Natural Product Sciences

The Korean Society of Pharmacognosy (한국생약학회)
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Antifibrotic Activity of Manassantin B from Saururus chinensis in HSC-T6 Hepatic Stellate Cells

  • Lee, Mi-Kyeong (Institute for Life Science, Elcom Science Co. Ltd) ;
  • Yang, Hye-kyung (College of Pharmacy and Research Institute of Pharmaceutical Science, Seoul National University) ;
  • Yang, Eun-Sun (College of Pharmacy and Research Institute of Pharmaceutical Science, Seoul National University) ;
  • Kim, Young-Choong (College of Pharmacy and Research Institute of Pharmaceutical Science, Seoul National University) ;
  • Sung, Sang-Hyun (College of Pharmacy and Research Institute of Pharmaceutical Science, Seoul National University)
  • Published : 2008.06.30
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Abstract

Manassantin B, a dilignan isolated from Saururus chinensis, significantly inhibited proliferation in HSC-T6 cells in concentration- and time-dependent manners. In addition, treatment of HSC-T6 cells with manassantin B changed cell morphology from flattened myofibroblastic membranous morphology, representing activation state, to slender shape, representing quiescent state. Furthermore, manassantin B effectively reduced collagen content in HSC-T6 cells. These results suggested that manassantin B exerted antifibrotic activity in HSCT6 cells, in part, via inhibition of cell proliferation and decrease of collagen production.

Keywords

References

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