

A finite element (FE) model for analyzing slender reinforced high-strength concrete (HSC) columns under biaxial eccentric loading is formulated in terms of the Euler-Bernoulli theory. The cross section of columns is divided into discrete concrete and reinforcing steel fibers so as to account for varied material properties over the section. The interaction between axial and bending fields is introduced in the FE formulation so as to take the large-displacement or P-delta effects into consideration. The proposed model aims to be simple, user-friendly, and capable of simulating the full-range inelastic behavior of reinforced HSC slender columns. The nonlinear model is calibrated against the experimental data for slender column specimens available in the technical literature. By using the proposed model, a numerical study is carried out on pin-ended slender HSC square columns under axial compression and biaxial bending, with investigation variables including the load eccentricity and eccentricity angle. The calibrated model is expected to provide a valuable tool for more efficiently designing HSC columns.

• Proceedings of the Korea Concrete Institute Conference
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• 1993.10a
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• pp.11-17
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• 1993

In this study, the fundamental properties of High-Strength Concrete(HSC), such as the slump loss, the temperature increment, the strength development, are considered by experiment. In reducing the temperature and the slump loss, and developing the strength of HSC, the application of silica fume as an admixtures is very effective. And when gypsum is added, the slump loss is reduced and the strength of HSC is improved remarkably, but the temperature of concrete is increased, thus a more study to reduce the temperature increment is required

• KSCE Journal of Civil and Environmental Engineering Research
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• v.30 no.6A
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• pp.561-572
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• 2010

This paper is a study about application of recently proposed Performance Based Mixture Design (PBMD) for design of high strength concrete (HSC) to obtain HSC mix proportion that satisfies required performances. The PBMD method which uses Satisfaction curve based on a Bayesian method is a performance oriented concrete mix proportion design procedure easily applicable to any condition and environment for a possible replacement to the current prescriptive design standards. Based on extensive experimental results obtained for various materials and performance parameters of HSC, the application feasibility of the developed PBMD procedure for HSC has been verified. Also, the proposed PBMD procedure has been used to perform application examples to obtain desired target performances of HSC with optimum concrete mixture proportions using locally available materials, local environmental conditions, and available concrete production technologies. The validity and precision of HSC mix proportion design obtained using the PBMD method is verified with the experimental and ACI presented results to check the feasibility for actual design usage.

• Structural Engineering and Mechanics
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• v.39 no.4
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• pp.559-578
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• 2011

In regions of high seismic risk, high-strength concrete (HSC) columns of tall buildings are designed to be fully ductile during earthquake attack by providing substantial amount of confining steel within the critical region. However. in areas of low to moderate seismic risk, the same provision of confining steel is too conservative because of the reduced seismic demand. More critically, it causes problematic steel congestion in the beam-column joints and column critical region. This will eventually affect the quality of concrete placing owing to blockage. To relieve the problem, the confining steel in the critical region of HSC columns located in low to moderate seismicity regions can be suitably reduced, while maintaining a limited ductility level. Despite the advantage, there are still no guidelines developed for designing limited ductility HSC columns. In this paper, a formula for designing limited ductility HSC columns is presented. The validity of the formula was verified by testing half-scale HSC columns subjected to combined high-axial load and flexure, in which the confining steel was provided as per the proposed formula. From the test results, it is evident that the curvature ductility factors obtained for all these columns were about 10, which is the generally accepted level of limited ductility.

• Journal of the Korean Ceramic Society
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• v.47 no.5
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• pp.357-364
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• 2010

This study was performed to get basic information about properties of high blaine slag cement(HSC) to use shotcrete(or sprayed concrete and mortar). Particle size distribution, setting time and compressive strength test, analysis like as SEM, DSC thermal analysis, XRD was carried out to investigate principle properties of HSC. Setting time of HSC was delayed slightly, but influence of accelerators was more bigger than ordinary portland cement(OPC). Compressive strength of HSC at 28 days was more higher than OPC regardless of using accelerators. Results of analysis showed early period hydration products of HSC is more small and located widely, because of the interface of between cement particle and water is increased as specific surface of cement increase. From the SEM observation and analysis of DSC and XRD results, aluminates accelerators bring on some hydration products like as calcium aluminium hydrates, alkali free accelerators increases ettringite and monosulfates. Aluminates accelerators has a advantage of setting time and early strength, alkali free accelerators increases strength after 7 days.

• Journal of the Korea Concrete Institute
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• v.23 no.5
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• pp.627-636
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• 2011

Recently, to prevent explosive spalling of high-strength concrete (HSC) members, the usage of nylon fiber instead of polypropylene fiber has increased. Past experimental studies have been conducted to examine the spalling and mechanical properties of HSC with nylon fibers when exposed to elevated temperature. However, the previous studies on HSC with nylon fibers subjected to high temperatures were performed only on the properties such as spalling, compressive strength, and elastic modulus rather than investigations on to the behaviors such as thermal strain, total strain, steady state creep, and transient creep. Therefore, in this study thermal strain, total strain, steady state creep, and transient creep of HSC mixed with nylon fibers with water to binder ratio of 0.30 to 0.15 were tested. The experimental results showed that nylon fibers did not affect the performance of HSC with nylon fibers at high temperatures. However, HSC with nylon fibers generated a larger transient creep strain than that of HSC without fibers and normal strength concrete.