• Title/Summary/Keyword: Hot cell

검색결과 906건 처리시간 0.025초

18FDG 합성시 핫셀장비 외부로 유출 방사선의 선량 평가 (Evaluation of the Radiation Dosage Flowing out of the Hot Cell During Synthesis of 18FDG)

  • 정홍문;정재은;조준호;원도연
    • 한국방사선학회논문지
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    • 제7권5호
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    • pp.365-369
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    • 2013
  • PET(positron emission tomography)을 촬영하기 위해서는 방사선 의약품 동위원소를 사용하여 인체 내에 정맥주사를 한다. 이 경우 대표적으로 사용하는 방사선 의약품은 $^{18}FDG$ (Fluorodeoxyglucose)이다. 의료용 싸이크로트론으로 생산하는 $^{18}F$에 deoxyglucose를 합성하기 위해서 합성용 카세트장치가 필요하다. 방사성 의약품 제조시에는 많은 양의 2차 방사선이 발생이 된다. 따라서 2차 방사선을 차폐하기 위하여 핫셀(Hot cell)을 사용한다. 우리는 $^{18}FDG$ 합성 또는 분배시에 핫 셀 외부로 유출되는 선량을 측정하였다. 이번 실험은 $^{18}FDG$ 제조 작업시에 의도하지 않게 발생할 수 있는 방사선 작업종사자의 피폭에 관한 선량정보를 제공하기 위함이다. 결론적으로 핫셀 내부에서 외부로 $^{18}FDG$ 합성시에 선량이 유출됨을 확인 할 수 있었다. 특히 핫셀에서 핫셀 내부를 볼 수 있는 납유리에서 외부로 방사선이 유출되는 것을 알 수 있었다. 결론적으로 $^{18}FDG$ 합성시 방사선 작업종사자의 피폭선량을 감소하기 위해서는 핫셀 존재하는 납유리의 개선점이 필요할 것으로 사료된다.

매운맛 선호도가 사람의 말초혈액에서 불리한 면역세포 활성에 미치는 영향 (Effect of Hot Taste Preference on Selected Immune Responses in Human Peripheral Immunocompetent Cells)

  • 표종옥;한인섭;김병삼;유리나
    • 한국식품영양과학회지
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    • 제26권6호
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    • pp.1194-1199
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    • 1997
  • The effect of hot taste preference on selected immune responses was investigated in human peripheral immunocompetent cells. Human lymphocytes and natural killer(NK) cells were prepared at a concentration of 2$\times$$10^{6}$ cells/ml in RPMI-1640 containing 10% fetal bovine serum. Lymphocytes proliferation was determined with the [$^{3}H$]-thymidine pulse for 18hrs after concanavalin A, phytohemagglutinin, Salmonella typhimurium mitogen, or media alone. NK cell activity was measured by cytolysis of $^51Cr$-labeled target cells K562. Serum antibodies levels such as IgM, IgG, IgA were also measured by ELISA method. There was no difference of serum IgM level among the groups, but IgG and IgA levels were greater in the group with hot taste preference than those of the group without hot taste preference. In lymphocytes of the group with hot taste preference there was a greater mitogen-induced lymphocyte proliferative responses compared to the group without hot taste preference. In addition, NK cell activity in group with hot taste preference was lower than that of the group without hot taste preference. These results suggest that the eating habit of spicy food containing hot components may affect immune status by modulating selective immunocompetent cells function.

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가감신기환(加減腎氣丸) 제형변화가 염증반응 사이토카인과 기억력감퇴에 미치는 영향 (The Effects of kagamSinKiHwan(KSKH) Hot water extract & ultra-fine Powder on Proinflammatory cytokine of Microglia & Memory Deficit of Amnesia Mice Model)

  • 임현주;정인철
    • 동의신경정신과학회지
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    • 제19권3호
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    • pp.85-100
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    • 2008
  • Objective: This experiment was designed to investigate the effect of the KSKH hot water extract & ultra-fine powder on microglia and memory deficit model. Method: The effects of the KSKH hot water extract on expression of IL-1$\beta$, IL-6, TNF-$\alpha$ mRNA and production of IL-1$\beta$, IL-6, TNF-$\alpha$ in BV2 microglial cell line treated by lipopolysacchaide(LPS) were investigated. The effects of the KSKH hot water extract & ultra-fine-fine powder on the behavior of the memory deficit mice induced by scopolamine and AChE in serum of the memory deficit mice induced by scopolamine were investigated. Results: 1. The KSKH hot water extract suppressed the expression of IL-1$\beta$, IL-6, TNF-$\alpha$ mRNA in BV2 microglial cell line treated by LPS. 2. The KSKH hot water extract suppressed the production of IL-1$\beta$, IL-6, TNF-$\alpha$ in 100$\mu g/m\ell$ concentration of BV2 microglial cell line culture supernatant. 3. The KSKH hot water extract & ultra-fine powder decreased AChE activation significantly in the serum of the memory deficit mice induced by scopolamine. 4. The KSKH hot water extract & ultra-fine powder showed significant effect on memory impairment in the stop-through latency type of Morris water maze test. Conclusions: This experiment shows that the KSKH hot water extract & ultra-fine powder might be effective for the prevention and treatment of amnesia and Alzheimer's disease. Investigation into the clinical use of the KSKH hot water extract & ultra-fine powder for amnesia and Alzheimer's disease is suggested for future research.

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환소단(還少丹)이 microglia 염증반응 cytokine과 건망증 생쥐모델에 미치는 영향 (The Effects of Hwanso-dan(Huanshaodan) Hot Water Extract & Ultra-fine Powder on Cytokine and Memory Deficit Model)

  • 윤종천;이상룡;정인철
    • 동의신경정신과학회지
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    • 제20권1호
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    • pp.43-57
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    • 2009
  • Objectives : This experiment was designed to investigate the effect of the Hwanso-dan hot water extract & ultra-fine powder on microglia and memory deficit model Methods : The effects of the Hwanso-dan hot water extract on expression of IL-l${\beta}$, IL-6, TNF-${\alpha}$ mRNA and production of IL-l${\beta}$, IL-6, TNF-${\alpha}$ in BV2 microglial cell line treated by lipopolysacchaide were investigated. The effects of the Hwanso-dan hot water extract & ultra-fine powder on the behavior of the memory deficit mice induced by scopolamine and uric acid & AChE in serum of the memory deficit mice induced by scopolamine were investigated. Results : 1. The Hwanso-dan hot water extract suppressed the expression of IL-l${\beta}$, IL-6, TNF-${\alpha}$ mRNA in BV2 microglial cell line treated by lipopolysacchaide. 2. The Hwanso-dan hot water extract suppressed the production of IL-l${\beta}$, IL-6, TNF-${\alpha}$ in BV2 microglial cell line. 3. The Hwanso-dan hot water extract & ultra-fine powder decreased uric acid and AChE significantly in the serum of the memory deficit mice induced by scopolamine. 4. The Hwanso-dan hot water extract & ultra-fine powder groups showed significantly inhibitory effect on the scopolamine${\sim}$induced impairment of memory in the experiment of Morris water maze. Conclusions : This experiment shows that the Hwanso-dan hot water extract & ultra-fine powder might be effective for the prevention and treatment of Memory deficit disease. Investigation into the clinical use of the Hwanso-dan hot water extract & ultra-fine powder for Alzheimer's disease is suggested for future research.

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팔미합총명탕(八味合聰明湯) 열수추출물, 초미세분말제형이 Alzheimer's Disease 병태 모텔에 미치는 영향 (The Effects of PalMihapChongMungTang(PMCMT) Hot Water Extract & Ultra-fine Powder on the Alzheimer's Disease Model)

  • 임정화;이상룡
    • 동의신경정신과학회지
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    • 제19권2호
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    • pp.95-110
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    • 2008
  • Objective : This experiment was designed to investigate the effects of the PMCMT hot water extract & ultra-fine powder on Alzheimer's Disease Model Induced by ${\beta}A$. Method : The effects of the PMCMT hot water extract on expression of proinf1ammatory cytokine mRNA in BV2 microglial cell cell line treated by lipopolysacchaide(LPS). The effects of the PMCMT hot water extract & ultra-fine powder on (1) the behavior (2) AChE in serum (3) the infarction area of the hippocampus, and brain tissue injury in Alzheimer's diseased mice induced with ${\beta}A$ were investigated. Result : 1. The PMCMT hot water extract suppressed the expression of proinflammatory cytokine mRNA in BV2 microglial cell line treated with LPS. 2. The PMCMT hot water extract & ultra-fine powder a significant inhibitory effect on the memory deficit was shown for the mice with Alzheimer's disease induced by ${\beta}A$ in the Morris water maze experiment, which measured stop-through latency and distance movement-through latency 3. The PMCMT hot water extract & ultra-fine powder suppressed the over-expression of AChE activity in the serum of the mice with Alzheimer's disease induced by ${\beta}A$. 5. The PMCMT ultra-fine powder reduced infarction area of hippocampus significantly, and the PMCMT hot water extract & ultra-fine powder controlled the injury of brain tissue in the mice with Alzheimer's disease induced by ${\beta}A$. Conclusions : These results suggest that the PMCMT hot water extract & ultra-fine powder may be effective for the prevention and treatment of Alzheimer's disease. Investigation into the clinical use of the PMCMT hot water extract & ultra-fine powder for Alzheimer's disease is suggested for future research.

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고추의 성숙에 따른 세포벽 다당류의 변화와 ${\beta}-Galactosidase$ Isozymes의 분리 (Ripening Related Changes in Hot Pepper Fruit Cell Walls Structural Alterations of Cell Wall Polysaccharides and Separation of Galactosidase Isozymes)

  • 김순동;강명수;김광수
    • 한국식품영양과학회지
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    • 제14권2호
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    • pp.157-163
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    • 1985
  • Various cell wall polysaccharides and related enzyme activities in hot pepper fruit were determined at different stages of maturity. The uronic acid content of cell walls decreased between immature green and turning stage fruit and then increased by red ripe stage. In contrast, cellulose content of cell walls changed only a little during ripening. Total neutal sugar content of cell wall material decreased 50% and galactose content of the walls decreased about 80% by the turning stage. Polygalacturonase and ${\beta}-galactosidase$ activities, as well as total hemicellulose from isolated cell walls of ripening hot pepper fruit were studied using gel filtration chromatography. Polygalacturonase activity was not detectable but 5 isozymes of ${\beta}-galactosidase$ were resolved. The activities of the enzymes were relatively high and gel filtration showed that they differed in molecular weight. Hemicellulose content decreased during ripening and softening. The molecular weight profiles shifted from high molecular weight to low molecular weight polymers during ripening. The changes in cell walls that may be associated with fruit softening involve the alteration of hemicellulose prior to the degradation of wall-bound uronic acid. It is suggested that the decrease in cell wall galactose involved changes in turnover of new cell wall components.

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광도전성저항을 이용한 열선유속계의 온도보상 (Temperature Compensation of Hot-Wire Anemometer with Photoconductive Cell)

  • 이신표;고상근
    • 대한기계학회논문집B
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    • 제20권1호
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    • pp.295-303
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    • 1996
  • A new temperature compensation technique for hot-wire anemometer is proposed in this article. In contrast to the available compensation techniques, a photoconductive cell is introduced here as a variable resistor in the bridge. The major advantage of adopting an active component such as photoconductive cell is that temperature compensation can be achieved by using any kind of temperature sensors, once the output of temperature sensor is given as a voltage. Thereby, the temperature compensation can be made automatically and intelligently by a computer software or a hardware device. Validation experiments using a photoconductive cell with a thermocouple-thermometer are conducted in the temperature range from 3$0^{\circ}C$ to 5$0^{\circ}C$ and the velocity ranges from 8 m/s to 18 m/s.

황금 에탄올 및 열수 추출물의 피부 개선 연구 (A Study on the Skin Improvement of Ethanol and Hot Water Extracts from Scutellaria baicalensis)

  • 조성미;원유림;박진오;이혜자
    • 대한화장품학회지
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    • 제49권2호
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    • pp.183-192
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    • 2023
  • 본 연구에서는 황금 70% 에탄올 및 열수 추출물의 항산화, 항염, 미백, 보습, 세포 재생 및 자외선 및 블루라이트에 대한 세포 보호 효능을 확인하였다. 항산화 실험 결과, 70% 에탄올 및 열수 추출물 모두 DPPH 라디칼 소거 활성을 나타내었으며, 항염 실험 결과, 70% 에탄올 및 열수 추출물 모두 NO, 전염증성 cytokine(IL-6) 및 PGE2의 생성을 억제하는 것을 확인하였다. 미백 실험 결과, 70% 에탄올 추출물과 열수 추출물 모두 멜라닌 생성을 저해하였으며, 보습 실험 결과, 70% 에탄올 및 열수 추출물 모두 보습 인자인 HA의 생성량이 증가시키는 것을 확인하였다. UVB 및 블루라이트에 대한 세포 보호 효과를 분석한 결과, 70% 에탄올 추출물과 열수 추출물 모두 UVB에 대한 세포 보호 효능을 나타내었으며, 70% 에탄올 추출물은 블루라이트에 대한 세포 보호 효능 또한 나타내었다. 또한, 세포 이동 및 증식 효능을 분석한 결과, 70% 에탄올 추출물에서 세포 성장이 촉진되는 것을 확인하였다. 이러한 결과를 바탕으로 황금 70% 에탄올 추출물, 열수 추출물은 항산화, 항염, 미백, 피부재생, 자외선 및 블루라이트에 대한 세포 보호 효과가 있는 화장품 관련 천연소재로써의 활용가능성이 있는 것으로 사료된다.

광도전성저항을 이용한 열선유속계의 하드웨어적 온도보상에 관한 연구 (Hardware temperature compensation technique for hot-wire anemometer by using photoconductive cell)

  • 이신표;고상근
    • 대한기계학회논문집B
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    • 제20권11호
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    • pp.3666-3675
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    • 1996
  • A new hardware temperature compensation method for hot-wire anemometer is investigated and an analog compensating circuit is proposed in this article. A photoconductive cell is introduced here as a variable resistor in the anemometer bridge and the linearized output of a thermistor is used to monitor the input of the photoconductive cell. In contrast with the conventional method, any type of temperature sensor can be used for compensation if once the output of thermometer varies linearly with temperature. So the present technique can diversify the compensating means from a conventional passive compensating resistance to currently available thermometers. Because the resistance of a photoconductive cell can be set precisely by adopting a stabilizing circuit whose operation is based on the integration function of the operational amplifier, the accuracy of compensation can be enhanced. As an example of linearized thermometer, thermistor sensor whose output is linearized by a series resistor was used to monitor the fluid temperature variation. Validation experiment is conducted in the temperature ranged from 30 deg. C to 60 deg. C and the velocity up to 40 m/s. It is found that the present technique can be adopted as a compensating circuit for anemometer and hot-wire type airflow meter.

귀비총명탕 열수추출물과 초미세분말제형이 Alzheimer's Disease 병태 모델에 미치는 영향 (Effect of KwyBiChongMung-Tang Hot Water Extract & Ultra-fine Powder on the Alzheimer's Disease Model)

  • 이승희;이상룡;정인철
    • 동의생리병리학회지
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    • 제21권4호
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    • pp.921-933
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    • 2007
  • This experiment was designed to investigate the effects of the KBCMT hot water extract & ultra-fine powder on Alzheimer's Disease Model Induced by ${\beta}A$. The effects of the KBCMT hot water extract on expression of $IL-1{\beta}$, IL-6, $TNF-{\alpha}$, NOS-II, COX-2 mRNA and production of $IL-1{\beta}$, IL-6, $TNF-{\alpha}$, NO in BV2 microglial cell line treated by lipopolysacchaide(LPS). The effects of the KBCMT hot water extract & ultra-fine powder on (1) the behavior (2) expression of $IL-1{\beta}$, $TNF-{\alpha}$, MDA, CD68 and CD11b; (3) AChE in serum (4) the infarction area of the hippocampus, and brain tissue injury in Alzheimer's diseased mice induced with ${\beta}A$ were investigated. The KBCMT hot water extract suppressed the expression of $IL-1{\beta}$, IL-6 and $TNF-{\alpha}$ mRNA in BV2 microglia cell line treated with LPS. The KBCMT hot water extract suppressed the production of $IL-1{\beta}$, IL-6, $TNF-{\alpha}$, NO in BV2 microglial cell line treated with LPS. The KBCMT hot water extract & ultra-fine powder a significant inhibitory effect on the memory deficit was shown for the mice with Alzheimer's disease induced by ${\beta}A$ in the Morris water maze experiment, which measured stop-through latency and distance movemet-through latency The KBCMT ultra-fine powder suppressed the expression of TNF-a protein significantly in the microglial cell of mice with Alzheimer's disease induced by ${\beta}A$. The KBCMT hot water extract & ultra-fine powder reduced the MDA and suppressed the over-expression of CD68, CD11b in the mice with Alzheimer's disease induced by ${\beta}A$. The KBCMT hot water extract & ultra-fine powder decreased AChE significantly in the serum of the mice with Alzheimer's disease induced by ${\beta}A$. The KBCMT hot water extract & ultra-fine powder reduced infarction area of hippocampus, and controlled the injury of brain tissue in the mice with Alzheimer's disease induced by ${\beta}A$. The KBCMT hot water extract & ultra-fine powder reduced the tau protein, GFAP, and presenilin1, 2 of hippocampus in the mice with Alzheimer's disease induced by ${\beta}A$. These results suggest that the KBCMT hot water extract & ultra-fine powder may be effective for the prevention and treatment of Alzheimer's disease. Investigation into the clinical use of the KBCMT hot water extract & ultra-fine powder for Alzheimer's disease is suggested for future research.