• 간호행정학회지
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• 제14권3호
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• pp.219-228
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• 2008

Purpose: The purpose of this study was to develop a measurement scale of nursing competence for nurses working in general wards, and to test the validity and reliability of the scale. Method: A methodological study design was used, consisting of 3 steps as conceptual framework decision, measurement items development, and testing of validity and reliability. In order to verify content validity, 16 experts reviewed the concept of each competences and measurement items. The developed measurement items were tested from 301 nurses in one hospital. Factor analysis and item analysis were applied to establish the scale's construct validity and reliability. Result: The final scale consists of nine dimensions with 70 items. The overall scale reliability had a Cronbach's alpha of 0.98, and the demensions Cronbach's alpha ranged from 0.88 to 0.95. The factor loading of construct validity was from 0.40 to 0.83. The explained variance from the 9 extracted factors was 70.93% of the total variance, and final factors were labeled as critical thinking, resources management and professional development, ability of ward management, application of nursing process, ethical accountability, respectful consideration, patient centered approach, crisis management, and leadership. Conclusion: This measurement scale can be utilized to evaluate nursing competence for nurses working in general wards.

• 품질경영학회지
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• 제42권1호
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• pp.71-79
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• 2014

Purpose: The purpose of this study is to develop the methods for evaluating patients' queue environment using decision tree and queueing theory. Methods: This study uses CHAID decision tree and M/G/1 queueing theory to estimate pain point and patients waiting time for medical service. This study translates hospital physical data process to logical process to adapt queueing theory. Results: This study indicates that three nodes of the system has predictable problem with patients waiting time and can be improved by relocating patients to other nodes. Conclusion: This study finds out three seek points of the hospital through decision tree analysis and substitution nodes through the queueing theory. Revealing the hospital patients' queue environment, this study has several limitations such as lack of various case and factors.

• Journal of Preventive Medicine and Public Health
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• 제21권2호
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• pp.442-450
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• 1988

충남지역에 소재한 모 대학 병원에 1986년 11월부터 1987년 11월까지의 기간중에 입원한 환자 1,400명중 본 조사에 응한 1,319명을 조사대상으로 병원써비스의 사회적 작용 과정 측면에서의 의료기술외적 제조건들이 병원 선택 태도에 미치는 영향을 설문지 조사방법으로 실시한 바 아래와 같은 결과를 얻어 요약한다. 1. 창구직원의 친절, 환자의 병실 방문 요청에 대한 의사 또는 간호사의 반응, 의사의 병세 설명에 대한 성실성, 주치의의 진료성실성, 의사에 대한 환자의 신뢰감, 간호사의 친절, 간호사에 대한 환자의 신뢰감, 병원의 청결, 환의의 청결, 침구의 청결, 병원식, 배선원의 친절, 병원의 휴식분위기 등 모든 조건이 비록 결정적인 병원선택의 조건은 아니나 복합적으로 작용하여 병원선택의 기준이 되고 있다. 2.사회적 작용 과정 측면에서의 병원써비스 조건들은 의료시설 또는 의료기술을 동기로 병원에 입원한 경우보다 단순히 교통조건을 동기로 병원에 입원한 경우가 차후 병원선택의 태도에 더욱 더 영향을 미치는 것으로 추정된다.

• The Korean Journal of Physiology and Pharmacology
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• 제25권2호
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• pp.131-137
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• 2021

Aging is the process spontaneously occurred in living organisms. Cardiac fibrosis is a pathophysiological process of cardiac aging. Mangiferin is a well-known C-glucoside xanthone in mango leaves with lots of beneficial properties. In this study, rat model of cardiac fibrosis was induced by injected with 150 mg/kg/d D-galactose for 8 weeks. The age-related cardiac decline was estimated by detecting the relative weight of heart, the serum levels of cardiac injury indicators and the expression of hypertrophic biomakers. Cardiac oxidative stress and local inflammation were measured by detecting the levels of malondialdehyde, enzymatic antioxidant status and proinflammatory cytokines. Cardiac fibrosis was evaluated by observing collagen deposition via masson and sirius red staining, as well as by examining the expression of extracellular matrix proteins via Western blot analysis. The cardiac activity of profibrotic TGF-β1/p38/MK2 signaling pathway was assessed by measuring the expression of TGF-β1 and the phosphorylation levels of p38 and MK2. It was observed that mangiferin ameliorated D-galactose-induced cardiac aging, attenuated cardiac oxidative stress, inflammation and fibrosis, as well as inhibited the activation of TGF-β1/p38/MK2 signaling pathway. These results showed that mangiferin could ameliorate cardiac fibrosis in D-galactose-induced aging rats possibly via inhibiting TGF-β/p38/MK2 signaling pathway.

• Biomolecules & Therapeutics
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• 제31권5호
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• pp.496-514
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• 2023

Cold atmospheric plasma (CAP), a redox modulation tool, is capable of inhibiting a wide spectrum of cancers and has thus been proposed as an emerging onco-therapy. However, with incremental successes consecutively reported on the anticancer efficacy of CAP, no consensus has been made on the types of tumours sensitive to CAP due to the different intrinsic characteristics of the cells and the heterogeneous design of CAP devices and their parameter configurations. These factors have substantially hindered the clinical use of CAP as an oncotherapy. It is thus imperative to clarify the tumour types responsive to CAP, the experimental models available for CAP-associated investigations, CAP administration strategies and the mechanisms by which CAP exerts its anticancer effects with the aim of identifying important yet less studied areas to accelerate the process of translating CAP into clinical use and fostering the field of plasma oncology.

• 간호행정학회지
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• 제13권1호
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• pp.82-97
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• 2007

Purpose: This study was to investigate the relationships among nurse managers' participation in decision-making process relation to human resource management and the influencing factors. Method: The subjects were 198 nurse managers who were in general hospitals over 900 beds. The data were collected from January 13 to March 13, 2006. The SPSS PC+ 12.0 program was used to analyze the data. Result: The nurse managers had greater participation in the identification phase of decision making than selection phase. The mean scores of three phases were significantly different. The satisfaction of decision making was evaluated. The higher participation in decision making, the higher satisfaction of decision making. Nurse managers' decision style tended to be more participative than autocratic. Personal and organizational factors(age and decentralization) influenced positively on participation in decision making. Decentralization and span of control influenced positively on satisfaction in decision making. Conclusion: It is necessary to permit the participation in decision making for nurse managers.

• International Journal of Quality Innovation
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• 제8권1호
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• pp.27-39
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• 2007

In this study, we investigated the effects of service quality on customer satisfaction in education service industry, focusing on the opinion of dissatisfied customers who have decided to switch the service provider. Additionally, in professional service industries such as law, hospital, and education, customers expect visible results which are often ignored in earlier service quality studies. Customer's comprehensive assessment of the professional service depends on both process quality experienced during service delivery and service result perceived after service delivery. The hypotheses on the causal relationships among service quality, customer satisfaction, intention to switch service provider, and service performance were tested by using Structural Equation Model.

• 한국엔터테인먼트산업학회논문지
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• 제13권6호
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• pp.319-328
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• 2019

병원 경영에서 가장 중요한 것은 환자들의 필요와 욕구를 파악하는 것이라고 할 수 있다. 이 연구에서는 이를 위해 상대적 중요도를 파악할 수 있는 분석기법인 AHP를 이용하여 환자들이 병원을 선택함에 있어서 AHP의 적용을 통한 그 요인들 간의 상대적인 우선순위를 파악하려는 데 그 목적이 있다. 환자들의 병원선택요인을 파악함으로써 의료기관이 중요성을 분석하여 병원이미지 개선 및 의료의 질 향상에 도움이 될 수 있도록 모색해 보고자 한다. 먼저 12개의 병원선택요인 중에서 병원의 전문성, 다양한 진료과목, 직원의 친절도, 의사의 설명 및 진찰시간 등과 같이 환자와 직접적으로 연관되어 있는 요인들이 중요도 및 가중치가 높게 나타났다. 또한 병원 주차장, 대중교통의 편의성, 의료장비 등이 상대적으로 중요도 및 가중치가 낮게 나타났다. 이러한 연구 결과는 병원의 효과적인 이미지 개선 및 의료의 질 향상 전략에 중요하다고 볼 수 있다. 따라서 광주시 소재 의료기관들은 병원 마케팅을 위해 병원선택에 영향을 미치는 요인들을 고려한 병원경영 방침을 개선하여 병원이미지 개선 및 의료의 질 향상에 노력할 필요가 있다.

• 한국멀티미디어학회논문지
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• 제11권3호
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• pp.386-397
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• 2008

본 연구는 HL7 버전 3의 객체지향 분석 및 개발 방법론인 HL7 개발 프레임워크(HDF)를 이용하여 투약관리의 임상문서구조의 개발을 통해 임상활동의 표준화 데이터 모델을 구현하는 것을 제안한다. 투약관리는 의료현장에서 임상전문가가 행하는 가장 중요한 업무이다. 표준화 된 데이터 모델 및 구조화된 병원정보시스템은 근거기반 임상 활동을 이루기 위해 상당히 중요한 과제이다. 임상문서구조를 생성하기 위해서 HDF와 제공된 도구들을 사용하였다. 본 연구자들은 투약관리활동에서 HDF의 각 단계의 다이어그램을 생성할 수 있었다. 그 결과, 임상 활동 중 하나인 투약관리에 대한 표준화 정보모델을 생성하였다. 이 모델은 보건의료정보시스템을 모델링하기 위한 정보통신개발자들에게 국제 표준방법론을 이해하기 위한 기본적 개념모델이 될 것이다.

• 한국임상약학회지
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• 제22권1호
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• pp.21-29
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• 2012

Modern biologics are biotechnology-derived therapeutics, including recombinant therapeutic proteins like monoclonal antibodies, cytokines and tissue growth factors. Although the pharmacokinetics of therapeutic biologics should be evaluated based on the same general principles as small molecules, careful considerations should be given to bioanalytics and pharmacokinetics when designing pharmacokinetic studies of biologics during their drug development, due to their different physicochemical properties compared with small molecules. The aim of this study was to develop a draft guidance on pharmacokinetic studies of therapeutic biologics in clinical studies. All the elements outlined in the current Food and Drug Administration (FDA), European Medicinal Agency (EMEA), and International Conference on Harmonisation (ICH) guidelines and regulations, and the related literatures previously published were searched and evaluated. In this draft guidance, the specific problems related to the pharmacokinetics of therapeutic biologics that need special consideration during drug development process were addressed, and differences in pharmacokinetic characteristics between biologics and small molecules affecting the content of the development programme were presented.