• 한국어병학회지
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• 제10권2호
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• pp.165-176
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• 1997

양식넙치의 병원바이러스인 HRV 및 FBV, 연어과 유래 바이러스이면서 해산어에 병원성을 나타내는 RVS를 대상으로 넙치사육해수, 2차증류수 및 Hanks' BSS중에서의 바이러스 감염가의 변화를 관찰하고 사육해수중에 존재하는 미생물과의 상호작용을 검토하였다. HRV, FBV, RVS의 감염가는 2차증류수 및 Hanks' BSS중에서 21일간 안정적이었으나, 사육해수 중에서 HRV는 $0^{\circ}C$를 제외한 5, 10, 15, $20^{\circ}C$의 실험구에서 바이러스 현탁후 7일째 부터 감염가의 저하를 확인할 수 있었고, RVS에서도 감염가의 하락이 확인되었다. HRV 및 RVS를 고압멸균, 여과처리 및 무처리 사육해수에 현탁시켜 본 결과 무처리 사육해수에서 바이러스감염가의 하락을 나타내는데 비하여 고압멸균 및 여과 처리한 사육해수중의 바이러스 감염가는 비교적 안정적이었다. 사육해수에 1% MEM10을 첨가하여 $15^{\circ}C$에서 7일간 배양한 후 여과 처리하여 얻은 여과액에 HRV를 현탁시켜 감염가의 변화를 관찰한 결과 1일에서 3일째에 감염가가 검출한계 이하로 하락하였으며, 해수배양액내의 세균 수는 $8.1{\times}10^8$ cells/ml이었고, Pseudomonas, Achromobacter, Flavobacterium 및 Vibrio속 세균이 분리되었다. 분리된 Pseudomonas 및 Vibrio속의 대표주에서 항바이러스작용 물질의 생산이 확인되었다.

• 대한약침학회지
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• 제12권3호
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• pp.31-40
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• 2009

Objective : This study was to investigate the effects of distilled Cervi Pantotrichum Cornu Pharmacopuncture and Zizyphi Spinosi Semen Pharmacopuncture on autonomic nervous system with Heart Rate Variability(HRV). Purpose of the trial was to observe what influence distilled Cervi Pantotrichum Cornu Pharmacopuncture and Zizyphi Spinosi Semen Pharmacopuncture have on the autonomic nervous system. Methods : 60 healthy male volunteers were divided into three groups which consist of two experimental groups such as Cervi Pantotrichum Cornu Pharmacopuncture and Zizyphi Spinosi Semen Pharmacopuncture, and a control group. Study design was a randomized, placebo-controlled, double-blind clinical trial. 20 subjects in experimental group were injected distilled Cervi Pantotrichum Cornu Pharmacopuncture at $GB_{21}$(Kyonjong), 20 subjects in other experimental group were injected distilled Zizyphi Spinosi Semen Pharmacopuncture and 20 subjects in control group were injected Normal Saline at $GB_{21}$(Kyonjong). One volunteer of each groups were excluded from analysis because of error during measuring HRV. At the end of the study 57 volunteers completed HRV analysis. HRV was measured by QECG-3:LXC3203(LAXTHA Inc. Korea) at P0, P1, P2, P3, P4, P5 and P6 and its time-course dependent change in each group was analyzed using paired t-test, and the difference of HRV fluctuation among two experimental group and a control was evaluated by one way ANOVA(p<0.05). Results : A. Time Domain Analysis 1. Analysis of Mean HRV, SDNN and Complexity After injection of distilled Cervi Pantotrichum Cornu Pharmacopuncture, Mean HRV was significantly decreased only at 20 minutes after injection. SDNN was significantly increased from 15 minute after injection. Complexity was significantly decreased only at 15 minute after injection. After injection of distilled Zizyphi Spinosi Semen Pharmacopuncture, Complexity was significantly decreased at 10, 15 and 30 minutes after injection. 2. Analysis of HRV index, pNN50 After injection of distilled Cervi Pantotrichum Cornu Pharmacopuncture, pNN50 was significantly decreased at 15, 20 and 25 minutes after injection. Compared with Normal Saline injection, distilled Cervi Pantotrichum Cornu Pharmacopuncture and Zizyphi Spinosi Semen Pharmacopuncture showed significant difference on HRV index and pNN50 at 5 minutes after injection. B. Frequency Domain Analysis 1. Analysis of Ln(TP), Ln(VLF) After injection of distilled Cervi Pantotrichum Cornu Pharmacopuncture, Ln(TP) was significantly increased at 15 and 30 minutes after injection. Ln(VLF) was significantly increased at 10, 15 and 30 minutes after injection. After injection of distilled Zizyphi Spinosi Semen Pharmacopuncture, Ln(VLF) was significantly increased only at 30 minutes after injection. Compared with Normal Saline injection, distilled Cervi Pantotrichum Cornu Pharmacopuncture showed significant difference on Ln(TP) after 5 minutes of injection. Conclusions : Our results suggest that Cervi Pantotrichum Cornu Pharmacopuncture and Zizyphi Spinosi Semen Pharmacopuncture in healthy adult man tend to activate the autonomic nervous system and sympathetic nervous system compared to Normal Saline within normal range.

• 한국정보통신학회논문지
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• 제14권9호
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• pp.2099-2104
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• 2010

본 연구에서는 마취 중 리턴맵 분석 방법을 적용하여 ECG 신호에서 R-R 간격의 변화로 표시될 수 있는 HRV 신호를 분석하였다. HRV신호는 자율신경계(autonomic nervous system : ANS)의 상태변이에 따른 심혈관계(cardio vascular system : CVS)의 변화 양상에 대한 객관적인 정보를 구할 수 있으므로 수술중 자율신경계의 변화를 관찰하여 마취심도를 평가할 수 있다. 리턴맵 분석 방법은 일련의 시계열 HRV 신호를 위상공간으로 사상하기 위해 지연시간과 매립차원을 구한 후 2차원의 위상공간에 신호를 재구성하였다. 위상공간에 재구성된 신호 분포를 타원형으로 근사화 한 후 장축과 단축의 길이를 구하여 마취심도를 구별하는데 이용하였다. 마취 단계별 마취심도를 평가하기 위하여 마취 단계를 7단계로 구분하여 분석하였다. 외부자극이 아주 강한 마취유도단계에서 장축과 단축 모두 통계적으로 유의하게 큰값을 나타내었으며, 외부 자극이 가해지지 않은 수술중 단계에서는 장축과 단축의 길이 모두 작은 값을 나타내었다. 따라서 2차원의 위상공간에 매립된 수술중의 HRV 신호를 이용하여 자율신경계의 영향을 판단하여 마취심도를 구분 할 수 있었다.

• 한국전기전자재료학회논문지
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• 제21권8호
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• pp.770-775
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• 2008

Autonomic nervous system of the anesthetized patients can be influenced by the many kinds of stimulations such as intubation, surgical incision and so on. The changes of the heart rates and blood pressures are surrogates of responses of the autonomic system to the external stimulations. Recently, the power spectral analysis of the heart rate variability (HRV) made it easy to know the fractions and changes of sympathetic and parasympathetic autonomic systems. In this study, the changes of pulse transit time, one of the response of vessels to stimulations, was investigated in relation to the HRV. Ten patients were examined and average age is 22.5 $\pm$ 11.04, average weight is 63 $\pm$ 14.4 kg. The patients were anesthetized only by sevoflurane inhalation. Pulse transit time is determined by calculating the difference of the time between the R peak of ECG and the characteristic point of the plethysmography. Power spectral density (PSD) of the HRV was achieved in the frequency of 0.04-0.15 (LF) and 0.15-0.4 (HF). Compared to preanesthetic period the values of LF and LF/HF ratio of HRV were decreased (p<0.05). HF and PTT was increased in anesthetic state with sevoflurane. Otherwise, after intubation, the HF was decreased and LF, LF/HF ratio and PTT were increased. PSD of the HRV is well-known for the index of the autonomic nervous activity. Not only HRV but PTT analysis also is a useful index reflecting the autonomic responses to various stimulations. And this analysis is useful in bed side monitoring because the calculating method is simple and it takes shorter processing time compared to the HRV analysis.

• 대한불안의학회지
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• 제2권2호
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• pp.101-107
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• 2006

Object : Since autonomic nerve system dysfunction was known as the mechanism of panic disorder, many researchers used heart rate variability (HRV) as means of measuring autonomic nerve function of patients with panic disorder. We aimed to examine the effect of paroxetine medication for 3 months on symptom improvement and change of heart rate variability of the patients with panic disorder. Methods : The subjects were patients with panic disorder who visited the psychiatric outpatient clinic of Samsung Medical Center in Seoul. We included panic disorder patients who were aged from 20 to 50 and in normal BMI range (from 18 to 30) to minimize the effect of age and weight on HRV data. We excluded the patients with EKG abnormalities, hypertension or other major psychiatric disorders. They took 20-40 mg paroxetine medication a day for 3 months. Alprazolam was used only during the first month to control the acute panic symptoms and was tapered off after that. We measured the acute panic inventory (API), Hamilton rating scale for anxiety and depression (HAM-A & HAM-D), Spielberger state-trait anxiety inventory (STAIS, STAIT), and Beck depression inventory (BDI) in order to assess clinical improvement of the patients. And we measured time and frequency domain HRV in the resting, standing and cognitive stress states to assess the change of HRV. All measurements were done before and after paroxetine treatment. Result : After paroxetine medication, patients showed significant improvement in all psychiatric scales. In time domain of HRV, standard deviations of all R-R intervals (SDNN) were significantly increased in all states. In frequency domain of HRV, the ratio of high frequency to total power (HF/TP) in the standing state was significantly increased. Conclusion : After 3 months paroxetine medication, panic disorder patients showed significant clinical improvement and change in HRV data such as SDNN in all states and HF/TP ratio in the standing state. This result suggests that paroxetine medication is effective for the improvement of autonomic nerve system dysfunction in panic disorder patients.

• 대한한방내과학회지
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• 제30권1호
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• pp.173-180
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• 2009

Objectives : The aim of this study was to investigate the evaluation of gastrointestinal parasympathetic nerve activity by comparing between HRV and bowel sound parameters in patients with functional dyspepsia. Methods : 62 patients (male 22, female 40) were enrolled. HRV was measured in all patients. and TP (total power), LF (low frequency density: 0.04$\sim$0.15Hz), HF (high frequency density: 0.15$\sim$0.4Hz). and LF/HF ratio were analyzed. HF band is a reflection of parasympathetic activity. and the LF-to-HF ratio is considered a marker of sympathovagal balance. Bowel sounds were recorded at the day after, and postprandial %BS was used to indicate the gastric vagal activity after eating. HRV and bowel sound parameters were compared. and correlation between them was analyzed. Results : There was no difference in LF/HF ratio between patient group and healthy group of other report. According to values of %BS, each patient was classified into a normal (>6 %BS) or hypoactivity (<6 %BS) of gastric vagus nerve group. HF component of the hypoactivity group was not significantly higher than that of the normal group. There was no correlation between HRV and bowel sound parameters. Conclusions : Because no correlation was found between HRV and bowel sound parameters in patients with functional dyspepsia, we concluded that it is not proper to evaluate gastric vagus nerve activity by HRV measurement.

• Journal of information and communication convergence engineering
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• 제8권2호
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• pp.201-204
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• 2010

In the mobile healthcare system, a very important vital sign in analyzing the status of user health is the HRV (heart rate variability). The used signals for measuring the HRV are electrocardiograph and PPG (photoplethysmograph). In extracting the HRV from the PPG signal, an important issue is that extract the exactly HRV from PPG signal distorted from the user's movements. This study suggested a design method of the Kalman filter to solve the problem, and evaluated the performances of a proposed method by PPG signals containing motion artifacts. In the results of experiments that compared with a variable step size adaptive filter proposed in recently, the proposed method showed better performance than an adaptive filter.

• 감성과학
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• 제2권2호
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• pp.31-36
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• 1999

본 연구의 목적은 후각 자극에 의한 감성의 변화를 주관적 검사와 동시에 시행한 심전도에서 추출한 HRV parameter와의 상관관계를 보고자 함이다. 후각 자극은 0.6% orange와 2.5% valeric acid를 일정 flow와 일정 농도를 코 점막에 건조를 방지하기 위해 수증기로 포화시킨 향자극기로 주었다. 향의 주관적 검사에서 오렌지향은 친숙하고 쾌하다고 하였으며, valeric acid의 경우 불쾌하고 성가시고 친숙하지 않는 감성을 표시하였다. 이러한 쾌하고 불쾌한 향자극에 대한 HRV 분의 활동이 우세하였음을 확인하였다. 결론적으로 HRV 스펙트럼 분석이 감성의 변화를 객관적인 지표로 나타내는데 유용한 정보로서의 가능성을 제시히고자 하였다.

• 대한한의진단학회지
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• 제12권2호
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• pp.74-83
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• 2008

Background and purpose : Health is characterized by variability, and the loss of variability is associated with aging and disease. Normal healthy respiratory patterns are characterized by breath to breath variability. Cold-Heat scores are quantified indices in Korean Medicine. The aim of this study is to analyze relations between 9 respiratory indices (including breath to breath variability) and HRV(heart rate variability). Method : Respiratory data were measured during a period of 15 minutes and transferred to text file. We calculated 9 respiratory parameters using MATLAB 7.1. Afterwards we did correlation analysis of the 9 respiratory indices and HRV. Results and conclusion : Respiratory variability showed significant correlation with HRV.

• 대한전기학회:학술대회논문집
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• 대한전기학회 2008년도 제39회 하계학술대회
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• pp.2007-2009
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• 2008

본 논문에서는 인체에 열을 가했을 때 심전도(ECG) 신호에서 얻어진 Heart Rate Variability(HRV)와 광전용적맥파(PPG)에서 얻어진 Photoplethymograph Variability(PV)의 상관관계를 보기 위하여 피실험자가 상온에서 누워 있을때와 65$^{\circ}C$의 온도로 누워있을때의 심전도와 PPG를 측정하여 두 파라메터의 상관관계를 분석하여 그 효용성을 평가하였다. 이를 위하여 우선 신체 건강한 26세에서 32세까지 총 3명의 남성을 대상으로 하여 ECG와 PPG를 위와 같은 조건에서 측정한 다음, 두 신호로부터 피크를 검출하고, 피크 간격을 시계열 신호로 변환하여 HRV와 PV신호를 얻어 내었다. 또한 얻어진 HRV신호와 PV신호의 주파수 분석을 통하여 HF 및 LF성분을 비교하여 HRV와 PV의 상관관계를 비교하였다.